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中华内科杂志 1989年第2期28卷 95-98页

作者：孟迅吾 Holi.,mf 中国医学科学院北京协和医院北京美国麻省总医院美国

Melanoma of the rectum: A rare entity

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World Journal of Gastroenterology 2008年第10期14卷 1633-1635页

作者： PM van Schaik mf Ernst HA Meijer K Bosscha Jeroen Bosch Hospital Department of Surgery 's-Hertogenbosch 5211 The Netherlands Jeroen Bosch Hospital Department of Pathology 's-Hertogenbosch 5211 The Netherlands

A 41-year-old man presented with a 6-mo history of changed defecation and rectal bleeding. A 3-cm polypoid tumor of the lower rectum was found at rectosigmoidos- copy, which proved to be a leiomyosarcoma upon biopsy. Dissemination studies did not show any metastases. He was underwent to an abdomino-perineal resection (APR). Histopathology of the specimen showed a melanoma (S-100 stain positive). Two years after the resection, me- tastases in the abdomen and right lung were found. He died one and half years later. Primary anorectal melano- ma is a rare and very aggressive disorder. According to current data, one should always perform a S-100 stain when anorectal sarcoma is suspected. A positive S-100 stain suggests the tumour to be most likely a melanoma. Subsequently, thorough dissemination studies need to be performed. Depending on the outcome of the dissemina- tion studies, a surgical resection has to be performed. Nowadays, a sphincter-saving local excision combined with adjuvant loco-regional radiotherapy should be pre- ferred in case of small tumors. The same loco-regional control is achieved with less "loss of function" compared to non-sphincter saving surgery. Only in the case of large and obstructing tumors an abdomino-perineal resection is the treatment of choice.

关键词： Melanoma Rectum Abdomino-perineal resection Cancer Surgery

Cyclophosphamide and Etoposide as a Salvage Treatment in Metastatic Osteosarcoma Patients

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Journal of Cancer Therapy 2018年第7期9卷 529-537页

作者： Fatma mf Akl Mohamed Farouk Akl Clinical Oncology and Nuclear Medicine Department Mansoura University Mansoura Egypt

Background and Objective: Osteosarcoma is a rare bone cancer with approximately 30% - 35% of patients who will relapse either systemically or locally, with the lung being the commonest site of relapse. The objective of this trial was to evaluate the efficacy of cyclophosphamide and etoposide, in treatment of metastatic osteosarcoma patients progressed after one or more chemotherapy lines, with the progression free survival and treatment response as the primary endpoints, while the secondary endpoints were overall survival and treatment toxicity. Patients and Methods: Twenty seven metastatic osteosarcoma patients were enrolled into this trial and received cyclophosphamide and etoposide chemotherapy. Cyclophosphamide was given at a dose of 500 mg/m2 per day, I.V for 5 days and etoposide (100 mg/m2 per day I.V for 5 days). Response was assessed after 3 cycles according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Chemotherapy Toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE). Results: The median overall survival time and progression-free survival were 12 months and 8 months, respectively. Four patients (14.8%) achieved partial response;14 patients (51.9%) had stationary disease (SD);and 9 (33.3%) expressed tumor progression. Hematologic toxicity was the main toxicity. None of the patients had G4 or life threatening toxicities. Conclusion: The combination of cyclophosphamide and etoposide represents an efficient and tolerable treatment option for patients with metastatic osteosarcoma.

关键词： Cyclophosphamide Etoposide Metastatic Osteosarcoma Salvage Chemotherapy

与红细胞膜及细胞骨架相互作用的疟原虫蛋白质

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国外医学（寄生虫病分册） 1992年第6期19卷 255-257页

作者： Wiser mf 江钢锋

感染疟原虫的红细胞膜表面存在源于疟原虫的某些蛋白质。这些蛋白质系由裂殖子侵入红细胞时滞留于红细胞膜上及由疟原虫在红细胞内生长发育过程中产生并通过某些机制转运到红细胞膜表面。这些蛋白质通称为疟原虫感染的红细胞骨架相关蛋... 详细信息

感染疟原虫的红细胞膜表面存在源于疟原虫的某些蛋白质。这些蛋白质系由裂殖子侵入红细胞时滞留于红细胞膜上及由疟原虫在红细胞内生长发育过程中产生并通过某些机制转运到红细胞膜表面。这些蛋白质通称为疟原虫感染的红细胞骨架相关蛋白。本文对其来源、特性、功能及与红细胞膜的相互作用进行了探讨。

关键词：疟原虫蛋白红细胞膜细胞骨架

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人类免疫缺陷病毒1型在人结肠细胞中的表达

国外医学（微生物学分册） 1993年第1期16卷 18-18,24页

作者： Kagnoff mf 吕世静

本文报告采用3株人结肠上皮细胞系(Sw_(620)、HT_(20)和T_(84))及人类免疫缺陷病毒(HIV)长末端重复序列(LTR)报道基因嵌合构成物作为研究结肠上皮细胞内基因转录调节的可用模型。

关键词：艾滋病毒结肠细胞表达

Effect of BATHE interview technique on patient satisfaction in an ambulatory family medicine centre in South India

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Family Medicine and Community Health 2020年第4期8卷 14-19页

作者： Navnee Chengappa Prince Christopher Rajkumar Honest Kirubah David Ruby Angeline Pricilla Sajitha mf Rahman Grace Rebecca Department of Family Medicine Christian Medical CollegeVelloreTamil NaduIndia Department of Community Medicine Christian Medical CollegeVelloreTamil NaduIndia Department of Biostatistics Christian Medical CollegeVelloreTamil NaduIndia

Objective The objective of the study is to determine the effect of background,affect,trouble,handling and empathy(BATHE)versus usual interview technique on patient satisfaction during regular consultation with family physicians in ambulatory *** The research design was a prospective,randomised control *** The trial took place in a family practice unit in South India,which was one of the clinical service units of the academic Department of Family Medicine of a tertiary *** The eligible participants were adults above the age of 18 years,who did not have any acute presenting *** participants should have given consent and also not have any cognitive disability.A total of 138 participants took part in the trial,70 in BATHE group and 68 in the non-BATHE *** participants entering the trial completed the *** The BATHE group had a significantly higher mean score for questions grouped under professional *** included questions on whether the patient felt that the physician treated them as a person and also whether they felt the appropriate clinical examination was communicated to *** questionnaire used for scoring satisfaction had 18 questions with a maximum possible score of *** taking a cut-off of 75%(68)from the total possible score of 90,72.9%(51)of the participants for whom the BATHE consultation technique was used were satisfied as compared with only 55.9%(30)for whom the routine consultation was carried *** was statistically significant(χ2=11.15,p value=0.0006)Conclusion The study suggests that using BATHE in this family practice centre is beneficial in improving the perception of person centeredness in the ***,further studies ruling out all possible bias are needed in our setting before the range of probable benefits of the BATHE technique can be fully gauged.

关键词： interview centre routine

Does granulocyte-colony stimulating factor administration induce damage or repair response in schistosomiasis?

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World Journal of Hepatology 2010年第12期2卷 434-441页

作者： Lobna Y Ghanem Uta Dahmen Olaf Dirsch Mona mf Nosseir Soheir S Mahmoud Wafaa AF Mansour Department of Electron Microscope Theodor Bilharz Research Institute Department of General Visceral and Transplantation SurgeryUniversity Hospital Essen Division of Pathology German Heart Institute Department of Pathology Theodor Bilharz Research Institute Department of Parasitology Theodor Bilharz Research Institute Department of Immunology Theodor Bilharz Research Institute

AIM:To introduce Granulocyte-colony stimulating factor (G-CSF) as a new therapeutic modality for schistosomiasis through stem cell mobilization,immunomodulation or fibrosis remodeling. METHODS:In this study,a 5 d course of human recombinant G-CSF (100 μg/kg sc) was applied to Schis-tosoma mansoni-infected mice at different stages of disease (5 d before infection as well as 3,5 and 7 wk post-infection). The animals were sacrificed at 10 d as well as 4,6 and 8 wk post infection. Mice were examined for:(1) Total leukocyte count which is an accepted surrogate marker for the stem cell mobilization into the circulation; (2) Egg count in intestine and liver tissue to assess the parasitic load; and (3) Histopathological changes in Hx/E and Masson trichrome stained sections as well as collagen content in Sirius redstained liver sections to determine the severity of liver fibrosis. RESULTS:Mice developed leukocytosis. The egg load and the number of granulomas were not affected by the G-CSF treatment but there was an obvious change in the composition of granulomas towards an increased cellularity. Moreover,fibrosis was significantly decreased in treated groups compared to untreated animals (collagen content either preinfection or at 3 and 5 wk post infection:5.8 ± 0.5,4.7 ± 0.5,4.0 ± 0.7 vs 8.2 ± 0.9; P ≤ 0.01). CONCLUSION:Although G-CSF did not cause direct elimination of the parasite,it enhanced granulomatous reaction and reduced the fibrosis. Further investigation of the underlying mechanisms of these two actions is warranted.

关键词： Schistosomiasis Granulocyte-colony stimulating factor Periovular granuloma Fibrosis Immunomodulation Stem cell mobilization

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血小板输血指南

国外医学（输血及血液学分册） 1993年第4期16卷 231-234页

作者： Murphy mf 林岳兴

本文的宗旨是提供血小板输血疗法指南,其中包括血小板输血适应证;血小板浓缩剂的控制和管理;血小板输血效果的评估和血小板输血无效性病人的处理,以及血小板输血后的反应等。此外,还就对可能需要反复输血的病人进行输血支持治疗提出一... 详细信息

本文的宗旨是提供血小板输血疗法指南,其中包括血小板输血适应证;血小板浓缩剂的控制和管理;血小板输血效果的评估和血小板输血无效性病人的处理,以及血小板输血后的反应等。此外,还就对可能需要反复输血的病人进行输血支持治疗提出一些建议。

关键词：血小板输血

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胎儿和新生儿同种免疫性血小板减少症的处理

国外医学（输血及血液学分册） 1989年第3期12卷 159-160页

作者： Reznikoff-Etievant mf 兰炯采

围产期同种免疫性血小板减少症(PAIT)类似于母婴红细胞不合引起的胎儿或婴儿溶血病。当母亲被胎儿的血小板抗原致敏后,便会产生血小板特异性抗体。如果这种抗体为IgG,便能通过胎盘进入胎儿血循环,破坏胎儿血小板。有人报告1/1000新生儿... 详细信息

围产期同种免疫性血小板减少症(PAIT)类似于母婴红细胞不合引起的胎儿或婴儿溶血病。当母亲被胎儿的血小板抗原致敏后,便会产生血小板特异性抗体。如果这种抗体为IgG,便能通过胎盘进入胎儿血循环,破坏胎儿血小板。有人报告1/1000新生儿患同种免疫性血小板减少症,其中9％为PAIT。

关键词：血小板减少症胎儿新生儿

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神经网络在肌电信号分析中的应用

国外医学（生物医学工程分册） 1991年第6期14卷 324-327页

作者： kelly mf 邰常峰

多自由度假肢可以用皮肤表面电极记录的肌电信号来控制。假肢的各种控制功能可以通过识别不同的肌肉收缩来实现。这种控制方法自第二次世界大战以来就已开始采用。为了识别不同肌肉的收缩,使用了包括单电极和多电撅方式在内的各种电极... 详细信息

多自由度假肢可以用皮肤表面电极记录的肌电信号来控制。假肢的各种控制功能可以通过识别不同的肌肉收缩来实现。这种控制方法自第二次世界大战以来就已开始采用。为了识别不同肌肉的收缩,使用了包括单电极和多电撅方式在内的各种电极设置方式。在临床应用中,考虑到电极与皮肤接触的可靠性和电极位置的准确性,一般不希望使用多电极方式。因此,

关键词：肌电信号神经网络分析控制