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Salsolinol as an RnA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of n~6-methyladenosine(m~6A)RnA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RnA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRnA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RnA methylation and suggest that Sal may act as an RnA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RnA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RnA methylation salsolinol YAP1 YTHDF2

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

Effect of noisy Fitness in Real-Time Strategy Games Player Behaviour Optimisation Using Evolutionary Algorithms

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Journal of Computer Science & Technology 2012年第5期27卷 1007-1023页

作者： Antonio M. Mora Antonio Fernndez-Ares juan J. merelo Pablo García-Snchez Carlos M. Fernandes Computer Architecture and Technology Department University of Granada Institute for Systems and Robotics Technical University of Lisbon

This paper investigates the performance and the results of an evolutionary algorithm （EA） specifically designed for evolving the decision engine of a program （which, in this context, is called bot） that plays Planet Wars. This game, which was chosen for the Google Artificial Intelligence Challenge in 2010, requires the bot to deal with multiple target planets, while achieving a certain degree of adaptability in order to defeat different opponents in different scenarios. The decision engine of the bot is initially based on a set of rules that have been defined after an empirical study, and a genetic algorithm （GA） is used for tuning the set of constants, weights and probabilities that those rules include, and therefore, the general behaviour of the bot. Then, the bot is supplied with the evolved decision engine and the results obtained when competing with other bots （a bot offered by Google as a sparring partner, and a scripted bot with a pre-established behaviour） are thoroughly analysed. The evaluation of the candidate solutions is based on the result of non-deterministic battles （and environmental interactions） against other bots, whose outcome depends on random draws as well as on the opponents＇ actions. Therefore, the proposed GA is dealing with a noisy fitness function. After analysing the effects of the noisy fitness, we conclude that tackling randomness via repeated combats and reevaluations reduces this effect and makes the GA a highly valuable approach for solving this problem.

关键词： real-time strategy game genetic algorithm noisy fitness player behaviour optimisation parameter adaptation

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《健康全书》与中世纪西欧养生文化

古代文明（中英文） 2025年第1期19卷 43-49,M0004页

作者：刘娟中国人民大学历史学院北京100872

养生指南是欧洲中世纪兴起的一种指导个人保健的书籍,《健康全书》是其典型代表。“非自然理论”为这类文本提供了理论支撑,它强调个人的主观能动性,同时侧重于对整体健康的关注。作为中世纪养生文化的重要载体,养生指南经历了从上层精... 详细信息

养生指南是欧洲中世纪兴起的一种指导个人保健的书籍,《健康全书》是其典型代表。“非自然理论”为这类文本提供了理论支撑,它强调个人的主观能动性,同时侧重于对整体健康的关注。作为中世纪养生文化的重要载体,养生指南经历了从上层精英向大众广泛传播的过程,其中传达的医学理论不仅成为指导个人规范生活方式的参考,也启发了该时期城市的公共卫生建设。对养生指南的考察,有助于深化对中世纪预防医学发展的认识。

关键词：《健康全书》养生指南非自然因素整体健康

Pancreas sparing duodenectomy in the treatment of primary duodenal neoplasms and other situations with duodenal involvement

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 485-492页

作者： juli Busquets Josefina Lopez-Dominguez Ana Gonzalez-Castillo Marina Vila nuria Pelaez Lluis Secanella Emilio Ramos juan Fabregat Department of Hepatobiliary and Pancreatic Surgery Hospital Universitari de BellvitgeResearch Group of Hepato-biliary and Pancreatic DiseasesInstitut d'InvestigacióBiomèdica de Bellvitge-IDIBELLBarcelona UniversityL’Hospitalet de LlobregatBarcelona 08907Spain Department of General Surgery Hospital del MarBarcelona 08907Spain Department of General Surgery Hospital de MataróBarcelona 08907Spain

Background:There are no clearly defined indications for pancreas-preserving *** present study aimed to analyze postoperative morbidity and the outcomes of patients undergoing pancreaspreserving ***:Patients undergoing pancreas-preserving duodenectomy from April 2008 to May 2020 were *** divided the series according to indication:scenario 1,primary duodenal tumors;scenario 2,tumors of another origin with duodenal involvement;and scenario 3,emergency ***:We included 35 *** duodenectomy was performed in 1 patient of adenomatous duodenal polyposis,limited duodenectomy in 7,and third+fourth duodenal portion resection in *** indications for scenario 1 were gastrointestinal stromal tumor(n=13),adenocarcinoma(n=4),neuroendocrine tumor(n=3),duodenal adenoma(n=1),and adenomatous duodenal polyposis(n=1);scenario 2:retroperitoneal desmoid tumor(n=2),recurrence of liposarcoma(n=2),retroperitoneal paraganglioma(n=1),neuroendocrine tumor in pancreatic uncinate process(n=1),and duodenal infiltration due to metastatic adenopathies of a germinal tumor with digestive hemorrhage(n=1);and scenario 3:aortoenteric fistula(n=3),duodenal trauma(n=1),erosive duodenitis(n=1),and biliopancreatic limb ischemia(n=1).Severe complications(Clavien-Dindo≥IIIb)developed in 14%(5/35),and postoperative mortality was 3%(1/35).Conclusions:Pancreas-preserving duodenectomy is useful in the management of primary duodenal tumors,and is a technical option for some tumors with duodenal infiltration or in emergency interventions.

关键词： Duodenectomy Duodenal neoplasms Organ sparing treatments Pancreatic surgery Duodenal diseases

Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

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Journal of Geriatric Cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez juan Luis Bonilla-Palomas María Anguita-Gámez María García JoséLuis Bernal náyade Del Prado Cristina Fernández-Pérez julián Pérez-Villacastin juan JoséGómez-Doblas Francisco Javier Elola Cardiology Department Hospital Universitario Severo OchoaMadridSpain Cardiology Department Hospital Universitario Reina SofíaCórdobaSpain Cardiology Department Hospital San Juan de la CruzÚbedaSpain Cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management Control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain Cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BACKGROUnD The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older ***,there are little data on in-hospital mortality in patients with HF≥75 years in *** A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and *** was performed using the International Classification of Diseases,10th ***≥75 years with HF as the principal diagnosis were *** calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(ICCU)in the *** We included 354,792 HF episodes of patients over 75 *** mean age was 85.2±5.5 years,and 59.2%of patients were *** most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%CI:1.07–1.07,Pnd was lower in women(OR=0.96,95%CI:0.92–0.97,Pn predictors of mortality were the presence of cardiogenic shock(OR=19.5,95%CI:16.8–22.7,Pnd advanced cancer(OR=2.6,95%CI:2.5–2.8,Pn hospitals with ICCU,the in-hospital risk-adjusted mortality tended to be lower(OR=0.85,95%CI:0.72–1.00,P=0.053).COnCLUSIOnS In-hospital mortality in patients with HF≥75 years between 2016 and 2019 was 12.7%,higher in males and elderly *** main predictors of mortality were cardiogenic shock,stroke,and advanced *** was a trend toward lower mortality in centers with an ICCU.

关键词： patients mortality diagnosis

Using GEDI lidar data and airborne laser scanning to assess height growth dynamics in fast-growing species:a showcase in Spain

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Forest Ecosystems 2021年第1期8卷 182-198页

作者： juan Guerra-Hernández Adrián Pascual 3edata Centro de iniciativas empresariaisFundación CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisbonPortugal Center for Global Discovery and Conservation Science Arizona State UniversityHiloHA 96720USA

Background:The nASA’s Global Ecosystem Dynamics Investigation(GEDI)satellite mission aims at scanning forest ecosystems on a multi-temporal short-rotation *** GEDI data can validate and update statistics from nationwide airborne laser scanning(ALS).We present a case in the northwest of Spain using GEDI statistics and nationwide ALS surveys to estimate forest dynamics in three fast-growing forest ecosystems comprising 211,346 *** objectives were:i)to analyze the potential of GEDI to detect disturbances,ii)to investigate uncertainty source regarding non-positive height increments from the 2015–2017 ALS data to the 2019 GEDI laser shots and iii)to estimate height growth using polygons from the Forest Map of Spain(FMS).A set of 258 national Forest Inventory plots were used to validate the observed height ***:The spatio-temporal assessment from ALS surveying to GEDI scanning allowed the large-scale detection of *** mean annual height growths were 0.79(SD=0.63),0.60(SD=0.42)and 0.94(SD=0.75)m for Pinus pinaster,Pinus radiata and Eucalyptus spp.,*** median annual values from the ALS-GEDI positive increments were close to nFI-based growth values computed for Pinus pinaster and Pinus radiata,*** effect of edge border,spatial co-registration of GEDI shots and the influence of forest cover in the observed dynamics were important factors to considering when processing ALS data and GEDI ***:The use of GEDI laser data provides valuable insights for forest industry operations especially when accounting for fast ***,errors derived from positioning,ground finder and canopy structure can introduce uncertainty to understand the detected growth patterns as documented in this *** analysis of forest growth using ALS and GEDI would benefit from the generalization of common rules and data processing schemes as the GEDI mission is increasingly being utilized in the forest remote sensing community.

关键词： Forest inventory Productivity Multi-temporal LiDAR Full-waveform(FW) Satellite mapping

Carbon pool dynamics after variable retention harvesting in nothofagus pumilio forests of Tierra del Fuego

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Ecological Processes 2023年第1期12卷 64-82页

作者： Jimena E.Chaves Marie-Claire Aravena Acuña julián Rodríguez-Souilla juan M.Cellini nolan J.Rappa María V.Lencinas Pablo L.Peri Guillermo J.Martínez Pastur Centro Austral de Investigaciones Científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Laboratorio de Investigaciones en Maderas(LIMAD) Universidad Nacional de la Plata(UNLP)Diagonal 113469(1900)La PlataBuenos AiresArgentina nature Conservation&Landscape Ecology University of FreiburgTennenbacherstrasse 479106 FreiburgGermany Instituto nacional de Tecnología Agropecuaria(InTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Cc 332(9400)Río GallegosSanta CruzArgentina

Background It is necessary to determine the implications for managing forest stands using variable retention harvesting for maintaining carbon and for calculating the effects of different harvesting practices on above-and below-ground carbon balance in forest *** this context,forest carbon management has gained more attention among managers and policy-makers during recent *** aim of this study was to determine carbon pool dynamics in different forest ecosystem components after variable retention harvesting(VRH)to characterize the ecological stability and quantify the recovery rate through the years-after-harvesting(YAH).Methods Carbon pool compartmentalization of 14 different components was determined in 60 harvested and primary unmanaged forests during the first 18 YAH in Tierra del Fuego(Argentina).We compared them using uni-and multi-variate methods,relativizing the outputs with primary unmanaged *** We determined the effectiveness to retain carbon components in post-harvested stands under different retention strategies(aggregated ***).The balance among carbon pool components changed between managed and unmanaged stands across the YAH,and was directly related to the impact *** retention improved the ecological stability of the harvested areas,where the below-ground components were more stable than the above-ground *** recovery rate was directly related to the post-harvesting natural dynamics of the *** studied period was not enough to fully recover the C levels of primary unmanaged for-ests,but VRH showed advantages to increase the C pools in the managed *** Promoting VRH can improve sustainable forestry at the landscape level and in the long term,generating positive synergies with biodiversity and the provision of ecosystem *** study provides important new insights into forest carbon management,in particular to setting standards in carbon projects and sets the ground

关键词： Carbon reservoir Temperate forest Ecological stability Recovery rate Forest carbon management

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Within plate seismicity analysis in the segment between the high Cordillera and the Precordillera of northern Mendoza(Southern Central Andes)

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Geodesy and Geodynamics 2018年第1期9卷 13-24页

作者： julián Olivar Silvina nacif Lucas Fennell Andrés Folguera COnICET-Universidad de Buenos Aires Instituto de Estudios Andinos"Don Pablo Groeber"(IDEAN)Facultad de Ciencias Exactas y NaturalesPabellón 11Ciudad UniversitariaBuenos AiresC1428EGAArgentina COnICET-Instituto Geofisico-Sismológico"lng.F.S.Volponi"(IGSV) Ruta 12 km17 Jardfn de los Poetas MarquesadoRivadaviaProvincia de San JuanArgentina

Crustal seismicity in northwestern Mendoza Province in Argentina, corresponding to the transition zone between the Chilean-Pampean flat subduction zone（26.5-33.5°S） and the Southern Central Andes normal subduction zone to the south, is studied in order to i） identify its relationship with the mapped structure, ii）determine deformational mechanisms and iii） constrain the geometry of the fold and thrust belt in the lower crust. Through this, we aim to determine which are the structures that contribute to Andean construction, east of the Frontal Cordillera in Argentina and at the western Principal Cordillera in Chile. Data from a temporary local seismic network are reprocessed in order to achieve a precise location of hypocenters and, whenever possible, to build focal mechanisms. Results are interpreted and compared with previous seismic studies and structural models. Analyzed seismicity is grouped around the eastern front of Frontal Cordillera, with hypocenters mainly at depths of 25-40 km. Contrastingly, earthquakes in the Principal Cordillera to the west are located at the axial Andean sector and Chilean slope, with depths shallower than 15 km. Obtained focal mechanisms indicate mainly strike-slip displacements, left lateral at Frontal Cordillera and right lateral at Principal Cordillera. Based on these observations, new possible structural models are proposed, where seismogenic sources could be either associated with inherited basement structures from the Cuyania-Chilenia suture; or correspond to deep-blind thrusts linked with a deeper-than-previously-assumed decollement that could be shared between Frontal Cordillera and western Precordillera. This deeper decollement would coincide in turn with the one determined from receiver function analysis for the eastern Sierras Pampeanas in previous works, potentially implying a common decollement all through the fold and thrust belt configuration. Apart from this, a new interpretation of seismogenic structures in Principal

关键词： Crustal seismicity Seismogenic structures Frontal cordillera Blind thrusts Decollement