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Salidroside Inhibits Lipopolysaccharide-ethanol-induced Activation of Proinflammatory Macrophages via Notch Signaling Pathway

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Current Medical Science 2019年第4期39卷 526-533页

作者： Jian-sha LI Lu-yao fan meng-dan YUAN Ming-you xing Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology School of Basic Medical ScienceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Activation of macrophages is a key event for the pathogenesis of various inflammatory *** signaling pathway recently has been found to be a critical pathway in the activation of proinflammatory *** (Sal),one of main bioactive components in Rhodiola crenulata (*** Thoms) ***,reportedly possesses anti-inflammatory activity and ameliorates inflammation in alcohol-induced hepatic ***,whether Sal regulates the activation of proinflammatory macrophages through Notch signaling pathway remains *** present study investigated the effects of Sal on macrophage activation and its possible mechanisms by using both alcohol and lipopolysaccharide (LPS) to mimic the microenvironment of alcoholic *** of THP-1-derived macrophages exhibited that Sal could significantly decrease the expression of tumor necrosis factor-α(TNF-α),interleukinbeta (IL-1β)and IL-6 in the macrophages at both mRNA and protein ***,Sal significantly suppressed NF-kB activation via Notch-Hes signaling pathway in a dose-dependent ***,in the microenvironment of alcoholic liver,the expression of Notch-dependent pyruvate dehydrogenase phosphatase 1 (PDP1) was elevated,and that of Ml gene expression [inducible NO synthase (NOS2)] was *** changes could all be effectively ameliorated by *** aforementioned findings demonstrated that Sal could inhibit LPS-ethanol-induced activation of proinflammatory macrophages via Notch signaling pathway.

关键词： THP-1 macrophages Salidroside Notch tumor necrosis factor-α monocyte chemoattractant protei-1

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Low temperature synthesis of high-entropy(Y_(0.2)Yb_(0.2)Sm_(0.2)Eu_(0.2)Er_(0.2))_(2)O_(3)nanofibers by a novel electrospinning method

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Journal of Materials Science & Technology 2022年第8期103卷 215-220页

作者： Yan xing Wenqing Dan Yicun fan xing’ao Li New Energy Technology Engineering Lab of Jiangsu Province School of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China

High-entropy ceramics(HECs)show outstanding properties such as amorphous-like thermal conductivities,colossal dielectric constant,superionic conductivity,enhanced electromagnetic wave absorption ability,super hardness and strength,which are promising for structural and functional ***,the high synthesis temperature has become the bottleneck that hinders the scale-up production and practical applications of *** is thus appealing to develop a novel low-temperature process for the synthesis of *** demonstrate the feasibility of low-temperature synthesis,herein,an electrospinning method has been utilized,for the first time,for the synthesis of high-entropy(Y_(0.2)Yb_(0.2)Sm_(0.2)Eu_(0.2)Er_(0.2))_(2)O_(3)*** has been found that after electrospinning from liquid precursors single phase(Y_(0.2)Yb_(0.2)Sm_(0.2)Eu_(0.2)Er_(0.2))_(2)O_(3) solid solution with bixbyite structure can be formed by calcining at a temperature as low as 500℃,which is at least about 1000℃ lower than that used in the solid-state synthesis *** as-prepared(Y_(0.2)Yb_(0.2)Sm_(0.2)Eu_(0.2)Er_(0.2))_(2)O_(3) nanofibers are continuous and uniform with a smooth surface and a small diameter of 150 *** is also intriguing that the average grain size of(Y_(0.2)Yb_(0.2)Sm_(0.2)Eu_(0.2)Er_(0.2))_(2)O_(3) is only about 10 nm,which is much smaller than that in the solid-state synthesized *** addition,all the elements are homogeneously distributed along the *** work demonstrates that high-entropy ceramic nanofibers can be synthesized from liquid precursors at low temperatures through a simple,efficient,and low-cost electrospinning method,which opens up a new avenue for the low-temperature synthesis of HECs.

关键词： High-entropy ceramics Nanofibers Electrospinning Rare earth metal oxides Synthesis

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湖南塔山岩体东段某金属矿成矿条件分析及成矿模式的建立

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世界有色金属 2024年第7期 76-78页

作者：蒋文武孟繁星沈亚飞程云涛韦光景湖南省核地质调查所湖南长沙410007

寒武-奥陶系构成的含矿基底层和多期多阶段复式含矿花岗岩体,为成矿提供丰富的矿源。本文通过对矿区地层、岩浆岩和断裂构造及热液活动特征的论述,分析矿区某金属矿成矿特征和成矿条件,认为某金属矿成矿是地层、岩浆岩、断裂构造三个因... 详细信息

寒武-奥陶系构成的含矿基底层和多期多阶段复式含矿花岗岩体,为成矿提供丰富的矿源。本文通过对矿区地层、岩浆岩和断裂构造及热液活动特征的论述,分析矿区某金属矿成矿特征和成矿条件,认为某金属矿成矿是地层、岩浆岩、断裂构造三个因素相互作用的结果,建立了塔山岩体东段某金属矿的成矿模式。

关键词：塔山岩体东段成矿特征成矿条件成矿模式

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基于中医证候的缺血性中风病复发早期预警模型的构建及验证

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中华中医药杂志 2022年第2期37卷 686-692页

作者：高阳谢雁鸣王志飞张景肖王蕾蔡业峰沈晓明赵德喜谢颖桢赵性泉孟繁兴于海青姜俊杰中国中医科学院中医临床基础医学研究所北京100700 北京中医药大学东方医院北京100078 中国人民大学北京100872 广东省中医院广州510120 河南中医药大学第一附属医院郑州450000 长春中医药大学附属医院长春130021 北京中医药大学东直门医院北京100700 首都医科大学附属北京天坛医院北京100070 太原市中医医院太原140107

目的:开发和验证中医证候的缺血性中风病复发早期预警模型和风险评估工具。方法:采用多中心、前瞻性的注册登记研究设计,在全国7家临床分中心,纳入2016年11月—2019年2月期间,1741例首发缺血性中风病的住院患者。采用距离相关系数、互... 详细信息

目的:开发和验证中医证候的缺血性中风病复发早期预警模型和风险评估工具。方法:采用多中心、前瞻性的注册登记研究设计,在全国7家临床分中心,纳入2016年11月—2019年2月期间,1741例首发缺血性中风病的住院患者。采用距离相关系数、互信息熵和统计相关性检验进行了单变量分析,变量多因素分析采用多因素的Cox回归模型并结合中风领域的专家意见进行建模变量的确定。使用Cox比例风险回归模型进行不同时间的中风复发预警模型构建和验证。使用ROC曲线下面积(AUC值)评估模型的预警能力。结果:随访时间1~3年,中位随访时间为1.42年(95%CI[1.37,1.47])。175例发生了复发事件,累积复发发生率为10.05%(95%CI[8.64,11.47])。模型训练集的AUC值为0.64±0.02,验证集AUC值为0.70±0.03。结论:中医证候模型可能较早的对中风病复发进行预警,为缺血性中风病的二级预防评估提供一定的参考。

关键词：缺血性中风病复发预警模型风险评估工具中医证候

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天芪益智颗粒对阿尔茨海默病大鼠学习记忆能力和突触功能的影响

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天津中医药 2017年第7期34卷 475-477页

作者：刘一川马涛王乐余青孟繁兴张允岭中国航空工业集团公司北京航空制造工程研究所门诊部中医科北京100024 北京中医药大学东方医院实验中心北京100078 北京中医药大学东方医院科研处北京100078 北京市丰台区铁营医院皮肤科北京100078 北京中医药大学东方医院脑病一科北京100078 北京中医药大学东方医院北京100078

[目的]研究天芪益智颗粒对阿尔茨海默病大鼠学习记忆能力及脑内突触素、微管相关蛋白-2(MAP-2)表达的影响。[方法]采用侧脑室注射Aβ_(1-42)的方法建立动物模型,将90只SD大鼠随机分成模型组、假手术组、阳性药组(石杉碱甲)、天芪益智颗... 详细信息

[目的]研究天芪益智颗粒对阿尔茨海默病大鼠学习记忆能力及脑内突触素、微管相关蛋白-2(MAP-2)表达的影响。[方法]采用侧脑室注射Aβ_(1-42)的方法建立动物模型,将90只SD大鼠随机分成模型组、假手术组、阳性药组(石杉碱甲)、天芪益智颗粒高、中、低剂量组,每组15只。连续给药30 d后,通过避暗实验评价大鼠的学习记忆能力,采用Western Blot方法测定大鼠脑内突触素、MAP-2。[结果]与模型组相比,天芪益智颗各剂量组大鼠潜伏期长于模型组(P<0.01),错误次数小于模型组(P<0.01)。模型组大鼠脑内突触素、MAP-2表达低于假手术组(P<0.01),天芪益智颗粒各剂量组突触素、MAP-2表达高于模型组(P<0.01)。[结论]天芪益智颗粒能改善阿尔茨海默病大鼠学习记忆能力,改善突触功能。

关键词：阿尔茨海默病天芪益智颗粒突触功能突触素微管相关蛋白-2

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Atmospheric stable and fexible Sn-based perovskite solar cells via a bioinspired antioxidative crystal template

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Journal of Energy Chemistry 2022年第3期31卷 612-618,I0016页

作者： Rui Guo Li Rao Qianjin Liu Hongyu Wang Chenxiang Gong Baojin fan Zhi xing Xiangchuan meng Xiaotian Hu School of Materials Science and Engineering Nanchang University999 Xuefu AvenueNanchang 330031JiangxiChina School of Future Technology Nanchang University999 Xuefu AvenueNanchang 330031JiangxiChina Institute of Polymers and Energy Chemistry Nanchang University999 Xuefu AvenueNanchang 330031JiangxiChina

Sn-based perovskite solar cells(PSCs)demonstrate a potential development in eco-friendly devices due to their ***,poor stability and crystalline quality are still the challenges for achieving high-performance and long-term operating *** this work,inspired by biological protein,nickelporphyrin(Ni-P)with electron cloud on conjugate ring is applied into Sn-based perovskite to prevent perovskite from being *** synergistic effect of water and oxygen is broken in grain boundaries and surface so that the stability of PSCs can be improved obviously,despite there is hardly any barrier for water to ***,the electron-rich molecules can passivate the defects of perovskite such as iodine ***,the ester group in Ni-P molecule can bind with SnI;to form complex and then restrain *** with the template effect of 2D molecular,the crystallization of perovskite films is ***,the Sn-based PSCs with Ni-P achieve a stabilized power conversion efficiency(PCE)of 7.79%with negligible hysteresis in fexible devices,***,the PSCs can maintain 80%of the pristine PCE after 300 h under air environment.

关键词： Lead-free Solar cell Flexible devices Molecular bionics Crystallization control

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Credit Risk Transfer in SME Loan Guarantee Networks

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Journal of Systems Science & Complexity 2017年第5期30卷 1084-1096页

作者： LENG Aolin xing Guangyuan fan Weiguo School of Management Xi'an Jiaotong UniversityXi'an 710049China School of Economics and Finance Xi'an Jiaotong UniversityXi'an 710061China Pamplin College of Business Virginia Tech24060USA

Joint loan guarantee contracts and mutual guarantee contracts among SMEs form the basis of SME guarantee networks. The expansion of these networks increases the fragility of a financial system as a result of the regional and industrial risk contagion embedded within them. By providing a theoretical framework of a loan guarantee network, a method is proposed for calculating the amount of risk spillover caused by loan guarantees taking the perspective of the entire network. In addition,the route of risk contagion in guarantee networks is analyzed, revealing that when default risk shocks occur, risk contagion travels along the nodes not once but for several rounds and that the risk control of one firm cannot prevent these systemic risks. Therefore, a risk control scheme is designed based on the location and importance of firms in the network. Using data from a real guarantee network,we demonstrate that identifying the node locations of firms' in the guarantee network(including the coritivity and closeness of the firm) can help in understanding risk contagion mechanisms and preventing systemic credit risk before a crisis occurs.

关键词： Closeness coritivity guarantee network risk contagion.

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Effects of Ce on catalytic combustion of methane over Pd-Pt/Al_2O_3 catalyst

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Journal of Environmental Sciences 2012年第3期24卷 507-511页

作者： xing fan fan Wang Tianle Zhu Hong He School of Chemistry and Environment Beihang UniversityBeijing 100191China College of Environmental and Energy Engineering Beijing University of TechnologyBeifing 100124China

Activity and stability of 1%Pd-0.2%Pt/Al2O3 and 1%Pd-0.2%Pt/0.6%Ce/Al2O3 catalysts prepared by impregnation method for catalytic combustion of methane in air were investigated. The catalysts before and after reaction were characterized by BET, CO chemisorption, XRD and XPS techniques. Results showed that the presence of Ce significantly increased the activity and thermal stability of the Pd-Pt/Al2O3 catalyst towards methane combustion, which could be attributed to more highly-dispersed active PdO particles over the Pd-Pt/Ce/Al2O3 catalyst surface as well as the retarded sintering of PdO and the maintained oxidized state of surface Pd during the combustion process in the presence of Ce.

关键词： catalytic combustion methane Pd-Pt/Ce/Al2O3 catalyst stability metal dispersion

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鹅细小病毒VP2和VP3蛋白酵母双杂交诱饵载体的构建及验证

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经济动物学报 2014年第2期18卷 77-80页

作者：徐浩孟繁兴胡桂学董浩张双齐宇李勇勇吉林农业大学动物科学技术学院吉林农业大学生命科学学院

为筛选与鹅细小病毒VP2和VP3蛋白相互作用的鹅胚成纤维细胞蛋白,构建VP2和VP3蛋白的诱饵载体pGBKT7-VP2和pGBKT7-VP3。从pGEX-4T-VP1质粒中PCR扩增VP2和VP3基因,克隆至pMD-18T载体中,经测序验证鉴定后定向克隆到酵母双杂交载体pGBKT7中... 详细信息

为筛选与鹅细小病毒VP2和VP3蛋白相互作用的鹅胚成纤维细胞蛋白,构建VP2和VP3蛋白的诱饵载体pGBKT7-VP2和pGBKT7-VP3。从pGEX-4T-VP1质粒中PCR扩增VP2和VP3基因,克隆至pMD-18T载体中,经测序验证鉴定后定向克隆到酵母双杂交载体pGBKT7中。将2个重组诱饵载体经PCR、酶切和测序验证后分别转化酵母菌H2YGold中,检测其在酵母细胞中有无自激活和毒性作用。结果表明:成功构建了pGBKT7-VP2和pGBKT7-VP3诱饵载体,且其对报告基因无自激活作用,对酵母细胞无毒性。由此说明,诱饵载体pGBKT7-VP2和pGBKT7-VP3可用于酵母双杂交系统筛选与VP2和VP3蛋白相互作用的细胞结合蛋白。

关键词：鹅细小病毒 VP2和VP3蛋白酵母双杂交

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Safety-enhanced Polymer Electrolytes with High Ambient-temperature Lithium-ion Conductivity Based on ABA Triblock Copolymers

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Chinese Journal of Polymer Science 2022年第1期40卷 21-28页

作者： Dong Liu fan Wu Zhi-Hao Shen xing-He fan Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Liquid electrolytes used in lithium-ion batteries suffer from leakage,flammability,and lithium dendrites,making polymer electrolyte a potential ***,a series of ABA triblock copolymers(ABA-x)containing a mesogen-jacketed liquid crystalline polymer(MJLCP)with a polynorbornene backbone as segment A and a second polynorbornene-based polymer having poly(ethylene oxide)(PEO)side chains as segment B were synthesized through tandem ring-opening metathesis *** block copolymers can self-assemble into ordered morphologies at 200℃.After doping of lithium salts and ionic liquid(IL),ABA-x self-assembles into cylindrical *** MJLCP segments with a high glass transition temperature and a stable liquid crystalline phase serve as physical crosslinking points,which significantly improve the mechanical performance of the polymer *** ionic conductivity of ABA-x/lithium salt/IL is as high as 10-3 S·cm-1 at ambient temperature owing to the high IL uptake and the continuous phase of conducting PEO *** relationship between ionic conductivity and temperature fits the Vogel-Tamman-Fulcher(VTF)*** addition,the electrolyte films are flame retardant owing to the addition of *** polymer electrolytes with good safety and high ambient-temperature ionic conductivity developed in this work are potentially useful in solid lithium-ion batteries.

关键词： ABA triblock copolymer Polymer electrolyte Ionic conductivity Inflammability Cylindrical structure

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