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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： meng yuan Yao Tang Tianwen Huang Lining Ke En Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Tough Polymeric Hydrogels Based on Amino Acid Derivative Mediated Dynamic Metal Coordination Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1578-1588,I0014页

作者： meng Li meng-yuan Zhang Wu-Xuan Lei Zhu-Ting Lv Qing-Hua Shang Zheng Zhao Jiang-Tao Li Yi-Long Cheng Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi’an Jiaotong UniversityXi’an710049China Polymer Materials&Engineering Department School of Materials Science&Engineering Chang’an UniversityXi’an710064China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China Department of Nuclear Medicine the First Affiliated Hospital of ChinaXi’an Jiaotong UniversityXi’an710049China

Abstract The development of physically crosslinked hydrogels with excellent mechanical and sensing properties is of importance for expanding the practical applications of intelligent soft hydrogel ***,after copolymerization of hydroxyl-containing amino acid derivative N-acryloyl serine(ASer)with acrylamide(AM),we introduce Zr4+through an immersion strategy to construct metal ion-toughened non-covalent crosslinked hydrogels(with tensile strength of up to 5.73 MPa).It is found that the synergistic coordination of hydroxyl and carboxyl groups with Zr^(4+)substantially increases the crosslinking density of the hydrogels,thereby imparting markedly superior mechanical properties compared to hydroxyl-free Zr^(4+)-crosslinked hydrogels,such as N-acryloyl alanine(AAla)copolymerized with AM hydrogels(with tensile strength of 2.98 MPa)Through the adjustment of the composition of the copolymer and the density of coordination bonds,the mechanical properties of the hydrogels can be modulated over a wide ***,due to the introduction of metal ions and the dynamic nature of coordination bonds,the hydrogels also exhibit excellent sensing performance and good self-recovery properties,paving the way for the development of flexible electronic substrates with outstanding comprehensive performances.

关键词： Hydrogel Amino acid Metal coordination Mechanical performance Flexible sensor

Prevalence of prolonged grief disorder and its symptoms among bereaved individuals in China:a systematic review and meta-analysis

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General Psychiatry 2024年第2期37卷 177-188页

作者： meng-Di yuan Jun-Fa Liu Bao-Liang Zhong Research Center for Psychological and Health Sciences China University of Geosciences(Wuhan)WuhanHubeiChina Department of Psychiatry Wuhan Mental Health CentreWuhanHubeiChina

Background The prevalence of prolonged grief disorder(PGD)and its symptoms among the bereaved population in China vary *** This meta-analysis aims to estimate the prevalence of PGD and its symptoms among bereaved individuals in *** We conducted a literature search in major Chinese and English databases from their inception to 4 October 2023,for cross-sectional studies on the prevalence of PGD or its symptoms in bereaved Chinese *** risk of bias of the included studies and certainty of the evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data(‘JBI checklist’)and the Grading of Recommendations,Assessment,Development and Evaluations(GRADE),***‘metaprop’package in R V.4.1.2 was used to synthesise the *** A total of 28 studies involving 10994 bereaved individuals were included in the analysis,with JBI checklist scores between 3 and *** combined prevalence(95%confidence interval)of PGD and its symptoms was 8.9%(4.2%to 17.6%)and 32.4%(18.2%to 50.8%),*** and its symptoms were most prevalent among those who had lost their only child(22.7%)and those bereaved by earthquakes(80.4%),*** GRADE system assigned a very low certainty level to the evidence for the pooled prevalence of PGD and its *** The pooled prevalence of PGD and its symptoms indicate a potential high need for grief counselling services among bereaved individuals in *** need is particularly pronounced in those who have lost their only child and those bereaved due to *** methodologically rigorous studies are needed to provide more accurate prevalence *** registration number CRD42023432553.

关键词： symptoms prevalence analysis

Solutions of the(2+1)-dimensional Harry Dym Equation via Darboux Transformation Revisited

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Acta Mathematicae Applicatae Sinica 2024年

作者： meng-yuan CUI Min XUE meng-xia ZHANG Department of Mathematics China University of Mining and TechnologyBeijing School of Mathematical Sciences Capital Normal University

The link of (2+1)-dimensional Harry Dym equation with the modified Kadomtsev-Petviashvili equation by the reciprocal transformation is shown. With the help of Darboux transformation, exact solutions of the (2+1)-dimen...

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Cross-border E-commerce and China's Exports during the COVID-19 Pandemic

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China & World Economy 2024年第3期32卷 215-242页

作者： Yi Che meng yuan Yan Zhang Lin Zhao School of Business East China University of Science and TechnologyChina School of Business Xiangtan UniversityChina School of Economics Shanghai University of Finance and EconomicsChina

China's exports experienced a rapid recovery after the outbreak of the 2019 COVID-19 pandemic.A primary engine was cross-border e-commerce(CBEC)trade,which bucked the downward export trend during the *** exploring the variation in the number of CBEC comprehensive pilot zones across provinces,we identified the causal impact of CBEC on exports using monthly province-product-destination data for 2019 and *** found strong and robust evidence that CBEC contributed to exports during the pandemic by promoting the expansion of incumbent exports(intensive margin)rather than through the expansion of product categories and exporting partners(extensive margin).Specifically,higher pandemic risk suppressed the role of CBEC at the intensive margin while enhancing it at the extensive *** to developed countries benefited more from CBEC,both intensively and *** with final products,a larger number of intermediate products were exported through CBEC after the outbreak of the pandemic.

关键词： China's exports COVID-19 pandemic cross-border e-commerce extensive margin of trade intensive margin of trade

A state-of-the-art review on delayed expansion of cemented paste backfill materials

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Rare Metals 2024年第8期43卷 3475-3500页

作者： meng-yuan Li Li-Jie Guo Yue Zhao Lei Zhang Kai Yang Xiao-Peng Peng Andrew Pan BGRIMM Technology Group Beijing 100160China National Centre for International Research On Green Metal Mining Beijing102628China Department of Civil and Mineral Engineering University of TorontoTorontoON M5S 1A4Canada

Utilizing delayed expansion cemented paste backfill materials(DECPB) in mine backfill operations offers an effective solution to the challenge of achieving proper contact between the in-situ cemented backfill mass and the roof in mined-out areas(backfill-roof contact).This article presents recent progress in both theoretical and experimental research concerning *** types and mechanisms of expansive additives,including expansive agents,foaming agents,and expansive mineral materials relevant to DECPB,are explained,along with their impact on the expansive properties and mechanical characteristics of *** composition,material characteristics,preparation methods,and controlled release mechanisms of microcapsules are *** methods for measuring the volume change rate of paste backfill slurries are *** indicates that an appropriate content of expansive additives not only enhances the expansive properties of cemented paste backfill materials but also contributes to improving their mechanical *** foaming agents and bentonite are found to be more suitable for preparing DECPB compared to expansive *** delayed expansion of cemented paste backfill material is influenced by microcapsules,with their wall materials,preparation parameters,and the alkaline slurry environment affecting their controlled release *** and optimizing precise measurement devices and methods forfor the volume change rate of cemented paste backfill materials is essential requirement for studying the performance of *** delayed expansion technology with retarding techniques in cemented paste backfill materials can provide a reliable solution for achieving proper backfill-roof contact in the future.

关键词： Paste backfill Delayed expansion Mining with backfill Expansive additives Tailings

A Bioorthogonal Post-modification of N^(6)-Isopentenyl Adenosine i^(6) A RNA in Live Cells

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CCS Chemistry 2024年第9期6卷 2241-2253页

作者： Li-Jun Xie Hou-Ping Cheng meng-yuan Chen Xin Wang Li Liu Bi-Feng yuan Liang Cheng Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Public Health Wuhan UniversityWuhan 430071 University of Chinese Academy of Sciences Beijing 100049

Selective methods for modulating RNA epigenetic modifications within living cells and organisms represent attractive techniques for investigating biological functions and medicinal *** contrast to enzymatic methods,abiotic chemical modulation offers access to diverse new-to-natural *** herein report a visible light-assisted bioorthogonal reaction involving flavin mononucleotide,sodium azide,and blue light *** concert with previous chemical approaches mimicking the demodification pathway,our system functions as a powerful and selective post-modification enzyme that targets N^(6)-prenyl adenosine i^(6) A in RNA and enables the efficient construction of an artificial N^(6)-cyanomethyl adenosine(cnm^(6) A).Notably,most endogenous biomacromolecular functions,including other common RNA epigenetics,remained ***,we have successfully modified i^(6) A in tRNA to cnm^(6) A in human cells and establish this system as a bona fide bioorthogonal reaction with potential applications in chemical biology and in-cell modulation.

关键词： chemical post-modification bioorthogonal reactions RNA modifications N^(6)-isopentenyl adenosine N^(6)-cyanomethyl adenosine

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Chinese Tourism13.0

中印对话（英文版） 2024年第1期38卷 4-5页

作者： yuan meng the Academy of Macroeconomic Researchof China's National Developmentand Reform Commission.

The emergence of internet-famous cities not only marked China's tourism market entering a new development stage,but also shed light on the huge development potential of China's tourism market thanks to people's increasing willingness to travel and pursuit for a better life,highlighting the great vitality and surging momentum of China's economy.

关键词： travel pursuit momentum

Multi-omics analyses provide insights into the evolutionary history and the synthesis of medicinal components of the Chinese wingnut

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Plant Diversity 2024年第3期46卷 309-320页

作者： Zi-Yan Zhang He-Xiao Xia meng-Jie yuan Feng Gao Wen-Hua Bao Lan Jin Min Li Yong Li College of Life Science and Technology Inner Mongolia Normal UniversityHohhot 010020China Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region Hohhot 010022China College of Landscape and Art Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China

Chinese wingnut(Pterocarya stenoptera)is a medicinally and economically important tree species within the family ***,the lack of high-quality reference genome has hindered its in-depth *** this study,we successfully assembled its chromosome-level genome and performed multiomics analyses to address its evolutionary history and synthesis of medicinal components.A thorough examination of genomes has uncovered a significant expansion in the Lateral Organ Boundaries Domain gene family among the winged group in *** notable increase may be attributed to their frequent exposure to flood-prone *** further differentiation between Chinese wingnut and Cyclocarya paliurus,significant positive selection occurred on the genes of NADH dehydrogenase related to mitochondrial aerobic respiration in Chinese wingnut,enhancing its ability to cope with waterlogging *** genomic analysis revealed Chinese wingnut evolved more unique genes related to arginine synthesis,potentially endowing it with a higher capacity to purify nutrient-rich water *** of terpene synthase families enables the production of increased quantities of terpenoid volatiles,potentially serving as an evolved defense mechanism against herbivorous *** combined transcriptomic and metabolomic analysis,we identified the candidate genes involved in the synthesis of terpenoid *** study offers essential genetic resources for Chinese wingnut,unveiling its evolutionary history and identifying key genes linked to the production of terpenoid volatiles.

关键词： Genome Medicinal components Metabolome Pterocarya stenoptera Transcriptome

Engineering disease-resistant plants with alternative translation efficiency by switching uORF types through CRISPR

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Science China(Life Sciences) 2024年第8期67卷 1715-1726页

作者： Jingjing Tian Zhijuan Tang Ruixia Niu Yulu Zhou Dan Yang Dan Chen Ming Luo Rui Mou meng yuan Guoyong Xu National Key Laboratory of Crop Genetic Improvement National Centre of Plant Gene Research(Wuhan)Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Hybrid Rice Institute for Advanced Studies(IAS)Wuhan UniversityWuhan 430072China Hubei Hongshan Laboratory Wuhan 430070China

Engineering disease-resistant plants can be a powerful solution to the issue of food ***,it requires addressing two fundamental questions:what genes to express and how to control their *** find a solution,we screen CRISPR-edited upstream open reading frame(uORF)variants in rice,aiming to optimize translational control of disease-related *** switching uORF types of the 5′-leader from Arabidopsis TBF1,we modulate the ribosome accessibility to the downstream firefly *** assume that by switching uORF types using CRISPR,we could generate uORF variants with alternative translation efficiency(CRISPR-aTrE-uORF).These variants,capable of boosting translation for resistance-associated genes and dampening it for susceptible ones,can help pinpoint previously unidentified genes with optimal expression *** test the assumption,we screened edited uORF variants and found that enhanced translational suppression of the plastic glutamine synthetase 2 can provide broad-spectrum disease resistance in rice with minimal fitness *** strategy,which involves modifying uORFs from none to some,or from some to none or different ones,demonstrates how translational agriculture can speed up the development of disease-resistant *** is vital for tackling the food security challenges we face due to growing populations and changing climates.

关键词： disease-resistant plants broad-spectrum disease resistance uORF uORF types uORF variants CRISPR