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Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 877-882页

作者： Ying Gao rong-Xin Lu Yun Tang Xin-Yi Yang Hu meng Chang-Lin Zhao Yi-Lu Chen Feng Yan Qian Cao Department of Ophthalmology Sir Run Run HospitalNanjing Medical UniversityNanjing 211112Jiangsu ProvinceChina Department of Ophthalmology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Thoracic surgery the First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Medical School Nanjing UniversityNanjing 210093Jiangsu ProvinceChina Department of Ophthalmology Taikang Xianlin Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210046Jiangsu ProvinceChina

AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were *** study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)*** relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic ***:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(P<0.001 for all);and higher in the PDR group than in the NDR group(P<0.001 for all).In the ROC curve analysis,the NLR,PLR,and SII were significant predictors of DR(P<0.001 for all).The highest area under the curve(AUC)was for the PLR(0.929 for PLR,0.925 for SII,and 0.821 for NLR).Multivariate regression analysis indicated that NLR,PLR,and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM[odds ratio(OR)=1.122,95%confidence interval(CI):0.200–2.043,P<0.05;OR=0.038,95%CI:0.018–0.058,P<0.05;OR=0.007,95%CI:0.001–0.01,P<0.05,respectively).CONCLUSION:The NLR,PLR,and SII may be used as predictors of DR.

关键词： diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index

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Output Feedback Stabilization of High-Order Nonlinear Time-Delay Systems With Low-Order and High-Order Nonlinearities

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1304-1306页

作者： meng-meng Jiang Kemei Zhang Xue-Jun Xie School of Mathematics Science Liaocheng UniversityLiaocheng 252059China School of Mathematics Science Qufu Normal UniversityQufu 273165China Institute of Automation Qufu Normal UniversityQufu 273165China

Dear Editor,to This letter deals with the output feedback stabilization of a class of high-order nonlinear time-delay systems with more general low-order and high-order *** constructing reduced-order observer,based on homogeneous domination theory together with the adding a power integrator method,an output feedback controller is developed guarantee the equilibrium of the closed system globally uniformly asymptotically stable.

关键词： Nonlinear stabilization guarantee

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Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays

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Nano Research 2024年第5期17卷 4329-4337页

作者： Yang Liu Xuwei He Zewei Lian Qian Guo Jimei Chi Xiaoxue Lin Liyue Zhang Zheng Liu Yingyuan Liu meng su Keyu Wang Qiangguo Ao Qingli Cheng Department of Nephrology The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China Chinese PLA Medical School Beijing 100853China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Department of Clinical Laboratory The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China

Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of *** this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the *** confirmed its efficacy in the early diagnosis of AKI using clinical urine *** quantitative detection of uKIM-1 was achieved within 10 *** lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal ***,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community ***,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare *** highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions.

关键词： photonic crystal point-of-care testing urine kidney injury molecule-1(KIM-1) acute kidney injury

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Gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model

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World Journal of Hepatology 2024年第8期16卷 1167-1176页

作者： Yuan-Yuan Chen Li Yang Jun Li Sheng-Xiang Rao Ying Ding meng-su Zeng Department of Radiology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Neoadjuvant chemotherapy can cause hepatic sinusoidal obstruction syndrome(SOS)in patients with colorectal cancer liver metastases and increases posto-perative morbidity and *** To evaluate T1 mapping based on gadoxetic acid-enhanced magnetic resonance imaging(MRI)for diagnosis of hepatic SOS induced by *** Twenty-four mice were divided into control(n=10)and experimental(n=14)*** experimental groups were injected with monocrotaline 2 or 6 days before *** parameters were:T1 relaxation time before enhancement;T1 relaxation time 20 minutes after enhancement(T_(1post));a reduction in T1 relaxation time(△T_(1)%);and first enhancement slope percentage of the liver parenchyma(ESP).Albumin and bilirubin score was *** results served as a *** parenchyma samples from the control and experimental groups were analyzed by western blotting,and organic anion transporter polypeptide 1(OATP1)was *** T_(1post),△T_(1)%,and ESP of the liver parenchyma were significantly different between two groups(all P<0.001)and significantly correlated with the total histological score of hepatic SOS(r=-0.70,0.68 and 0.79;P<0.001).△T_(1)%and ESP were positively correlated with OATP1 levels(r=0.82,0.85;P<0.001),whereas T_(1post) had a negative correlation with OATP1 levels(r=-0.83;P<0.001).INTRODUCTION Hepatic sinusoidal obstruction syndrome(SOS)is also known as hepatic veno-occlusive disease of the liver[1].The main pathological feature of hepatic SOS is damage to liver terminal vessels,and the clinical symptoms of it include ascites and abdominal pain[2].It was first proposed in 1979 as an early complication of hematopoietic stem cell transplantation[3].The prevalence ranges from 5%to 60%,and hepatic SOS is a potentially severe complication and can even lead to death in severe cases[4].Recently,systemic neoadjuvant chemotherapy became widely regarded as one of the causes hepatic SOS in the patients with ad

关键词： T_(1)mapping Gadoxetic acid Sinusoidal obstruction syndrome Organic anion transporter polypeptides Magnetic resonance imaging

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Structural regulation of coal-derived hard carbon anode for sodium-ion batteries via pre-oxidation

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Rare Metals 2024年第6期43卷 2585-2596页

作者： meng-Yuan su Kai-Yang Zhang Edison Huixiang Ang Xue-Li Zhang Yan-Ning Liu Jia-Lin Yang Zhen-Yi Gu Faaz A.Butt Xing-Long Wu Faculty of Chemistry Northeast Normal UniversityChangchun 130024China MOE Key Laboratory for UV Light-Emiting Materials and Technology.Northeast Normal University.Ministry of Education Changchun 130024China Natural Sciences and Science Education National Institute of EducationNanyang Technological UniversitySingapore 637616Singapore Materials Engineering Department NED University of Engineering and TechnologyKarachi 75300Pakistan

Hard carbon(HC)is broadly recognized as an exceptionally prospective candidate for the anodes of sodium-ion batteries(SIBs),but their practical implementation faces substantial limitations linked to precursor factors,such as reduced carbon yield and increased ***,a cost-effective approach is proposed to prepare a coal-derived HC anode with simple pre-oxidation followed by a post-carbonization process which effectively expands the d_(002)layer spacing,generates closed pores and increases defect *** these modifications,the resulting HC anode attains a delicate equilibrium between plateau capacity and sloping capacity,showcasing a remarkable reversible capacity of 306.3 mAh·g^(-1)at 0.03 A·g^(-1).Furthermore,the produ ced HC exhibits fast reaction kinetics and exceptional rate performance,achieving a capacity of 289 mAh·g^(-1)at 0.1 A·g^(-1),equivalent to~94.5%of that at 0.03 A·g^(-1).When implemented in a full cell configuration,the impressive electrochemical performance is evident,with a notable energy density of 410.6 Wh·kg^(-1)(based on cathode mass).In short,we provide a straightforward yet efficient method for regulating coal-derived HC,which is crucial for the widespread use of SIBs anodes.

关键词： Sodium-ion batteries Hard carbon Anode Coal Pre-oxidation

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Towards the Jacobian Conjecture

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ALGEBRA COLLOQUIUM 2024年第3期31卷 361-388页

作者： su, Yucai Jimei Univ Dept Math Xiamen 361021 Peoples R China Tongji Univ Sch Math Sci Shanghai 200092 Peoples R China

We first show that if there is a counterexample to the two-dimensional Jacobian conjecture, then there exists a nonempty closed smooth affine surface in C-2 x C-2 satisfying various properties. Next, we conjecture tha... 详细信息

关键词： two-dimensional Jacobian conjecture Keller maps Jacobian pairs

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Cationic ordering transition in oxygen-redox layered oxide cathodes

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Carbon Energy 2024年第1期6卷 197-206页

作者： Xinyan Li Ang Gao Qinghua Zhang Hao Yu Pengxiang Ji Dongdong Xiao Xuefeng Wang Dong su Xiaohui rong Xiqian Yu Hong Li Yong-Sheng Hu Lin Gu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijingChina Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials School of Materials Science and EngineeringTsinghua UniversityBeijingChina Beijing Advanced Innovation Center for Materials Genome Engineering Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijingChina

Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na-ion ***,we reveal the correlation between cationic ordering transition and OR degradation in ribbon-ordered P3-Na_(0.6)Li_(0.2)Mn_(0.8)O_(2) via in situ structural *** two different voltage windows,the OR capacity can be improved approximately twofold when suppressing the in-plane cationic ordering *** find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to Jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical ***-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective Jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates OR *** findings unravel the relationship between in-plane cationic ordering and OR reversibility and highlight the importance of superstructure protection for the rational design of reversible OR-active layered oxide cathodes.

关键词： cationic ordering layered oxide cathodes oxygen redox sodium-ion batteries

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U-Net Models for Representing Wind Stress Anomalies over the Tropical Pacific and Their Integrations with an Intermediate Coupled Model for ENSO Studies

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Advances in Atmospheric Sciences 2024年第7期41卷 1403-1416页

作者： Shuangying Du rong-Hua Zhang Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao266071China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing210044China Laosan Laboratory Qingdao266237China University of Chinese Academy of Sciences Beijing100049China

El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been developed to simulate and predict *** some simplified coupled ocean-atmosphere models,the relationship between sea surface temperature(SST)anomalies and wind stress(τ)anomalies can be constructed by statistical methods,such as singular value decomposition(SVD).In recent years,the applications of artificial intelligence(AI)to climate modeling have shown promising prospects,and the integrations of AI-based models with dynamical models are active areas of *** study constructs U-Net models for representing the relationship between SSTAs andτanomalies in the tropical Pacific;the UNet-derivedτmodel,denoted asτUNet,is then used to replace the original SVD-basedτmodel of an intermediate coupled model(ICM),forming a newly AI-integrated ICM,referred to as *** simulation results obtained from ICM-UNet demonstrate their ability to represent the spatiotemporal variability of oceanic and atmospheric anomaly fields in the equatorial *** the ocean-only case study,theτUNet-derived wind stress anomaly fields are used to force the ocean component of the ICM,the results of which also indicate reasonable simulations of typical ENSO *** results demonstrate the feasibility of integrating an AI-derived model with a physics-based dynamical model for ENSO modeling ***,the successful integration of the dynamical ocean models with the AI-based atmospheric wind model provides a novel approach to ocean-atmosphere interaction modeling studies.

关键词： U-Net models wind stress anomalies ICM integration of AI and physical components

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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao su meng-qing LI Lan YU Ai-ling CHEN Ken HUANG Yun-ke ZHAO Qiu-long HUANG Wen-ya HUANG Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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Maximal operators of pseudo-differential operators with rough symbols

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 174-180页

作者： Ramla Benhamoud ZHU Xiang-rong School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China

Consider a pseudo-differential operator T_(a)f(x)=∫_(R^(n))e^(ix,ζ)a(x,ζ)f(ζ)dζwhere the symbol a is in the rough Hormander class L^(∞)S_(ρ)^(m)with m∈R andρ∈[0,1].In this note,when 1≤p≤2,if n(ρ-1)/p and a∈L^(∞)S_(ρ)^(m),then for any f∈S(R^(n))and x∈R^(n),we prove that M(T_(a)f)(x)≤C(M(|f|^(p))(x))^(1/p) where M is the Hardy-Littlewood maximal *** theorem improves the known results and the bound on m is sharp,in the sense that n(ρ-1)/p can not be replaced by a larger constant.

关键词： pseudo-differential operator rough Hormander class H-L maximal operator

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