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Chinese Journal of Structural Chemistry 2006年第7期25卷 837-843页

作者： meng fan-xia liu kun chen ya-guang Institute of Polyoxometalate Chemistry Faculty of Chemistry Northeast Normal University Changchun 130024 China

An unusual inorganic-organic hybrid hexatungstate complex [Cu（phen）3][W6O19] 1 （C36H24 CuN6O19W6, Mr= 2011.20） was hydrothermally synthesized and characterized by singlecrystal X-ray diffraction, IR spectrum, UV-VIS spectrum and elemental analyses. This compound crystallizes in the monoclinic system, space group C2/c with a = 19.1005（11）, b = 11.2585（11）, c = 20.2867（15） A, β= 102.177（2）°, V= 4264.4 A^ 3, μ（MoKa） = 16.691 mm^-1, Dc = 3.133 g/cm^3, Z = 4, F（000） = 3628, the final R = 0.0338 and wR = 0.0798 for 4090 observed reflections with I 〉 2σ（I）. The result of structure determination shows that the crystal structure is constructed from [W6O19]^2- cluster anions and [Cu（phen）3]^2＋ complex fragments, which are held together into a three-dimensional network through hydrogen-bonding interactions.

关键词： hydrothermal synthesis tungstates polyoxometalates copper coordination complexes

Synthesis,Crystal Structure and Thermal Stability of Homopolytungstate Supporting Nickel(Ⅱ) Coordination Fragments

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Chemical Research in Chinese Universities 2007年第4期23卷 391-394页

作者： liu kun meng fan-xiaI MA Feng-xia chen ya-guang Key Laboratory of Polyoxometalates Science of Ministry of Education College of Chemistry Northeast Normal University Changchun 130024 P. R. China Basic Science Department Jilin Agricultural Science and Technology College Jilin 132101 P. R. China

The orsano-inorganic hybrid compound [ Ni（phen）3] [ （H2W12O40） { Ni（phen）2H2O} { Ni（trien） } ]·2H2O was synthesized from Na2 WO4·2H2O, NiSO4·6H2O, CH3COOK, triethylenetetramine and 1,10-phenanthroline in water by the hydrothermal reaction, and characterized by IR, X-ray single crystal diffraction, and TG-DTA analysis. This compound crystallized in the monoclinic system, space group P2 （1）/n, with lattice constants： a =1.80998 （6） nm, b =2.36504（8） nm, c =2.29199（7） nm,β= 110.2220（10）°, V=9.2065（5） nm, Z=4. Final R indices R1=0.0532. ωR2=0.1295. The compound is decomposed at 593℃.

关键词： Isopolytungstate Nickel complex Crystal structure Organo-inorganic hybrid Supramolecular architecture Thermal stability

Distributions of HLA-A and-B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第2期11卷 127-135页

作者： Bo-feng ZHU guang yaNG Chun-mei SHEN Hai-xia QIN Shun-zhi liu ya-jun DENG Shuan-liang fan Li-bin DENG Feng chen Ping ZHANG Jie fanG Li-ping chen Hong-dan WANG Zhen-yuan WANG Rudolf LUCAS Department of Forensic Medicine School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University Xi 'an 710061 China Vascular Biology Center Medical College of Georgia Augusta Georgia 30912 USA Shaan'xi Blood Center Xi 'an 710061 China Institute of Molecular Medicine and Genetics Medical College of Georgia Augusta Georgia 30912 USA Department of Public Health School of Medicine Xi'an Jiaotong University Xi'an 710061 China Center of Forensic Sciences Beijing Genomics Institute Beijing 101300 China Faculty of Basic Medical Science Nanchang University Nanchang 330006 China

Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and-B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and-B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and-B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

关键词： Yi ethnic minority Human leukocyte antigen (HLA)-A HLA-B Allele Haplotype Polymerase chain reaction-sequence-based typing (PCR-SBT)

Experimental study on the improvement of insomnia model mice's symptoms by Sanwei Anmian Decoction and its disassembled prescription

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Food Therapy and Health Care 2020年第4期2卷 176-188页

作者： Yu-kun chen fan Yun xiao-fan Wang Shi-ya Feng Han yang Shu-guang Wei Nuo-Nan Zhang Gui-xiang Zhao Yu Kong Ke Dong Jin-Chan xia Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200032China Hubei University of Chinese Medicine Wuhan430065China Dongfang Hospital Beijing University of Chinese Medicine Beijing 100078China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine Beijing 100007China First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou 450000China The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei 230038China First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou 450046China College of Basic Medicine Henan University of Traditional Chinese MedicineZhengzhou 450008China

Background:Insomnia is a sleep disorder,which seriously affects people's physical and mental *** experimental study will further explain the efficacy and mechanism of the traditional Chinese medicine prescription Sanwei Anmian Decoction as well as the single drug treatment for insomnia,and provide scientific basis for TCM decoction to cure more insomnia ***:42 mices,half male and half female,were randomly divided into 7 groups,6 in each group,Blank group,Model group,Positive group,Sanwei Anmian Decoction group(abbreviated as Sanwei group),Suanzaoren group,Maidong group,Yuanzhi *** injection(ip)of PCPA 350 mg·kg^-1 in other groups except Blank group to establish a mice model of *** the next day after the successful modeling,10ml·kg^-1 corresponding decoction was given to Sanwei group,Suanzaoren group,Yuanzhi group and Maidong group respectively,0.8mg·kg^-1 estazolam for Positive group,Blank group and the Model group with the same amount of normal saline,three times a day for two *** body weight and the number of autonomous activities of mice were *** sleep rate,sleep latency and sleep time were recorded after the last administration,and the contents of serum 5-hydroxytryptamine(5-HT)and dopamine(DA)were ***:The changes of hair yellowing,alarm,food loss and weight loss in mice showed that the model was *** the last administration,compared with the Model group and the Blank group,the weight of mice in Sanwei Anmian Decoction and each disassembled prescription group increased,the autonomous activity decreased,the number of mice fell asleep increased,the concentration of 5-HT in serum increased and the concentration of DA decreased,P<0.01,which was statistically ***:Sanwei Anmian Decoction can effectively improve the symptoms of PCPA insomnia mice *** single drug,Suanzaoren Decoction has the most obvious effect on the treatment of insomnia.

关键词： Sanwei Anmian Decoction Chlorophenylalanine Insomnia Mice Experimental study

Keggin和Dawson结构多金属氧酸盐光催化脱色偶氮染料

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化学研究与应用 2009年第7期21卷 1042-1045页

作者：马凤霞刘坤孟凡霞陈亚光徐文娟东北师范大学化学学院吉林长春130024 吉林农业科技学院文理学院吉林吉林132101 长春市第二中学吉林长春130061 集安市第一中学吉林集安134200

The investigation photocatalytic degradation of three azo dyes solution(Acid Mordant Navy Blue RRN,Acid Mordant Black PV,Acid Mordant Brown RH) under UV light irradiation using the polyoxometalates as catalyst was reported in this *** research results showed that the photocatalytic activity of Keggin catalyst is higher than that of Dawson,and the catalyst α-H4SiW12O40 had the best efficiency to the photocatalytic decoloration of *** 350 mg·L-1(30 mL) RRN solution,the optimum reaction condition was as follow:the amount of catalyst α-H4SiW12O40 is 75 μmol·L-1,V(methanol)=3.0 mL,pH=*** the above condition,the decolorization rate of RRN at 40 minutes comes up to 98.66%.

关键词：多金属氧酸盐偶氮染料光催化降解

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan Li Wei Dong Yu-Qi liu yang Wu Da-Xuan Tang Fu-Chun Zhang meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin chen yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao xiao-fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying xiao You-Zhi Hu xiao-Yu Huang kun Xing Xin Jiang Chao-Feng liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying yang yao-Rong Dong Lei Zhang guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun xia Jun liu fan liu Wen-Jin He Ying Li Jian-Cong Tan yang Lin ya-Bin Zhou Jian-Fei yang Guo-Qing Ma Hui-Jun chen He-Ping liu Zong-Wu liu Jian-Xiong liu xiao-Jia Luo xiao-Hong Bin ya-Nan Yu Hai-xia Dang Bing Li Fei Teng Wang-Min Qiao xiao-Long Zhu Bing-Wei chen Qi-guang chen Chun-Ti Shen Yong-yan Wang Yun-Dai chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai xiao-Dong Wang Hai-Feng Wang Chun-Long liu Hong-Ji Zhang guang Zhang Yunqi Wang Shi-Jie liu Hong-Xin Zhang Lei liu Shi-Lei Mao yang liu Jia-Hao Peng Peng Wang Liang Sun yang liu Zhen-Wei Han yan-Long Wang kun Wu guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi xia Qing-Wen Wu Jin-Jiang Xie ya chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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Nuclear Science and Techniques 2024年第10期35卷 149-160页

作者： Jin-cheng Wang Jie Ren Wei Jiang Xi-Chao Ruan Ying-Yi liu Hao-Lan yang Kuo-Zhi Xu Xin-Yi Pan Qi Sun Jie Bao Han-Xiong Huang Hao-fan Bai Jiang-Bo Bai Ping Cao Qi-Ping chen Yong-Hao chen Wen-Hao Duan An-Chuan fan Rui-Rui fan Chang-Qing Feng Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He yang Hong Yi-Wei Hu Zhi-Jie Jiang Ling Kang Chang-Lin Lan Bo Li Feng Li Qiang Li xiao Li yang Li Jie liu Rong liu Shu-Bin liu Yi-Na liu guang-Yuan Luan Chang-Jun Ning Yi-Jia Qiu Wen-Kai Ren Zhi-Zhou Ren Zhao-Hui Song Kang Sun Zhi-Xin Tan Jing-Yu Tang Sheng-Da Tang Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Zhong-Wei Wen xiao-guang Wu Xuan Wu Ze-Peng Wu Cong xia Li-kun Xie Han Yi Tao Yu Yong-Ji Yu Guo-Hui Zhang Hang-Chang Zhang Qi-Wei Zhang xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Mao-Yuan Zhao Zhi-Hao Zhou Ke-Jun Zhu Chong Zou Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230027China

The back-streaming white-neutron beamline(Back-n)of the China Spallation Neutron Source is an essential neutronresearch platform built for the study of nuclear data,neutron physics,and neutron *** types of cross-sectional neutron-reaction measurements have been performed at Back-n since early *** measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron *** gamma rays,commonly referred to as in-beam gamma rays,can induce a non-negligible experimental background in neutron-reaction *** the characteristics of in-beam gamma rays is important for understanding the experimental ***,measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons;thus,discriminating between neutron-induced signals and those from in-beam gamma rays is *** this study,we propose the use of the black resonance filter method and a CeBr_(3) scintillation detector to measure the characteristics of the in-beam gamma rays of *** types of black resonance filters,^(181)Ta,^(59)Co,^(nat)Ag,and^(nat)Cd,were used in this *** time-of-flight(TOF)technique was used to select the detector signals remaining in the absorption region of the TOF spectra,which were mainly induced by in-beam gamma *** energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr_(3) scintillation detector and using Monte Carlo *** on the results of this study,the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated,which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n CeBr_(3)scintillator Black filter resonance technique

三维超分子化合物[Cu^Ⅰ (en) 2 ] [ PW2^ⅤW10^ⅥO39 ] (Hen) 2· 2H2O的合成与表征

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东北师大学报（自然科学版） 2008年第1期40卷 65-70页

作者：刘洪波刘志红陈亚光孟凡霞石冬梅庞海军东北师范大学化学学院教育部多酸科学重点实验室吉林长春130024 长春医学高等专科学校药学系吉林长春130031

采用水热合成法制备了三维超分子化合物[Cu^Ⅰ （en） 2 ] [ PW2^ⅤW10^ⅥO39 ] （Hen） 2· 2H2O（en为乙二胺）．通过元素分析、红外光谱和X射线单晶衍射确定了化合物的组成和晶体结构．结果表明：晶体属于三斜晶系，P-1空间群；晶胞... 详细信息

采用水热合成法制备了三维超分子化合物[Cu^Ⅰ （en） 2 ] [ PW2^ⅤW10^ⅥO39 ] （Hen） 2· 2H2O（en为乙二胺）．通过元素分析、红外光谱和X射线单晶衍射确定了化合物的组成和晶体结构．结果表明：晶体属于三斜晶系，P-1空间群；晶胞参数a=1．09091（9）nm，b=1．16257（10）nm，C=1．94343（15）nm，α=81．38^＊，β=84．47^＊，γ=65．29^＊，V=2．2122（3）nm^3，Z=2，R1=0．0804，wR2=0．2003．标题化合物由1个α-Keggin型杂多阴离子单元、1个[Cu（en）2]^＋配阳离子、2个质子化的en分子和2个结晶水构成．多阴离子单元通过共用端氧的方式形成无限延展的一维链，一维链通过复杂的氢键网络堆积成具有哑铃型孔道的三维有机-无机超分子化合物．

关键词：多金属氧酸盐水热合成晶体结构一维链哑铃形孔状结构

Impact of newly recommended HbAlc-based diabetes diagnostic criteria on the prevalence of diabetes and high risk individual in clinical and community population in China

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Chinese Medical Journal 2010年第8期123卷 1103-1104页

作者： Ji Li-nong liu Wei liu Jing Dong yan-hu Wang Chang-jiang Zhu Da-long Li Qi-fu chen Lu-lu Xu Zhang-rong Tian Hao-ming xia Ning Zhang fan Li Hong liu Jie Shan Zhong-yan yao xiao-li Su Ben-li Zhou Zhi-guang Feng Ping Peking Univ Peoples Hosp Dept Endocrinol & Metab Beijing 100044 Peoples R China Shanghai Jiao Tong Univ Dept Endocrinol & Metab Renji Hosp Shanghai 200001 Peoples R China Gansu Prov Hosp Dept Endocrinol & Metab Lanzhou 730000 Gansu Peoples R China Qingdao Diabet Hosp Dept Endocrinol & Metab Qingdao 266071 Shandong Peoples R China Anhui Med Univ Dept Endocrinol & Metab Affiliated Hosp 1 Hefei 230022 Anhui Peoples R China Nanjing Univ Dept Endocrinol & Metab Sch Med Affiliated Drumtower Hosp Nanjing 210008 Jiangsu Peoples R China Chongqing Med Univ Dept Endocrinol & Metab Affiliated Hosp 1 Chongqing 400016 Peoples R China Huazhong Univ Sci & Technol Dept Endocrinol & Metab Tongji Hosp Tongji Med Coll Wuhan 430030 Hubei Peoples R China 306th Hosp Chinese Peoples Liberat Army Dept Endocrinol & Metab Beijing 100101 Peoples R China Sichuan Univ Dept Endocrinol & Metab W China Hosp Chengdu 610041 Sichuan Peoples R China guangxi Med Univ Dept Endocrinol & Metab Affiliated Hosp 1 Nanning 530021 Guangxi Peoples R China Peking Univ Dept Endocrinol & Metab Shenzhen Hosp Shenzhen 518036 Guangdong Peoples R China Zhejiang Univ Dept Endocrinol & Metab Sir Run Run Shaw Hosp Hangzhou 310016 Zhejiang Peoples R China Shanxi Prov Hosp Dept Endocrinol & Metab Taiyuan 030012 Shanxi Peoples R China China Med Univ Affiliated Hosp 1 Dept Endocrinol & Metab Shenyang 110001 Liaoning Peoples R China Xi An Jiao Tong Univ Affiliated Hosp 1 Dept Endocrinol & Metab Xian 710061 Shaanxi Peoples R China Dalian Med Sch Dept Endocrinol & Metab Affiliated Hosp 2 Dalian 116031 Liaoning Peoples R China Cent China Univ Dept Endocrinol & Metab Xiang Ya Hosp 2 Changsha 410011 Hunan Peoples R China Tianjin Med Univ Dept Endocrinol & Metab Gen Hosp Tianjin 300052 Peoples R China

To the editor： Recently, the International Expert Committee recommended using HbAlc as a diagnosing tool for diabetes and suggested HbAlc value of 6.5% as cut-off for the diagnosis. In this recommendation, pre-diabetes was replaced by ＂sub-diabetes or high risk status＂ which was defined by HbAlc between 6.0% and 6.5%. The recommendation has triggered wide discussion on its potential influence on diabetes care, for example, the impact of the new diabetes diagnosis criteria on the prevalence of diabetes. We have noticed that the level of HbAlc correlated with oral glucose tolerance test （OGTr） based diabetes diagnosis criteria2 is lower than 6.5%.3,4 We hypothesized that the new diagnosis criteria will reduce the prevalence of both diabetes and high risk population in Chinese population. To test this hypothesis,

关键词： China individual high risk population diagnostic criteria diagnosis criteria oral glucose tolerance test HbAlc based International influence OGTT defined Chinese new impact level care