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污水处理厂尾水排放对受纳河流细菌和真菌微生物群落的影响

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环境科学 2024年第4期45卷 2246-2258页

作者：郭有顺余仲郝文彬孟凡刚中山大学环境科学与工程学院广州510006 广东省环境科学研究院广州510045

污水处理厂尾水的持续排放会重塑受纳河流的理化和生物条件,对河流水质和水生态产生潜在影响.选取惠州市东江沿线2座污水处理厂的受纳河流进行水样采集及分析,利用高通量测序进行样品DNA分析,系统研究细菌和真菌群落的组成结构及其分布... 详细信息

污水处理厂尾水的持续排放会重塑受纳河流的理化和生物条件,对河流水质和水生态产生潜在影响.选取惠州市东江沿线2座污水处理厂的受纳河流进行水样采集及分析,利用高通量测序进行样品DNA分析,系统研究细菌和真菌群落的组成结构及其分布,结合水体的理化指标更全面地反映尾水排放对受纳河流的影响.结果表明,污水处理厂尾水排放口处TP和NH_(4)^(+)-N等营养盐指标均高于受纳河流上游,尾水排放对受纳河流微生物的影响显著,细菌群落的丰富度明显降低.对受纳河流微生物群落组成和水体理化指标进行统计分析,发现DOM、TP和NH_(4)^(+)-N的变化对浮游微生物群落结构可能起关键作用.通过对浮游细菌和真菌群落结构及水体的理化性质综合分析研究,能够更加全面地揭示污水处理厂尾水排放对受纳河流引起的复合生态效应,对污水处理厂提标改造和城市河流的保护具有重大意义.

关键词：污水处理厂(WWTPs) 尾水受纳河流饮用水水源微生物群落东江

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耳后磨骨槽技术在脑深部电刺激术中的应用

中国现代神经疾病杂志 2024年第7期24卷 522-524页

作者：孟凡刚张建国北京市神经外科研究所、首都医科大学附属北京天坛医院神经外科 100070

脑深部电刺激术已广泛应用于帕金森病、特发性震颤、肌张力障碍、难治性癫痫等神经精神疾病,操作步骤复杂,临床应用易引起一定的并发症如颅内出血、感染等手术并发症,电极断裂、电极移位等硬件并发症,以及感觉异常、肌肉痉挛等刺激并发... 详细信息

脑深部电刺激术已广泛应用于帕金森病、特发性震颤、肌张力障碍、难治性癫痫等神经精神疾病,操作步骤复杂,临床应用易引起一定的并发症如颅内出血、感染等手术并发症,电极断裂、电极移位等硬件并发症,以及感觉异常、肌肉痉挛等刺激并发症,其中电极断裂、皮肤破溃感染是常见并发症且主要位于耳后。首都医科大学附属北京天坛医院于2012年将耳后磨骨槽技术应用于临床,显著降低耳后电极断裂和皮肤破溃感染的风险。本文重点介绍耳后磨骨槽技术及其临床应用注意事项,供同道参考借鉴。

关键词：深部脑刺激法耳后磨骨槽技术(非MeSH词) 手术后并发症综述

小脑齿状核脑深部电刺激术对脑卒中后运动功能的改善作用

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中国现代神经疾病杂志 2024年第7期24卷 507-509页

作者：孟凡刚许天奇季玉陈张树新北京市神经外科研究所、首都医科大学附属北京天坛医院神经外科 100070 郑州大学第一附属医院神经外科 450052 山东省东阿县人民医院神经外科聊城252201

脑卒中可以导致长期运动障碍,降低生活质量。尽管传统康复治疗取得的进展为患者带来曙光,仍有众多患者面临康复治疗效果有限的问题。神经调控技术即显示出突破性治疗潜力。本文旨在概述脑卒中后神经可塑性机制,探究小脑齿状核脑深部电... 详细信息

脑卒中可以导致长期运动障碍,降低生活质量。尽管传统康复治疗取得的进展为患者带来曙光,仍有众多患者面临康复治疗效果有限的问题。神经调控技术即显示出突破性治疗潜力。本文旨在概述脑卒中后神经可塑性机制,探究小脑齿状核脑深部电刺激术改善脑卒中后运动功能的作用机制、总结研究进展,以为临床实践提供科学依据及新的治疗视角。

关键词：深部脑刺激法小脑核卒中运动障碍

长期施肥对强筋专用小麦籽粒营养及磨粉品质性状的影响

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植物营养与肥料学报 2024年第1期30卷 190-198页

作者：贾靖孟繁港朱紫鑫张玉璐刘帅刘树堂赵长星山东省旱作农业技术重点实验室/青岛农业大学农学院山东青岛266109 青岛农业大学资源与环境学院山东青岛266109

【目的】分析不同施肥措施对小麦品质性状的影响,为优质小麦提供指导性建议。【方法】有机无机肥配合施用试验位于青岛农业大学莱阳长期定位试验站,始于1978年,共设9个处理,分别为不施肥对照(CK)、适量化肥氮138 kg/hm^(2) (N1)、适量... 详细信息

【目的】分析不同施肥措施对小麦品质性状的影响,为优质小麦提供指导性建议。【方法】有机无机肥配合施用试验位于青岛农业大学莱阳长期定位试验站,始于1978年,共设9个处理,分别为不施肥对照(CK)、适量化肥氮138 kg/hm^(2) (N1)、适量有机肥30000 kg/hm^(2) (M1)、有机肥30000 kg/hm^(2)+化肥氮138 kg/hm^(2)(M1N1)、过量化肥氮276 kg/hm^(2) (N2)、过量有机肥60000 kg/hm^(2) (M2)、有机肥30000 kg/hm^(2)+化肥氮276 kg/hm^(2)(M1N2)、有机肥60000 kg/hm^(2)+化肥氮138 kg/hm^(2) (M2N1)、有机肥60000 kg/hm^(2)+化肥氮276 kg/hm^(2) (M2N2),其中N1和M1为等氮量处理,N2和M2为等氮量处理。于2021年小麦成熟期,取籽粒样测定了籽粒营养与加工品质指标。【结果】适量氮肥显著提高了小麦籽粒Fe、粗蛋白、干湿面筋含量,提高出粉率,且化肥的提升效果优于有机肥。N2显著降低了小麦淀粉含量,影响糊化特性;M2处理小麦籽粒各项品质指标较M1得到提升,糊化特性也得到相应改善。与单施化肥(N1、N2)、有机肥(M1、M2)相比,M2N1显著改善了小麦籽粒品质,M2N1与CK相比分别提高Fe (34.26%)、Zn (19.77%)、出粉率(7.98%)、粗蛋白含量(30.75%)、淀粉含量(12.82%)、峰值黏度(24.93%)、崩解值(14.81%)、回复值(27.64%)。相比于M2N1,M2N2则降低了Zn含量、出粉率、容重、粗蛋白、淀粉含量、糊化特性。相关性分析显示,面粉中支链淀粉、总淀粉、支链淀粉/直链淀粉与峰值黏度、谷值黏度、最终黏度呈极显著正相关,容重、硬度与峰值黏度、谷值黏度呈极显著负相关,直链淀粉与峰值黏度、谷值黏度、最终黏度呈负相关。【结论】单施化肥可以显著提升小麦出粉率、蛋白质和面筋含量等品质,单施有机肥改善小麦面粉淀粉含量和糊化特性的效果更好,有机肥与氮肥配施可同时提升小麦的营养和加工品质,综合各项指标,最有利于小麦品质的施肥措施为年施有机肥60000 kg/hm^(2)+化肥氮138 kg/hm^(2)。

关键词：强筋小麦有机无机肥配施微量元素磨粉品质淀粉特性

Time Series and Spatial Epidemiological Analysis of the Prevalence of Iodine Deficiency Disorders in China

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Biomedical and Environmental Sciences 2022年第8期35卷 735-745页

作者： fan Li Jun GAO Yun Yan meng fan gang LIU Chang LIU Lan Chun DU Yang LIU Li Xiang LI Ming SU Xiao Hui LIU Shou Jun LIU Peng Institute of lodine DeficiencyDisorders Center for Endemic Disease ControlChinese Center forDisease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina National Health Commission&Education Bureau of Heilongjiang Province Key laboratory of Etiology and EpidemiologyHarbin Medical UniversityHarbin 150081HeilongjiangChina

Objective To recognize the spatial and temporal characteristics of iodine deficiency disorders(IDD),China national IDD surveillance data for the years of 1995–2018 were *** Time series analysis was used to describe and predict the IDD related indicators,and spatial analysis was used to analyze the spatial distribution of salt iodine *** In China,the median urinary iodine concentration increased in 1995–1997,then decreased to adequate levels,and are expected to remain appropriate in 2019–*** goiter rate continually decreased and is expected to be maintained at a low *** 2002,the coverage rates of iodized salt and the consumption rates of qualified iodized salt(the percentage of qualified iodized salt in all tested salt) increased and began to decline in 2012;they are expected to continue to *** epidemiological analysis indicated a positive spatial correlation in 2016–2018 and revealed feature regarding the spatial distribution of salt related indicators in coastal areas and areas near iodine-excess *** Iodine nutrition in China showed gradual ***,a recent decline has been observed in some areas following changes in the iodized salt supply in *** the future,more regulations regarding salt management should be issued to strengthen IDD control and prevention measures,and avoid the recurrence of IDD.

关键词： Salt iodine lodine deficiency disorders Time series analysis Space epidemiology Reform for the salt industry system

Comparison of membrane fouling during short-term filtration of aerobic granular sludge and activated sludge

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Journal of Environmental Sciences 2007年第11期19卷 1281-1286页

作者： ZHOU Jun YANG Feng-lin meng fan-gang AN Peng WANG Di School of Environmental and Biological Science and Technology Dalian University of Technology Dalian 116024 China

Aerobic granular sludge was cultivated adopting internal-circulate sequencing batch airlift reactor. The contradistinctive experiment about short-term membrane fouling between aerobic granular sludge system and activated sludge system were investigated. The membrane foulants was also characterized by Fourier transform infrared （FTIR） spectroscopy technique. The results showed that the aerobic granular sludge had excellent denitrification ability; the removal efficiency of TN could reach 90%. The aerobic granular sludge could alleviate membrane fouling effectively. The steady membrane flux of aerobic granular sludge was twice as much as that of activated sludge system. In addition, it was found that the aerobic granular sludge could result in severe membrane pore-blocking, however, the activated sludge could cause severe cake fouling. The major components of the foulants were identified as comprising of proteins and polysaccharide materials.

关键词： membrane bioreactor membrane fouling pore-blocking cake layer resistance aerobic granular sludge

Hippocampus chronic deep brain stimulation induces reversible transcript changes in a macaque model of mesial temporal lobe epilepsy

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Chinese Medical Journal 2021年第15期134卷 1845-1854页

作者： Ning Chen Jian-Guo Zhang Chun-Lei Han fan-gang meng Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Beijing Key Laboratory of Neuromodulation Beijing Municipal Science and Technology CommissionBeijing 100070China ieijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Chinese Institute for Brain Research Beijing 102206China

Background:Deep brain stimulation(DBS)has seizure-suppressing effects but the molecular mechanisms underlying its therapeutic action remain *** study aimed to systematically elucidate the mechanisms underlying DBS-induced seizure suppression at a molecular ***:We established a macaque model of mesial temporal lobe epilepsy(mTLE),and continuous high-frequency hippocampus DBS(hip-DBS)was applied for 3 *** effects of hip-DBS on hippocampus gene expression were examined using high-throughput microarray analysis followed by bioinformatics ***,the microarray results were validated using quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot ***:The results showed that chronic hip-DBS modulated the hippocampal gene *** identified 4119 differentially expressed genes and assigned these genes to 16 model *** test of cluster analysis showed that profiles 5,3,and 2 were the predominant expression ***,profile 5 was mainly involved in focal adhesion and extracellular matrix-receptor interaction *** dysregulated genes(Arhgap5,Colla2,Itgbl^Pik3rl,Lama4,Fnl,Col3al,Itga9,and Shc4)and three genes(Colla2,Itgbl,and Flna)in these two pathways were further validated by qRT-PCR and Western blot analyses,respectively,which showed a ***:Our findings suggest that hip-DBS could markedly reverse mTLE-induced abnormal gene *** from this study establish the basis for further investigation of the underlying regulatory mechanisms of DBS for mTLE.

关键词： Deep brain stimulation Gene expression profile Hippocampus Temporal lobe epilepsy

Internal Pallidum and Subthalamic Nucleus Deep Brain Stimulation for Oromandibular Dystonia

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Chinese Medical Journal 2016年第13期129卷 1619-1620页

作者： Xue-Min Zhao Jian-Guo Zhang fan-gang meng Department of Functional Neurosu rgery Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China Beijing Key Laboratory of Neuromodulation Beijing Municipal Science and Technology Commission Beijing 100050 China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Dystonia is a neurologic disorder characterized by sustained involuntary movements or abnormal posture. Oromandibular dystonia is a form of focal dystonia that is characterized by forceful contractions of face, jaw, o... 详细信息

关键词： Deep Brain Stimulation Globus Paliidus Intemus Oromandibular Dystonia Subthalamic Nucleus

Preface of the Special Issue on Symplectic Geometry and Mathematical Physics

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Acta Mathematica Sinica,English Series 2024年第1期40卷 1-2页

作者： Huijun fan Xiaobo Liu gang Tian Peking University BeijingChina

Symplectic geometry is a branch of differential geometry and differential topology and has its origins in the Hamiltonian formulation of classical *** the last few decades,symplectic geometry has experienced enormous progress and has had interactions with many other branches of mathematics,including enumerative geometry,low-dimensional topology,mathematical physics,Hamiltonian dynamics,integrable systems etc..

关键词： geometry topology Hamiltonian