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光明中医 2011年第7期26卷 1324-1325页

作者：李孝波门九章邓晓鹏山西中医学院太原030024 山西省中西医结合医院太原030013

选取门九章教授应用附子汤治疗失眠、慢性乙型肝炎、干燥综合征3个典型病例,探讨附子汤的辨证运用及用方技巧,主张以"脉象沉细、四肢厥冷、颜面苍白、不欲饮水"四点作为临证辨识附子汤证的重要脉证,从而扩大附子汤应用范围,活用古方。

关键词：附子汤失眠慢性乙型肝炎口干名医经验门九章

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门九章运用雄芍汤治疗肝硬化经验

上海中医药杂志 2020年第1期54卷 27-29页

作者：徐广东李霞门九章段彦青赵小婷山西中医药大学山西太原030019 山西省中西医结合医院消化科山西太原030013

介绍门九章教授运用雄芍汤治疗肝硬化的临床经验。认为肝硬化的病机关键为肝失疏泄、脾失健运、肾失气化,气滞、血瘀、水湿为病理产物,病久及肾,命门火衰,而成脾肾阳虚之证,总属本虚标实。临证以温肾健脾为治则,研创特色方药雄芍汤,疗... 详细信息

介绍门九章教授运用雄芍汤治疗肝硬化的临床经验。认为肝硬化的病机关键为肝失疏泄、脾失健运、肾失气化,气滞、血瘀、水湿为病理产物,病久及肾,命门火衰,而成脾肾阳虚之证,总属本虚标实。临证以温肾健脾为治则,研创特色方药雄芍汤,疗效颇佳;同时重视顾护胃气,擅用联合方组。并附验案2则。

关键词：肝硬化雄芍汤温肾健脾名医经验门九章

从《伤寒论》太阴病治则谈门九章教授“大病以胃”思想

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新中医 2018年第6期50卷 225-227页

作者：许凯霞李孝波门九章山西中医药大学山西晋中030619

《伤寒论》太阴病治则为"当温之,宜服四逆辈",而四逆汤为少阴病主方,太阴病进一步发展,正气进一步减弱则发为少阴病。说明这一治则是仲景以疾病发展的眼光来确立的。同时四逆汤中的干姜、炙甘草实为治中焦脾胃之药,反映了疾病进展至全... 详细信息

《伤寒论》太阴病治则为"当温之,宜服四逆辈",而四逆汤为少阴病主方,太阴病进一步发展,正气进一步减弱则发为少阴病。说明这一治则是仲景以疾病发展的眼光来确立的。同时四逆汤中的干姜、炙甘草实为治中焦脾胃之药,反映了疾病进展至全身阳虚阶段必须要顾护中焦脾胃的思想。门九章教授发现,多种系统的大病进展至后期,呈现功能虚衰状态,此时必须注重顾护脾胃,以理中汤、香砂六君子汤甚至四逆汤等方为基础进行化裁,皆能起到良效,并据此提出"大病以胃"思想,实为对仲景思想的深入理解,对临床用药尤其是对大病的治疗,具有重要的指导意义。

关键词：《伤寒论》太阴病治则大病以胃门九章

Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第1期14卷 140-148页

作者： Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru Shi men Yu Qingxia Huang Huiru Tang State Key Laboratory of Genetic Engineering School of Life SciencesHuman Phenome InstituteZhangjiang Fudan International Innovation CenterMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsZhongshan HospitalFudan UniversityShanghai200032China Wuhan Laboratory for Shanghai Metabolome Institute(SMI)Ltd. Wuhan430000China

Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection 0.992), accuracy (relative error 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices.

关键词： Acylcarnitine UPLC-MS/MS Quantitative structure-retention relationship Molecular phenotype

Boosted Electrocatalytic Glucose Oxidation Reaction on Noble-Metal-Free MoO_(3)-Decorated Carbon Nanotubes

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Transactions of Tianjin University 2024年第1期30卷 63-73页

作者： Yu-Long men Ning Dou Yiyi Zhao Yan Huang Lei Zhang Peng Liu Department of Chemical Engineering School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Thyroid Breast and Vascular Surgery Shanghai Fourth People’s Hospital Affi liated to Tongji University School of MedicineShanghai 200081China Department of Vascular Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China

Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell ***,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)*** the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 ***,MC-60 has superior stability and anti-interference ability to impurities in the *** better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C *** Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the ***,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.

关键词： Interface eff ect Electrocatalysis Molybdenum oxide Glucose Oxidation reaction

基于“大病以胃”思想诊治新型冠状病毒肺炎的肺脾相关性探讨

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云南中医学院学报 2022年第6期45卷 11-14页

作者：刘青李孝波门九章昆明市中医医院云南昆明650011 山西中医药大学山西太原030024 山西中医药大学附属医院山西太原030000

注重胃气是中医学独特的诊疗特色。“大病以胃”思想是山西门氏杂病流派治疗疑难疾病的一项重要治则。“大病”之“大”,既指疾病的病程,又指症状、病情、预后等。在新型冠状病毒肺炎(corona virus disease 2019,COVID-19)诊治过程中,... 详细信息

注重胃气是中医学独特的诊疗特色。“大病以胃”思想是山西门氏杂病流派治疗疑难疾病的一项重要治则。“大病”之“大”,既指疾病的病程,又指症状、病情、预后等。在新型冠状病毒肺炎(corona virus disease 2019,COVID-19)诊治过程中,要充分认识到新型冠状病毒肺炎的病位不仅在肺,同时也在脾,与宗气相关。治疗时当从人体整体功能状态出发,肺脾同调,扶助胃气,调整脏腑功能,增强宗气,促进患者机体恢复正常的功能状态,从而治愈疾病。“大病以胃”思想作为中医药传承几千年形成的经典理论,是中医实证精华,是秉承中医最好的表达。“大病以胃”思想可为COVID-19的诊疗提供新的诊疗思路。

关键词：大病以胃新型冠状病毒肺炎诊治肺脾相关性

Self-powered stimuli responsive material for dual stimulation of heat and guest molecules

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Chinese Chemical Letters 2024年第2期35卷 590-593页

作者： Jintao men Ke Xu Taiting Sha Lei He Yan Xu Jie Mu Tijian Yin Qiong Ye Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Stimuli-responsive smart materials exhibit reverse chemical/physical changes in response to external stimuli and research on stimuli-responsive smart materials with self-powered properties is still uncultivated ***,we report perovskite crystalline self-powered multiple stimuli-responsive materials triggered by chemical and thermal stimuli.[HMEP]PbI_(3)·(H_(2)O)(1;HMEP is a hydroxytris(1-methylethyl)phosphorus cation)crystallizes in a chiral space group P 21 at 293 K and has the piezoelectric reaction(d_(33)=10 pC/N and output voltage=1 V)of self-powered modes,this value is larger than the value of 3 pC/N for the classical piezoelectric material *** materials can generate energy due to mechanical deformation,and using thermal heating to lose water,[HMEP]PbI_(3)(2)can be obtained.2 crystallizes in the non-centrosymmetric space group,undergoes two reversible phase transitions at 243/255 K and 315/348 K,and shows second harmonic generation ***,2 can return to the hydrated form 1 after absorbing *** work will lay the foundation for self-powered stimuli-responsive compounds and contribute to the construction of novel organic-inorganic hybrid materials with second harmonic generation switching.

关键词： Self-powered Dual stimulation reactive Phase transition SHG switch Organic-inorganic hybrid perovskite

Pollutant emissions from biomass burning:A review on emission characteristics,environmental impacts,and research perspectives

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Particuology 2024年第2期85卷 296-309页

作者： Ke Jiang Ran Xing Zhihan Luo Wenxuan Huang Fan Yi Yatai men Nan Zhao Zhaofeng Chang jinfeng Zhao Bo Pan Guofeng shen College of Urban and Environmental Sciences Peking UniversityBeijing100871China Beijing Key Lab Plant Resources Research and Development Beijing Technology and Business UniversityBeijing100048China College of Ecology and Environment Zhengzhou UniversityZhengzhou450001China Facultyof Environmental Sciences and Engineering Kunming University of Science and TechnologyYunnan Provincial Key Laboratoryof Soil Carbon Sequestration and Pollution ControlKunming650500China Institute of Carbon Neutrality Peking UniversityBeijing100871China

Biomass is one most abundant resource on the earth providing important energies in support of so-cioeconomic development in many *** of biomass fuels comprises to nearly 10%of the total energy from anthropogenic combustion processes:however,as the burning is usually incomplete,this process yields products of incomplete combustion posing consequently significant impacts on air quality,human health,and climate ***,we analyzed spatiotemporal characteristics in intentional and unintentional biomass burning from different sectors,discussed impacts of biomass burning emissions on indoor and outdoor air quality,and consequent influences on human *** global total con-sumption amount of biomass including both natural and anthropogenic sources was approximately 7900 Tg in 2019,with significantly large regional and sectorial discrepancies among ***,anthropogenic biomass burning amounts increased gradually,but notably in some developing countries like China residential consumption of biomass fuels,as one large sector of biomass use,decreased over *** biomass consumption needs to be accurately *** are relatively rich datasets of pollutant emission factors from biomass burning,including laboratory and field tests,but still large variations exit and contribute substantially to the uncertainty in emission *** pri-mary PM2.5,black carbon and organic carbon emissions from biomass burning were about 51,4.6,and 29 Tg,respectively,contributing to nearly 70%,55%,and 90%of the total emission from all sources,and emissions from the residential sector and open fires are major *** carbon emissions from biomass burning attracts growing interests but available studies adopted different methodologies challenging the comparability of those *** burning emissions polluted not only ambient air but more severely indoor air quality,adversely affecting human *** studies that should be emphasiz

关键词： Biomass burning Carbonaceous aerosol Emission Air quality Human health

Extrusion 3D printing of carbon nanotube-assembled carbon aerogel nanocomposites with high electrical conductivity

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Nano Materials Science 2024年第3期6卷 312-319页

作者： Lukai Wang Jing men Junzong Feng Yonggang Jiang Liangjun Li Yijie Hu Jian Feng Science and Technology on Advanced Ceramic Fibers and Composites Laboratory College of Aerospace Science and EngineeringNational University of Defense Technology109 De Ya RdChangshaHunan410073PR China

Carbon nanotubes(CNTs)with high aspect ratio and excellent electrical conduction offer huge functional improvements for current carbon ***,there remains a major challenge for achieving the on-demand shaping of carbon aerogels with tailored micro-nano structural textures and geometric ***,a facile extrusion 3D printing strategy has been proposed for fabricating CNT-assembled carbon(CNT/C)aerogel nanocomposites through the extrusion printing of pseudoplastic carbomer-based inks,in which the stable dispersion of CNT nanofibers has been achieved relying on the high viscosity of carbomer *** extrusion printing,the chemical solidification through polymerizing RF sols enables 3D-printed aerogel nanocomposites to display high shape fidelity in macroscopic *** from the micro-nano scale assembly of CNT nanofiber networks and carbon nanoparticle networks in composite phases,3D-printed CNT/C aerogels exhibit enhanced mechanical strength(fracture strength,0.79 MPa)and typical porous structure characteristics,including low density(0.220 g cm^(-3)),high surface area(298.4 m^(2)g^(-1)),and concentrated pore diameter distribution(~32.8nm).More importantly,CNT nanofibers provide an efficient electron transport pathway,imparting 3D-printed CNT/C aerogel composites with a high electrical conductivity of 1.49 S cm^(-1).Our work would offer feasible guidelines for the design and fabrication of shape-dominated functional materials by additive manufacturing.

关键词： Carbon aerogel Extrusion 3D printing Carbon nanotube Electrical conductivity Rheology

Climate warming is likely to weaken the performance of two-phase closed thermosyphon on the Qinghai-Tibet Plateau

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Advances in Climate Change Research 2024年第1期15卷 90-100页

作者： Guan-Li JIANG Zi-Teng FU Xin-Yu men Hong-Ting ZHAO Si-Ru GAO Yong-Zhi LI Qing-Bai WU State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Beiluhe Observation and Research Station on Frozen Soil Engineering and Environment in the Qinghai-Tibet Plateau Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Muli Field Scientific Observation and Research Station for Gas Hydrate China Geological SurveyBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China School of Civil Engineering and Architecture Jiaxing Nanhu UniversityJiaxing 314001China

Over the years,numerous geotechnical approaches have been implemented to mitigate the adverse effects of climate warming on various infrastructures in the permafrost region of the Qinghai-Tibet Plateau(QTP),such as the Qinghai-Tibet Highway and Railway,and achieved the expected engineering ***,little attention has been given to whether the performance of these geotechnical approaches has changed during the ongoing process of climate *** investigate the performance variation of one of these geotechnical approaches,which is two-phase closed thermosyphon(TPCT),during sustained climate warming,we conducted a statistical analysis of soil temperature monitoring data in 2003-2020 from eight regular embankments and six TPCT embankments in our permafrost monitoring *** results indicate that TPCT undeniably has a cooling effect on the permafrost beneath embankments,even rapidly eliminated previously formed taliks beneath ***,further analysis reveals that the performance of TPCT has been weakening during sustained climate warming,which has confirmed by the re-forming of the taliks beneath embankment where they had been previously *** on the current understanding,we attributed the weakening of thermosyphon performance to a significant reduction in the air temperature freezing index caused by ongoing climate *** this study,we aimed to draw attention to the evolving performance of geotechnical approaches in permafrost regions amid climate warming,prompting necessary engineering innovations to address this situation and ensure the sustainable development of the permafrost region on the QTP.

关键词： Two-phase closed thermosyphon Climate warming Supra-permafrost talik Permafrost degradation Qinghai-Tibet Highway