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Shengmai Yin formula promotes ventricular remodeling in chronic heart failure rats by inhibiting excessive autophagy via activating AKT/mTOR pathway

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TMR Integrative Medicine 2023年第29期7卷 1-8页

作者： Ye Li Qiang Xu Wei Zhou mei-juan lu Jian-Zhong Pang juan Wang Tian Li Xiao-Yue Cai Yan-Kun Liu Department of Cardiology The Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Background:Shengmai Yin(SMY)formula,a traditional Chinese medicine,shows a definite therapeutic effect on chronic heart failure(CHF)in clinical practice,but the molecular mechanism remains largely *** PI3K/Akt/mTOR pathway is a classic pathway of autophagy and plays a pivotal role in the occurrence and development of ***,we aimed to investigate whether SMY formula treat CHF rats by inhibiting excessive ***:Echocardiography was conducted to evaluate cardiac *** electron microscopy was used to observe the arrangement of myocardial *** linked immunosorbent assay analysis was performed to quantitative detecting the content of N-terminal pro-B-type natriuretic peptide,stromelysin-2,TNF-α in rat *** blotting was used to detect the expression of AKT,p-AKT,mTOR,p-mTOR,light chain 3(LC3),and *** vitro,myocardial cells were treated with hypoxia reoxygenation and then intervened with *** counting kit-8 method was used to measure the cell *** immunofluorescence expression of LC3 protein were also ***:In vivo,SMY intervention assisted in the ventricular remodeling,reduced the levels of N-terminal pro-B-type natriuretic peptide,stromelysin-2,TNF-αin serum,and recovered myocardial cell structure in CHF *** with SMY significantly promoted the ratio of p-AKT/AKT,p-mTOR/mTOR,and down-regulated the expression level of p62 and the ratio of LC3-Ⅱ/LC3-Ⅰ.In vitro,when the concentration of SMY containing serum reached 40% in the medium,the activity of myocardial cells reached the highest at 135.14%.SMY inhibited the expression of LC3 in hypoxic-reoxygenation embryonic ventricular myocytes *** the hypoxic reoxygenation cells treated with p-mTOR inhibitor,rapamycin,or p-AKT inhibitor,API-1,SMY could also down-regulated the LC3 expression ***:SMY formula functions in restoring cardiac function and promoting myocardial ultrastructural recovery by reducing autophagy act

关键词： chronic heart failure ventricular remodeling

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying lu Jingjie Ge Mingjia Chen Ruixin Yao mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Proteome Analysis of Neisseria meningitidis Serogroup Strains C Associated with Outbreaks in China

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Biomedical and Environmental Sciences 2010年第4期23卷 251-258页

作者： YUAN HU ZHU-JUN SHAO XIAO-mei YAN BO-QING LI FEI ZHAO DI XIAO JUN REN MING-HUAN ZHENG CHUN-XIANG FAN LI-HUA HE LI XU YI-XIN GU HAI JIANG FENG-HUA GUO ZHEN-WEI DAI HONG-YU REN mei-juan lu XIA CHEN QING-HUA ZOU FAN-LIANG MENG JIAN-ZHONG ZHANG National Institute for Communicable Disease Control and Prevention China CDC P O Box 5 Changping Beijing 102206 China Anhui Provincial Center for Disease Control and Prevention Hefei 230061 Anhui China

Objective During 2003-2005, an outbreak of meningitis due to Neisseria meningitidis serogroup C occurred in China. With the aim to find strain clues result in the final epidemics, the ancestral strain 053442, a clinical isolate, and a carrier strain 053426 with different gene type were analyzed. Methods Clinical strain 053442 and carrier strain 053426 were cultured on GC agar plates under the same condition. Two-dimensional electrophoresis was performed using the pH 3–10 nonlinear IPG strips of 24 cm length, and all the protein spots were identified by matrix-assisted laser desorption/ionization time of flight spectrometry. Results 502 and 380 protein spots were identified in 053426 and 053442 respectively, relating to 266 and 202 different genes covering a wide range of cellular functions. The express volume and number of proteins involved in energy metabolism, protein synthesis and amino acid biosynthesis in 053426 were higher than in 053442. Virulence factor Opa, Opc and a series of proteins involved in pilus assembly and retraction were identified in 053442, which appear to be of primary importance in colonization and invasion of human cells. Compared to 053442, virulence protein species were less in 053426, with lower express volumes too. No Opa and Opc were detected in 053426. Conclusion The different protein expression profiles of the clinical strain 053442 and carrier strain 053426 in the present study provide some clues of the different pathogenicity of the two strains, which may account for result in the final epidemics.

关键词： Neisseria meningitidis Reference map Two-dimensional gel electrophoresis MALDI-TOF/TOF-MS

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抑郁症患者血清TNF-α、IL-8、ICAM-1、NF-κB水平及其意义

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中国现代医学杂志 2018年第32期28卷 117-120页

作者：陆梅娟莫亚莉浙江省湖州市第三人民医院心身科浙江湖州313000 浙江省杭州市第七人民医院精神科浙江杭州310013

目的探讨抑郁症患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、细胞间黏附分子(ICAM-1)、核因子-κB(NF-κB)水平及其意义。方法选择2016年1月-2017年12月在该院就诊的抑郁症患者80例作为抑郁症组,健康体检者80例作为对照组。... 详细信息

目的探讨抑郁症患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、细胞间黏附分子(ICAM-1)、核因子-κB(NF-κB)水平及其意义。方法选择2016年1月-2017年12月在该院就诊的抑郁症患者80例作为抑郁症组,健康体检者80例作为对照组。采用酶联免疫吸附实验测定血清TNF-α、IL-8、ICAM-1、NF-κB水平。采用汉密尔顿抑郁量表(HAMD)评定患者的抑郁情绪。结果抑郁症组患者血清TNF-α、IL-8、ICAM-1、NF-κB水平和HAMD评分高于对照组(P<0.05);治疗后血清TNF-α、IL-8、ICAM-1、NF-κB水平和HAMD评分低于治疗前(P<0.05)。抑郁症患者血清TNF-α、IL-8、ICAM-1、NF-κB水平与HAMD评分呈正相关(P <0.05)。抑郁症患者血清TNF-α、IL-8、ICAM-1与NF-κB水平呈负相关(P<0.05)。结论抑郁症患者血清TNF-α、IL-8、ICAM-1、NF-κB水平升高,炎症反应参与抑郁症的发病过程。

关键词：抑郁症肿瘤坏死因子-α 白细胞介素-8 细胞间黏附分子核因子-κB

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao juan-Han Yu Yi-Hua Wang Yi-Xin Liu lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： juan Liu Yan-Ping Guo Yan-mei lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(PluSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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The masking condition for the quantum state in two-dimensional Hilbert space

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Communications in Theoretical Physics 2022年第11期74卷 77-83页

作者： mei-yi Wang Su-juan Zhang Chen-ming Bai lu Liu Department of Mathematics and Physics Shijiazhuang Tiedao UniversityShijiazhuang 050043China

This paper focuses on quantum information masking for the quantum state in two-dimensional Hilbert *** present a system of equations as the condition of quantum information *** is shown that quantum information contained in a single qubit state can be masked,if and only if the coefficients of the quantum state satisfy the given system of *** observing the characteristics of non-orthogonal maskable quantum states,we obtain a related conclusion,namely,if two non-orthogonal two-qubit quantum states can mask a single qubit state,they have the same number of terms and the same ***,for maskable orthogonal quantum states,we analyze two special examples and give their images for an intuitive description.

关键词： quantum information masking limited conditions two-qubit

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秸秆还田模式对农田土壤碳库特性及产量的影响

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自然资源学报 2017年第5期32卷 755-764页

作者：王海候金梅娟陆长婴施林林周新伟沈明星季国军张永春江苏太湖地区农业科学研究所江苏苏州215155 江苏省农业科学院资源与环境研究所农业部江苏耕地保育科学观测实验站南京210014 农业部苏州水稻土生态环境重点野外科学观测试验站江苏苏州215155

为探明南方稻麦两熟制农田秸秆还田模式对土壤总有机碳、活性有机碳、碳库管理指数和稻麦产量的影响,论文通过8 a的水稻-小麦轮作田间定位试验,设置了4个秸秆还田模式处理:秸秆不还田(CK)、秸秆稻麦季均还田(RW)、仅麦秸稻季还田(W)、... 详细信息

为探明南方稻麦两熟制农田秸秆还田模式对土壤总有机碳、活性有机碳、碳库管理指数和稻麦产量的影响,论文通过8 a的水稻-小麦轮作田间定位试验,设置了4个秸秆还田模式处理:秸秆不还田(CK)、秸秆稻麦季均还田(RW)、仅麦秸稻季还田(W)、仅稻秸麦季还田(R)。结果表明,与CK处理相比,秸秆还田显著提高了0~20 cm土壤的总有机碳、活性有机碳、稳定态有机碳(P0.05),RW处理的活性有机碳、碳库活度指数、碳库管理指数与R处理无显著差异性(P>0.05),显著大于W处理(P0.05),显著大于W处理;活性有机碳、碳库管理指数与水稻产量均值呈极显著相关(P0.05);上述结果表明,与稻麦两季还田模式相比,南方稻麦两熟制农田实施仅稻秆麦季还田模式,并不影响作物稳产性与土壤地力的提升。

关键词：土壤秸秆还田模式活性有机碳碳库管理指数产量稻麦两熟制

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Large Deviations for Hitting Times of a Random Walk in Random Environment on a Strip

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Acta Mathematica Sinica,English Series 2014年第3期30卷 395-410页

作者： mei juan ZHANG School of Statistics and Mathematics Central University of Finance and Economics

We consider a random walk in random environment on a strip, which is transient to the right. The random environment is stationary and ergodic. By the constructed enlarged random environment which was first introduced by Goldsheid （2008）, we obtain the large deviations conditioned on the environment （in the quenched case） for the hitting times of the random walk.

关键词： Random walk in random environment strip large deviations quenched enlarged randomenvironment

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Robust predictive control of polytopic uncertain systems with both state and input delays

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Journal of Systems Engineering and Electronics 2007年第3期18卷 616-621页

作者： lu mei Shao Huihe Inst. of Automation Shanghai Jiaotong Univ. Shanghai 200030 P. R. China

A robust model predictive control algorithm for discrete linear systems with both state and input delays subjected to constrained input control is presented, where the polytopic uncertainties exist in both state matrices and input matrices. The algorithm optimizes an upper bound with respect to a state feedback control law. The feedback control law is presented based on the construction of a parameter-dependent Lyapunov function. The above optimization problem can be formulated as a LMI-based optimization. The feasibility of the optimization problem guarantees that the algorithm is robustly stable. The simulation results verify the effectiveness of the proposed algorithm.

关键词： predictive control robust control time-delay system linear matrix inequality.

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