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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing Gu Hong-Xin Long Dan-Dan Zhang mei-feng Ruan Guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 495-501页

作者： Jun-Jun Jia Ya-Fen Cheng mei-Bao feng Li Liu Ming-Qi Shuai Xiao-Dong Shen Xiao-feng Tang Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of International Healthcare Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Library the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Biliary mucinous cystic neoplasms(BMCNs) are rare hepatobiliary cystic tumors, which can be divided into noninvasive and invasive types. This study aimed to investigate the diagnosis, treatment, and prognosis of BMCNs in a large single center. Methods: We analyzed 49 patients with BMCNs confirmed by postoperative pathology at the First Afflliated Hospital, Zhejiang University School of Medicine between January 2007 and December 2021. Results: Among the 49 patients, 37 were female(75.5%), and the average age was 57.04 years. Common symptoms included abdominal discomfort, jaundice and fever, while 22 patients(44.9%) had no symptoms. Serum carbohydrate antigen(CA) 19-9 and CA125 concentrations were elevated in 34.8% and 19.6% of patients, respectively. Forty-eight patients had tumors in the intrahepatic bile ducts and only one had a tumor in the extrahepatic bile duct. Forty-eight patients with noninvasive intrahepatic BMCNs were further analyzed in terms of pathological features: 34(70.8%) had low-grade intraepithelial neoplasms(LGINs), and 14(29.2%) had high-grade intraepithelial neoplasms(HGINs). The potential immunohistochemical markers of BMCNs were cytokeratin(CK) 19, CK7, estrogen receptor and progesterone receptor. Follow-up data for 37 patients with intrahepatic BMCNs were obtained. The median overall survival(OS) of BMCNs was not reached. The longest survival time was 137 *** 5-and 10-year OS rates were 100% and 85.4%, respectively. The 5-and 10-year recurrence-free survival(RFS) rates were 93.9% and 80.2%, respectively. Conclusions: BMCNs are rare cystic neoplasms that commonly occur in middle-aged females. BMCNs can only be diagnosed and classified by postoperative pathology, as there are no specific clinical presentations, serological indicators or imaging modalities for preoperative diagnosis. Complete surgical resection is necessary for BMCNs, and the postoperative prognosis is favorable.

关键词： Biliary mucinous cystic neoplasms Low-grade intraepithelial neoplasms High-grade intraepithelial neoplasms Overall survival Recurrence-free survival

Present situation and prospect of immunotherapy for unresectable locally advanced esophageal cancer during peri-radiotherapy

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 1-7页

作者： feng-mei Wang Peng Mo Xue Yan Xin-Yue Lin Zhi-Chao Fu Department of Obstetrics and Gynecology Fuzong Clinical Medical College(900th Hospital)Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Department of Obstetrics and Gynecology Dongfang HospitalXiamen UniversityFuzhou 350025Fujian ProvinceChina Department of Radiotherapy Fuzong Clinical Medical College(900th Hospital)Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Department of Radiotherapy Dongfang HospitalXiamen UniversityFuzhou 350025Fujian ProvinceChina

Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death protein(PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer,from the aspects of proof of concept,long-term survival,overall survival rate and progression-free *** unresectable or inoperable nonmetastatic esophageal cancer,concurrent radiotherapy and chemotherapy is the standard treatment recommended by various *** its curative effect is still not ideal,it is necessary to explore radical radiotherapy and chemotherapy in the future,and it is considered to be promising to combine them with immunotherapeutic drugs such as *** paper mainly discusses how to combine radical concurrent radiotherapy and chemotherapy with immunotherapy for unresectable local advanced esophageal cancer.

关键词： Esophageal carcinoma Locally advanced Radiotherapy Immunotherapy

Single-atom sites regulation by the second-shell doping for efficient electrochemical CO_(2)reduction

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Chinese Chemical Letters 2024年第9期35卷 360-363页

作者： Qian-Qian Tang Li-Fang feng Zhi-Peng Li Shi-Hao Wu Long-Shuai Zhang Qing Sun mei-feng Wu Jian-Ping Zou Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China National-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063China

Nitrogen-doped carbon loaded single-atom catalysts(SACs)are promising candidates for electrocatalytic conversion of CO_(2)into high-valuable chemicals,and the modification of catalysts by heteroatom-doping strategy is an effective approach to enhance the CO_(2)reduction ***,the large difference exists in atomic radius between nitrogen atoms and the doped heteroatoms may lead to the poor stability of active *** this study,we have synthesized a Ni single atom catalyst with S doping at the secondshell on the ultrathin carbon nanosheets support(Ni-N_(4)-SC)by solid-phase *** S atom in the second-shell contributes to the higher efficiency of CO_(2)conversion at lower potentials while the Ni-N_(4)-SC can be more *** experimental results and theoretical calculations indicate that the S atom in second-shell breaks the uniform charge distribution and reduces the free energy of hydrogenation,which can increase the adsorption of CO_(2),accelerate charge transfer,and reduce the reaction energy *** work reveals the close relationship between the second-shell and the electrocatalytic activity of single atom sites,which also provides a new perspective to design efficient single atom catalysts.

关键词： Single-atom catalyst Heteroatom-doping Second shell CO_(2)electroreduction Electronic structure regulation

The Velocity Aberration Effect of the CSST Main Survey Camera

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Research in Astronomy and Astrophysics 2024年第9期24卷 119-127页

作者： Hui-mei feng Zi-Huang Cao Man ILam Ran Li Hao Tian Xin Zhang Peng Wei Xin-feng Li Wei Wang Hugh RAJones Mao-Yuan Liu Chao Liu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China University of Chinese Academy of Sciences Beijing 100049China Technology and Engineering Center for Space Utilization Chinese Academy of SciencesBeijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK

In this study,we conducted simulations to find the geometric aberrations expected for images taken by the Main Survey Camera of the Chinese Space Station Telescope(CSST)due to its *** anticipated by previous work,our findings indicate that the geometric distortion of light impacts the focal plane's apparent scale,with a more pronounced influence as the size of the focal plane *** models suggest that the effect consistently influences the pixel scale in both the vertical and parallel *** apparent scale variation follows a sinusoidal distribution throughout one orbital *** reveal that the effect is particularly pronounced in the center of the Galaxy and gradually diminishes along the direction of ecliptic *** low ecliptic latitudes,the total aberration leads to about a 0.94 pixel offset(a 20 minute exposure)and a 0.26 pixel offset(a 300 s exposure)at the edge of the field of *** processings for the geometric effect during the CSST pre-and post-observation phases are presented.

关键词： astrometry telescopes Astronomical Instrumentation Methods and Techniques

All-sky Guide Star Catalog for CSST

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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-mei feng Zi-Huang Cao Man I Lam Ran Li Hao Tian Da-Yi Yin Yuan-Yu Yang Xin Zhang Dong-Wei Fan Yi-Qiao Dong Xin-feng Li Wei Wang Long Li Hugh RAJones Yi-Han Tao Jia-Lu Nie Pei-Pei Wang Mao-Yuan Liu He-jun Yang Chao Liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

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丧亲者哀伤评估工具的研究进展

军事护理 2024年第3期41卷 86-88页

作者：冯梅罗丹华中科技大学同济医学院附属同济医院急诊科湖北武汉430030 武汉大学护理学院湖北武汉430071

哀伤是指丧亲者在亲人离世后的几天、几周甚至几个月内出现的生理、心理、情感及行为反应[1]。可分为自然哀伤和病理哀伤[2]。短时间内可自行缓解的为自然哀伤,否则将发展为病理哀伤。当丧亲者的哀伤情绪持续时间超过6个月以上,有孤独... 详细信息

哀伤是指丧亲者在亲人离世后的几天、几周甚至几个月内出现的生理、心理、情感及行为反应[1]。可分为自然哀伤和病理哀伤[2]。短时间内可自行缓解的为自然哀伤,否则将发展为病理哀伤。当丧亲者的哀伤情绪持续时间超过6个月以上,有孤独感、无意义感和情感分离等反应,严重损害生理。

关键词：丧亲哀伤哀伤评估评估工具

Mechanism,prevention,and control of mining-induced dynamic disasters in underground metal mines in China:Challenges and solutions

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Journal of Central South University 2024年第8期31卷 2549-2606页

作者： LI Peng CAI mei-feng MIAO Sheng-jun REN Fen-hua GORJIAN Mostafa PENG Chao Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Department of Earth Ocean and Atmospheric SciencesUniversity of British ColumbiaVancouverBCCanada Deep Mining Laboratory of Shandong Gold Group Co. Ltd.Laizhou 261442China

Metal mineral resources play an indispensable role in the development of the national *** disasters in underground metal mines seriously threaten mining safety,which are major scientific and technological problems to be solved *** this article,the occurrence status and grand challenges of some typical dynamic disasters involving roof falling,spalling,collapse,large deformation,rockburst,surface subsidence,and water inrush in metal mines in China are systematically presented,the characteristics of mining-induced dynamic disasters are analyzed,the examples of dynamic disasters occurring in some metal mines in China are summarized,the occurrence mechanism,monitoring and early warning methods,and prevention and control techniques of these disasters are highlighted,and some new opinions,suggestions,and solutions are proposed ***,some shortcomings in current disaster research are pointed out,and the direction of efforts to improve the prevention and control level of dynamic disasters in China’s metal mines in the future is *** integration of forward-looking key innovative theories and technologies in the abovementioned aspects will greatly enhance the cognitive level of disaster prevention and mitigation in China’s metal mining industry and achieve a significant shift from passive disaster relief to active disaster prevention.

关键词： underground metal mines dynamic disasters mechanism monitoring and early warning prevention and control

服务型制造能缓解企业的融资约束吗?——基于准自然实验的分析

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经济问题 2024年第9期 59-67页

作者：冯梅刘佳陈楚北京科技大学经济管理学院北京100083

服务型制造是基于“服务化”等概念而提出的一个具有中国特色的概念,是我国推进先进制造业和现代服务业深度融合的重要方向。以服务型制造示范遴选工作为准自然实验,采用PSM-DID方法研究了服务型制造对企业融资约束的缓解效果及其作用... 详细信息

服务型制造是基于“服务化”等概念而提出的一个具有中国特色的概念,是我国推进先进制造业和现代服务业深度融合的重要方向。以服务型制造示范遴选工作为准自然实验,采用PSM-DID方法研究了服务型制造对企业融资约束的缓解效果及其作用机制。结果发现:服务型制造能够缓解企业的融资约束,且该结论具有稳健性;服务型制造通过改善生产效率、提升企业绩效和强化企业创新渠道发挥作用,且效果受到地理区位、行业竞争以及企业所有权性质等异质性因素的影响。

关键词：服务型制造融资约束产业融合

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常见慢性病与带状疱疹相关性的研究进展

中华全科医师杂志 2024年第4期23卷 419-424页

作者：王敏高静冯玫山西医科大学第三医院(山西白求恩医院、山西医学科学院、同济山西医院)全科医学科太原030032

带状疱疹是由水痘-带状疱疹病毒再激活所引起的感染性皮肤病,其临床表现和并发症表现形式多样。研究证实,慢性病是带状疱疹的独立危险因素之一。常见慢性疾病,如糖尿病、心血管疾病、慢性阻塞性肺疾病及类风湿性关节炎与带状疱疹的发生... 详细信息

带状疱疹是由水痘-带状疱疹病毒再激活所引起的感染性皮肤病,其临床表现和并发症表现形式多样。研究证实,慢性病是带状疱疹的独立危险因素之一。常见慢性疾病,如糖尿病、心血管疾病、慢性阻塞性肺疾病及类风湿性关节炎与带状疱疹的发生发展之间相互作用。文章对带状疱疹的临床特征、与常见慢性病的相关性及预防的最新研究进展进行综述,以期为减轻带状疱疹的疾病负担提供参考。

关键词：带状疱疹临床特征慢性病预防