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Rare Metals 2022年第11期41卷 3878-3886页

作者： Chun jian Su ting ting Xu Ke Zhang Ke Zhang Shu mei Lou Qing Wang College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao266590China

The research of forming parameters on the ultrasonic vibration single-point incremental forming of magnesium alloy plastic deformation can provide a theoretical basis for the establishment of the forming *** to the forming characteristics of magnesium alloy sheet,a new method of ultrasonic vibration-as sis ted single-point incremental forming was *** influence of forming parameters on the plastic deformation of magnesium alloy was studied by finite element simulation and *** influence of vibration frequency,amplitude,friction coefficient,and tool head size on stress and thinning rate of magnesium alloy during ultrasonic vibration-as sis ted single-point asymptotic forming was *** results show that the vibration frequency of 20 kHz and forming tool radius of about 5 mm are beneficial for plastic deformation magnesium alloy in ultrasonic vibration-assisted single-point incremental *** vibration amplitude increasing,the maximum shear stress tends to decrease as a whole,but at the amplitude of 0.16 mm,the thinning rate is large and fracture occurs *** friction coefficient increasing,the maximum shear stress tends to increase,and there is a good linear relationship between the maximum thinning rate and the friction coefficient.

关键词： Magnesium alloy Ultrasonic vibration Incremental forming Forming parameters Plastic deformation

The putative NAD(P)H Nitroreductase,Rv3131,is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis

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Biomedical and Environmental Sciences 2022年第7期35卷 652-656页

作者： DONG Wen Zhu shi Jin CHU Ping LIU Rong mei WEN Shu An ZHANG ting ting PANG Yu lu Jie Department of Infectious Diseases The First People's Hospital of ZiyangZiyang 641300SichuanChina Department of Bacteriology and Immunology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing 101149China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryMOE Key Laboratory of Major Diseases in ChildrenBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 101149China

Tuberculosis(TB),which is caused by the intracellular pathogen,Mycobacterium tuberculosis(Mtb),remains one of the deadliest infectious diseases worldwide,accounting for 1.45 million deaths in 2018[1].Thus,there is an increasing need to develop new antibiotics or to repurpose old drugs that have the potential to shorten the current duration of ***(MTZ)is a 5-nitroimidazole antibiotic that is mainly used in the treatment of anaerobic and protozoal infections[2].The action of mechanism for metronidazole has not been fully *** a prodrug,MTZ is inactive until taken up and reduced by anaerobic bacteria and *** is possible that the reduction of Mtz leads to the production of toxic metabolites,which bind to deoxyribonucleic acid and electron-transport proteins of microbial pathogens,thus blocking nucleic acid synthesis[3].The impressive potency of MTZ against anaerobic bacteria indicates the potential for killing Mtb under anaerobic conditions.A previous in vitro study demonstrated that MTZ has potent activity against tubercle bacilli under anaerobic conditions[4].In a non-human primate model,MTZ has been shown to prevent reactivation of latent Mtb infection,indicating the in vivo role in targeting Mtb within an anaerobic environment[5].Although there is strong evidence for the role of MTZ in affecting anaerobic bacilli,the mechanism of action has not been elucidated in Mtb considering that MTZ must be catalyzed to a nitro-free radical form with endogenous *** provide insight=into how MTZ is activated in anaerobic Mtb bacilli,we first characterized the nitroreductase gene,Rv3131,and identified the key residue conferring the activation of MTZ in Mtb.

关键词： Tuberculosis action latent

Facile synthesis of C_(3)N_(4)-supported metal catalysts for efficient CO_(2) photoreduction

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Nano Research 2022年第1期15卷 551-556页

作者： Yun-Nan Gong Bi-Zhu Shao jian-Hua mei wei Yang Di-Chang Zhong Tong-Bu lu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and EngineeringSchool of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China Key Laboratory of jiangxi University for Functional Material Chemistry College of Chemistry&Chemical EngineeringGannan Normal UniversityGanzhou 341000China

Facile synthesis of photocatalysts with highly dispersed metal centers is a high-priority target yet still a significant *** this work,a series of Co-C_(3)N_(4) photocatalysts with different Co contents atomically dispersed on g-CaN4 have been prepared via one-step thermal treatment of cobalt-based metal-organic frameworks(MOFs)and urea in the *** to the highly dispersed and rich exposed Co sites,as well as good charge separation efficiency and abundant mesopores,the optimal 25-Co-C_(3)N_(4),in the absence of noble metal catalysts/sensitizers,exhibits excellent performance for photocatalytic C0_(2) reduction to CO under *** irradiation,with a high CO evolution rate of 394.4μmol·g^(-1)·h^(-1),over 80 times higher than that of pure g-C_(3)N_(4)(4.9μmol·g^(-1)·h^(-1)).In:addition,by this facile synthesis strategy,the atomically dispersed Fe and Mn anchoring on g-C_(3)N_(4)(Fe-C_(3)N_(4) and Mn-C_(3)N_(4))have been also obtained,indicating the reliability and universality of this strategy in synthesizing photocatalysts with highly dispersed metal *** work paves a new way to develop cost-effective photocatalysts for photocatalytic C0_(2) reduction.

关键词： metal-organic frameworks highly dispersed metal g-C_(3)N_(4) photocatalysts C02 reduction

Synthesis of energetic coordination polymers based on 4-nitropyrazole by solid-melt crystallization in non-ionization condition

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Defence Technology（防务技术） 2023年第10期28卷 13-22页

作者： ting-wei Wang Shu Bu Kun Wang lu Zhang Zhen-xin Yi Shun-guan Zhu jian-guo Zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei230601China

Based on the theory of crystallization,a solvent-free solid-liquid phase crystallization method called solid-melt crystallization was designed to prepare energetic coordination *** target compounds[Cu(NPyz)_(4)NO_(3)]·NO_(3)(ECPs-1)and Cu(NPyz)_(4)(ClO_(4))_(2)(ECCs-2)were prepared through programmed heating and cooling by using 4-nitropyrazole(NPyz),(Cu(NO_(3))_(2)·5H_(2)O and Cu(ClO_(4))_(2)·5H_(2)O) as raw *** addition,crystallization pre-experiments and annealing experiments also verified the feasibility of the *** structures were confirmed by IR,elemental analysis,single-crystal X-ray diffraction and powder X-ray *** physicochemical properties and sensitivity test results showed that ECCs-2 has better thermal stability(T_(d)=221℃),while ECPs-1 is less sensitive to mechanical stimuli(IS=12 J,FS=240 N).Calculations based on EXPLO5 and the Kamlet-Jacobs equation showed that ECCs-2 has more considerable detonation performance(P=25.2 GPa,D=7.5 km/s).In comparison,the more intuitive results from the HN test,flame test,thermal resistance test and lead plate explosion test revealed that ECCs-2 has an“acceptable”detonation *** laser detonation test also showed that ECCs-2 is a promising excellent laser detonation material(E=408 mJ,P=24 W,τ=17 ms).

关键词： 4-Amino-1,2,5-oxadiazole-3-carbohydrazide Crystallization Coordination polymers Laser Primary explosives

适于玉米杂交种复杂样品纯度鉴定的SSR复合检测方案的建立

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玉米科学 2024年第1期32卷 74-81页

作者：施昕晨王蕊葛建镕张云龙任洁王璐易红梅王凤格北京市农林科学院玉米研究中心/玉米DNA指纹及分子育种北京市重点实验室北京100097

为了解决玉米复杂样品纯度中存在遗传不稳定及回交株等难以鉴定的问题,通过分析3998份国家和省级审定玉米品种,结合快速提取、多重扩增体系等技术,构建一套适用于复杂样品纯度检测的复合检测方案。分析53份不同来源的郑单958纯度测试样... 详细信息

为了解决玉米复杂样品纯度中存在遗传不稳定及回交株等难以鉴定的问题,通过分析3998份国家和省级审定玉米品种,结合快速提取、多重扩增体系等技术,构建一套适用于复杂样品纯度检测的复合检测方案。分析53份不同来源的郑单958纯度测试样品,结果表明,对于复杂样品使用单个位点进行纯度判定时,不同位点间结果会有较大差别,使用3个或3个以上位点综合判定时能够有效获得准确稳定的纯度检测结果。复合检测方案能够在时间和成本未大幅增加、仅增加少数引物的条件下获得多个SSR标记指纹,使复杂样品得到更加全面、精准解析,从而为种子生产中复杂样品的质量问题提供解决方案。

关键词：玉米杂交种复杂样品纯度 SSR标记复合检测方案

luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway

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Traditional Medicine Research 2024年第10期9卷 1-9页

作者： Bo-Wen Zhang Di Yang Jin-Tao Li mei-Hao Peng Jia-Qing Liao Qi Zhao Yi-Xi Yang Qiu-Xia lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China

Background:luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuroprotective,*** to its hepatoprotective properties,luteolin was selected to co-treat with sorafenib,one of the approved protein kinase inhibitors,to reduce sorafenib-induced normal liver cell ***:The BRL-3A cell line was treated with sorafenib to establish a liver injury model,followed by luteolin *** cell viability was detected,and the mechanism of action was detected by immunofluorescence,western blotting,and real-time quantitative ***:The research findings demonstrated that luteolin could increase cystine/glutamate transporter xCT(SLC7A11)and glutathione peroxidase 4(GPX4)expression and display a chelating effect on iron,which led to increased glutathione and decreased malondialdehyde,Fe^(2+) and lipid reactive oxygen species contents in BRL-3A cells,and the sorafenib-induced mitochondrial membrane potential decrease was also *** addition,when sorafenib caused the accumulation of lipid reactive oxygen species,luteolin could help release this oxidative stress by activating nuclear factor E2-related factor 2(Nrf2)and up-regulating the expression of the associated genes heme oxygenase 1(HO-1)and quinone oxidoreductase 1(NQO1).Conclusion:Therefore,luteolin may ameliorate sorafenib-induced ferroptosis by activating the Nrf2-associated pathway without any impact on sorafenib anti-cancer *** can be used as an adjuvant to sorafenib to reduce liver injury in patients with hepatocellular carcinoma.

关键词： luteolin sorafenib liver injury ferroptosis Nrf2/GPX4

正畸修复联合疗法对改善深覆[牙合]伴下前牙严重磨耗患者咀嚼功能的效果评价

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上海口腔医学 2024年第2期33卷 190-194页

作者：路茜王静庞淑婷周建营冯艳芬卢文娟张倩沧州市人民医院口腔内科河北沧州061000 沧州市人民医院口腔正畸科河北沧州061000 沧州市人民医院口腔修复科河北沧州061000

目的:观察正畸修复联合治疗对深覆[牙合]伴下前牙严重磨耗患者咀嚼功能的改善效果。方法:选择2018年1月—2022年1月接诊的164例深覆[牙合]伴下前牙严重磨耗患者,根据治疗方案不同分为2组,即对照组72例(单纯口腔修复治疗)和试验组92例(... 详细信息

目的:观察正畸修复联合治疗对深覆[牙合]伴下前牙严重磨耗患者咀嚼功能的改善效果。方法:选择2018年1月—2022年1月接诊的164例深覆[牙合]伴下前牙严重磨耗患者,根据治疗方案不同分为2组,即对照组72例(单纯口腔修复治疗)和试验组92例(正畸修复联合治疗)。评价2组咀嚼效能,计算颞下颌关节功能障碍指数(dysfunction index,DI)、肌肉压痛指数(palpation index,PI)与颞下颌关节紊乱指数(cranio-mandibular index,CMI)。评价面容美观满意度、中文版口腔健康影响程度量表(OHIP-14)评分和修复满意度评分,并比较2组不良事件发生情况。采用SPSS 23.0软件包对数据进行统计学分析。结果:治疗后,试验组咀嚼效能较对照组显著提高,DI、PI和CMI较对照组显著降低(P<0.05)。治疗后,试验组面容美观满意度和修复满意度显著高于对照组,OHIP-14评分显著低于对照组(P<0.05)。与对照组的不良事件(25.00%)相比,试验组(6.52%)降低显著(P<0.05)。结论:正畸修复联合治疗可提高深覆[牙合]伴下前牙严重磨耗患者的治疗效果,改善患者咀嚼功能及颞下颌关节平衡,提高患者满意度及生活质量,减少不良事件发生风险。

关键词：正畸修复深覆[牙合] 磨耗咀嚼功能

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油莎豆茎叶代谢物与块茎形态的关联研究

中国油料作物学报 2024年第1期46卷 62-71页

作者：麻剑南单成彬冯旭马越王力伟张向前赵小庆路战远张德健马超美内蒙古大学生命科学学院牧草与特色作物生物学教育部重点实验室内蒙古呼和浩特010030 内蒙古医科大学药学院内蒙古呼和浩特010110 内蒙古自治区农牧业科学院内蒙古呼和浩特010031

为研究油莎豆表型差异与茎叶代谢物间的关联,比较分析了10份油莎豆样本的叶宽、块茎宽度、块茎厚度、块茎高度等表型参数,同时利用超高效液相色谱-串联质谱(UHPLC-MS/MS)技术定性定量分析其茎叶代谢物。10份油莎豆样本分为2个表型,即宽... 详细信息

为研究油莎豆表型差异与茎叶代谢物间的关联,比较分析了10份油莎豆样本的叶宽、块茎宽度、块茎厚度、块茎高度等表型参数,同时利用超高效液相色谱-串联质谱(UHPLC-MS/MS)技术定性定量分析其茎叶代谢物。10份油莎豆样本分为2个表型,即宽叶圆粒型和窄叶长粒型,其叶宽与块茎宽度和块茎厚度呈正相关。用UHPLC-MS/MS对油莎豆茎叶中28个主要代谢物,包括黄烷-3醇、咖啡酸衍生物和黄酮类成分的相对含量进行测定分析比较。结果表明,4个黄酮类化合物即木犀草素-7-二葡萄糖醛酸苷、荭草苷、木犀草素-7-葡萄糖醛酸苷和木犀草素在宽叶圆粒型油莎豆茎叶中的含量显著高于窄叶长粒型油莎豆茎叶。利用KEGG和PlantCyc推导绘制了4种差异黄酮代谢物在油莎豆茎叶中的生物合成途径,并预测宽叶圆粒型油莎豆相较于窄叶长粒型更具有耐旱性,可为油莎豆的品种鉴定、选育和茎叶资源利用提供依据。。

关键词：油莎豆表型二次代谢产物超高效液相色谱-串联质谱

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Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine:A methodological investigation with evidence map

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Journal of Integrative Medicine 2022年第3期20卷 213-220页

作者： ting-ting lu Cun-cun lu mei-xuan Li Li-xin Ke Hui Cai Ke-hu Yang Institution of Clinical Research and Evidence-Based Medicine Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000Gansu ProvinceChina Hepatobiliary and Pancreatic Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Background:Acupuncture has been widely used to relieve migraine-related ***,the findings of previous systematic reviews(SRs)and meta-analyses(MAs)are still not completely *** quality is also unknown,so a comprehensive study is ***:To evaluate the reporting and methodological quality of these MAs concerning acupuncture for migraine,and summarize evidence about the efficacy and safety of acupuncture for *** strategy:Pub Med,Embase,Cochrane Library,China National Knowledge Infrastructure,Chinese Biomedical Databases,Wanfang Data,and VIP databases were searched from inception to September 2020,with a comprehensive search *** criteria:The pairwise MAs of randomized controlled trials(RCTs)concerning migraine treated by acupuncture or acupuncture-based therapies,with a control group that received sham acupuncture,medication,no treatment,or acupuncture at different acupoints were *** extraction and analysis:Two independent investigators screened studies,extracted relevant data,and assessed reporting and methodological quality using Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2009 and A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),then all results were *** correlation test was used to evaluate the correlation between reporting and methodological quality ***:A total of 20 MAs were included in this *** included MAs indicated that acupuncture was efficacious and safe in preventing and treating migraine when compared with control *** was a high correlation between reporting and methodological quality scores(rs=0.87,Pluded SRs needs to be improved mainly with regard to protocol and prospective registration,using a comprehensive search strategy,summarizing the strength of evidence body for key outcomes,a full list of excluded studies with reasons for exclusion,reporting of RCTs’fundin

关键词： Migraine Acupuncture Systematic review Meta-analysis AMSTAR 2 PRISMA

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聚合物胶束体内命运分析技术的研究进展

化学试剂 2024年第7期46卷 75-84页

作者：于璐瑶刘美辰郭莹霞尤建嵩史美云尹磊大连理工大学化工海洋与生命学院辽宁盘锦124221 艾美诚信生物制药有限公司辽宁大连116600

聚合物胶束(PMs)是研究非常广泛的纳米给药系统。它是由两亲性聚合物组成的自聚集纳米颗粒,这些聚合物在临界胶束浓度(CMC)以下以单分子形式存在于溶液中,在CMC以上则会自组装形成胶束。相对于其他纳米载体,PMs具有独特的性质:相对较小... 详细信息

聚合物胶束(PMs)是研究非常广泛的纳米给药系统。它是由两亲性聚合物组成的自聚集纳米颗粒,这些聚合物在临界胶束浓度(CMC)以下以单分子形式存在于溶液中,在CMC以上则会自组装形成胶束。相对于其他纳米载体,PMs具有独特的性质:相对较小的尺寸,疏水性核对疏水性化合物具有良好溶解性,亲水性壳能延长药物在血液的循环时间。对PMs体内时空命运的未知,使得PMs从实验室设计到临床应用的成功转化仍然面临重大挑战。目前,一系列分析测试技术已经开发出来用于揭示PMs的体内命运,包括放射性示踪,荧光共振能量转移(FRET)、聚集诱导发射(AIE)、聚集荧光猝灭(ACQ)、液质联用(LC-MS),透射电子显微镜(TEM)等。主要叙述了一系列分析技术在PMs体内命运研究中的进展。

关键词：聚合物胶束体内命运荧光生物成像分析技术研究进展

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