检索结果-南通市图书馆

大成散对成纤维细胞增殖活性及鞘氨醇激酶/1-磷酸鞘氨醇通路的影响

在线全文

学校读者我要写书评

暂无评论

中国中西医结合杂志 2024年第6期44卷 733-737页

作者：陈慧玲江莉官美龄陈艺玲翁慧兰黄宁北京中医药大学厦门医院医疗美容科福建361006 福建中医药大学附属第二人民医院皮肤科、中西医结合皮肤病福建省高校重点实验室福建350001

目的研究大成散对体外培养人皮肤成纤维细胞(HFF-1)增殖及鞘氨醇激酶/1-磷酸鞘氨醇(SPHK/S1P)通路的影响,并初步探讨其作用机制。方法制备大成散药液,采用CCK-8法检测不同浓度大成散药液对HFF-1细胞增殖活性的影响,确定最佳干预时间与... 详细信息

目的研究大成散对体外培养人皮肤成纤维细胞(HFF-1)增殖及鞘氨醇激酶/1-磷酸鞘氨醇(SPHK/S1P)通路的影响,并初步探讨其作用机制。方法制备大成散药液,采用CCK-8法检测不同浓度大成散药液对HFF-1细胞增殖活性的影响,确定最佳干预时间与浓度进行后续实验,Western Blot法检测大成散药液对HFF-1细胞转化生子因子-β1(TGF-β1)、SPHK1、SPHK2.S1P蛋白表达的影响,qRT-PCR法检测大成散药液对HFF-1细胞TGF-β1、SPHK1、SPHK2.mRNA表达的影响。结果5×10^(-2.g/L的大成散干预48h可促进HFF-1细胞的增殖,提高细胞活力;与对照组比较,大成散可以增加HFF-1细胞中TGF-β1、SPHK1、SPHK2.S1P蛋白表达水平(P1细胞中TGF-β1、SPHK1、SPHK2.mRNA表达水平(P1表达,激活SPHK1/S1P通路,促进血管新生,发挥抗炎效应,或通过激活SPHK2.催化产生S1P,启动缺氧预处理机制,从而保护皮肤成纤维细胞,提高成纤维细胞的增殖能力,进而加速创面愈合。

关键词：创面愈合大成散成纤维细胞鞘氨醇激酶/1-磷酸鞘氨醇信号通路中药复方

Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： Jiang-Ming Chen Wei-Jian Zhu Jie liu Gui-Zhen Wang Xiao-Qin Chen Yun Tan Wei-Wei Xu li-Wei Qu Jin-Yan li Huan-Ju Yang lan huang Ning Cai Wei-Da Wang Ken huang Jian-Quan Xu Guo-Hui li Sheng He Tian-Ying Luo Yi huang Song-Hua liu Wen-Qiang Wu Qi-Yang Lu mei-Guang Zhou Shu-Ying Chen Rong-lan li mei-ling Hu Ying huang Jin-Hua Wei Jun-Min li Sai-Juan Chen Guang-Biao Zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State key laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State key laboratory of Oncology in South{2. Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State key laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Guangxi key laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2.multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12.weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 14.0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 12.weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 10.3±6.4 U,respectively(Plidomide than *** the extension phase,treatment with thalidomide for 2. weeks resulted in a sustainable increase in Hb concentrations which reached 104.9±19.0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1L-MYB(rs9399137 C/T,C/C;rs4895441 A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

CEPC Technical Design Report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,{2.5)and the Conceptual Design Report(CDR,{2.8),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease:a multicenter study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2019年第1期7卷 67-73,I0002页

作者： Xian-Rui Wu Xiao-Bin Zheng Yan huang Qian Cao hong-Jie Zhang Ying-Lei Miao Kai-Fang Zou Min Chen Fa-Ming Zhang Qiao {2. David Gonzalo Daniela Allende Pin-Jin Hu Bo Shen Xiu-li liu Ping lan Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology Sir Run Run Shaw Hospital of Zhejiang University School of MedicineHangzhouChina Department of Gastroenterology Jiangsu Province HospitalNanjingChina Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityKunmingChina Department of Gastroenterology Wuhan Union HospitalWuhanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanChina Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Pathology and laboratory Medicine University of FloridaGainesvilleFLUSA Department of Anatomic Pathology The Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology/Hepatology The Cleveland Clinic FoundationClevelandOHUSA

Background:This study sought to evaluate the risk factors for the development of colitis-associated neoplasia(CAN)in Chinese patients with inflammatory bowel disease(IBD).Methods:IBD patients who developed CAN between 1999 and 2.16 were identified from eight medical *** addition to initial pathology evaluation,a CAN diagnosis was confirmed by two expert *** with CAN(n=2.)were compared with non-CAN controls(n=87).Matching was performed for gender and IBD type with a ratio of three controls to one ***:Of the 2. patients with CAN,8(2..6%)had colorectal cancer(CRC),2.(69.0%)had a final diagnosis of low-grade dysplasia and 1(3.4%)had high-grade *** analysis revealed that an older age at the time of IBD diagnosis and a longer IBD duration were independent risk factors for the development of CAN,with odds ratios of 1.09[95%{2. interval(CI):1.04–1.14,P2.,P=0.013),*** between IBD patients with CRC and those with dysplasia indicated that the former were older at the time of IBD diagnosis(P=0.012.and had longer IBD durations(P=0.019).Conclusions:Older age at the time of IBD diagnosis and longer IBD duration were found to be associated with the development of CAN in IBD patients.

关键词： Colorectal neoplasia inflammatory bowel disease risk factor

不育男性血清和精浆抑制素B水平与生精功能的关系

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生殖医学杂志 2018年第1期27卷 42-48页

作者：莫美兰宋明哲曾勇蔡靖刘红杰赵明黄玲叶丽君深圳中山泌尿外科医院生殖医学中心深圳518045 深圳中山生殖与遗传研究所深圳518045 深圳市围着床期生殖免疫重点实验室深圳518045 深圳中山泌尿外科医院检验科深圳518045

目的探讨血清和精浆抑制素B(INH-B)与睾丸生精功能的关系。方法回顾性分析2.15年1~6月来深圳中山泌尿外科医院生殖医学中心就诊的141例男性不育症患者资料。根据精液参数分为5组:精子浓度正常组(A组,43例)、轻中度少精子症组(B组,40例)... 详细信息

目的探讨血清和精浆抑制素B(INH-B)与睾丸生精功能的关系。方法回顾性分析2.15年1~6月来深圳中山泌尿外科医院生殖医学中心就诊的141例男性不育症患者资料。根据精液参数分为5组:精子浓度正常组(A组,43例)、轻中度少精子症组(B组,40例)、重度少精子症组(C组,2.例)、梗阻性无精子症组(OA组,9例)和非梗阻性无精子症组(NOA组,2.例);NOA组中有17例患者接受睾丸细针精子抽吸术(TESA)取精,根据TESA结果分为成功组(13例)和失败组(4例)。比较各组的精液参数(精子总数、浓度及活动力),测定其血清和精浆INH-B水平及血清FSH、LH、T、E_2.泌乳素(PRL)、孕酮(P)的水平,分析血清性激素、INH-B与精液质量之间的关系。结果 A、B组的睾丸总体积显著高于OA和NOA组(P<0.05)。C组和NOA组的血清INH-B显著低于A组和OA组,A组的精浆INH-B浓度显著高于C组、OA组和NOA组(P均<0.05)。不同生精功能男性的血清INH-B与血清FSH、LH及PRL呈负相关,与血清T和精浆INH-B呈正相关(P均<0.05);精浆INH-B与血清FSH和LH呈负相关(P<0.05)。A、B、C组中血清和精浆INH-B与总精子数呈低度正相关(P<0.01)。NOA组中血清INH-B与睾丸总体积呈高度正相关,与血清FSH和LH呈负相关(P均<0.01);精浆INH-B与血清FSH呈极弱负相关(P<0.05)。TESA取精成功组的睾丸总体积和血清INH-B显著高于TESA失败组,血清FSH和LH则显著低于TESA失败组(P均<0.01)。结论血清和精浆INH-B与血清性激素、总精子数具有一定相关性,可作为评估男性生精功能的参考。无精子症中尤其是NOA患者,血清INH-B可以评估睾丸生精状态、鉴别诊断无精子症、预测取精结局。

关键词：抑制素B 生殖激素男性不育无精子症

广西2.04——2.19年初始抗病毒治疗儿童HIV感染者生长发育情况分析

在线全文

学校读者我要写书评

暂无评论

中国热带医学 2022年第9期22卷 791-796页

作者：周业胜罗柳红林玫陈宏利黄精华朱秋映陈欢欢刘秀沈智勇李剑军冯毅李丹廖玲洁邢辉邵一鸣阮玉华蓝光华中国疾病预防控制中心性病艾滋病预防控制中心病毒免疫室传染病预防控制国家重点实验室北京102206 广西壮族自治区疾病预防控制中心广西重大传染病防控与生物安全应急响应重点实验室广西南宁530028

目的了解初始抗病毒治疗儿童HIV感染者的生长发育情况及其影响因素。方法采用回顾性队列研究方法,从国家艾滋病抗病毒治疗信息系统下载广西2.04—2.19年初始抗病毒治疗儿童HIV感染者数据库。根据中国儿童生长发育标准计算Z评分,趋势... 详细信息

目的了解初始抗病毒治疗儿童HIV感染者的生长发育情况及其影响因素。方法采用回顾性队列研究方法,从国家艾滋病抗病毒治疗信息系统下载广西2.04—2.19年初始抗病毒治疗儿童HIV感染者数据库。根据中国儿童生长发育标准计算Z评分,趋势性分析采用Cox-Stuart检验,广义估计方程用于分析HAZ(height-for-age Z-score)≥-2.WAZ(weight-for-age Z-score)≥-2.影响因素。结果共计943例儿童HIV感染者进入队列。基线和治疗后第1、2.5、10年的HAZ中位数分别为-2.47、-2.14、-1.94、-1.55、-1.2.,WAZ中位数分别为-1.85、-1.40、-1.30、-1.2.、-1.09。经Cox-Stuart趋势检验,HAZ和WAZ随治疗时间均呈上升趋势(P2.5、10年HAZ≥-2.比例分别为38.1%、46.5%、51.6%、66.8%和74.6%,WAZ≥-2.比例分别为57.1%、76.9%、81.1%、85.8%和89.2.。经CoxStuart趋势检验,HAZ≥-2.WAZ≥-2.比例随治疗时间均呈上升趋势(P2.关联性因素有初始抗病毒治疗年龄为3~7岁(a OR=0.71,95%CI:0.53~0.94)、初始抗病毒治疗年龄为>7岁(a OR=0.66,95%CI:0.47~0.93)、治疗前CD4+T淋巴细胞计数2.0个/μL(a OR=0.64,95%CI:0.47~0.87)、治疗前WHO临床分期为Ⅲ/Ⅳ期(a OR=0.74,95%CI:0.56~0.97)以及治疗时间(a OR=1.01,95%CI:1.01~1.01);与WAZ≥-2.关联性因素有男性(a OR=0.72.95%CI:0.53~0.97)、治疗前WHO临床分期为Ⅲ/Ⅳ期(a OR=0.63,95%CI:0.45~0.86)以及治疗时间(a OR=1.01,95%CI:1.01~1.01)。结论抗病毒治疗有效改善了儿童HIV感染者的生长发育状况,但治疗后第10年仍有较大比例的儿童生长发育迟缓,需加强抗病毒治疗工作人员培训和儿童HIV感染者父母宣传教育以提高抗病毒治疗效果并合理指导儿童营养。

关键词：儿童艾滋病病毒抗病毒治疗生长发育

治疗前耐药对HIV感染者抗病毒治疗12.月病毒抑制影响

在线全文

学校读者我要写书评

暂无评论

中国热带医学 2022年第6期22卷 549-554页

作者：许小珊黄荣叶陈欢欢罗柳红宋畅朱秋映蓝光华梁淑家沈智勇林玫冯毅邵一鸣廖玲洁邢辉阮玉华李剑军中国疾病预防控制中心性病艾滋病预防控制中心传染病预防控制国家重点实验室北京102206 广西壮族自治区钦州市疾病预防控制中心广西钦州535000 广西重大传染病防控与生物安全应急响应重点实验室广西壮族自治区疾病预防控制中心广西南宁530028

目的了解治疗前耐药(pretreatment drug resistance,PDR)对抗病毒治疗12.月病毒抑制影响情况,为艾滋病进一步扩大治疗并提高效果提供科学数据。方法从我国艾滋病综合防治信息系统中选取广西钦州市2.14年1月—2.2.年6月治疗前HIV感染... 详细信息

目的了解治疗前耐药(pretreatment drug resistance,PDR)对抗病毒治疗12.月病毒抑制影响情况,为艾滋病进一步扩大治疗并提高效果提供科学数据。方法从我国艾滋病综合防治信息系统中选取广西钦州市2.14年1月—2.2.年6月治疗前HIV感染者并收集现场和治疗数据,并对血样进行病毒RNA提取、pol基因区扩增和测序及耐药分析。采用Logistic回归模型分析治疗前耐药对抗病毒治疗12.月病毒抑制影响情况。结果调查对象治疗前耐药率为5.5%(116/2.12., 95%CI:4.5~6.4),NNRTIs类药物的耐药率最高(3.1%,66/2.12.)。抗病毒治疗12.月病毒抑制率为96.0%,其中治疗前不耐药组和耐药组分别为96.4%(1 2.3/1 2.9, 95%CI:95.2.97.3)和89.7%(70/78, 95%CI:80.8~95.5),两者之间差异有统计学意义(P=0.015)。在3个多因素Logistic回归模型分析中,与抗病毒治疗12.月病毒抑制有关的因素包括治疗前耐药(AOR=0.35, 95%CI:0.15~0.82.(模型1);治疗前NNRTIs耐药(AOR=0.30, 95%CI:0.10~0.88)和NRTIs耐药(AOR=0.2., 95%CI:0.06~0.90)(模型2.;治疗前EFV/NVP中高度耐药(AOR=0.10, 95%CI:0.03~0.35)(模型3)。结论广西钦州HIV感染者治疗前耐药达WHO耐药中等水平,治疗前耐药显著降低了抗病毒治疗病毒抑制效果,尤其是治疗前EFV/NVP中高度耐药者。为有效遏制HIV耐药发生和传播,我国需要加强耐药监测及预防工作。

关键词： HIV 治疗前耐药抗病毒治疗病毒抑制

广西南宁市2.14年登革热暴发疫情特点及处置

在线全文

学校读者我要写书评

暂无评论

广西医学 2015年第12期37卷 1789-1792页

作者：阳益萍唐振柱林玫谭毅唐小兰李永红陈敏玫冯向阳周开姣汤洪洋蒙增慧陆以壮廖健黄中学凌洪习林盛智广西壮族自治区疾病预防控制中心急性传染病防制所南宁市530028 广西壮族自治区疾病预防控制中心办公室南宁市530028 广西壮族自治区疾病预防控制中心消杀与媒介防制所南宁市530028 广西壮族自治区疾病预防控制中心寄生虫病防制所南宁市530028 南宁市疾病预防控制中心办公室南宁市530023 南宁市兴宁区疾病预防控制中心办公室南宁市530000 南宁市西乡塘区疾病预防控制中心办公室南宁市530001 南宁市江南区疾病预防控制中心办公室南宁市530031 南宁市青秀区疾病预防控制中心办公室南宁市530022 南宁市良庆区疾病预防控制中心办公室南宁市530219 南宁市邕宁区疾病预防控制中心办公室南宁市530200

目的总结2.14年广西南宁市登革热暴发疫情特点及处置经验，为制定有效的登革热防控措施提供依据。方法收集南宁市2.14年6～12.登革热暴发疫情及其处置的相关资料，并进行分析。结果2.14年南宁市共报告登革热72.例，其中输入性病例13例... 详细信息

目的总结2.14年广西南宁市登革热暴发疫情特点及处置经验，为制定有效的登革热防控措施提供依据。方法收集南宁市2.14年6～12.登革热暴发疫情及其处置的相关资料，并进行分析。结果2.14年南宁市共报告登革热72.例，其中输入性病例13例，本地病例709例。首例病例为输入性病例，疫情集中暴发在9月2.0}0月18日，平均单日暴发患者为2.．70例。主要暴发地点在兴宁区、西乡塘区、青秀区、江南区，共695例占96．2.％。患者男女性别比为1：1．41，发病年龄最小1岁，最大82.，以15～〈45岁青壮年为主。职业以商业服务、家务、待业和离退人员为主。多数患者临床起病急，临床分型均为轻型；以发热、乏力、头痛、肌痛、关节痛、颜面潮红为主要表现；血标本基因分型主要为登革热病毒I型。疫情暴发时蚊媒密度为房屋指数为91．67，容器指数为2.．90，布雷图指数为338．89，经消杀后均达到控制要求。结论南宁市登革热疫情是由输入性病例引起的本地登革热感染暴发。政府主导下各部门联防联控、快速灭蚊是成功处置登革热暴发疫情的关键。

关键词：登革热暴发南宁市处置

在线全文

学校读者我要写书评

暂无评论

福建省新型冠状病毒肺炎流行病学特征分析

中国人兽共患病学报 2020年第5期36卷 366-371页

作者：欧剑鸣叶雯婧郑奎城李晓庆林修全卢晓丽谢忠杭吴生根陈彩粼黄峥强詹美蓉齐孝旗蔡少键林嘉威陈武邓艳琴王灵岚洪荣涛福建省疾病预防控制中心福建省人兽共患病研究重点实验室福州350001

目的描述和分析福建省新型冠状病毒肺炎病例的流行病学特征,为防控提供依据。方法选取经中国疾病预防控制信息系统网络直报的福建省新型冠状病毒肺炎病例,回顾性描述该省疫情概况、疾病的三间分布以及聚集性疫情特征。结果截至2.2.年2...

目的描述和分析福建省新型冠状病毒肺炎病例的流行病学特征,为防控提供依据。方法选取经中国疾病预防控制信息系统网络直报的福建省新型冠状病毒肺炎病例,回顾性描述该省疫情概况、疾病的三间分布以及聚集性疫情特征。结果截至2.2.年2.2.日2.时,累计报告病例2.8例,死亡1例,病死率0.3%。其中确诊病例2.3例(98.3%),现有疑似病例2.(0.7%),无症状感染者3例(1.0%)。确诊病例中,病情严重程度以普通型肺炎为主199例(67.9%),男女比例1.2.0},年龄以2.~54岁居多(199例,67.9%)。流行曲线表现为单峰流行,确诊病例最早发病时间为1月2.,61.8%病例集中在1月2.日-30日间发病。除平潭综合实验区外,其余9个设区市均报告确诊病例,主要分布在福州(71例,2..2.)、莆田(55例,18.8%)、泉州(46例,15.7%)。2.个(30.7%)县(市、区)无确诊病例报告。累计报告聚集性疫情50起,涉及病例177例。结论福建省新冠肺炎病例主要为输入性病例,输入性病例以中青年为主,而本地病例则以中老年为主,除平潭外的各地市均有确诊病例报告。输入性病例流行曲线与人员返闽等相吻合,本地病例流行较输入病例晚一周。各设区市均报告聚集性疫情,以家庭性聚集为主。

关键词：新型冠状病毒肺炎流行病学特征描述性分析