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Understanding “software-defined” from an OS perspective: technical challenges and research issues

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Science China(Information Sciences) 2017年第12期60卷 271-273页

作者： hong mei Beijing Institute of Technology Key Laboratory on High-Confidence Software Technologies(MOE) Peking University

What is"software-defined"?Software-defined has become one of the hottest buzzwords in the information technology(IT)*** is used to describe a family of technologies,including software-defined networking(SDN),softwaredefined storage(SDS),and software-defined data centers(SDDC).These are part of a broader trend that is referred to as software-defined everything

关键词： OS from an OS perspective Understanding software-defined technical challenges and research issues

Learning a graph-based classifier for fault localization

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Science China(Information Sciences) 2020年第6期63卷 195-216页

作者： Hao Zhong hong mei Department of Computer Science and Engineering Shanghai Jiao Tong University

Because software emerged, locating software faults has been intensively researched, culminating in various approaches and tools that have been applied in real development. Despite the success of these developments, improved tools are still demanded by programmers. Meanwhile, some programmers are reluctant to use any tools when locating faults in their development. The state-of-the-art situation can be naturally improved by learning how programmers locate faults. The rapid development of open-source software has accumulated many bug fixes. A bug fix is a specific type of comments containing a set of buggy files and their corresponding fixed files, which reveal how programmers repair bugs. Feasibly, an automatic model can learn fault locations from bug fixes, but prior attempts to achieve this vision have been prevented by various technical challenges. For example, most bug fixes are not compilable after checking out, which hinders analyzing bug fixes by most advanced static/dynamic tools. This paper proposes an approach called ClaFa that trains a graph-based fault classifier from bug fixes. ClaFa is built on a recent partial-code tool called Grapa, which enables the analysis of partial programs by the complete code tool called WALA. Once Grapa has built a program dependency graph from a bug fix, ClaFa compares the graph from the buggy code with the graph from the fixed code, locates the buggy nodes, and extracts the various graph features of the buggy and clean nodes. Based on the extraction result, ClaFa trains a classifier that combines Adaboost and decision tree learning. The trained ClaFa can predict whether a node of a program dependency graph is buggy or *** evaluate ClaFa on thousands of buggy files collected from four open-source projects: Aries, Mahout,Derby, and Cassandra. The f-scores of ClaFa achieves are approximately 80% on all projects.

关键词： fault classifier partial code analysis bug fix analysis

A constructive model for collective intelligence

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National Science Review 2020年第8期7卷 1273-1277页

作者： Wei Zhang hong mei Key Laboratory of High Confidence Software Technology (Peking University) Ministry of Education Institute of Software Department of Computer Science and Technology Peking University

Natural phenomena of collective intelligence(CI) occurring in physical space show a potential approach to effective large-scale human collaboration in cyberspace. Based on existing explanatory understanding of CI, this perspective proposes a constructive model for building artificial CI systems, i.e., problem-oriented CI phenomena with AI-powered information integration and feedback.

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A Self-consistent Field Study on the Adsorption of Symmetrical Triblock Copolymers between Two Parallel Planes

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Chinese Journal of Polymer Science 2015年第12期33卷 1691-1701页

作者： Dao-hong mei 邱东 State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

Using the continuum self-consistent field theory （SCFT）, the adsorption of flexible symmetrical triblock polymers onto the surfaces of two identical parallel planes immersed in a neutral solution was studied. The effects of various parameters, such as the interface adhesive energy, the polymer composition and the bulk polymer concentration, on the conformations and total adsorption amount of polymers were explored. It was found that the dependence of the amount of bridges on the interface adhesion and that of the amount of tails on the length of adhesive blocks were both non-monotonous. The amounts of the four chain conformations scaled nearly linearly to the copolymer bulk concentration. The non- equivalence of the dependence of the adsorbed structure behaviors on the interface affinity and the length of sticky blocks was revealed as well.

关键词： SCFT Symmetrical triblock adsorption Conformation.

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Embracing informationization 3.0—an era of computing intelligence

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Science China(Information Sciences) 2018年第1期61卷 5-6页

作者： hong mei SCIENCE CHINA Information Sciences

Information,after materials and energy,is viewed as the third strategic resource in human *** technology and its applications,i.e.,informationization,have broadly and profoundly impacted *** history of informationizat... 详细信息

关键词： Embracing informationization 3.0 an era of computing intelligence

Can big data bring a breakthrough for software automation?

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Science China(Information Sciences) 2018年第5期61卷 288-290页

作者： hong mei Lu ZHANG Key Laboratory on High-Confidence Software Technologies (Ministry of Education) Peking University Beijing Institute of Technology

Software automation[1]aims to automatically generate computer programs from formal or informal *** it may release programmers from tedious programming tasks,software automation has long been a dream of computer ***,since software systems constantly evolve during their life cycles,software automation should cover all development activities related to both generating new code and changing

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Oligomerization of drug transporters:Forms,functions,and mechanisms

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1924-1938页

作者： Chunxu Ni mei hong College of Life Sciences South China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms South China Agricultural UniversityGuangzhou 510642China

Drug transporters are essential players in the transmembrane transport of a wide variety of clinical *** broad substrate spectra and versatile distribution pattern of these membrane proteins infer their pharmacological and clinical *** our accumulating knowledge on the three-dimensional structure of drug transporters,their oligomerization status has become a topic of intense study due to the possible functional roles carried out by such kind of post-translational modification(PTM).In-depth studies of oligomeric complexes formed among drug transporters as well as their interactions with other regulatory proteins can help us better understand the regulatory mechanisms of these membrane proteins,provide clues for the development of novel drugs,and improve the therapeutic *** this review,we describe different oligomerization forms as well as their structural basis of major drug transporters in the ATP-binding cassette and solute carrier superfamilies,summarize our current knowledge on the influence of oligomerization for protein expression level and transport function of these membrane proteins,and discuss the regulatory mechanisms of ***,we highlight the challenges associated with the current oligomerization studies and propose some thoughts on the pharmaceutical application of this important drug transporter PTM.

关键词： Drug development Drug transporters Oligomerization Protein expression Protein–protein interaction Regulatory mechanism Structural basis Transport function

R-matrix for the 8-Dimensional Spin Representation of Uq(so7)

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Acta Mathematica Sinica,English Series 2024年第2期40卷 485-497页

作者： hong mei HU Nai hong HU School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009P.R.China School of Mathematical Sciences MOE Key Laboratory of Mathematics and Engineering Applications&Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241P.R.China

The purpose of the paper is to describe the solution to the quantum Yang-Baxter equation associated with the 8-dimensional spin representation Tsp of Uq(so7).The self-duality of Tsp and the symmetry of the corresponding braiding matrix are ***,the minimal polynomial of the braiding R-matrix of Tsp is presented explicitly in an ingenious method by taking advantage of nice features of the spin representation Tsp.

关键词： Braiding R-matrix spin module minimal polynomial

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Type I interferon pathway in pediatric systemic lupus erythematosus

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World Journal of Pediatrics 2024年第7期20卷 653-668页

作者： Yu Zhou hong‑mei Song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalBeijingChina

Background The role of type I interferon(IFN-I)signaling in systemic lupus erythematosus(SLE)has been well ***,unanswered questions remain regarding the applicability of these findings to pediatric-onset *** aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset *** sources A literature search was conducted in the PubMed database using the following keywords:“pediatric systemic lupus erythematosus”and“type I interferon”.Results IFN-I signaling is increased in pediatric SLE,largely due to the presence of plasmacytoid dendritic cells and pathways such as cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase 1 and Toll-like receptor(TLR)4/*** extracellular traps and oxidative DNA damage further stimulate IFN-I *** variants in IFN-I-related genes,such as IFN-regulatory factor 5 and tyrosine kinase 2,are linked to SLE susceptibility in pediatric *** addition,type I interferonopathies,characterized by sustained IFN-I activation,can mimic SLE symptoms and are thus important to *** on interferonopathies also contribute to exploring the pathogenesis of *** IFN-I activation is crucial for SLE diagnosis and *** IFNstimulated gene expression and serum IFN-α2 levels are common *** cytometry markers such as CD169 and galectin-9 are promising ***-IFN therapies,such as sifalimumab and anifrolumab,show promise in adult patients with SLE,but their efficacy in pediatric patients requires further *** kinase inhibitors are another treatment option for severe pediatric SLE *** This review presents an overview of the IFN-I pathway in pediatric *** the intricate relationship between IFN-I and pediatric SLE may help to identify potential diagnostic markers and targeted therapies,paving the way for improved patient care and outcomes.

关键词： Interferonopathies Pediatric systemic lupus erythematosus Type I interferon