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Sedimentary records of contaminant inputs in Frobisher Bay,Nunavut

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Environmental Science and Ecotechnology 2024年第2期18卷 28-42页

作者： meaghan C.Bartley Tommy Tremblay Amila O.De Silva CMichelle Kamula Stephen Ciastek Zou Zou A.Kuzyk Centre for Earth Observation Science Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Department of Environment and Geography Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Canada-Nunavut Geoscience Office IqaluitNunavutX0A 0H0Canada Environment and Climate Change Canada BurlingtonOntarioL7S 1A1Canada Department of Earth Sciences Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada

Contaminants,such as polychlorinated biphenyls(PCBs),polycyclic aromatic hydrocarbons(PAHs),heavy metals,and per and polyfluoroalkyl substances(PFASs),primarily reach the Arctic through long-range atmospheric and oceanic ***,local sources within the Arctic also contribute to the levels observed in the environment,including legacy sources and new sources that arise from activities associated with increasing commercial and industrial *** City of Iqaluit in Frobisher Bay,Nunavut(Canada),has seen rapid population growth and associated development during recent decades yet remains a site of interest for ocean protection,where Inuit continue to harvest country *** the present study,seven dated marine sediment cores collected in Koojesse Inlet near Iqaluit,and from sites in inner and outer Frobisher Bay,respectively,were analyzed for total mercury(THg),major and trace elements,PAHs,PCBs,and *** sedimentary record in Koojesse Inlet shows a period of Aroclor 1260-like PCB input concurrent with military site presence in the 1950e60s,followed by decades of input of pyrogenic PAHs,averaging about ten times background ***-surface sediments in Koojesse Inlet also show evidence of transient local-source inputs of THg and PFASs,and recycling or continued slow release of PCBs from legacy land-based *** in PFAS congener composition clearly distinguish the local sources from long-range *** Koojesse Inlet but still in inner Frobisher Bay,9.2 km from Iqaluit,sediments showed evidence of both local source(PCB)and longrange *** outer Frobisher Bay,an up-core increase in THg and PFASs in sediments may be explained by ongoing inputs of these contaminants from long-range *** context for ocean protection and country food harvesting in this region of the Arctic clearly involves both local sources and long-range transport,with past human activities leaving a long legacy insofar as levels of persistent o

关键词： Arctic sediments Mercury Polycyclic aromatic hydrocarbons(PAHs) Polychlorinated biphenyls(PCBs) Per and polyfluoroalkyl substances(PFASs) Persistent organic pollutants(POPs)

Muscle energy technique for chronic obstructive pulmonary disease:A feasibility study

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Journal of Integrative Medicine 2023年第3期21卷 245-253页

作者： Danielle A.Baxter meaghan E.Coyle Catherine J Hill Christopher Worsnop Johannah L.Shergis School of Health and Biomedical Sciences Royal Melbourne Institute of Technology UniversityBundooraVictoria 383Australia Department of Physiotherapy Austin HealthHeidelbergVictoria 3084Australia Institute for Breathing and Sleep HeidelbergVictoria 3084Australia

Objective:This study aimed to investigate the feasibility of implementing a manual therapy technique(muscle energy technique,MET)protocol in a hospital pulmonary rehabilitation(PR)program for patients with moderate to severe chronic obstructive pulmonary disease(COPD).Methods:Participants aged 40 years and over,with moderate to severe COPD,were recruited into this 12-week *** primary outcome measures were feasibility(acceptability of the intervention and attendance/adherence to the trial)and safety(adverse events,AEs).All participants received the MET and PR *** and assessors were ***-standardized MET was delivered on 6 occasions(a maximum of once per week)at the hospital directly before a PR *** undertook PR sessions as per the hospital program at a frequency of two days per week for 8 *** were contacted 4 weeks after their final MET treatment via a telephone call to assess acceptability of the ***:Thirty-three participants were enrolled,with a median age of 74 years(range 45-89 years).The median number of MET sessions that participants attended was 5(range O-6)out of a possible 6 sessions(83%attendance).At follow-up,participants overwhelmingly enjoyed the MET treatment with some subjectively reporting improved *** were no major AEs related to the intervention,with the majority of AEs classified as expected events related to COPD ***:It is feasible to implement a manual therapy protocol using MET as an adjunct to PR in a hospital *** rates were satisfactory and there were no AEs related to the MET component of the intervention.

关键词： Manual therapy Pulmonary rehabilitation Chronic obstructive pulmonary disease

Economic Assessment and Review of Waterless Fracturing Technologies in Shale Resource Development: A Case Study

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Journal of Earth Science 2017年第5期28卷 933-948页

作者： Iman Oraki Kohshou Reza Barati meaghan Cassey Yorro Tim Leshchyshyn Adebola T. Adejumo Usman Ahmed Imre Kugler Murray Reynolds James McAndrew University of Wyoming Department of Petroleum Engineering Laramie WY 82071 USA Department of Chemical & Petroleum Engineering University of Kansas Lawrence KS 66045 USA Forum Energy Technologies Houston TX 77024 USA FracKnowledge//Fracturing Horizontal Well Completions Inc. Calgary AB 72G 0X8 Canada Halliburton Houston TX 77032 USA Unconventional Oil and Gas technology and Development and WellDog Laramie WY 82070 USA IHS Markit Houston TX 77077 USA Ferus Calgary AB T2P 3C5 Canada AirLiquide Greater Philadelphia Area Philadelphia 19019 USA

Our database tracking of USA water usage per well indicates that traditionally shale operators have been using, on average 3 to 6 million gallons of water; even up to 8 million for the en- tire life cycle of the well based on its suitability for re-fracturing to stimulate their long and lateral ho- rizontal welis. According to our data, sourcing, storage, transportation, treatment, and disposal of this large volume of water could account for up to 10% of overall drilling and completion costs. With in- creasingly stringent regulations governing the use of fresh water and growing challenges associated with storage and use of produced and flowback water in hydraulic fracturing, finding alternative sources of fracturing fluid is already a hot debate among both the scientific community and industry experts. On the other hand, waterless fracturing technology providers claim their technology can solve the concerns of water availability for shale development. This study reviews high-level technical issues and opportunities in this challenging and growing market and evaluates key economic drivers behind water management practices such as waterless fracturing technologies, based on a given shale gas play in the United States and experience gained in Canada. Water costs are analyzed under a variety of scenarios with and without the use of （fresh） water. The results are complemented by surveys from several oil and gas operators. Our economic analysis shows that fresh water usage offers the greatest economic return. In regions where water sourcing is a challenge, however, the short-term economic advantage of using non-fresh water-based fracturing outweighs the capital costs required by waterless fracturing methods. Until waterless methods are cost competitive, recycled water usage with low treatment offers a similar net present value （NPV） to that of sourcing freshwater via truck, for in- stance.

关键词： shale gas gas exploration fracturing techology fracturing fluid waterless fracturing.

Prolonged Disease Stabilization and Tolerability in a Nuclear Protein in Testis Midline Carcinoma Patient Treated with Dual Histone Deacetylase and Phosphoinositide 3-Kinase Inhibitor CUDC-907

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Case Reports in Clinical Medicine 2018年第7期7卷 451-460页

作者： Pamela Munster Nilson Wu meaghan McMahon Robert Gharavi David Tuck Division of Hematology and Oncology University of California San Francisco USA Curis Inc.LexingtonMassachusettsUSA

Introduction: Nuclear protein in testis midline carcinoma (NMC) is a rare and extremely aggressive carcinoma (median survival Case Report: A 61-year old female NMC patient enrolled on study CUDC-907-102 (NCT02307240) after rapidly progressing through two prior treatments. The patient’s assessable sites of disease consisted of right pleural effusion, right hilar soft tissue, and segment IV liver. Treatment was well tolerated with toxicities primarily consisting of manageable diarrhea and thrombocytopenia. The patient remains on active treatment after more than 32 months of stable disease. Discussion: Dysregulation of MYC in NMC is believed to play a central role in pathogenesis. CUDC-907 has demonstrated potent suppression of MYC expression and anti-tumor activity in preclinical NMC models, providing a mechanistic rationale for the prolonged disease stabilization observed here. The treatment of additional NMC patients with CUDC-907 is needed to further evaluate this promising report. Conclusion: This case demonstrates a rare success in the treatment of a devastating disease using only a novel small molecule, warranting further investigation of CUDC-907 in NMC.

关键词： NMC MYC CUDC-907 HDAC PI3K

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跨年夜餐桌上的美味与吉祥

疯狂英语(初中天地) 2017年第12期 21-22页

作者： meaghan Cameron 范婕

一说起跨年夜大餐,你肯定又开始饿了吧,哈哈!在跨年夜,人们都喜欢吃些什么呢?咱们一看便知!在跨年夜,人们为了获得吉祥好兆头,总会吃一些特定的食物,这已成为传统。人们认为这些食物会给他们带来一整年的兴旺与健康。1.绿色蔬菜人们在... 详细信息

一说起跨年夜大餐,你肯定又开始饿了吧,哈哈!在跨年夜,人们都喜欢吃些什么呢?咱们一看便知!在跨年夜,人们为了获得吉祥好兆头,总会吃一些特定的食物,这已成为传统。人们认为这些食物会给他们带来一整年的兴旺与健康。1.绿色蔬菜人们在跨年夜会吃绿色蔬菜,大概是因为它们与钱币的颜色相似。2.豆子和蔬菜一样,豆子也与钱币相似,只是更具体一些,它们象征着硬币。无论你是选择吃黑豆还

关键词：绿色蔬菜加油站

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自轻容貌害处多

疯狂英语（初中天地） 2016年第7期 23-24页

作者： meaghan Ramsey 德孟

你对自己的外貌感到满意吗？你是否知道对自身外貌的不自信,会导致学习成绩退步、自尊心低下、健康损害严重,甚至还会影响到整个经济大环境？Ten thousand people every month google,＂Am I ugly？＂What’s leading them to do this？... 详细信息

你对自己的外貌感到满意吗？你是否知道对自身外貌的不自信,会导致学习成绩退步、自尊心低下、健康损害严重,甚至还会影响到整个经济大环境？Ten thousand people every month google,＂Am I ugly？＂What’s leading them to do this？Well,today’s teenagers are rarely alone.

关键词：容貌 google every 学习成绩 this Well 自尊心外貌

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榜样的力量

中华家教 2017年第5期 24-25页

作者：学院君 meaghan Elderkin

本文给大家介绍的是一位很擅长给女儿传授“榜样的力量”的母亲——她就是来自美国的自由插画家meaghan Elderkin。

关键词：家庭教育教育方法孩子父母

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中小型企业如何激发活力超越大型竞争对手

中国中小企业 2016年第9期 60-60页

作者： meaghan Sullivan

大多数企业都认为,获取相关数据是企业运营的关键。但是,随着企业对实时决策和即时响应的需求愈加迫切,企业采用数据分析的方式也在不断改变,这在中小型企业中尤其明显。

关键词：中小型企业竞争对手激发企业运营实时决策

Insights into myelodysplastic syndromes from current preclinical models

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World Journal of Hematology 2016年第1期5卷 1-22页

作者： Shuh Ying Tan Monique F Smeets Alistair M Chalk Harshal Nandurkar Carl R Walkley Louise E Purton meaghan Wall Stem Cell Regulation Unit St. Vincent’s Institute of Medical Research Department of Medicine St. Vincent’s Hospital Department of Hematology St. Vincent’s Hospital Victorian Cancer Cytogenetics Service St. Vincent’s Hospital

In recent years, there has been significant progress made in our understanding of the molecular genetics of myelodysplastic syndromes(MDS). Using massively parallel sequencing techniques, recurring mutations are identified in up to 80% of MDS cases, including many with a normal karyotype. The differential role of some of these mutations in the initiation and progression of MDS is starting to be elucidated. Engineering candidate genes in mice to model MDS has contributed to recent insights into this complex disease. In this review, we examine currently available mouse models, with detailed discussion of selected models. Finally, we highlight some advances made in our understanding of MDS biology, and conclude with discussions of questions that remain unanswered.

关键词： Myelodysplastic syndromes Mouse models Genetic mutations