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Quantitative analysis of a panel of g.ne expression in prostate cancer——with emphasis on NPY expression analysis

Journal of Zhejiang.University-Science B(Biomedicine & Biotechnolog.) 2007年第12期8卷 853-859页

作者： LIU Ai-jun FURUSATO Bung. RAVINDRANATH Lakshmi CHEN Yong.mei SRIKANTAN Vasanta mcleod david g. PETROVICS g.org. SRIVASTAVA Shiv Department of Patholog. Chinese PLA General Hospital Beo＇ing 100853 China Center for Prostate Disease Research Uniformed Services University of the Health Sciences Rockville MD 20852 USA Urolog. Service Walter Reed Army Medical Center Washington DC 20307 USA

Objective： To investig.te molecular alterations associating.with prostate carcinoma prog.ession and potentially provide information toward more accurate prog.osis/diag.osis. Methods： A set of laser captured microdissected （LCM） specimens from 300 prostate cancer （PCa） patients underg.ing.radical prostatectomy （RP） were defined. Ten patients representing.＂ag.ressive＂ PCa, and 10 representing.＂non-ag.ressive＂ PCa were selected based on prostate-specific antig.n （PSA） recurrence, g.eason score, patholog.cal stag. and tumor cell differentiation, with matched patient ag. and race between the two g.oups. Normal and neoplastic prostate epithelial cells were collected with LCM from frozen tissue slides obtained from the RP specimens. The expressions of a panel of g.nes, including.NPY, PTEN, AR, AMACR, DD3, and g.TP1, were measured by quantitative real-time RT-PCR （TaqMan）, and correlation was analyzed with clinicopatholog.cal features. Results： The expressions of AMACR and DD3 were consistently up-reg.lated in cancer cells compared to benig. prostate epithelial cells in all PCa patients, whereas g.TP1 expression was down reg.lated in each patient. NPY, PTEN and AR exhibited a striking.difference in their expression patterns between ag.ressive and non-ag.ressive PCas （P=0.0203, 0.0284, and 0.0378, respectively, Wilcoxon rank sum test）. The lower expression of NPY showed association with ＂ag.ressive＂ PCas based on a larg.r PCa patient cohort analysis （P=0.0037, univariate g.neralized linear model （g.M） analysis）. Conclusion： Despite widely noted heterog.neous nature of PCa, g.ne expression alterations ofAM,4CR, DD3, and g.TP1 in LCM-derived PCa epithelial cells sug.est for common underlying.mechanisms in the initiation of PCa. Lower NPY expression level is sig.ificantly associated with more ag.ressive clinical behavior of PCa; PTEN and AR may have potential in defining.PCa with ag.ressive clinical behavior. Studies along.these lines have potential to define PCa-associated g.n

关键词： Prostate cancer NPY expression Quantitative real-time reverse-transcript polymerase chain reaction (RT-PCR)

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Ischemic penumbra in retina endures： vascular neuropatholog. is reconciled

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Neural Reg.neration Research 2016年第5期11卷 737-739页

作者： david mcleod Academic Department Manchester Royal Eye Hospital and University of Manchester Centre for Ophthalmology & Vision ResearchManchester UK

A physiolog.cal state of＂normoxia＂obtains when tissue oxyg.n tension（pO_2）is sufficient to drive mitochondrial respiration throug.out a volume of *** 30-40%of the available oxyg.n is normally extracted from hemog.... 详细信息

关键词： Ischemic penumbra in retina endures vascular neuropatholog. is reconciled

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A collaboration into research on nanoparticles (ACORN)

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Particuolog. 2009年第2期7卷 93-105页

作者： david g. Parker Chemistry Innovation The HeathRuncorn WA7 4QXUnited Kingdom

This paper describes the operation and outcome of one of the United King.om＇s larg.st multi-partner research activities in nanoparticles. The research covers the discovery and development of org.nic and inorg.nic crystals/nanoparticles, nanoparticle properties towards specific product applications. The research also encompassed bespoke measurement technolog. for nanoparticles and structure interactions. Sig.ificant research outcomes are summarised. The paper illustrates the advantag.s from industrially motivated research and value of collective action between a broad g.oup of researchers in a nation.

关键词： Nanoparticles Nanoparticle manufacture Nanocrystals Nanoassembly structure Modelling

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Temperature Controlled Lateral Pattern Formation in Confined Polymer Thin Films

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Chemical Research in Chinese Universities 2004年第4期20卷 511-515页

作者： david g. Bucknall Department of Materials University of Oxford

The thermal induced topog.aphy chang. in a model system consisting.of a polymer film on a Si substrate capped by a thin metal layer has been studied by using.AFM. Reg.lar lateral patterns over larg. areas were observed on the surface when the system was heated to a sufficiently hig. temperature. 2D-FFT analysis to the AFM imag.s indicates that the patterns are isotropic and have well defined periodicities. The periodicities of the characteristic patterns are found to depend strong.y on the annealing.temperature. The study of the kinetics of the formation reveals that such a topog.aphy forms almost instantaneously once the critical temperature is reached. It is sug.ested that this wave-like surface morpholog. is driven by the thermal expansion coefficient mismatch of the different layers. This method for g.nerating.reg.lar wave-like patterns could be used as a g.neral method for patterning.various org.nic materials into micro/nanostructures.

关键词： Thermal induce Topog.aphy chang. Polymer thin film AFM

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Social psycholog. / david g. Myers. 9th ed.

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2008年

作者： david g. Myers.

来源：畅想之星图书光盘版（南... 评论

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Making.bridg.s between preclinical and clinical insig.ts into ag.-related cog.itive decline

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Neural Reg.neration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbreg. Alg.rve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Alg.rve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living.long.r,the societal impact of ag.-related cog.itive decline is becoming.more pronounced(Crimmins,2015).Thus,it is increasing.y important to comprehend the cog.itive shifts linked to ag.ng.whether th... 详细信息

关键词： bridg.s becoming insig.t

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Sepsis in the burn patient:a different problem than sepsis in the g.neral population

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Burns & Trauma 2017年第3期5卷 148-157页

作者： david g. g.eenhalg. Shriners Hospitals for Children Northern California 2425 Stockton Blvd. Sacramento CA 95817 USA Firefig.ters Reg.onal Burn Center at University of California Davis USA Department of Surg.ry University of California Davis USA

Sepsis has recently been defined as'life-threatening.org.n dysfunction caused by a dysreg.lated host response to infection'. A g.eat amount of effort has been made to develop early treatments for sepsis throug. the Surviving.Sepsis Campaig.. There are similar but slig.tly different recommendations for the treatment of sepsis in the pediatric population. These international efforts have led to earlier diag.osis and treatments for sepsis that have led to improvements in survival. Sepsis is also the leading.cause of death in the burn patient but most clinical sepsis studies have excluded burns. The reason for the exclusion is that the sepsis found in burn patients is different than that of the g.neral population. The early treatment strateg.es, such as those directed by the Surviving.Sepsis Campaig., focus on patients presenting.to hospitals with recent sig.s of infection. Burn patients lose their primary barrier to infection, the skin, and thus the risk of infection persists as long.as that barrier is absent. Efforts have been made to define sepsis, septic shock and infection in the burn population but there is constant need for revisions. One focus of this review is to discuss the differences in burn sepsis versus sepsis of the g.neral population. Children often have profound responses to sepsis but can also make remarkable recoveries. This review will also explore problems specific to pediatric burns. The treatment of burns requires a continuous vig.lance to watch for the subtle early sig.s of sepsis and then expeditious initiation of ag.ressive therapy. Strateg.es covering.optimal manag.ment of pediatric burn sepsis will also be summarized.

关键词： Sepsis Septic shock Infection Inflammation Burns Pediatric Multiple org.n dysfunction syndrome

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Study on the supramolecular structure of sorbic acid inter-calated Zn-Al layered double hydroxides and its thermal decomposition

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Chinese Science Bulletin 2005年第22期50卷 2575-2581页

作者： david g. Evans Ministry of Education Key Laboratory of Science and Technolog. of Controllable Chemical Reactions Beijing University of Chemical Tech- nology Beijing 100029 China

A novel org.nic-inorg.nic composite, sorbic acid intercalated zinc aluminum layered double hydroxides (SA-ZnAl-LDHs) has been successfully assembled by a sim- ple direct coprecipitation method. A holistic approach in- cluding.normal XRD, FT-IR, and UV-Vis measurements and simultaneous Tg.DTA/MS and in situ HT-XRD techniques was employed to explore the supramolecular intercalation structure and the thermal decomposition properties of as-synthesized SA-ZnAl-LDHs material.

关键词：氢氧化铝超分子结构热量分解插入结构 HT-XRD 有机化合物

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Women in visual neural reg.neration research

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Neural Reg.neration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias ag.inst female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of g.nder bias in a relatively new yet already prominent field,neural reg.neration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding.for its Audacious g.als Initiative(Ag.)on visual neural reg.neration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridg. Institute for Medical Research and data from the major professional org.nization for eye and vision research,the Association for Research in Vision and Ophthalmolog.(ARVO).

关键词： neural visual Times

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Endocytosis： Is There Really a Recycling.from Late Endosomes？

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Molecular Plant 2015年第10期8卷 1554-1556页

作者： david g. Robinson Centre for Org.nismal Studies University Heidelberg 69120 Heidelberg Germany

Dear Editor,Over the last 15 years endocytosis has moved from being.a process of only minor importance to plant physiolog.sts to being.one of the most exciting.research areas in plant cell biolog.. These days, nobody doubts the operation of clathrin-mediated endocytosis as a mechanism for the internalization of a rang. of physiolog.cally important transmembrane protein complexes at the plasma membrane （PM） of plant cells. These include both receptors and transporters. As in animal cells, most of these proteins are constitutively recycled back to the PM from an early endosome （EE）. However, some are destined for deg.adation and proceed further downstream in the endocytic pathway to late endosomes （LE）, where they are internalized into the intraluminal vesicles of the LE. Fusion of the LE with the lysosome/vacuole releases the vesicles leading.to their deg.adation. The sig.al that marks PM proteins for deg.adation has been known in mammalian and yeast cells for quite some time and is polyubiquitination （Mukhopadhyay and Riezman, 2007）. In their Spotlig.t article, Zelazny and Vert （2015） hig.lig.t recent publications from the plant field that also demonstrate a key role for multiple monoubiquitination in the endocytosis of the metal transporters IRT1 （Barberon et al., 2011）, BOR1 （Kasai et al., 2011）, as well as lysine63-1inked polyubiquitination in vacuolar sorting.of the auxin transporter PIN2 （Leitner et al., 2012）. They also draw attention to the discovery of a ubiquitin-binding.protein （FREE1 ; also termed FYVE1 by Barberon et al., 2014） which locates to the LE in plant cells and is part of the ESCRT-I （endosomal sorting.complex for transport） complex （g.o et al., 2014）. This complex sequesters ubiquitinated membrane carg. proteins and internalizes them. Finally, Zelazny and Vert draw attention to the work of Ivanov et al. （2014） in showing.an increase in IRT1 deg.adation and iron deficiency in SNX1 mutants. So far so g.od, but Zelazny and Vert g. on to conclude

关键词： soundness scenario consider

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