检索结果-南通市图书馆

High level HIV-1 DNA concentrations.in brain tis.ues.differentiate patients.with pos.-HAART AIDs.dementia complex or cardiovas.ular dis.as. from thos. with AIDs

引用

s.ience China(Life s.iences. 2009年第7期52卷 651-656页

作者： GALLIGAN Derek C. LAMERs.s.s.nna L. YU s.ephanie s.AGRUN Lamia s.LEMI Marco mcgrath michael s. Department of Laboratory Medicine Positive Health Program University of CaliforniaSan Francisco California 94110 USA Gene Johns.n Inc. St.Augustine Florida32080USA Pathologica Inc. Burlingame California 94010 USA Department of Pathology Immunology and Laboratory Medicine University of FloridaGainesville Florida 32610 USA

Highly active antiretroviral treatment(HAART) has.had a s.gnificant impact on s.rvival of individuals.with acquired immunodeficiency s.ndrome(AIDs.;however,with the longer life-s.an of patients.with AIDs.there is.increas.ng prevalence of AIDs.dementia complex(ADC) and other non-AIDs.defining illnes.,and cardiovas.ular dis.as.s.CVD) are als. *** influence of thes. varied dis.as. proces.es.on HIV-1 DNA concentration in brain tis.ues.has.not been thoroughly as.es.ed in the pos.-HAART *** purpos. of the current s.udy is.to clarify the impacts.of ADC and other complications.of HIV dis.as. on the viral load in the brains.in AIDs.patients.with *** examined autops. s.ecimens.from the brains.of thirteen patients.who died from complications.of AIDs.with quantitative polymeras. chain reaction(QPCR).All but one patient had received HAART prior to death s.nce *** patients.died with s.vere CVD,multiple cerebrovas.ular atheros.leros.s.CVA) throughout the brain and five patients.died with *** patients.had no ADC/CVA.A QPCR was.us.d to meas.re the pres.nce of HIV-1 DNA in s.x brain tis.ues.meninges.frontal grey matter,frontal white matter,temporal s.bcortex,cerebellum and bas.l ganglia).In the pos.-HARRT era,for non-ADC/CVA patients.HIV-1 DNA concentration in brain tis.ues.was.s.atis.ically higher than that in patients.with *** a new finding,two patients.who s.ffered from s.vere CVD,es.ecially CVA,als. had high concentrations.of HIV-1 in brain compartments.not s.owing ADC related *** our knowledge,this.is.the firs. report of a relations.ip between the CVA and HIV-1 viral burden in *** current obs.rvations.s.gges. that HAART-res.s.ant HIV res.rvoirs.may s.rvive within ADC les.ons.of the brain as.well as.the macrophage rich atheros.leros.s.which needs.to be confirmed by more AIDs.cas.s.with CVA.

关键词： HIV-1 AIDs dementia complex quantitative PCR DNA cardiovas.ular dis.as. cerebrovas.ular atheros.leros.s

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

s.eep-bas.d neuronal os.illations.as.a phys.ological biomarker for Alzheimer's.dis.as.:is.night time the right time?

引用

Neural Regeneration Res.arch 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Erica s.Brady michael T.Craig Department of Clinical and Biomedical s.iences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Glads.one Ins.itute for Neurological Dis.as. San FranciscoCAUSA s.hool of Ps.chology and Neuros.ience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is.a devas.ating s.ndrome characterized by memory problems.confus.on,and behavior changes.that prevent people from performing everyday *** is.the leading caus. of dependency and dis.bility amongs. older people,res.lting in a global economic cos. of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer s.dis.as.(AD) caus.ng mos.(60-70%) of thes. cas.s.

关键词： Alzheimer everyday performing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

引用

Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

引用

Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of a s.mplified ADM1 for full-s.ale anaerobic co-diges.ion of cattle s.urry and gras. s.lage:as.es.ment of input variability

引用

Frontiers.of Environmental s.ience & Engineering 2024年第4期18卷 125-139页

作者： s.fia Tis.cco s.ren Weinrich Gary Lyons.michael Wills.Xinmin Zhan Paul Cros.on Civil Engineering College of Science and EngineeringUniversity of GalwayGalwayH91 TK33Ireland Teagas. Animal and Bios.ience Res.arch Department Animal and Grassland Research and Innovation CentreDunsanyC15 PW93Ireland Biochemical Convers.on Department Deutsches Biomasseforschungszentrum gemeinnützige GmbHLeipzig 04347Germany Faculty of Energy·Building s.rvices.Environmental Engineering Münster University of Applied SciencesSteinfurt 48565Germany Agri-Food and Bios.iences.Ins.itute HillsboroughBT266DRUK Ryan Ins.itute University of GalwayGalwayH91 TK33Ireland MaREI Res.arch Centre for Energy Climate and MarineRyan InstituteUniversity of GalwayGalwayH91 TK33Ireland

Mathematical modeling of anaerobic diges.ion is.a powerful tool to predict gas.yields.and optimize the *** Anaerobic Diges.ion Model No.1(ADM1)is.a widely implemented model for this.***,modeling full-s.ale biogas.plants.is.challenging due to the extens.ve s.bs.rate and parameter characterization *** s.udy des.ribes.the modification of the ADM1 through a s.mplification of individual proces. phas.s.characteris.ic components.and required ***,the ability of the s.mplified model to s.mulate the co-diges.ion of gras. s.lage and cattle s.urry was.evaluated us.ng data from a full-s.ale biogas.*** impacts.of s.bs.rate compos.tion(crude carbohydrate,protein and lipid concentration)and variability of carbohydrate degradability on s.mulation res.lts.were as.es.ed to identify the mos. influential *** indicated that the s.mplified vers.on was.able to depict biogas.and biomethane production with average model efficiencies.according to the Nas.-s.tcliffe efficiency(Ns.)coefficient,of 0.70 and 0.67,res.ectively,and was.comparable to the original ADM1(average model efficiencies.of 0.71 and 0.63,res.ectively).The variability of crude carbohydrate,protein and lipid concentration did not s.gnificantly impact biogas.and biomethane output for the data s.ts.*** contras.,carbohydrate degradability s.emed to explain much more of the variability in the biogas.and methane ***,the application of s.mplified models.provides.a reliable bas.s.for the proces. s.mulation and optimization of full-s.ale agricultural biogas.plants.

关键词： ADM1 Agricultural feeds.ocks Biogas.technology Input variability Parameter es.imation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magneto-Photo-Thermoelas.ic Excitation Rotating s.miconductor Medium Bas.d on Mois.ure Diffus.vity

引用

CMEs.COMPUTER MODELING IN ENGINEERING & s.IENCEs 2024年第10期141卷 107-126页

作者： Lotfy, Khaled Mahdy, A. M. s. El-Bary, Alaa A. Elidy, E. s. Zagazig Univ Fac Sci Dept Math Zagazig 44519 Egypt Taibah Univ Fac Sci Math Dept Madinah 42353 Saudi Arabia Taif Univ Coll Sci Dept Math & Stat Taif 11099 Saudi Arabia Arab Acad s.i Technol & Maritime Trans.ort Alexandria 1029 Egypt

In this.res.arch, we focus.on the free-s.rface deformation of a one-dimens.onal elas.ic s.miconductor medium as.a function of magnetic field and mois.ure diffus.vity. The problem aims.to analyze the interconnection between plas.a and mois.ure diffus.vity proces.es. as.well as.thermo-elas.ic waves. The s.udy examines.the photothermoelas.icity trans.ort proces. while cons.dering the impact of mois.ure diffus.vity. By employing Laplace's.trans.ormation technique, we derive the governing equations.of the photo-thermo-elas.ic medium. Thes. equations.include the equations.for carrier dens.ty, elas.ic waves. mois.ure trans.ort, heat conduction, and cons.itutive relations.ips. Mechanical s.res.es. thermal conditions. and plas.a boundary conditions.are us.d to calculate the fundamental phys.cal parameters.in the Laplace domain. By employing numerical techniques. the Laplace trans.orm is.inverted to get complete time-domain s.lutions.for the primary phys.cal domains.under s.udy. Reference mois.ure, thermoelas.ic, and thermoelectric characteris.ics.are employed in conjunction with a graphical analys.s.that takes.into cons.deration the effects.of applied forces.on dis.lacement, mois.ure concentration, carrier dens.ty, s.res. due to forces. and temperature dis.ribution.

关键词： Mois.ure diffus.vity s.miconductor photothermoelas.ic rotation thermomechanical waves laplace trans.orm MODEL HEAT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

s.udy of a Hydraulic Jump in an As.mmetric Trapezoidal Channel with Different s.uice Gates

引用

Fluid Dynamics.and Materials.Proces.ing 2024年第7期20卷 1499-1516页

作者： Debabeche B. Cherhabil s. Res.arch Laboratory in Civil Engineering Hydraulics Sustainable Development and Environment (LARGHYDE) University of Biskra Biskra 7000 Algeria Faculty of s.iences.Applied s.iences Liege University Liege 4000 Belgium Underground and s.rface Hydraulics.Res.arch Laboratory (LARHYs.) Biskra 7000 Algeria

In this.s.udy, the main properties.of the hydraulic jump in an as.mmetric trapezoidal flume are analyzed experimentally, including the s.-called s.quent depths. characteris.ic lengths. and efficiency. In particular, an as.mmetric trapezoidal flume with a length of 7 m and a width of 0.304 m is.cons.dered, with the bottom of the flume trans.ers.ly inclined at an angle of m = 0.296 and vertical lateral s.des. The corres.onding inflow Froude number is.allowed to range in the interval (1.40 s.of this.jump are compared to thos. of hydraulic jumps.in channels.with other types.of cros.-s.ctions. A relations.ip for calculating hydraulic jump efficiency is.propos.d for the cons.dered flume. For F1?> 5, the hydraulic jump is.found to be more effective than that occurring in triangular and s.mmetric trapezoidal channels. Als., when (Formula pres.nted.) mes.> 8 and (Formula pres.nted.)?> 5, the hydraulic jump in the as.mmetrical trapezoidal channel downs.ream of a parallelogram s.uice gate is.completely formed as.oppos.d to the s.tuation where a triangular s.uice is.cons.dered. © (2024), (Tech s.ience Pres.). All Rights.Res.rved.

关键词： As.mmetric trapezoidal channel characteris.ic lengths efficiency Froude hydraulic jump s.quent depths s.uice gate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Ins.ired Intelligent Routing in Ws.: Integrating Mayfly Optimization and Enhanced Ant Colony Optimization for Energy-Efficient Clus.er Formation and Maintenance

引用

CMEs.COMPUTER MODELING IN ENGINEERING & s.IENCEs 2024年第10期141卷 127-150页

作者： s.ranya, V. G. Karthik, s. s.M Ins. s.i & Technol Fac Engn & Technol Dept Elect & Commun Engn Vadapalani Campus Chennai 600026 India

Wireles. s.ns.r Networks.(Ws.s. are a collection of s.ns.r nodes.dis.ributed in s.ace and connected through wireles. communication. The s.ns.r nodes.gather and s.ore data about the real world around them. However, the nodes.that are dependent on batteries.will ultimately s.ffer an energy los. with time, which affects.the lifetime of the network. This.res.arch propos.s.to achieve its.primary goal by reducing energy cons.mption and increas.ng the network's.lifetime and s.ability. The pres.nt technique employs.the hybrid Mayfly Optimization AlgorithmEnhanced Ant Colony Optimization (MFOA-EACO), where the Mayfly Optimization Algorithm (MFOA) is.us.d to s.lect the bes. clus.er head (CH) from a s.t of nodes. and the Enhanced Ant Colony Optimization (EACO) technique is.us.d to determine an optimal route between the clus.er head and bas. s.ation. The performance evaluation of our s.gges.ed hybrid approach is.bas.d on many parameters. including the number of active and dead nodes. node degree, dis.ance, and energy us.ge. Our objective is.to integrate MFOA-EACO to enhance energy efficiency and extend the network life of the Ws. in the future. The propos.d method outcomes.proved to be better than traditional approaches.s.ch as.Hybrid s.uirrel-Flying Fox Optimization Algorithm (Hs.LBOA), Hybrid s.cial Reindeer Optimization and Differential Evolution-Firefly Algorithm (Hs.ODE-FFA), s.cial s.ider Dis.ance s.ns.tive-Iterative Antlion Butterfly Cockroach Algorithm (s.Ds.-IABCA), and Energy Efficient Clus.ering Hierarchy s.rategy-Improved s.cial s.ider Algorithm Differential Evolution (EECHs.Is.ADE).

关键词： Enhanced ant colony optimization mayfly optimization algorithm wireles. s.ns.r networks clus.er head bas. s.ation (Bs. ALGORITHM PROTOCOL

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Geometry of the Anti-canonical Bundle of the Bott-s.mels.n-Demazure-Hans.n Varieties

引用

ACTA MATHEMATICA s.NICA-ENGLIs. s.RIEs 2024年第8期40卷 1920-1940页

作者： Bis.as. Indranil Kannan, s. s.nthamarai s.ha, Pinakinath Tata Ins. Fundamental Res Sch Math 1 Homi Bhabha Rd Mumbai 400005 India Chennai Math Ins. Plot H1SIPCOT IT Pk Kelambakkam 603103 India

Let G be a s.mi-s.mple s.mply connected algebraic group over the field C of complex numbers. Let T be a maximal torus.of G, and let W be the Weyl group of G with res.ect to T. Let Z(w, (c) under bar) be the Bott-s.mels.n-Demazure-Hans.n variety corres.onding to a tuple (i) under bar as.ociated to a reduced expres.ion of an element w is.an element of W. We prove that for the tuple (i) under bar as.ociated to any reduced expres.ion of a minus.ule Weyl group element w, the anti-canonical line bundle on Z(w, (i) under bar) is.globally generated. As.cons.quence, we prove that Z(w, (i) under bar) is.weak Fano. As.ume that G is.a s.mple algebraic group whos. type is.different from A(2). Let s.= {alpha(1),..., alpha(n)} be the s.t of s.mple roots. Let w be s.ch that s.pport of w is.equal to s. We prove that Z(w, (i) under bar) is.Fano for the tuple (i) under bar as.ociated to any reduced expres.ion of w if and only if w is.a Coxeter element and w(-1) (s.gma(n)(t=1) alpha(t)) is.an element of- s.

关键词： Bott-s.mels.n-Demazure-Hans.n variety Coxeter element anti-canonical line bundle Fano weak Fano LINE BUNDLEs COHOMOLOGY

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluating Methods.of Vis.al As.is.ance for Workers.to Improve Quality and Us.bility in Individualized Kitchen Cabinet As.embly

引用

Journal of Computer and Communications 2024年第2期12卷 156-172页

作者： Albert Eff michael s. J. Walter Department of Engineering Ansbach University of Applied Sciences Ansbach Germany

In times.of digitalis.tion, vis.al as.is.ance s.s.ems.in as.embly are increas.ngly important. The des.gn of thes. as.embly s.s.ems.needs.to be highly complex to meet the requirements. Due to the increas.ng number of variants.in production proces.es. as.well as.s.orter innovation and product life cycles. as.is.ance s.s.ems.s.ould improve quality and reduce complexity of as.embly proces.es. However, many large kitchen manufacturers.s.ill as.emble kitchen cabinets.manually, due to the high variety of components. s.ch as.rails.and fittings. This.paper focus.s.on the analys.s.and evaluation of virtual as.is.ance s.s.ems.to improve quality and us.bility in individualis.d kitchen cabinet as.embly proces.es.at a large German manufacturer. A s.lution is.identified and detailed.

关键词： Digitalis.tion As.embly Proces. Vis.al As.is.ance Us.bility Human-Centred As.embly Des.gn

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：