检索结果-南通市图书馆

A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study

引用

Oncology Research 2023年第2期31卷 207-220页

作者： GUSTAVO MARTÍN VILLOLDO MARÍA TERESA POMBO mariana aris JOAQUÍN CHEMI PABLO MANDÓ SUPRIYA NAGARAJU JUAN CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA AMAT JOSÉLEÓN MELLADO JOSÉMORDOH ALBERTO VILLARONGA MARÍA MARCELA BARRIO Urology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immunohistochemistry Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Centro de Investigaciones Oncológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Department MD Anderson Cancer CenterHoustonTX77030USA Pathology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive *** induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor *** searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment ***-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by *** polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+*** addition,PD-1/PD-L1 staining was *** results correlated with BCG *** most non-responders,Th1/Th2 markers were compared in pre-and post-BCG *** was 65.6%in the study *** responders had a higher G/T ratio and a greater number of degranulated EPX+*** combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower ***-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of ***-L1/PD-1 expression was not associated with the response to *** results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity.

关键词： Non-muscle invasive bladder cancer BCG predictive biomarkers Lymphocyte polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A model to standardize safety and quality of care for cupping therapy

引用

Journal of Integrative Medicine 2021年第4期19卷 327-332页

作者： Riska Siregar aris Setyawan Syahruramdhani Syahruramdhani Lembaga Mitra Sehat Manfaat Relief-Health Partnership SocietySleman 55292Yogyakarta ProvinceIndonesia School of Nursing Institute of Health ScienceSurya Global YogyakartaBantul 55194Yogyakarta ProvinceIndonesia School of Nursing Universitas Muhammadiyah Yogyakarta ProvinceIndonesia

Cupping therapy has historical, traditional and religious value. It is increasingly popular in the field of complementary, alternative and integrative medicine. However, standards for safety and quality of service are absent. Although it is generally considered safe, cupping therapy can cause adverse *** of these events are predictable and preventable. A comprehensive approach to patient eligibility and therapist selection, along with compliance with standard operational procedures is essential to regulate the safety of the practice. Here we discuss a model framework for standardizing safety and quality of care. We recommend that this model be used routinely by cupping therapists and their associations on a nation-wide scale.

关键词： Cupping therapy Safety Theoretical models Practice management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental determination of Cd^2＋ adsorption mechanism on low-cost biological waste

引用

Frontiers of Environmental Science & Engineering 2013年第3期7卷 356-364页

作者： Farhah Amalya ISMAIL Ahmad Zaharin aris Environmental Forensics Research Centre Faculty of Environmental Studies Universiti Putra Malaysia UPM Serdang 43400 Malaysia

Carbonate shells have an astonishing ability in the removal of Cd^2＋ in a short time period with emphasis on being a low cost adsorbent. In the present study, the sorption capacity of carbonate shells was studied for Cd^2＋ in batch experiments. The influence of different carbonate shell sizes and physico-chemical factors were evaluated and the results were analyzed for its correlation matrices by using Predictive Analytics Software （PASW）. The miner- alogy state of aqueous solution regarding the saturation index was simulated using PHREEQC to identify the Cd^2＋ uptake mechanism. The Cd uptake rates were calculated as well as Ca^2＋, HCO3- concentration, pH, ambient humidity and temperature were measured. Cd2＋ removal of 91.52% was achieved after 5 h adsorption. The adsorption efficiencies were significantly influenced by pH as they increased with the increase of pH from acidic solution （5.50±0.02） to slightly alkaline （7.60±0.05）. In addition, the mineralogy state of aqueous solution calculated from PHREEQC confirmed that the increment of Ca^2＋ and HCO3- concentrations in solution was attributed to the dissolution of carbonate shells. Moreover, the ion exchange adsorption mechanism of Cd^2＋ toward Ca^2＋ was identified as the process involved in Cd^2＋ uptake.

关键词： carbonate shell cadmium heavy metal,adsorption mechanism saturation state

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Management of autoimmune hepatitis induced by hepatitis delta virus

引用

World Journal of Gastroenterology 2024年第8期30卷 799-805页

作者： Eleni Gigi Vasileios Lagopoulos aris Liakos Hepatology Unit The Second Internal Medicine DepartmentAristotle University Medical SchoolHippokrateio General HospitalThessaloniki 54642Greece Department of Surgical AHEPA General Hospital of ThessalonikiThessaloniki 54636Greece Clinical Research and Evidence-Based Medicine Unit Second Medical DepartmentHippokratio General HospitalAristotle University ThessalonikiThessaloniki 54642Greece

Approximately 12-72 million people worldwide are co-infected with hepatitis B virus(HBV)and hepatitis delta virus(HDV).This concurrent infection can lead to several severe outcomes with hepatic disease,such as cirrhosis,fulminant hepatitis,and hepatocellular carcinoma,being the most *** the past few decades,a correlation between viral hepatitis and autoimmune diseases has been ***,autoantibodies have been detected in the serum of patients co-infected with HBV/HDV,and autoimmune features have been ***,to date,very few cases of clinically significant autoimmune hepatitis(AIH)have been reported in patients with HDV infection,mainly in those who have received treatment with pegylated ***,there are some patients with HBV infection and AIH in whom HDV infection is unearthed after receiving treatment with ***,several questions remain unanswered with the challenge to distinguish whether it is autoimmune or“autoimmune-like”hepatitis being the most ***,it remains uncertain whether autoimmunity is induced by HBV or delta ***,we investigated whether the cause of AIH lies in the previous treatment of HDV with pegylated *** pressing issues should be elucidated to clarify whether new antiviral treatments for HDV,such as Bulevirtide or immu-nosuppressive drugs,are more appropriate for the management of patients with HDV and AIH.

关键词： Autoimmune hepatitis Hepatitis delta virus Bulevirtide Prednisolone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Origin and genomic characteristics of SARS-CoV-2 and its interaction with angiotensin converting enzyme type 2 receptors, focusing on the gastrointestinal tract

引用

World Journal of Gastroenterology 2020年第41期26卷 6335-6345页

作者： Michail Galanopoulos aris Doukatas Maria Gazouli Department of Gastroenterology 401 General Military Hospital of AthensAthens 11525AttikiGreece Medical Office of Hellenic Army General Staff 401 General Military Hospital of AthensAthens 11525AttikiGreece Laboratory of Biology School of MedicineNational and Kapodistrian University of AthensAthens 11527AttikiGreece

The emergence of coronavirus disease-2019 induced by a newly identified bcoronavirus, namely severe acute respiratory syndrome coronavirus 2(SARSCoV-2) has constituted a public health emergency. Even though it was considered a zoonotic disease, the virus has also spread among humans via respiratory secretions. The expression and distribution of angiotensin converting enzyme type 2(ACE2) in various human organs might also show other possible infection routes. High ACE2 ribonucleic acid expression has been identified in the gastrointestinal tract(GI) indicating its importance as a possible infection pathway of SARS-CoV-2. ACE2 induces viral entry into the host and most importantly has been found to be associated with the function of the gut. Its deficiency has been implicated in several pathologies such as colorectal inflammation. The renin-angiotensin system(RAS) is an essential regulatory cascade operating both at a local tissue level and at the systemic or circulatory level. The RAS may be important in the pathogenesis of chronic liver disease and is associated with the up-regulation of ACE2. Thus, the aim of this review is firstly, the analysis of some important general and genome characteristics of SARS-CoV-2 and secondly, and most importantly, to focus on the utility of ACE2 receptors in both SARS-CoV-2 replication and pathogenesis, especially in the GI tract.

关键词： SARS-CoV-2 COVID-19 Gastrointestinal tract Angiotensin converting enzyme type 2 Angiotensin converting enzyme type 2 receptor Renin-angiotensin system Angiotensin converting enzyme

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoaccumulation and distribution of heavy metals in the urban river sediment

引用

International Journal of Sediment Research 2014年第3期29卷 368-377页

作者： Nur Aliaa SHAFIE Ahmad Zaharin aris Hazzeman Haris Environmental Forensics Research Centre Faculty of Environmental StudiesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

Current study presents the application of chemometric techniques to comprehend the interrelations among sediment variables whilst identifying the possible pollution source at Langat River,*** sediment samples（0-10 cm）were collected at 22 sampling stations and analyzed for total metals(48Cd,29Cu,30Zn,82Pb),pH,redox potential（Eh）,salinity,electrical conductivity（EC）,loss on ignition（LOI）and cation exchange capacity（CEC）.The principal component analysis（PCA）scrutinized the origin of environmental pollution by various anthropogenic and natural activities:four principal components were obtained with 86.34%（5 cm）and88.34%（10 cm）.Standard,forward and backward stepwise discriminant analysis effectively discriminate 2variables（84.06%）indicating high variation of heavy metals accumulation at both *** cluster analysis accounted for high input of Zn and Pb at LA8,LA 10,LA 11 and LA 12 that mergers three（5 cm）and four（10cm）into *** is consistent with the contamination factor（C1）that shows high Cd（LA 1）and Pb（LA 7,LA 8,LA 10,LA 11 and LA 12）contaminations at *** indicate that Pb and Zn are the most bioavailable metals in the sediment with significant positive linear relationship at both sediment ***,this approach is a good indication of environmental pollution status that transfers new findings on the assessment of heavy metals by interpreting large complex datasets and predicting the fate of heavy metals in the sediment.

关键词： Heavy metals Principal Component Analysis Cluster Analysis River Sediment

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current protocols and outcomes of ABO-incompatible kidney transplantation

引用

World Journal of Transplantation 2020年第7期10卷 191-205页

作者： Maurizio Salvadori aris Tsalouchos Department of Transplantation Renal Unit Careggi University HospitalFlorence 50139Italy Nephrology and Dialysis Unit Saints Cosmas and Damian HospitalPescia 51017Italy

One of the principal obstacles in transplantation from living donors is that approximately 30%are immunologically incompatible because of the presence in the recipient of antibodies directed against the human leukocyte antigen system of the donor or because of the incompatibility of the ABO *** aim of this review is to describe the more recent data from the literature on the different protocols used and the clinical outcomes of ABO-incompatible kidney *** different strategies are used to overcome these barriers:desensitization of the recipient to remove the antibodies and to prevent their rebound after transplantation and the exchange of organs between two or more *** largest part of this review is dedicated to describing the techniques of *** if the first reports of successful renal transplantation between ABO-incompatible pairs have been published by 1980,the number of ABO-incompatible transplants increased substantially in this century because of our improved knowledge of the immune system and the availability of new *** has substantially replaced *** technique of apheresis has improved and more recently a tailored desensitization proved to be the more efficient strategy avoiding an excess of immunosuppression with the related side *** reports document outcomes for such transplantation similar to the outcomes of standard transplantation.

关键词： ABO-incompatible transplants Desensitization strategies Immunological aspects B cell depletion Immunomodulation Apheresis techniques Kidney paired donation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Therapeutic apheresis in kidney transplantation: An updated review

引用

World Journal of Transplantation 2019年第6期9卷 103-122页

Therapeutic apheresis is a cornerstone of therapy for several conditions in transplantation medicine and is available in different technical variants. In the setting of kidney transplantation, immunological barriers such as ABO blood group incompatibility and preformed donor-specific antibodies can complicate the outcome of deceased-or living-donor transplantation. Postoperatively,additional problems such as antibody-mediated rejection and a recurrence of primary focal segmental glomerulosclerosis can limit therapeutic success and decrease graft survival. Therapeutic apheresis techniques find application in these issues by separating and selectively removing exchanging or modifying pathogenic material from the patient by an extracorporeal aphaeresis system. The purpose of this review is to describe the available techniques of therapeutic aphaeresis with their specific advantages and disadvantages and examine the evidence supporting the application of therapeutic aphaeresis as an adjunctive therapeutic option to immunosuppressive agents in protocols before and after kidney transplantation.

关键词： Kidney transplantation Therapeutic plasma exchange Double-filtrationplasmapheresis Immunoadsorption Extracorporeal photopheresis Desensitization Antibody-mediated rejection Focal segmental glomerulosclerosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Innovative immunosuppression in kidney transplantation:A challenge for unmet needs

引用

World Journal of Transplantation 2022年第3期12卷 27-41页

作者： Maurizio Salvadori aris Tsalouchos Department of Renal Transplantation Careggi University HospitalFlorence 50139Italy Division of Nephrology Santa Maria Annunziata HospitalFlorence 50012Italy

Due to the optimal results obtained in kidney transplantation and to the lack of interest of the industries,new innovative drugs in kidney transplantation are difficult to be *** best strategy to find the new drugs recently developed or under development is to search in the sections of kidney transplantation still not completely covered by the drugs on the *** unmet needs are the prevention of delayed graft function(DGF),the protection of the graft over the long time and the desensitization of preformed anti human leukocyte antigen antibodies and the treatment of the acute antibody-mediated *** needs are particularly relevant due to the expansion of some kind of kidney transplantation as transplantation from non-heart beating donor and in the case of antibody-incompatible *** first are particularly exposed to DGF,the latter need a safe desensitization and a safe treatments of the antibody mediated rejections that often *** caution is needed in treating these ***,they are described in very recent studies and the follow-up of their effect is of course rather ***,some of these drugs are still in an early phase of study,even if in well-conducted randomized controlled *** caution and a careful check need to be used in trials launched 2 or 3 years ***,is always necessary to verify whether the study is still going on or whether and why the study itself was abandoned.

关键词： New drugs Unmet needs in kidney transplantation Delayed graft function Long-term outcomes Kidney inflammation Anti-human leukocyte antigen antibodies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microbiota,renal disease and renal transplantation

引用

World Journal of Transplantation 2021年第3期11卷 16-36页

Aim of this frontier review has been to highlight the role of microbiota in healthy subjects and in patients affected by renal diseases with particular reference to renal *** microbiota has a relevant role in conditioning the healthy status and the *** particular gut microbiota is essential in the metabolism of food and has a relevant role for its relationship with the immune *** indigenous microbiota in patients with chronic renal failure is completely different than that of the healthy subjects and pathobionts *** abnormality in microbiota composition is called dysbiosis and may cause a rapid deterioration of the renal function both for activating the immune system and producing large quantity of uremic ***,after renal transplantation the microbiota changes with the appearance of pathobionts,principally in the first period because of the assumption of immunosuppressive drugs and *** changes may deeply interfere with the graft outcome causing acute rejection,renal infections,diarrhea,and renal interstitial *** addition,change in the microbiota may modify the metabolism of immunosuppressive drugs causing in some patients the need of modifying the immunosuppressant *** restoration of the indigenous microbiota after transplantation is important,either to avoiding the complications that impair the normal renal graft,and because recent studies have documented the role of an indigenous microbiota in inducing tolerance towards the *** use of prebiotics,probiotics,smart bacteria and diet modification may restore the indigenous microbiota,but these studies are just at their beginning and more data are needed to draw definitive conclusions.

关键词： Gut commensals Microbioma Microbiota Renal disease Renal transplantation Transplant outcomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：