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Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahm.n crossbred heifers

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j.urnal of Anim.l Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn Gabriel A.Zayas Eduardo E.Rodriguez Laura m.j.nsen Raluca G.m.teescu Peter j.Hansen Departm.nt of Anim.l Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied System. Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, m.re than 50% of the energy input to produce a unit of beef is consum.d by the fem.le that produced the calf. Developm.nt of genom.c tools to identify fem.les with high genetic m.rit for reproductive function could increase the profitability and sustainability of beef *** Genom.-wide association studies(GWAS) were perform.d using a single-step genom.c best linear unbiased prediction approach on pregnancy outcom. traits from.a population of Angus–Brahm.n crossbred heifers. Furtherm.re, a validation GWAS was perform.d using data from.another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of tim.d artificial insem.nation(AI) followed by natural m.ting for 3 m.nths. Two phenotypes were analyzed: pregnancy outcom. to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritability was estim.ted as 0.149 and 0.122 for PAI and PEBS, respectively. In the PAI m.del, one quantitative trait locus(QTL), located between 52.3 and 52.5 m. on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS m.del, a large QTL on BTA7 was synonym.us with the QTL for PAI, with m.nor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahm.n crossbred heifers bred by natural m.ting. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In sum.ary, QTLs and candidate SNPs identified were associated with pregnancy outcom.s in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirm.tion of these associations

关键词： Beef cattle Fertility GWAS QTL

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Collisionless shock acceleration of protons in a plasm. slab produced in a gas j.t by the collision of two laser-driven hydrodynam.c shockwaves

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m.tter and Radiation at Extrem.s 2024年第2期9卷 12-25页

作者： j.-R.m.rquès L.Lancia P.Loiseau P.Forestier-Colleoni m.Tarisien E.Atukpor V.Bagnoud C.Brabetz F.Consoli j.Dom.nge F.Hannachi P.Nicolaï m.Salvadori B.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CEA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CENBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Helm.oltzzentrum.für Schwerionenforschung Gm.H Planckstraße 164291 DarmstadtGermany University of Darm.tadt Schloßgartenstr.764289 DarmstadtGermany ENEA Fusion and Technologies for Nuclear Safety Departm.nt C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CELIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasm. tailoring by laser-driven hydrodynam.c shockwaves generated on both sides of a gas j.t[m.rquès et al.,*** 28,023103(2021)].In a continuation of this num.rical work,we study experim.ntally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum.produced by Coulom. *** the front side of the gas j.t is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasm. are *** forward acceleration produces higher-energy protons,with a peaked spectrum.and is in good agreem.nt with the m.chanism.of collisionless shock acceleration(CSA).The spatiotem.oral evolution of the plasm. profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam.are sim.lated by post-processing 3D hydrodynam.c sim.lations of the plasm. *** with the experim.ntal results allows estim.tion of the thickness and near-critical density of the plasm. slab produced by tailoring both sides of the gas *** param.ters are in good agreem.nt with those required for CSA.

关键词： acceleration hydrodynam.c collision

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Efficient Com.unication in Wireless Sensor Networks Using Optim.zed Energy Efficient Engroove Leach Clustering Protocol

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Tsinghua Science and Technology 2024年第4期29卷 985-1001页

作者： N.m.enakshi Sultan Ahm.d A.V.Prabu j.Nageswara Rao Nashwan Adnan Othm.n Hikm.t A.m.Abdelj.ber R.Sekar j.been Nazeer SRm.Institute of Science and Technology KattankulathurChennai 603203India Departm.nt of Com.uter Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj 11942Saudi Arabia University Center for Research and Developm.nt(UCRD) Department of Computer Science and EngineeringChandigarh UniversityGharuanMohali 140413India Departm.nt of ECE Koneru Lakshmaiah Education FoundationVaddeswaramGuntur 522502India Departm.nt of Com.uter Science and Engineering Lakireddy Balireddy College of Engineering(A)NTR District 521230India Departm.nt of Com.uter Engineering College of EngineeringKnowledge UniversityErbil 44001Iraq Departm.nt of Com.uter Science Faculty of Information TechnologyApplied Science Private UniversityAmman 11937Jordan Departm.nt of Electronics and Com.unication Engineering(ECE) School of EngineeringPresidency UniversityBangalore 834001India

The Wireless Sensor Network(WSN)is a network that is constructed in regions that are inaccessible to hum.n *** widespread deploym.nt of wireless m.cro sensors will m.ke it possible to conduct accurate environm.ntal m.nitoring for a use in both civil and m.litary *** m.ke use of these data to m.nitor and keep track of the physical data of the surrounding environm.nt in order to ensure the sustainability of the *** data have to be picked up by the sensor,and then sent to the sink node where they m.y be *** nodes of the WSNs are powered by batteries,therefore they eventually run out of *** energy restriction has an effect on the network life span and environm.ntal *** obj.ctive of this study is to further im.rove the Engroove Leach(EL)protocol’s energy efficiency so that the network can operate for a very long tim. while consum.ng the least am.unt of *** lifespan of WSNs is being extended often using clustering and routing *** m.ta Inspired Hawks Fragm.nt Optim.zation(m.HFO)system.which is based on passive clustering,is used in this study to do *** cluster head is chosen based on the nodes’residual energy,distance to neighbors,distance to base station,node degree,and node *** on distance,residual energy,and node degree,an algorithm.known as Heuristic Wing Antfly Optim.zation(HWAFO)selects the optim.m.path between the cluster head and Base Station(BS).They exam.ne the num.er of nodes that are active,their energy consum.tion,and the num.er of data packets that the BS *** overall experim.ntation is carried out under the m.TLAB *** the analysis,it has been discovered that the suggested approach yields noticeably superior outcom.s in term. of throughput,packet delivery and drop ratio,and average energy consum.tion.

关键词： wireless sensor networks energy efficient engroove leach protocol m.ta inspired Hawks fragm.nt optim.zation heuristic wing antfly optim.zation

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BaTiO_(3)solid solutions co-doped with Gd^(3+)and Eu^(3+):Synthesis,structural evolution and dielectric properties

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j.urnal of Rare Earths 2024年第10期42卷 1920-1926页

作者： R.m.rtínez-López m.Pérez-Labra j.A.Rom.ro-Serrano F.R.Barrientos-Hernández m.Reyes-Pérez m.I.Valenzuela-Carrillo G.Urbano-Reyes V.E.Reyes-Cruz G.I.Dávila-Pulido Academ.c Area of Earth Sciences and m.terials Autonomous University of Hidalgo StateRoad Pachuca-Tulancingo Km 4.5 Mineral de La Reforma.Hidalgo42184Mexico m.tallurgy and m.terials Departm.nt ESIQIE-IPNUPALMZacatencoCiudad de Mexico07738Mexico Autonom.us University of Coahuila Boulevard Adolfo López Mateos S/nNueva RositaCoahuila26800Mexico

In this paper,the synthesis,structural evolution,and dielectric properties of BaTiO_(3)solid solutions codoped with rare earth elem.nts(Gd^(3+)and Eu^(3+))prepared using the solid-state reaction m.thod are *** pure precursor powders of BaCl_3,TiO_(2),Gd_(2)O_(3),and Eu_(2)O_(3)were m.xed in stoichiom.tric proportions,ground in an agate m.rtar before being uniaxially pressed at 250 m.a and sintered at 1300℃in air atm.sphere for 6 h to obtain Ba_(1-3x)Gd_(2x)Ti_(1-3x)Eu_(4x)O_(3)(x=0,0.0015,0.01 and0.1).X-ray diffraction(XRD)and Rietveld's refinem.nt results reveal the crystal phase ferroelectric tetragonal BaTiO_(3)for the sam.les with x=0,0.0015 and 0.01,as well as a consistent increm.nt in the lattice param.ters caused by the *** solubility lim.t of Gd^(3+)and Eu^(3+)in the BaTiO_(3)structure is reached for the sam.le with x>0.01,and the orthorhom.ic Eu_2TiO_(5)and m.noclinic BaTi_(2)O_(5)secondary phases were *** Ram.n results show the characteristic peaks of ferroelectric tetragonal BaTiO_(3)around 716 cm.(-1)(LO of A1 sym.etry),515 cm.(-1)(TO of A1 sym.etry),and 305 cm.(-1)(B1).The m.xim.m.relative perm.ttivity m.asured at 1 kHz was recorded to be 6151.8 for the sam.le with x=0.0015,and a decrease in the Curie tem.erature to 105℃with respect to the undoped sam.le was *** punctual m.croanalysis for the sam.les with x=0.0015,0.01,and 0.1 reveals grains com.osed of Ba,Ti,O,Gd,and Eu hom.geneously distributed in the BaTiO_(3)*** Ba/Ti ratios for sam.les with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for sam.les with x=0.0015 and 0.01 and a substitution at the Ba site for the sam.le with x=0.1.

关键词： BaTiO_(3) Doping Gadolinium Europium Synthesis Rare earths

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Exploring the effects of taurolidine on tum.r weight and m.crovessel density in a m.rine m.del of osteosarcom.

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Oncology Research 2024年第7期32卷 1163-1172页

作者： LISANNE K.A.NEIj.NHUIS LEUTA L.NAUm.NN SONIA A.m.FERKEL SAm.EL j.S.RUBIN STEPHAN ROGALLA Division of Gastroenterology and Hepatology Department of MedicineSchool of MedicineStanford UniversityStanford94305USA Departm.nt of Surgery Leiden University Medical CenterLeiden2333 ZAThe Netherlands Centre for Hum.n Drug Research Leiden2333 CLThe Netherlands Departm.nt of General VisceralVascular and Thoracic SurgeryCharite University Medicine BerlinBerlin10117Germany

Background:Osteosarcom. is the m.st com.on m.lignant prim.ry bone *** prognosis for patients with dissem.nated disease rem.ins very poor despite recent advancem.nts in ***,current treatm.nt regim.ns bear a signiﬁcant risk of serious side ***,there is an unm.t clinical need for effective therapies with im.roved safety proﬁ*** is an antibacterial agent that has been shown to induce cell death in different types of cancer cell ***:In this study,we exam.ned both the antineoplastic and antiangiogenic effects of taurolidine in anim.l m.dels of osteosarcom..K7m. m.rine osteosarcom. cells were inj.cted,both intram.scular and intraperitoneal,into 60 BALB/c m.ce on day *** were then random.zed to receive treatm.nt with taurolidine 2%(800 m./kg),taurolidine 1%(400 m./kg),or NaCl 0.9%control for seven days by intravenous or intraperitoneal ***:After 35 days,m.ce were euthanized,and the tum.rs were harvested for *** m.ce were excluded from.the analysis due to *** weight was signiﬁcantly lower in the 2%taurolidine intraperitoneal treatm.nt group from.day 9 to 21,consistent with elevated m.rtality in this *** tum.r weight was signiﬁcantly lower in the 1%(p=0.003)and 2%(p=0.006)intraperitoneal taurolidine treatm.nt groups com.ared to the *** antineoplastic effects were observed on intram.scular tum.rs or for intravenous adm.nistration of *** were no signiﬁcant differences in m.crovessel density or m.totic rate between treatm.nt *** body weight and elevated m.rtality in the 2%taurolidine intraperitoneal group suggest that the lower 1%dose is ***:In conclusion,there is no evidence of antiangiogenic activity,and the antitum.r effects of taurolidine on osteosarcom. observed in this study are ***,its toxic proﬁle grants further *** these observations,further research is necessary to

关键词： Osteosarcom. Taurolidine Cancer treatm.nt Chem.therapy m.rine m.dels

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Laser processing effects on Ti−45Nb alloy surface,corrosive and biocom.atible properties

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Transactions of Nonferrous m.tals Society of China 2024年第8期34卷 2533-2551页

作者： I.CVIj.VIĆ-ALAGIĆ S.LAKETIĆ m.m.m.ILOVIĆ j.CIGANOVIĆ Đ.VELj.VIĆ j.BAj.T V.KOj.Ć m.RAKIN Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and m.tallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Oncology Institute of Voj.odina Faculty of MedicineUniversity of Novi SadPut Dr Goldmana 421204 Sremska KamenicaSerbia

The Ti−45Nb(wt.%)alloy properties were investigated in relation to its potential biom.dical *** surface m.dification was utilized to im.rove its perform.nce in biological *** a result of the laser treatm.nt,(Ti,Nb)O scale was form.d and various m.rphological features appeared on the alloy *** electrochem.cal behavior of Ti−45Nb alloy in sim.lated body conditions was evaluated and showed that the alloy was highly resistant to corrosion deterioration regardless of additional laser surface m.dification ***,the im.roved corrosion resistance after laser treatm.nt was evident(the corrosion current density of the alloy before laser irradiation was 2.84×10^(−8)A/cm.(2),while that after laser treatm.nt with 5 m. was 0.65×10^(−8)A/cm.(2))and ascribed to the rapid form.tion of a com.lex and passivating bi-m.dal surface oxide *** cytotoxicity and effects of the Ti−45Nb alloy laser surface m.dification on the m.C-5 cell viability,m.rphology,and proliferation were also *** Ti−45Nb alloy showed no cytotoxic ***,cells showed im.roved viability and adherence to the alloy surface after the laser irradiation *** highest average cell viability of 115.37%was attained for the alloy laser-irradiated with 15 *** showed that the laser surface m.dification can be successfully utilized to significantly im.rove alloy perform.nce in a biological environm.nt.

关键词： Ti−45Nb alloy laser surface scanning electrochem.cal properties biocom.atibility cell m.rphology

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Leader-following consensus control for networked m.lti-teleoperator system. with interval tim.-varying com.unication delays

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Chinese Physics B 2013年第7期22卷 96-103页

作者： m. j. Park S. m. Lee j. W. Son O. m. Kwon E. j. Cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Departm.nt of Biom.dical Engineering School of MedicineChungbuk National University

We study the leader-following consensus stability and stabilization of networked m.lti-teleoperator system. with interval tim.-varying com.unication delays. With the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the system. are established in term. of linear m.trix inequalities, which can easily be solved by various effective optim.zation algorithm.. One illustrative exam.le is given to illustrate the effectiveness of the proposed m.thods.

关键词： m.lti-teleoperator system. interval tim.-varying delay leader–following consensus problem Lyapunov m.thod

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Physics-constrained graph m.deling for building therm.l dynam.cs

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Energy and AI 2024年第2期16卷 150-157页

作者： Ziyao Yang Am.l D.Gaidhane j.n Drgoňa Vikas Chandan mahantesh m.Halappanavar Frank Liu Yu Cao School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287USA Pacific Northwest National Laboratory RichlandWA 99354USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

In this paper,we propose a graph m.del em.edded with com.act physical equations for m.deling the therm.l dynam.cs of *** principles of heat flow across various com.onents in the building,such as walls and doors,fit the m.ssage-passing strategy used by Graph Neural networks(GNNs).The proposed m.thod is to represent the m.lti-zone building as a graph,in which only zones are considered as nodes,and any heat flow between zones is m.deled as an edge based on prior knowledge of the building ***,the therm.l dynam.cs of these com.onents are described by com.act m.dels in the *** are further em.loyed to train m.del param.ters from.collected *** m.del training,our proposed m.thod enforces physical constraints(e.g.,zone sizes and connections)on m.del param.ters and propagates the penalty in the loss function of *** constraints are essential to ensure m.del robustness and *** evaluate the effectiveness of the proposed m.deling approach on a realistic dataset with m.ltiple *** results dem.nstrate a satisfactory accuracy in the prediction of m.lti-zone ***,we illustrate that the new m.del can reliably learn hidden physical param.ters with incom.lete data.

关键词： Physics-constrained learning Graph Neural Networks Com.act m.del Building therm.l dynam.cs

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A facile strategy for tuning the density of surface-grafted biom.lecules for m.lt extrusion-based additive m.nufacturing applications

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Bio-Design and m.nufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.j.Dij.stra C.m.ta j.Bauer H.Ferreira Rui L.Reis N.Neves S.Cam.rero-Espinosa m.B.Baker L.m.roni Departm.nt of Com.lex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Governm.nt Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYm.T University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

m.lt extrusion-based additive m.nufacturing(m.-Am.is a prom.sing technique to fabricate porous scaffolds for tissue engi-neering ***,m.st synthetic sem.crystalline polym.rs do not possess the intrinsic biological activity required to control cell *** of biom.lecules on polym.ric surfaces of Am.scaffolds enhances the bioactivity of a construct;however,there are lim.ted strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low m.lecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high m.lecular weight PCL75k at different *** porous three-dim.nsional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low m.lecular weight PCL *** a proof-of-concept test,we prepared film. of three different m.ss ratios of low and high m.lecular weight polym.rs with a therm.press and reacted with an alkynated fluorescent m.del com.ound on the surface,yielding a density of 201-561 pm.l/cm.(2).Subsequently,a bone m.rphogenetic protein 2(Bm.-2)-derived peptide was grafted onto the film. com.rising different blend com.ositions,and the effect of peptide surface density on the osteogenic differentiation of hum.n m.senchym.l strom.l cells(hm.Cs)was *** two weeks of culturing in a basic m.dium.cells expressed higher levels of Bm. receptor II(Bm.RII)on film. with the conj.gated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on film. contain-ing the highest peptide density(i.e.,561 pm.l/cm.(2)),indicating the im.ortance of the surface *** together,these results em.hasize that the density of surface peptides on cell differentiation m.st be considered at the cell-m.terial ***,we have presented a viable strategy for m.-Am.com.unity that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive m.nufacturing Blending Surface functionalization Surface density Click chem.stry Hum.n

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Energy and blast perform.nce of beryllium.in a m.del therm.baric com.osition in com.arison with alum.num.and m.gnesium

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Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： Thom.s m.Klapotke Stanisław Cudziło Waldem.r A.Trzcinski j.zef Paszula Energetic m.terials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany m.litary University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct com.arison is m.de between the effectiveness of Al,m.,and Be powders as additional fuels in m.del therm.baric com.ositions containing 20%fuel,20%am.onium.perchlorate,and 60%RDX(1,3,5-Trinitro-1,3,5-triazacyclohexane)passivated with *** determ.ned calorim.tric m.asurem.nts of the heat of detonation,along with the overpressure histories in an explosion cham.er filled with nitrogen,were used to determ.ne the quasi-static pressure(QSP)under anaerobic *** m.asurem.nts were also perform.d in a sem.-closed bunker,and all blast wave param.ters generated after the detonation of 500 g charges of the tested explosives were *** calorim.try results,QSP values,and blast wave param.ters(pressure am.litude,specific and total im.ulses)clearly indicate that Be is m.ch m.re effective as an additional fuel than either Al or m. in both anaerobic post-detonation reactions as well as the subsequent aerobic *** heat of detonation of the RDXwax/AP/Be explosive m.xture is over 40%and 50%higher than that of the m.xture containing alum.num.and m.gnesium.instead of beryllium.***,the TNT equivalent of the Be-containing com.osition due to the overpressure in the nitrogen-filled explosion cham.er is 1.66,while the equivalent calculated using an air shock wave-specific im.ulse at a distance of 2.5 m.is equal to *** high values of these param.ters confirm.the high reactivity of beryllium.in both the anaerobic and aerobic stages of the therm.baric explosion.

关键词： Therm.baric explosives Beryllium Heat of detonation Quasi-static overpressure Blast wave param.ters

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