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Coconut oil nanoemulsion attenuates methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第12期10卷 540-546页

作者： Shaza A.Alyamani mayson h.alkhatib Faiza Abdu Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biological Sciences Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To evaluate the protective effect of the coconut oil nanoemulsion against methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing Swiss albino ***:Forty mice were divided into four ***Ⅰserved as the untreated Ehrlich ascites carcinoma-bearing mice while Ehrlich ascites carcinoma-bearing mice in groupsⅡ–Ⅳreceived an intraperitoneal injection of 0.2 m L/kg coconut oil nanoemulsion,20 mg/kg methotrexate as well as 0.2 m L/kg coconut oil nanoemulsion mixed with 20 mg/kg methotrexate,*** toxicities of the treatments were assessed by determining the complete blood count,performing the serum analysis for liver and kidney functions,evaluating the oxidative status and visualizing histological changes in the liver and kidney ***:Treatment with methotrexate and coconut oil nanoemulsion markedly diminished the liver parameters including aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,total protein,direct bilirubin and total bilirubin which were raised by methotrexate treatment(Phe indicators of kidney function,were dramatically lowered in the combination treatment group compared to the methotrexate group(Ph methotrexate and coconut oil nanoemulsion reduced the malondialdehyde and increased catalase,glutathione reductase and superoxide dismutase,in the liver and kidney tissues(Phe treatment with methotrexate and coconut oil nanoemulsion reduced white blood cell count and increased the hemoglobin amount(Phange in platelets and red blood cell ***:Coconut oil nanoemulsion as a nanocarrier has great potential in reducing the adverse side effects induced by methotrexate.

关键词： Chemotherapeutic agents Oxidative stress Serum analysis Complete blood count Nanocarrier

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Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and anti-invasion activities against the ovarian cancer cells

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BIOCELL 2021年第3期45卷 695-703页

作者： mayson h.alkhatib SALWA M.AL-hAShEMI hANA M.GAShLAN Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Regenerative Medicine Unit King Fahd Center for Medical ResearchKing Abdulaziz UniversityJeddahSaudi Arabia

Inorporation of etoposide(ETP)into nanoemulsion(NE)containing polyunsaturated faty adids(PUFAS)may potentially augment its antiproliferation efet on the cancer cll The current study aimed to examine the in vitro antitumor activity of a novel formulation(ETP-BC/EP-NE)produced by combining the anticancer drug(ETP)with NE(BCEP-NE)consisting of the blasck currant seed and organic ewening primrose *** produced formulas were physically charaterized using 2etasizer *** ceytotoxkc efect was testfied at concentrations ranges from 0.0001 to 5μM using *** and ant-invasion efects were evaluated using the assays of mitochondrtal membrane potental,annexin V-FITC double *** fragmentation,and collagen-based cell *** to the zetasizer charaterization,the nano-suspensions of ETP-BC/EP-NE have z-average diameters of 87.63土3.30 nm with an average surface zeta potential of-0.605土0.003 mV.A reduction of 50%in the growth of SK-OV-3 cells was found at a distinetly lower concentration of ETP-BCEP-NE(IlCso=0.04土0.2μM)than that of ETP(ICsu=4.75土0.1μM).Resuts indicated that FTP-BCIEP-NE had a greater apoptotic ffect than FTP on SK-OV-3 cllsl which was attibuted to the larger amount of late apoptotic cells(41.9土1.05%)higher loss of mitochondrial membrane potential,and more intensive fragmented DNA The ETP-BC/EP-NE treatment suppressed the cllular invasion by 55%,whereas EIP impeded the ellular invasion by only 3%,Formulting ETP with PUFAs in NE had ameliorated the efcacy of ETP.

关键词： Black currant seed oil Organic evening primrose oil Chemotherapeutic agent Cellular growth Apoptosis

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