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Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2840-2842页

作者： jörg Fahrer Division of Food Chemistry and Toxicology Department of ChemistryRPTU Kaiserslautern-Landau67663 KaiserslauternGermany

A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,cancer,and other disorders.2 As an outstanding achievement,the authors identified DSCC1(DNA Replication And Sister Chromatid Cohesion 1)as a critical gene protecting against early developmental defects,genomic instability,reduced proliferative capacity,cohesinopathy-related phenotypes,and tumor development in vivo.

关键词： chromosomal linking Replication

High-dimensional neural network potentials for magnetic systems using spin-dependent atom-centered symmetry functions

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npj Computational Materials 2021年第1期7卷 1541-1551页

作者： Marco Eckhoff jörg Behler Universität Göttingen Institut für Physikalische ChemieTheoretische ChemieTammannstrasse 637077 GöttingenGermany Universität Göttingen International Center for Advanced Studies of Energy Conversion(ICASEC)Tammannstrasse 637077 GöttingenGermany

Machine learning potentials have emerged as a powerful tool to extend the time and length scales of first-principles quality ***,most machine learning potentials cannot distinguish different electronic spin arrangements and thus are not applicable to materials in different magnetic *** we propose spin-dependent atom-centered symmetry functions as a type of descriptor taking the atomic spin degrees of freedom into *** used as an input for a high-dimensional neural network potential(HDNNP),accurate potential energy surfaces of multicomponent systems can be constructed,describing multiple collinear magnetic *** demonstrate the performance of these magnetic HDNNPs for the case of manganese oxide,*** method predicts the magnetically distorted rhombohedral structure in excellent agreement with density functional theory and *** efficiency allows to determine the Néel temperature considering structural fluctuations,entropic effects,and *** method is general and is expected to be useful also for other types of systems such as oligonuclear transition metal complexes.

关键词： magnetic symmetry neural

Development of ^(18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography

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Neuroscience Bulletin 2014年第5期30卷 777-811页

作者： Peter Brust jrg van den Hoff jrg Steinbach Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer ResearchPermoserstrasse 15Leipzig04318Germany

Positron emission tomography （PET） is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases. PET uses biomolecules as probes which are labeled with radionuclides of short half-lives, synthesized prior to the imaging studies. These probes are called radiotracers. Fluorine-18 is a radionuclide routinely used in the radiolabeling of neuroreceptor ligands for PET because of its favorable half-life of 109.8 min. The delivery of such radiotracers into the brain provides images of transport, metabolic, and neurotransmission processes on the molecular level. After a short introduction into the principles of PET, this review mainly focuses on the strategy of radiotracer development bridging from basic science to biomedical application. Successful radiotracer design as described here provides molecular probes which not only are useful for imaging of human brain diseases, but also allow molecular neuroreceptor imaging studies in various small-animal models of disease, including genetically- engineered animals. Furthermore, they provide a powerful tool for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets, to investigate pathophysiology, to discover potential drug candidates, and to evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo.

关键词： Alzheimer's disease autoradiography blood-brain barrier brain tumor cholinergic system kinetic modeling metabolism molecular imaging neurodegeneration positron emission tomography precursor psychiatric disorder radiotracer sigma receptor

Tracking moving magnetic features in the photosphere

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1737-1748页

作者： BCHNER jrg Max-Planck-Institut fr Sonnensystemforschung

This research aims for an objective identification, tracking, and a statistical analysis of the Moving Magnetic Features (MMFs) around sunspots using SOHO/MDI high-resolution magnetograms. To this end, we develop a computerized tracking program and study the motion and magnetism of the outflows of MMFs around 26 sunspots. Our method locates 4-27 MMFs per hour, with higher counts for large sunspots. We differentiate MMFs into type α that have a polarity opposite to the parent sunspots, and type β that share the sunspot's polarity. These sunspots' MMF subsets exhibit a wide range of central tendencies which have distinctive correlations with the sunspots. In general, α-MMFs emerge farther from the sunspot, carry less flux, and move faster than β-MMFs. The typical α/β-MMFs emerge at 2.2 - 8.1/0.1 - 3.2 Mm outside the penumbra limb, with lifetimes of 1.1 - 3.1/1.3 - 2.0 h. They are 1.1 - 6.6/1.4 - 3.6 Mm2 in area and carry 1.4 - 12.5/4.8 - 11.4 ×1018 Mx of flux. They travel a distance of 2.7 - 5.9/2.8 - 3.6 Mm with the speed of 0.5 - 0.9/0.4 - 0.7 km/s. Compared to the α-MMFs produced by large sunspots, those of small spots are smaller. They emerge closer to sunspot, move farther, live longer, and carry less flux. β-MMFs show much less correlation with the sunspots. The flux outflow carried by the MMFs ranges from 0.2 to 8.3 × 1019Mx· h-1 and does not show obvious correlation with the sunspots' evolution. The frequency distributions of the MMFs' distance traveled, area, and flux are exponential. This suggests the existence of numerous small, weak, and short-timescale magnetic objects which might contribute to the sunspot flux outflow.

关键词： sun activity magnetic fields photosphere sunspots moat moving magnetic features

Switching off DNA repair—how colorectal cancer evades targeted therapies through adaptive mutability

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2343-2344页

作者： jörg Fahrer Division of Food Chemistry and Toxicology Department of ChemistryTechnical University of Kaiserslautern67663 KaiserslauternGermany

A very recent study by Russo et *** in Science demonstrates that colorectal cancer(CRC)cells adapt to targeted therapies by downregulating DNA repair at the expense of an increased mutation frequency and microsatellite instability(MSI).1 The authors intriguingly showed that CRC cells are capable of activating stress-induced mutagenesis similar to unicellular organisms in a transient and controlled manner,allowing them to survive under targeted therapies(Fig.1).

关键词： targeted colorectal al

Entire curves,integral sets and principal bundles

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Science China Mathematics 2011年第8期54卷 1803-1814页

作者： WINKELMANN jrg Lehrstuhl Analysis Ⅱ Mathematisches InstitutRuhr-Universitt BochumBochum 44780Germany

We compare the behaviour of entire curves and integral sets,in particular in relation to locally trivial fiber bundles,algebraic groups and finite ramified covers over semi-abelian varieties.

关键词： entire curves integral point sets semi-abelian variety algebraic group

Indoor localization for pedestrians with real-time capability using multi-sensor smartphones

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Geo-Spatial Information Science 2019年第2期22卷 73-88,I0001页

作者： Catia Real Ehrlich jörg Blankenbach Geodetic Institute and Chair for Computing in Civil Engineering&Geo Information Systems RWTH Aachen UniversityAachenGermany

The localization of persons or objects usually refers to a position determined in a spatial reference ***,this is usually accomplished with Global Navigation Satellite Systems(GNSS).However,the automatic positioning of people in GNSS-free environments,especially inside of buildings(indoors)poses a huge ***,satellite signals are attenuated,shielded or reflected by building components(*** or ceilings).For selected applications,the automatic indoor positioning is possible based on different technologies(***,RFID,or UWB).However,a standard solution is still not *** indoor positioning systems are only suitable for specific applications or are deployed under certain conditions,*** infrastructures or sensor ***,as popular cost-effective multi-sensor systems,is a promising indoor localization platform for the mass-market and is increasingly coming into ***’s devices are equipped with a variety of sensors that can be used for indoor *** this contribution,an approach to smartphone-based pedestrian indoor localization is *** novelty of this approach refers to a holistic,real-time pedestrian localization inside of buildings based on multisensor smartphones and easy-to-install local positioning *** this purpose,the barometric altitude is estimated in order to derive the floor on which the user is *** 2D position is determined subsequently using the principle of pedestrian dead reckoning based on user's movements extracted from the smartphone *** order to minimize the strong error accumulation in the localization caused by various sensor errors,additional information is integrated into the position *** building model is used to identify permissible(***,passageways)and impermissible(***)building areas for the *** technologies contributing to higher precision and robustness are also *** the fusion of diffe

关键词： Indoor positioning MEMS recursive Bayesian estimation particle filter sensor fusion Bluetooth beacons WLAN fingerprinting magnetic anomalies

Three-dimensional CityGML building models in mobile augmented reality: a smartphone-based pose tracking system

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International journal of Digital Earth 2021年第1期14卷 32-51页

作者： Christoph Blut jörg Blankenbach Geodetic Institute Department of Computing in Civil Engineering and Geo-Information SystemsRWTH Aachen UniversityAachenGermany

Many augmented reality(AR)systems are developed for entertainment,but AR and particularly mobile AR potentially have more application possibilities in other *** example,in civil engineering or city planning,AR could be used in combination with CityGML building models to enhance some typical workflows in planning,execution and operation processes.A concrete example is the geo-referenced on-site visualization of planned buildings or building parts,to simplify planning processes and optimize the communication between the participating *** of the main challenges for the visualization lies in the pose tracking,*** real-time estimation of the translation and rotation of the mobile device to align the virtual objects with *** this paper,we introduce a proof-of-concept fine-grained mobile AR CityGML-based pose tracking system aimed at the mentioned *** system estimates poses by combining 3D CityGML data with information derived from 2D camera images and an inertial measurement unit and is fully self-sufficient and operates without external *** results of our evaluation show that CityGML and low-cost off-the-shelf mobile devices,such as smartphones,already provide performant and accurate mobile pose tracking for AR in civil engineering and city planning.

关键词： Mobile augmented reality pose tracking CityGML 3D city model Android smartphone

Enhancing the OGC WPS interface with GeoPipes support for real-time geoprocessing

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International journal of Digital Earth 2018年第1期11卷 48-63页

作者： Stefan Herle jörg Blankenbach Geodetic Institute and Chair for Computing in Civil Engineering and Geo Information Systems RWTH Aachen UniversityAachenGermany

Real-time geospatial information is used in various applications such as risk management or alerting ***,the rise of new sensing technologies also increases the demand for processing the data in real ***’s spatial data infrastructures,however,do not meet the requirements for real-time *** OpenGIS®Web Processing Service(WPS)is not designed to process real-time *** has some major drawbacks in asynchronous processing and cannot handle(geo)data streams out of the *** previous papers,we introduced the GeoPipes approach to share spatiotemporal data in real *** implemented the concept extending the Message Queue and Telemetry Transport(MQTT)protocol by a spatial and temporal dimension,which we call *** this paper,we demonstrate the integration of the GeoPipes idea in the WPS interface to expose standardized real-time geoprocessing *** proof of the concept is illustrated in some exemplary real-time geo processes.

关键词： Real-time geoprocessing web processing service sensor web Internet-ofthings GeoPipes