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Advances in Manufacturing 2019年第2期7卷 155-173页

作者： Kedarnath Rane matteo Strano Department of Mechanical Engineering Politecnico di Milano Via La Masa 1 Milan Italy

The extrusion-based additive manufacturing (EAM) technique is recently being employed for rapid production of metals and ceramic components. This technique involves extruding the metal or ceramic material in solid powder form mixed with a binder (i.e., an expendable viscous fluid), which is removed from the part after 3D printing. These technologies rely on the large design freedom allowed and the cost efficiency advantage over alternative metal additive manufacturing processes that are based on high energy beams, such as laser or electron beams. The EAM of metals and ceramics is not yet widespread, but published scientific and technical literature on it is rapidly growing. However, this literature is still less extensive than that on the fused deposition modeling (FDM) of plastics or the selective laser melting (SLM) of metals. This paper aims at filling this gap. FDM and powder injection molding are identified as preceding or enabling technologies for EAM. This paper systematically reviews all aspects of the feedstock EAM processes used for production of complex-shaped parts. The unique characteristics and advantages of these processes are also discussed with respect to materials and process steps. In addition, the key process parameters are explained to illustrate the suitability of the EAM process for diverse application domains.

关键词： Feedstock extrusion Rapid production Complex-shaped metallic Ceramic parts

Hepatic effector CD8＋ T-cell dynamics

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Cellular & Molecular Immunology 2015年第3期12卷 269-272页

作者： matteo Iannacone Division of Immunology Transplantation and Infectious Diseases I RCCS San Raffaele Scientific Institute and Vita-Saiute San Raffaele University Milan Italy

CD8＋ T cells play a critical role in hepatitis B virus （HBV） pathogenesis. During acute, self-limited infections, these cells are instrumental to viral clearance; in chronic settings, they sustain repetitive cycles of hepatocellular necrosis that promote hepatocellular carcinoma development. Both CD8＋ T-cell defensive and destructive functions are mediated by antigen-experienced effector cells and depend on the ability of these cells to migrate to the liver, recognize hepatocellular antigens and perform effector functions. Understanding the signals that modulate the spatiotemporal dynamics of CD8＋ T cells in the liver, particularly in the context of antigen recognition, is therefore critical to gaining insight into the pathogenesis of acute and chronic HBV infection. Here, we highlight recent data on how effector CD8＋ T cells traffic within the liver, and we discuss the potential for novel imaging techniques to shed light on this important aspect of HBV pathogenesis.

关键词： CD8+ T cells hepatitis B virus intravital microscopy liver immunopathology platelets

Mechatronic Design of a Robot for Upper Limb Rehabilitation at Home

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Journal of Bionic Engineering 2021年第4期18卷 857-871页

作者： Elio matteo Curcio Giuseppe Carbone Department of Mechanical Energyand Management EngineeringUniversity of Calabria Via BucciCubo 46C87036 RendeItaly

This paper addresses the design of a novel bionic robotic device for upper limb rehabilitation tasks at *** main goal of the design process has been to obtain a rehabilitation device,which can be easily portable and can be managed remotely by a professional *** allows to treat people also in regions that are not easily reachable with a significant cost *** potential benefits can be envisaged,for instance,in the possibility to keep social distancing while allowing rehabilitation treatments even during a pandemic *** attention has been devoted to design the main mechatronic components by developing specific kinematics and dynamics *** design process includes the implementation of a specific control hardware and *** experimental tests are reported to show the effectiveness and feasibility of the proposed design solution.

关键词： bionic robot design simulations parallel robots upper limb rehabilitation

On the formation of Basu’s Type Ⅲ(peeled orange) gunshot residues

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Defence Technology（防务技术） 2019年第1期15卷 23-26页

作者： Felice Nunziata matteo Donghi the Chartered Society of Forensic Science Arma dei Carabinieri Reparto Investigazioni Scientifiche

In a famous paper published in 1982, a very special class of gunshot residue particles(GSR) was named by Samarendra Basu "peeled orange", due to their particular structure, consisting of a barium/antimony core covered by an outer lead leaflet. In this class of GSR particles the surface may show nodular structures of lead. Basu proposed an explanation in terms of a nucleus of antimony and barium that captures lead vapours produced after the explosion of a cartridge into a firearm: as solidification points of antimony and barium are close one another, both higher than solidification point of lead, he stated that lead occurs as a layer around the core in peeled orange GSR particles. In this paper we study the thermodynamic of the barium/antimony alloy and we hypothesize a formation process in terms of colloidal metal growth, charged particles and electrostatic attraction. We propose an updated model of formation for peeled orange GSR particles that explains the existence of outer lead leaflet and nodules in terms of electrostatic attraction of lead nanoparticles and instability of lead droplets.

关键词： Peeled orange particles GSR CDR Charged particles Electrostatic attraction Rayleigh droplet stability

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

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World Journal of Gastroenterology 2020年第25期26卷 3577-3585页

作者： matteo Tardelli Division of Gastroenterology and Hepatology Joan and Sanford I Weill Cornell Department of MedicineWeill Cornell Medical CollegeNew YorkNY 10021United States Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and HepatologyInternal Medicine IIIMedical University of ViennaVienna 1040Austria

Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,which eventually progress to cirrhosis and hepatocellular *** lipase is the last enzymatic step in the hydrolysis of triglycerides,generating glycerol and fatty acids(FAs),which are signaling precursors in physiology and ***,monoacylglycerol lipase(MGL)also hydrolyzes 2-arachidonoylglycerol,which is a potent ligand within the endocannabinoid system,into arachidonic acid-a precursor for prostaglandin synthesis;thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from FA metabolism to inflammation,pain and *** inhibition has been shown protective in limiting several liver diseases as FAs may drive hepatocyte injury,fibrogenesis and de-activate immune cells,however the complexity of MGL network system still needs further and deeper *** present review will focus on MGL function and FA partitioning in the horizons of liver disease.

关键词： Lipid metabolism Monoacylglycerol lipase Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Cannabinoid Nuclear receptors

Refining selection criteria to further increase survival benefit in liver transplantation for unresectable colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 490-492页

作者： matteo Serenari matteo Ravaioli General Surgery and Transplant Unit Department of Medical and Surgical SciencesUniversity of BolognaBolognaItaly

Liver transplantation(LT)for hepatocellular carcinoma(HCC)was characterized in its early experience by high recurrence rates due to extensive tumor burden(1).Only after the adoption of Milan criteria(2),LT was recognized as a standard treatment for HCC(3).Besides HCC,other hepatic malignancies were proposed to be treated in the past with LT but due to the poor results observed(4),these indications were *** them,colorectal liver metastases(CRLM)were considered an absolute contraindication until recently.

关键词： colorectal metastases absolute

Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

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Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian Alfredo De Giorgi matteo Guarino Michele Malagu matteo Bertini Department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy Department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

Objective To investigate whether chronic kidney disease could negatively impact survival in older adults needing pacemaker implantation after admission for bradyarrhythmias. Methods This retrospective observational study considered 538 older adults consecutively admitted, who had been followed-up for 31 ± 20 months. Subjects with poor short-term prognosis were excluded. Charlson comorbidity index （CCI） and estimated glomerular filtration rate （eGFR） was calculated, along with the independent relationship between all-cause mortality and clinical data. Hazard Ratio （HR） was calculated by Cox regression analysis. Results Mean age of the population was 85 ± 3.7 years, and causes for implantation were atrioventricular block in 51.9% and other bradyarrhythmias in 48.1% of cases. Mean eGFR was 58.3 ± 24 mL/min per 1.73 m2, and mean CCI was 3.65 ± 2.28. Death for all-causes was recorded in 213 subjects. Deceased patients were older, had lower eGFR, higher comorbidity, higher prevalence of myocardial infarction, congestive heart failure, cerebrovascular disease, dementia and chronic pulmonary disease. Age （HR： 1.081, 95% CI： 1.044-1.119; P 〈 001）, CCI （HR： 1.651, 95% CI： 1.286-2.121, P 〈 001） and eGFR 〈 45 mL/min per 1.73 m2 （HR： 1.360, 95% CI： 1.024-1.806; P = 0.033） were predictors of death. Conclusions Renal dysftmction, as well as comorbidity, impacts negatively survival of older adults treated with pacemaker implantation because of bradyarrhythmias.

关键词： Bradyarrhythmias Charlson comorbidity index Chronic kidney disease Comorbidity Glomerular filtration rate Mortality Pacemaker

CUBE, a Cable-driven Device for Limb Rehabilitation

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Journal of Bionic Engineering 2019年第3期16卷 492-502页

作者： Daniele Cafolla matteo Russo Giuseppe Carbone IRCCS Neuromed Via delFelettronica 86077 Pozzilli IS Italy University of Nottingham Advanced Manufacturing Building C47 Nottingham NG8 IBB UK DIMEG University of Calabria Via Bucci Cubo 46C 87036 Rende Italy CESTER Technical University of Cluj-Napoca MunciiAve. 103-105 400641 Cluj-Napoca Romania

In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises.

关键词： cable-driven robots medical robots parallel robots rehabilitation devices

The impact of extent of pancreatic and venous resection on survival for patients with pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 389-394页

作者： matteo Serenari Giorgio Ercolani Alessandro Cucchetti matteo Zanello Enrico Prosperi Guido Fallani Michele Masetti Raffaele Lombardi matteo Cescon Elio Jovine Department of Medical and Surgical Sciences S.Orsola-Malpighi HospitalAlma Mater Studiorum-University of BolognaBolognaItaly Department of General Surgery Maggiore Hospital-Bologna Local Health DistrictBolognaItaly

Background:Borderline resectable pancreatic cancer may require extended resections in order to achieve tumor-free margins,especially in the case of up-front resections,but it is important to know the limits of surgical therapy in this *** study aimed to investigate the impact of extent of pancreatic and venous resection on short-and long-term outcomes in patients with pancreatic adenocarcinoma(PDAC).Methods:This was a retrospective study from a prospectively maintained database of pancreatic resections for ***-and long-term outcomes were analyzed in patients having borderline resectable PDAC submitted to up-front total pancreatectomy(TP)or pancreaticoduodenectomy(PD)with simultaneous portal vein(PV)and/or superior mesenteric vein(SMV)*** resections were carried out as tangential venous resection(TVR)or segmental venous resection(SVR).Patients were divided into 4 groups:(1)PD+TVR,(2)PD+SVR,(3)TP+TVR,(4)TP+***-and multivariate Cox regression analysis were performed to identify factors associated with ***:Ninety-nine patients were submitted to simultaneous pancreatic and venous resection for *** them,25 were submitted to PD+TVR(25.3%),12 to PD+SVR(12.1%),23 to TP+TVR(23.2%),and 39 to TP+SVR(39.4%).Overall,major morbidity(Clavien-Dindo grade≥IIIA)was 26.3%.Thirty-and 90-day mortality were 3%and 11.1%,*** were no significant differences among groups in terms of short-term *** overall survival of patients submitted to PD+TVR was significantly higher than those to TP+SVR(29.5 vs 7.9 months,P=0.001).Multivariate analysis identified TP(HR=2.11;95%CI:1.31–3.44;P=0.002)and SVR(HR=2.01;95%CI:1.27–3.15;P=0.003)as the only independent prognostic factors for overall ***:Up-front TP associated to SVR was predictive of worse survival in borderline resectable *** treatments in high-risk surgical groups may improve such poor outcomes.

关键词： Pancreatic resection Vascular resection Pancreatic cancer surgery

Modeling cells spreading,motility,and receptors dynamics:a general framework

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Acta Mechanica Sinica 2021年第6期37卷 1013-1030,I0003页

作者： Mattia Serpelloni matteo Arricca Claudia Bonanno Alberto Salvadori Universitàdegli Studi di Brescia DIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DRIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DICACIM-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly

The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different *** this sake,it is not completely appropriate to provide a cell with classical notions of the mechanics of materials,as for“rheology”or“mechanical response”.Rather,a cell is an alive system with constituents that show a reproducible response,as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network,but that reorganize in response to external cues in a non-exactly-predictable and reproducible *** of such complexity,in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility,accounting for the relocation of proteins on advecting lipid membranes.

关键词： Mechanobiology Receptor dynamics Cell motility