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尼日利亚东南部异位性皮炎的流行病学研究

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 14-16页

作者： Nnoruka e.N. 刘超 Sub-Department of Dermatology College of Medic ine Univ. of Nigeria Teaching Hospital Enugu Nigeria Dr.

Background. Atopic dermatitis (AD) is a common pruritic, eczematous s kin diso rder that runs a chronic and relapsing course. In Nigeria, it is currently on th e increase, particularly amongst infants, and has created cost burdens for families. It occurs in association with a personal or family history of asthm a, allergic rhinitis and conjunctivitis. Major and minor criteria exist as guide lines for arriving at a diagnosis of AD, and surveys from Western countries have shown that these features, in particular the minor features, vary with ethnicit y and genetic background and can be used to aid diagnosis. African dermatologist s have also voiced concern that the much used Hanifin criteria for diagnosis of AD may need some adaptation for use in Africa. Objective. To document the featur es and disease outcomes of AD seen amongst dermatology hospital patients in enug u, south-eastern Nigeria, with a view to reflecting current features amongstNi gerianBlacks. Methods. Aprospective study of AD patients seen over a 2-year pe riod at a tertiary referral dermatology clinic (University of Nigeria Teaching H ospital, enugu, Nigeria) was carried out. A total of 1019 patients aged between 4 weeks and 57 years were included in the study. Results. The prevalence of AD w as 8.5% , which is much higher than the prevalence of AD reported in various pa rts of Nigeria 15 years ago. AD occurred before the age of 10 years in 523 (51.3 % ) patients, whilst 250 (24.5% ) had onset after 21 years. The earliest age o f onset in infants was in the first 6 weeks of life, and this was found in 129 p atients (12.7% ). education and occupation of household headswere the most sign ificant (P ed with seeking proper health care for the c hild’s AD. Four hundred and forty-one (43.3% ) patients presented with suba cute atopic eczema and 326 (32% ) patients with severe impeteginized eczema. Fo ur hundred and twenty-five patients (41.7% ) had at least one first-degree family me

关键词：异位性皮炎流行病学研究异位性湿疹药物反应过敏性鼻炎过敏性结膜炎传染性软疣掌红斑干皮病大学教学医院

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叙述性回顾:外观类似感染性蜂窝织炎的疾病

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 42-43页

作者： Falagas M.e. Vergidis P.I. 罗素菊 Dr. Alfa HealthCare 9 Neapoleos Str eet 151 23 Marousi Athens Greece

For cellulitis that does not respond to conventional antimicrobial treatment, clinicians should consider, among other explanations, several noninfectious diso rders that might masquerade as infectious cellulitis. Diseases that commonly mas querade as this condition in clude thrombophlebitis, contact dermatitis, insect stings, drug reactions, eosinophilic cellulitis (the Wells syndrome), gouty arth ritis, carcinoma erysipelatoides, familial Mediterranean fever, and foreign-bod y reactions. Diseases that uncommonly masquerade as infectious cellulitis includ e urticaria, lymphedema, lupus erythematosus, sarcoidosis, lymphoma, leukemia, P aget disease, and panniculitis. Clinicians should do an initial diagnostic work -up directed by the findings from a detailed history and complete physical exam ination. In many cases, skin biopsy is the only tool that helps identify the cor rect diagnosis. Special tests may also be needed.

关键词：蜂窝织炎感染性家族性地中海热叙述性丹毒样癌痛风性关节炎嗜酸性细胞临床医生体格检查皮肤活检

动作性肌阵挛-肾衰综合征:一种独特的脑肾功能障碍性疾病特征

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 26-27页

作者： Badhwar A. Berkovic S.F. Dowling J.P. e. Andermann 陈云春 Neurogenetics Unit Montreal Neurol. Hosp. and Institute 38 01 University Street Montreal Que. H3A 2B4 Canada Dr.

Action myoclonus renal failure syndrome (AMRF) is a distinctive form of progr essive myoclonus epilepsy associated with renal dysfunction. The syndrome was no t recognized prior to the advent of dialysis and renal transplantation because o f its rapidly fatal course if renal failure is untreated. The first and only des cription of AMRFwas in fourFrench Canadian patients in three families (Andermann et al., 1986). We now describe 15 individuals with AMRF from five countries, in cluding a fol low up of the four French Canadian patients, allowing a more com plete characterization of this disease. Our 15 patients with AMRF belong to nine different families. Segregation analyses were compatible with autosomal recessive inheritance. In addition, our findings sho w that AMRF can present with either renal or neurological features. Tremor (onse t 17-26 years, mean 19.8 years, median 19 years) and progressively disabling ac tion myoclonus (onset 14-29 years, mean 21.7 years, median 21 years), with infr equent generalized seizures (onset 20-28 years, mean 22.7 years, median 22 year s) and cerebellar features are characteristic. Proteinuria, detected between age s 9 and 30 years in all cases, progressed to renal failure in 12 out of 15 patie nts within 0-8 years after proteinuria detection. Brain autopsy in two patients revealed extraneuronal pigment accumulation. Renal biopsies showed collapsing g lomerulopathy, a severe variant of focal glomerulosclerosis. This study extends the AMRF phenotype, and demonstrates a more extensive ethnic and geographic dist ribution of a syndrome originally believed to be confined to individuals of Fren ch Canadian ancestry. The independent progression of neurological and renal diso rders in AMRF suggests a unitary molecular lesion with pleiotropic effects. Our results demonstrate that the renal lesion in AMRF is a recessive form of collaps ing glomerulopathy. Genes identified for focal segmental glomerulosclerosis and involved with the function

关键词：疾病特征肌阵挛功能障碍性动作性抗癫痫药物肾功能进行性加重肾小球病描述性研究肾小球基底膜

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腔隙性脑梗死患者介入治疗术后认知功能变化

中华行为医学与脑科学杂志 2012年第7期21卷 577-579页

作者：赵秀芹赵冰夏章勇杨华张凤娥郭存举曲怀谦聊城市中医院聊城252000 聊城市市直机关公费医疗门诊部神经内科聊城市人民医院神经内科山东省心脑血管病微创治疗工程技术研究中心聊城市第三人民医院神经内科

目的探讨腔隙性脑梗死患者介入治疗术后认知的功能变化特点。方法43例伴颈动脉狭窄的腔隙性脑梗死患者分别于术前及术后1个月、6个月、12个月进行神经心理学测验，并与41例正常人比较。结果与对照组比较，治疗组患者术前简易智能状态检... 详细信息

目的探讨腔隙性脑梗死患者介入治疗术后认知的功能变化特点。方法43例伴颈动脉狭窄的腔隙性脑梗死患者分别于术前及术后1个月、6个月、12个月进行神经心理学测验，并与41例正常人比较。结果与对照组比较，治疗组患者术前简易智能状态检查量表（MMSe）评分[（26．33±1．94）分]、记忆力、执行能力均降低，差异有统计学意义（P〈0．05或P〈0．01）。与术前比较，治疗组患者MMSe评分术后1月[（27．17±2．15）分]、术后6月[（27．78±2．12）分]、术后12月[（28．15±1．98）分]，及记忆力、执行能力大都明显改善，差异有统计学意义（P〈0．05或P〈0．01）。结论腔隙性脑梗死患者急性期（发病1周内）大部分认知功能损害较重，介入治疗12月后大都恢复正常，其机制可能与慢性脑供血不足的改善有关。

关键词：腔隙性脑梗死颈动脉狭窄介入治疗认知障碍