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Unresectable esophageal cancer treated with multiple chemotherapies in combination with chemoradiotherapy:A case report

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World Journal of Clinical Cases 2021年第12期9卷 2801-2810页

作者： Masahiro Yura Kazuo Koyanagi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano Kumiko Hongo kikuo Yo Kimiyasu Yoneyama Yoshifumi Tamai Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Radiology Hiratsuka City HospitalKanagawa 2540065Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Definitive chemoradiotherapy(dCRT)using cisplatin plus 5fluorouracil(CF)with radiation is considered the standard treatment for unresectable locally advanced T4 esophageal squamous cell carcinoma(ESCC).Recently,induction chemotherapy has received attention as an effective treatment *** SUMMARY We report a successful case of a 59-year-old female with unresectable locally advanced T4 ESCC treated by two additional courses of chemotherapy with CF after induction chemotherapy with docetaxel,cisplatin and fluorouracil(DCF)followed by *** esophagogastroduodenoscopy(EGD)detected a type 2 advanced lesion located on the middle part of the esophagus,with *** tomography detected the primary tumor with suspected invasion of the left bronchus and 90°of direct contact with the aorta,and upper mediastinal lymph node *** findings from biopsy revealed squamous cell *** initially performed induction chemotherapy using three courses of DCF,but the lesion was still evaluated unresectable after DCF ***,we subsequently performed dCRT treatment(CF and radiation).After dCRT,prominent reduction of the primary tumor was recognized but a residual tumor with ulceration was detected by *** the patient had some surgical risk,we performed two additional courses of CF and achieved a clinically complete *** 14 mo from last administration of CF chemotherapy,recurrence has not been detected by computed tomography and EGD,and biopsy from the scar formation has revealed no cancer *** We report successful case with tumor remnants even after DCF and subsequent dCRT,for whom a complete response was finally achieved with two additional courses of CF *** CF chemotherapy could be one radical treatment option for residual ESCC after treatment with induction DCF followed by dCRT to avoid salvage surgery,especially for high-risk patients.

关键词： Unresectable esophageal cancer Induction docetaxel,cisplatin and fluorouracil Chemoradiotherapy Complete response Additional chemotherapy Case report

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Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction

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World Journal of Biological Chemistry 2010年第5期1卷 69-80页

作者： Yutaka matsui Junko Morimoto Toshimitsu Uede Department of Matrix Medicine Institute for Genetic MedicineHokkaido UniversityKita-15Nishi-7Kita-kuSapporo 060-0815Japan Division of Molecular Immunology Institute for Genetic MedicineHokkaido UniversityKita-15Nishi-7Kita-kuSapporo 060-0815Japan

After onset of myocardial infarction(MI),the left ventricle(LV) undergoes a continuum of molecular,cellular,and extracellular responses that result in LV wall thinning,dilatation,and *** dynamic changes in LV shape,size,and function are termed cardiac *** the cardiac healing after MI does not proceed properly,it could lead to cardiac rupture or maladaptive cardiac remodeling,such as further LV dilatation and dysfunction,and ultimately *** the precise molecular mechanisms in this cardiac healing process have not been fully elucidated,this process is strictly coordinated by the interaction of cells with their surrounding extracellular matrix(ECM) *** components of ECM include basic structural proteins such as collagen,elastin and specialized proteins such as fibronectin,proteoglycans and matricellular *** proteins are a class of non-structural and secreted proteins that probably exert regulatory functions through direct binding to cell surface receptors,other matrix proteins,and soluble extracellular factors such as growth factors and *** small group of proteins,which includesosteopontin,thrombospondin-1/2,tenascin,periostin,and secreted protein,acidic and rich in cysteine,shows a low level of expression in normal adult tissue,but is markedly upregulated during wound healing and tissue remodeling,including *** this review,we focus on the regulatory functions of matricellular proteins during cardiac tissue healing and remodeling after MI.

关键词： Matricellular proteins Myocardial infarction Cardiac healing Cardiac remodeling Extracellular matrix

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Pancreaticoduodenectomy after neoadjuvant chemotherapy for gastric cancer invading the pancreatic head:A case report

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World Journal of Gastroenterology 2021年第6期27卷 534-544页

作者： Masahiro Yura Kiminori Takano Kiyohiko Adachi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Yoichiro Ikoma Hiroto Fujisaki Akira Hirata Kumiko Hongo kikuo Yo Kimiyasu Yoneyama Reiko Dehari Kazuo Koyanagi Motohito Nakagawa Department of Surgery Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Surgical Pathology Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259193KanagawaJapan

BACKGROUND Pancreaticoduodenectomy(PD)for advanced gastric cancer is rarely performed because of the high morbidity and mortality rates and low survival ***,neoadjuvant chemotherapy for advanced gastric cancer has improved,and chemotherapy combined with trastuzumab may have a preoperative tumorreducing effect,especially for human epidermal growth factor receptor 2(HER2)-positive *** SUMMARY We report a case of successful radical resection with PD after neoadjuvant S-1 plus oxaliplatin(SOX)and trastuzumab in a patient(66-year-old male)with advanced gastric cancer invading the pancreatic *** esophagogastroduodenoscopy detected a type 3 advanced lesion located on the lower part of the stomach obstructing the pyloric *** tomography detected lymph node metastasis and tumor invasion to the pancreatic head without distant *** findings revealed adenocarcinoma and HER2 positivity(immunohistochemical score of 3+).We performed staging laparoscopy and confirmed no liver metastasis,no dissemination,negative lavage cytological findings,and immobility of the distal side of the stomach due to invasion to the *** gastrojejunostomy was performed at that *** course of SOX and three courses of SOX plus trastuzumab were *** computed tomography showed partial response;therefore,PD was performed after neoadjuvant chemotherapy,and pathological radical resection was *** We suggest that radical resection with PD after neoadjuvant chemotherapy plus trastuzumab is an option for locally advanced HER2-positive gastric cancer invading the pancreatic head in the absence of non-curative factors.

关键词： Pancreaticoduodenectomy Gastric cancer Neoadjuvant chemotherapy Trastuzumab Human epidermal growth factor receptor 2 Case report

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Efficacy of intra-arterial contrast-enhanced ultrasonography during transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma

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World Journal of Hepatology 2018年第1期10卷 95-104页

作者： Kazue Shiozawa Manabu Watanabe Takashi Ikehara Shuhei Yamamoto Takashi matsui Yoshinori Saigusa Yoshinori Igarashi Iruru Maetani Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University Medical Center Ohashi Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University Medical Center Omori Hospital

AIM To assess the usefulness of intra-arterial contrastenhanced ultrasonography(IAUS) during transarterial chemoembolization(TACE) with drug-eluting beads(DEB) for hepatocellular carcinoma(HCC).METHODS Thirty two patients with 39 HCC underwent DEB-TACE guided with IAUS, and examined by contrast-enhanced ultrasonography(CEUS) or dynamic CT after DEB-TACE were enrolled in this study. CEUS findings before DEBTACE and IAUS findings were compared. Treatments judged to be complete and incomplete for lesions were appropriate and insufficient, respectively. Findings on CEUS and/or dynamic CT performed 1, 3 and 6 mo after DEB-TACE were evaluated using m RECIST(CR/PR/SD/PD).RESULTS The treatments were complete and incomplete in 26 and 13 lesions, respectively. On imaging evaluation using CEUS and/or dynamic CT one month after treatment, 25 and 1 lesions were judged to be CR and PR, respectively, and at 6 mo after treatment, the results were CR, PR, SD and PD for 24, 1, 0 and 1 of these lesions, respectively, in the 26 completely treated lesions. Of the 13 lesions in which treatment was incomplete, the results on imaging at one month after treatment were CR, PR, SD and PD for 0, 6, 4 and 3 lesions, respectively. The overall CR rate at 6 mo after treatment was 61.5%(24/39).CONCLUSION A combination of DEB-TACE with IAUS can improve the therapeutic effects in patients with HCC.

关键词： Hepatocellular carcinoma Contrast-enhanced ultrasonography Drug-eluting beads Transarterial chemoembolization Intra-arterial contrast-enhanced ultrasonography

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Reliable Multicast File Transfer on the Inter-University Satellite Network

Reliable Multicast File Transfer on the Inter-University Sat...

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2000 International Conference on Communication Technology(WCC2000·ICCT2000)

作者： kikuo ASAI Noritaka OSAWA Kimio KONDO Kiyohiro YUKI National Institute of Multimedia Education

We developed a reliable multicast program module to transfer les e±ciently on the inter-university satellite network which is called SCS(Space Collaboration System). SCS consists of 139 VSAT(Very Small Aperture Terminal) stations at universities and has been used for sharing classes,debates,and symposiums at distant places,exchanging audiovisual *** provide data sharing services,we try to install a function of the multicast le transfer to SCS as the rst step of computer *** error control is necessary for the reliable le *** program uses selective-repeat ARQ(Automatic Repeat Request) with multiple *** implemented the reliable multicast le transfer program to two VSAT stations in order to measure the performance using a satellite link with a transmission rate of 1536 kbps and a terrestrial network of the 10 Mbps *** results show a throughput of 1.3 Mbps including the overheads,which is the maximum performance of the multicast program in the network conguration.

关键词： Reliable Multicast File Transfer Satellite Network Selective-Repeat ARQ Multiple Transmissions

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Modified stool color card with digital images was efficient and feasible for early detection of biliary atresia——a pilot study in Beijing, China

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世界儿科杂志:英文版 2016年第4期12卷 415-420页

作者： Yuan-Yuan Kong Jin-Qi Zhao Jie Wang Lei Qiu Hai-He Yang Mei Diao Long Li Yan-Hong Gu Akira matsui Department of Newborn Screening Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina Department of Surgery Capital Institute of PediatricsBeijingChina Graduate School of Public Health Teikyo UniversityTokyoJapan Department of Hygiene and Public Health Teikyo UniversityTokyoJapan National Medical Center for Children and Mothers National Center for Child Health and DevelopmentTokyoJapan

Background:The aim of this pilot study in Beijing,China,was to validate a screening system for early detection of biliary atresia(BA)by using a modified version of the stool color card(SCC).Methods:From 2013 to 2014,a total of 29799 live born infants were *** was distributed in maternal *** were asked to check their infants’stool colors daily using SCC up until four months after *** screening results among 92.5%of participants were *** deemed as high risk were referred to a surgical department ***:Based on the results reported by the guardians,24 infants showed pale-pigmented stools,of which two males without obvious signs of jaundice were diagnosed with BA at 52 and 55 days of age,*** sensitivity was 100%and specificity was 99.9%.Four infants were confirmed as having other *** female patients failed to be screened by the SCC because they had severe jaundice and were referred to the Neonatal Intensive Care Unit after *** were diagnosed as BA at 14 and 17 days after birth,*** overall prevalence of BA in this study was 1.3 in 10000 live ***:The modified SCC was effective and feasible for early detection of BA,especially for patients with no apparent jaundice.

关键词： early detection jaundice Kasai procedure sensitivity specificity

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Effectiveness and safety of a laparoscopic training system combined with modified reconstruction techniques for total laparoscopic distal gastrectomy

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World Journal of Gastroenterology 2020年第13期26卷 1490-1500页

作者： Shun Zhang Hajime Orita Hiroyuki Egawa Ryota matsui Suguru Yamauchi Yukinori Yube Sanae Kaji Toru Takahashi Shinichi Oka Noriyuki Inaki Tetsu Fukunaga Department of Gastroenterology and Minimally Invasive Surgery Juntendo University HospitalTokyo 113-8431Japan Department of Gastrointestinal Surgery Shanghai East HospitalTongji UniversityShanghai 200120China Department of Surgery Juntendo Urayasu HospitalJuntendo UniversityChiba 2790021Japan

BACKGROUND Total laparoscopic distal gastrectomy(TLDG)is increasing due to some advantages over open surgery,which has generated interest in gastrointestinal ***,TLDG is technically demanding especially for lymphadenectomy and gastrointestinal *** the course of training,trainee surgeons have less chances to perform open gastrectomy compared with that of senior *** To evaluate an appropriate,efficient and safe laparoscopic training procedures suitable for trainee *** Ninety-two consecutive patients with gastric cancer who underwent TLDG plus Billroth I reconstruction using an augmented rectangle technique and involving trainees were *** trainees were taught a laparoscopic view of surgical anatomy,standard operative procedures and practiced essential laparoscopic *** TLDG procedure was divided into regional lymph node dissections and gastrointestinal reconstruction for analyzing trainee *** surgical outcomes were compared between trainees and trainers to clarify the feasibility and safety of TLDG performed by *** curves were used to assess the utility of our training *** Five trainees performed a total of 52 TLDGs(56.5%),while 40 TLDGs were conducted by two trainers(43.5%).Except for depth of invasion and pathologic stage,there were no differences in clinicopathological *** performed more D2 gastrectomies than *** total operation time was significantly longer in the trainee *** time spent during the lesser curvature lymph node dissection and the Billroth I reconstruction were similar between the two *** difference was found in postoperative complications between the two *** learning curve of the trainees plateaued after five TLDG *** Preparing trainees with a laparoscopic view of surgical anatomy,standard operative procedures and practice in essential laparoscopic skills enabled trainees to perform TLDG sa

关键词： Gastric cancer Total laparoscopic gastrectomy Education system Trainees Augmented rectangle technique Standard procedure

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Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

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Open Journal of Ophthalmology 2014年第3期4卷 79-85页

作者： Yuji Kumano Yumi Soejima Shinichiro Numa Hiroyasu matsui Ikuko Zushi Masahito Shigematsu Takaaki matsui Teruo Nishida Department of Oral and Maxillofacial Surgery Saga University Saga Japan Ohshima Hospital of Ophthalmology Fukuoka Japan Zushi Eye Clinic Fukuoka Japan

Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

关键词： BSCVA LASEK Loss of Two or More Lines Preoperative Myopia Re-Evaluation

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Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps

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World Journal of Gastroenterology 2009年第17期15卷 2162-2165页

作者： Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba Department of Gastroenterology Aso Iizuka Hospital Iizuka 820-8505 Japan Department of Pathology Aso Iizuka Hospital Iizuka 820-8505 Japan Fujifilm Corporation Saitama 331-9624 Japan

Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin.

关键词：直肠类癌黏膜下内镜剪刀剥离并发症发生率落刺激因子组织学诊断

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Does Embankment Improve Quality of a River? A Case Study in To Lich River Inner City Hanoi, with Special Reference to Heavy Metals

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Journal of Environmental Protection 2013年第4期4卷 361-370页

作者： Nguyen Thi Thuong Minoru Yoneda Yasuto matsui Lab of Environmental Risk Analysis Department of Environmental Engineering Graduate School of Engineering Kyoto University Kyoto Japan

To Lich River (TLR) system receives wastewaters from a population of nearly two million people and 100 manufactories of five industrial zones in inner city Hanoi, Vietnam. To improve quality of TLR, the embankment was carried out in 1998 and finished in 2002, resulted in width of 20 - 45 m, depth of 2 - 4 m, and maximum water flow capacity of 30 m3/s. Water and sediment quality indices based on heavy metal concentrations were used to evaluate current river environment compared to that of pre-embankment. Mass balance model was employed to estimate total metal loads for specific river reaches, which corresponds to various types of wastewater discharged along the river. The results indicated that currently there is about284,000 m3sediment accumulated in TLR bed, which is under high contamination of Cr, Mn, Fe, Ni Cu, Zn, As, Cd, and Pb with a total of 7347 tons of all concerned metals. Domestic-discharged river reaches received much lower metal loads, roughly 8% - 28% compared to river reaches of both domestic and industrial inputs. Total load of all nine concerned metals at the end of TLR is161.7 kg/day, which is finally discharged to Nhue River at South Hanoi. Water quality was improved much right after finishing embankment, then it gradually deteriorated. Meanwhile, sediment quality became even much worse after embankment. Relative river quality index as equal weight for both water and sediment quality indices indicated that quality of TLR was not much improved after the embankment. It even became worse due to the urbanization in recent years.

关键词： Industrial Discharge Mass Balance Metal Load River Quality Index Sediment Accumulation

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