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Chemical Research in Chinese Universities 2021年第3期37卷 629-638页

作者： ahmed Khan MUHAMMAD Asghar MOHAMMED Yaqoob masood ahmed siddiqui SAMAR Ali Department of Chemistry University of BalochistanSariab RoadQuetta87300Pakistan

A sensitive and selective method employing chemiluminescence(CL)coupled with flow injection(FI)is reported for nalbuphine hydrochloride(NAL)assay in pharmaceutical *** enhancement effect of NAL on the CL reaction between tris(2,2′-bipyridyl)ruthenium(II)chloride-diperiodatocuprate(III){Ru[(bpy)_(3)]^(2+)-Cu(III)complex}in acidic medium is used as analytical *** optimal conditions of the CL reaction were sulfuric acid 1.0×10^(−3) mol/L,Ru[(bpy)s]2+7.5×10^(−5) mol/L,Cu(III)/Ag(III)complexes 4.0×10^(−4)/5.0×10^(−4) mol/L,sample loop volume of 120µL and flow rate of 2.5 mL/*** sensitivities of the method in terms of detection(S/N=3)and quantification(S/N=10)limits are 5×10^(−4) and 0.001 ppm(1 ppm=1 mg/L),*** linear response of the instrument in the form of CL intensity with respect to NAL concentration is over the range 0.001-15.0 ppm(R^(2)=0.9999)with relative standard deviation from 0.8%to 3.2%and injection throughput of 120 injection/*** applications of the method include the quantitative analysis of NAL in pharmaceutical injection *** and the average results of the proposed method are not significantly different from the results of a reported method by applying F-and paired student *** most likely CL reaction mechanism is written in accordance with spectrophotometric and CL studies.

关键词： Ru[(bpy)_(3)]^(2+) Cu(III)/Ag(III)complex Chemiluminescence Flow injection analysis Nalbuphine hydrochloride Pharmaceutical

Aldosterone synthase inhibitor“Baxdrostat”for resistant hypertension:A clinical approach or futuristic idea?

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Chronic Diseases and Translational Medicine 2024年第2期10卷 146-148页

作者： Muhammad Osama siddiqui Ayaan ahmed Qureshi Arooba siddiqui Noor ul ain Liaquat National Hospital and Medical College KarachiSindhPakistan Karachi Medical and Dental College KarachiSindhPakistan

The American College of Cardiology/American Heart Association defines resistant hypertension(RH)as a clinical blood pressure(BP)reading of>130/80 mmHg in patients taking three antihypertensive drugs,including a renin–angiotensin system inhibitor,a calcium channel blocker(CCB),and a diuretic at well-tolerated doses.1,2 It is reported from multiple population-based surveys that in the United States,there is an approximately 12%–15%prevalence of RH among adults diagnosed with hypertension.2 A prospective study demonstrates that 20%of people diagnosed with RH had primary hyperaldosteronism.3,4 In addition to the classic three antihypertensive drugs,spironolactone and mineralocorticoid are also administered for ***,with respect to the safety profile of spironolactone,it has been reported to have several side effects such as low testosterone production,menstrual irregularities,and excessively raised serum potassium levels,leaving the drug unfit for the longitudinal therapeutic purpose of treating RH.

关键词： hypertension drugs hypertensive

Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir ahmed siddiqui Md.Muzahid ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan siddiqui Misbah Shaikh Afia Salman Muhammad ahmed Ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I²=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I²=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I²=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I2=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I2=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatment.

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

EXACT SOLUTIONS FOR MAGNETOHYDRODYNAMIC FLOW IN A ROTATING FLUID

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Acta Mechanica Sinica 2002年第3期18卷 244-251页

作者： S. Asghar masood Khan A.M. siddiqui T. Hayat Department of Mathematics Quaid-i-Azam University Islamabad Pakistan Department of Mathematics Pennsylvania State University York Campus 1031 Edgecomb Avenue New York PA 17403 USA

An analytical solution is obtained for the flow due to solid-body rotations an oscillating porous disk and of a fluid at infinity. Neglecting the induced magnetic field, the effects of the transversely applied magnetic field on the flow are studied. Further, the flow confined between two disks is also discussed. It is found that an infinite number of solutions exist for the flow confined between two disks.

关键词： rotating fluid porous disk double disks magnetohydrodynamic flow

Modeling, analysis, and optimization of dimensional accuracy of FDM-fabricated parts using definitive screening design and deep learning feedforward artificial neural network

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Advances in Manufacturing 2021年第1期9卷 115-129页

作者： Omar ahmed Mohamed Syed Hasan masood Jahar Lal Bhowmik School of Engineering Deakin UniversityGeelongAustralia Department of Mechanical Engineering Higher Institute of Engineering TechnologyBani WalidLibya Department of Mechanical and Product Design Engineering Swinburne University of TechnologyHawthornVIC 3122Australia Department of Health Science and Biostatistics Swinburne University of TechnologyHawthornVIC 3122Australia

Additive manufacturing(AM)technologies such as fused deposition modeling(FDM)rely on the quality of manufactured products and the process ***,the dimensional accuracy and stability of any AM process is essential for ensuring that customer specifications are satisfied at the highest standard,and variations are controlled without significantly affecting the functioning of processes,machines,and product *** study aims to investigate the effects of FDM fabrication conditions on the dimensional accuracy of cylindrical *** this study,a new class of experimental design techniques for integrated second-order definitive screening design(DSD)and an artificial neural network(ANN)are proposed for designing experiments to evaluate and predict the effects of six important operating *** determining the optimum fabrication conditions to obtain better dimensional accuracies for cylindrical parts,the time consumption and number of complex experiments are reduced considerably in this *** optimum fabrication conditions generated through a second-order DSD are verified with experimental *** results indicate that the slice thickness,part print direction,and number of perimeters significantly affect the percentage of length difference,whereas the percentage of diameter difference is significantly affected by the raster-to-raster air gap,bead width,number of perimeters,and part print ***,the results demonstrate that a second-order DSD integrated with an ANN is a more attractive and promising methodology for AM applications.

关键词： Artificial neural network(ANN) OptimizationDefinitive screening design(DSD) Analysis of variance(ANOVA) Fused deposition modeling(FDM) Dimensional accuracy

Nickel-titanium shape memory alloys made by selective laser melting:a review on process optimisation

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Advances in Manufacturing 2022年第1期10卷 24-58页

作者： Omar ahmed Mohamed Syed Hasan masood Wei Xu School of Engineering Deakin UniversityGeelongVIC 3216Australia Department of Mechanical Engineering The Higher Institute of Engineering TechnologyBani WaledLibya Department of Mechanical and Product Design Engineering Swinburne University of TechnologyHawthornVIC 3122Australia

Selective laser melting(SLM)is a mainstream powder-bed fusion additive manufacturing(AM)process that creates a three-dimensional(3D)object using a high power laser to fuse fine particles of various metallic powders such as copper,tool steel,cobalt chrome,titanium,tungsten,aluminium and stainless *** the past decade,SLM has received significant attention due to its capability in producing dense parts with superior mechanical *** a premier shape memory alloy,the nickel-titanium(NiTi)shape memory alloy is attractive for a variety of biomedical applications due to its superior mechanical properties,superelasticity,corrosion resistance and *** paper presents a comprehensive review of the recent progress in NiTi alloys produced by the SLM process,with a particular focus on the relationship between processing parameters,resultant microstructures and *** research gaps,challenges and suggestions for future research are also addressed.

关键词： Additive manufacturing(AM) Selective laser melting(SLM) Microstructure NiTi alloy Mechanical properties

Effect of controlled rolling on the martensitic hardenability of dual phase steel

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 165-169页

作者： Mohammad Ajmal masood ahmed Tindyala Ron Priestner Department of Metallurgical & Materials Engineering University of Engineering & TechnologyG.T. Road Lahore-54890Pakistan Manchester Materials Science Center University of Manchester Institute of Science and Technology (UMIST)ManchesterM1 7HSUK

The C-Mn and C-Mn-Nb steels were thermo-mechanically processed to develop dual phase steel and to study the effect of controlled rolling on the martensitic hardenability of austenite. The steel specimens were intercritically annealed at 790℃, rolled at that temperature to the reductions of 10%, 23%, and 47% and immediately cooled at different rates. Quantitative metallography was used to construct the microstructure map, which illustrated that increasing deformation progressively reduced the proportion of new ferrite formed at all cooling rates and increased the amount of martensite at fast and intermediate rates. The martensitic hardenability of austenite remaining after all the rolling reductions was plotted as a function of cooling rates. It was observed that for the austenite-martensite conversion efficiencies greater than about 25%, controlled rolling increased the martensitic hardenability of austenite.

关键词： controlled rolling dual phase steel intercritical annealing hardenability phase transformation

Achieving Energy Efficiency in Wireless Sensor Networks Using Dynamic Channel Polling and Packet Concatenation

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China Communications 2021年第8期18卷 249-270页

作者： Shama siddiqui Anwar ahmed Khan Sayeed Ghani Department of Computer Science DHA Suffa UniversityKarachiPakistan Department of Computer Science Institute of Business AdministrationKarachiPakistan Department of Computer Science Sindh Institute of Management&TechnologyKarachiPakistan

There has been a significant interest of researchers to combine different schemes focused on optimizing energy performance while developing aMAC protocol for Wireless Sensor Networks(WSNs).In this paper,we propose to integrate two cross-layer schemes:dynamic channel polling and packet concatenation using a recent asynchronous MAC protocol“Adaptive&Dynamic Polling MAC”(ADPMAC).ADP-MAC dynamically selects the polling interval distribution based on characterization of incoming traffic patterns using Coefficient of variation(CV).Packet Concatenation(PC)refers to combining the individually generated data packets into a single super packet and sending it at the polling ***,the Block Acknowledgement(BA)scheme has been developed for ADP-MAC to work in conjunction with the packet *** proposed schemes have been implemented in Tiny-OS for Mica2 platform and Avrora emulator has been used for conducting *** results have revealed that the performance both in terms of energy&packet loss improves when ADP-MAC is used in conjunction with the additional features of PC&***,the proposed scheme has been compared with a stateof-art packet concatenation primitive PiP(Packet-in-Packet).It has been observed that ADP-MAC supersedes the performance of PiP in terms of PDR(Packet Delivery Ratio)due to better management of synchronization between source and sink.

关键词： energy efficiency concatenation dynamic polling

＇Runs＇ from a run： A case of exercise induced ischemic colitis

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World Journal of Emergency Medicine 2017年第4期8卷 302-304页

作者： ahmed Faress Sameer masood ahmed Mian Department of Medicine University of British Columbia Vancouver Canada Division of Emergency Medicine the Department of Medicine University of Toronto Toronto Canada Harvard School of Public Health Harvard University Boston USA Department of Community and Family Medicine University of Toronto Toronto Canada University Health Network Toronto ON Canada

Marathon running is a strenuous activity that placesstress on the gastrointestinal system.[1] In fact, 30% to81% of runners report gastrointestinal complaints, whichinclude bloating, abdominal cramps, rectal incontine... 详细信息

关键词： Marathon running strenuous activity placesstress