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Rectosigmoid findings are not associated with proximal colon cancer: Analysis of 6 196 consecutive cases undergoing total colonoscopy

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World Journal of Gastroenterology 2005年第15期11卷 2249-2254页

作者： Makoto Okamoto Takao Kawabe Yutaka Yamaji Jun Kato Tsuneo Ikenoue Goichi Togo Haruhiko Yoshida Yasushi Shiratori masao Omata Department of Gastroenterology

AIM: To review the risk of proximal colon cancer in patients undergoing ***: We estimated the risk of advanced proximal adenomas and cancers in 6 196 consecutive patients that underwent colonoscopy (mean age 60 years, 65% males,without prior history of colorectal examination). Neoplasms were classified as diminutive adenoma (5 mm or less),small adenoma (6-9 mm), advanced adenoma (10 mm or more, with villous component or high-grade dysplasia)and cancer (invasive adenocarcinoma). The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal colon (from cecum to descending colon).RESULTS: The trend of the prevalence of advanced proximal adenoma was to increase with severe rectosigmoid findings, while the prevalence of proximal colon cancer did not increase with severe rectosigmoid findings. Among the 157 patients with proximal colon cancer, 74% had no neoplasm in the rectosigmoid colon. Multivariate logisticregression analysis revealed that age was the main predictor of proximal colon cancer and existence of rectosigmoid adenoma was not a predictor of proximal colon ***: Sigmoidoscopy is inadequate for colorectal cancer screening, especially in older populations.

关键词： Colorectal cancer Advanced adenoma Rectosigmoid colon Proximal colon

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Tadao Ando

Diagnostic value of antigenemia assay for cytomegalovirus gastrointestinal disease in immunocompromised patients

作者： masao Furuyama translation from Japanese Linda Hoaglund.

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World Journal of Gastroenterology 2011年第9期17卷 1185-1191页

作者： Naoyoshi Nagata masao Kobayakawa Takuro Shimbo Kazufusa Hoshimoto Tomoyuki Yada Takuji Gotoda Junichi Akiyama Shinichi Oka Naomi Uemura Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Department of Clinical Research and Informatics International Clinical Research Center Research Institute National Center for Global Health and Medicine Department of Clinical Laboratory Pathological Division National Center for Global Health and Medicine Department of Gastroenterology and Hepatology National Center for Global Health and MedicineKohnodai Hospital Division of Aids Clinical Center National Center for Global Health and Medicine

AIM:To investigate the utility of the cytomegalovirus(CMV)antigenemia assay for the diagnosis of CMV gastrointestinal disease(GID). METHODS:One hundred and thirty immunocompromised patients were enrolled in this *** with a history of anti-CMV treatment and who had not undergone examination using the antigenemia assay were ***-GID was defined as the detection of large cells with intranuclear inclusions alone or associated with granular cytoplasmic inclusions by *** sections were stained with hematoxylin and eosin and immunohistochemically stained with *** evaluated the association between CMV-GID and patient characteristics(symptoms,underlying disease,medication,leukocyte counts,and antigenemia assay).All patients were checked with an human immunodeficiency virus(HIV)antibody test before endoscopic *** blood cell(WBC)counts were obtained from medical records within 1 wk of *** was defined as a total WBC count<5000 cells/mm 3 . For HIV patients,we also checked CD4+counts from medical records. RESULTS:A total of 99 patients were retrospectively selected for *** the immunocompromised patients,19 had malignant disease,18 had autoimmune disease,19 had disorders of biochemical homeostasis, three had undergone transplantation,and 45 had HIV infection.A total of 50 patients had received immunosuppressive *** patients had inflammatory bowel ***-five patients were diagnosed as having *** analysis indicated an association between HIV infection,leukopenia,and positive antigenemia and CMV-GID(P<0.05).Multivariate analysis using logistic regression revealed that HIV infection and positive antigenemia were the only independent factors related to CMV-GID(P<0.01).The sensitivity,specificity,positive predictive value,and negative predictive value of antigenemia for CMV-GID were 65.4%,93.6%, 91.9%,and 71.0%,*** a subgroup analy-sis,patients with leukopenia displayed

关键词： Cytomegalovirus Gastrointestinal disease Antigenemia assay Real-time polymerase chain reaction Human immunodeficiency virus infection

Large mucinous cystic neoplasm of the pancreas associated with pregnancy

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World Journal of Gastroenterology 2008年第47期14卷 7252-7255页

作者： Shin-ichi Ikuta Tsukasa Aihara Chiaki Yasui Hiroya Iida Hidenori Yanagi masao Mitsunobu Ayako Kakuno Naoki Yamanaka Department of Surgery Meiwa General HospitalHyogo 663-8186Japan Department of Pathology Meiwa General HospitalHyogo 663-8186Japan

Mucinous cystic neoplasms (MCNs) of the pancreas occur mostly in females and are potentially sex hormone-sensitive. However, a MCN occurring during pregnancy is quite rare. A 30-year-old woman in the tenth week of pregnancy was referred to us because of a rapid increase in left hypochondrial distending pain. On ultrasound, the patient had a large intra-abdominal cystic lesion. She was thereafter diagnosed with missed abortion and a computed tomography scan showed that the lesion was a cystic tumor 18 cm in diameter originating from the pancreatic tail. The patient subsequently underwent tumor resection with distal pancreatectomy, sparing the spleen. Histopathological analysis of the specimen revealed a pancreatic MCN with moderate dysplasia. Immunohistochemically, the tumor was positive for both estrogen and progesterone receptors. To our knowledge, this is the first reported case of pancreatic MCN with moderate dysplasia in association with pregnancy. Our case strongly indicates that pancreatic MCN is female-hormone dependent.

关键词： Mucinous cystic neoplasm Pancreatic tumor Pregnancy

日本CBCC指导委员会成员masao Seki:CSR在日本企业扎根

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WTO经济导刊 2010年第6期 59-60页

作者： masao Seki 日本CBCC指导委员会日本财产保险公司

“企业社会责任对你们的企业意味着什么？”根据我们对成员企业的调查，82％认为，企业社会责任可以为建设可持续社会做出贡献。排名第二的答案是，可以作为创造企业价值的方法。排名第三的答案是，可以反映利益相关者对企业活动的希望。

关键词：日本企业成员企业委员会 CSR 企业社会责任利益相关者企业价值企业活动

Isolated neutropenia caused by copper deficiency due to jejunal feeding and excessive zinc intake:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8825-8830页

作者： Hiromitsu Ohmori Hiroko Kodama Masahiko Takemoto Masami Yamasaki Tomio Matsumoto masao Kumode Takafumi Miyachi Ryo Sumimoto Department of Pediatrics National Hospital Organization Yanai Medical CenterYanai 742-1352YamaguchiJapan Doctoral Program in Health and Dietetics Graduate School of Health SciencesTeikyo Heisei UniversityToshima-ku 170-8445TokyoJapan Department of Surgery National Hospital Organization Yanai Medical CenterYanai 742-1352YamaguchiJapan Department of Neurology National Hospital Organization Yanai Medical CenterYanai 742-1352YamaguchiJapan Department of Pediatrics Biwako Gakuen Kusatsu Medical and Welfare Center for Children and Persons with Severe Motor and Intellectual DisabilitiesKusatsu 525-0034ShigaJapan

BACKGROUND Percutaneous endoscopic gastrostomy with jejunal extension(PEG-J)is often used to treat patients with neurological impairment and difficulty in ***,these patients often develop copper *** report describes a case of isolated neutropenia,which is a rare manifestation of copper *** SUMMARY Our patient was a 19-year-old boy with neurological impairment and gastroesophageal *** received PEG-J feeding,including an enteral supplement containing copper and ***,as his serum zinc level was low(53μg/dL)at the age of 19 years and 2 mo,we changed to a zinc-rich supplement containing 22 mg/d of zinc and 1.0 mg/d of *** supplement comprised a mixture of isocal 1.0 junior(5 packs/d),Tezon[2 packs(250 mL)/d],and cocoa *** months later,he had neutropenia(606/mm^(3))with a serum copper level of 16μg/*** were no other manifestations of copper deficiency,including *** deficiency and neutropenia both improved following the administration of cocoa powder and *** In patients receiving long-term PEG-J feeds,white blood cell counts,hemoglobin,and serum levels of copper and zinc should be regularly monitored.

关键词： Percutaneous endoscopic gastrostomy with jejunal extension feeding Neutropenia Copper Zinc Deficiency Case report

Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

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World Journal of Gastrointestinal Oncology 2017年第6期9卷 257-262页

作者： Yoshinori Fujiwara Shuichi Fukuda Masanori Tsujie Hajime Ishikawa Kotaro Kitani Keisuke Inoue masao Yukawa Masatoshi Inoue Department of Digestive Surgery Nara HospitalKindai University School of Medicine Department of Digestive Surgery Kawasaki Medical School

To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting (IPTW) method using propensity score. METHODSWe enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old (Group A), and 333 patients were aged < 79 years old (Group B). We compared the surgical outcomes and survival of the two groups after IPTW. RESULTSPostoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B (P < 0.05). Overall survival (OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage I disease, OS was significantly lower in Group A (P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection were independent prognostic values for OS. CONCLUSIONWhen the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients.

关键词： Gastric cancer Mortality Morbidity Elderly Lymphadenectomy Propensity score matching Prognosis Survival

Saposin C stimulates growth and invasion,activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells

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Asian Journal of Andrology 2005年第2期7卷 147-158,页

作者： Shahriar Koochekpour Oliver Sartor masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff ArdalanMinokadeh DavidY.Patten Department of Microbiology Immunology and Parasitology Stantey S.Scott Cancer Center Stanley S.Scott Cancer Center Department of Medicine Department of Neurosciences University of CaliforniaSan DiegoCenter for Molecular GeneticsLa JollaCalifornia 92093USA Department of Microbiology Immunology and Parasitology Stanley S.Scott Cancer Center Department of Urology Louisiana State University Health Sciences CenterNew OrleansLouisiana 70112USA Kekul■-Institut fuer Organische Chemie Und Biochemie Universitaet BonnD-53121 BonnGermany Department of Microbiology Immunology and Parasitology Stanley S.Scott Cancer Center

Aim:To determine the effect of saposin C (a known trophic domain of prosaposin) on proliferation,migration and invasion,as well as its effect on the expression of urokinase plasmonogen activator (uPA),its receptor (uPAR) and matrix metalloproteinases (MMP)-2 and -9 in normal and malignant prostate *** addition,we tested whether saposin C can activate p42/44 and stress-activated protein kinase/c-Jun NH_2-terminal kinase (SAPK/JNK) signal transduction pathways of the mitogen-activated protein kinase (MAPK) ***:We employed West- ern blot analysis,phospho-specific antibodies,cell proliferation assay,reverse transcriptase-polymerase chain reaction, in vitro kinase assays and migration and invasion to determine the effect of saposin C on various biological behaviors of prostate stromal and cancer ***:Saposin C,in a cell type-specific manner,upregulates uPA/uPAR and immediate early gene c-Jun expression,stimulates cell proliferation,migration and invasion and activates p42/44 and SAPK/JNK MAPK pathways in prostate stromal and cancer *** prostate epithelial cells were not responsive to saposin C treatment in the above ***:Saposin C functions as a multipotential modulator of diverse biological activities in prostate cancer and stromal *** results strongly suggest that saposin C functions as a potent growth factor for prostatic cells and may contribute to prostate carcinogenesis and/or the development of hormone-refractory prostate cancer.

关键词： saposin C prostate cancer uPA/uPAR prosaposin invasion growth factor SAPK/JNK MAPK MMP c-Jun

Inflammatory pseudotumor of the liver and peripheral eosinophilia in autoimmune pancreatitis

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World Journal of Gastroenterology 2005年第6期11卷 922-925页

作者： Naoki Sasahira Takao Kawabe Akira Nakamura Kenji Shimura Haruhisa Shimura Ei Itobayashi Manabu Asada Yasushi Shiratori masao Omata Department of Gastroenterology

AIM: Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion, the etiology of which remains *** is not associated with any particular diseases apart from phlebitis and Crohn's ***: A middle-aged male with hepatic IPT and peripheral eosinophilia associated with autoimmune pancreatitis (AIP) was selected for this study and review of ***: A 59-year-old male was admitted with obstructive jaundice, marked eosinophilia (1 343/mm3)and hypergammaglobulinemia (4 145 mg/dL). Imaging techniques revealed dilatation of the intrahepatic bile duct,stenosis of the common bile duct with diffuse wall thickening, gallbladder wall thickening, irregular narrowing of the pancreatic duct, and swelling of the pancreatic parenchyma. Multiple liver masses were also demonstrated and diagnosed as IPT by biopsy specimens. Six months later, the abnormal features of the biliary tree remarkably improved by the oral administration of prednisolone, and the liver masses disappeared. The swelling of the pancreatic head also improved. The peripheral eosinophil count normalized. IPT associated with AIP, as we know,has not been reported in the literature. The clinical features of the present case mimicked those of pancreatic cancer with liver metastasis. This case deserves to be documented to prevent misdiagnosis of similar cases.

关键词： Inflammatory pseudotumor Autoimmune pancreatitis