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orgasm-associated urinary in continence(climacturia)following radical prostatectomy:a review of pathophysiology and current treatment options

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Asian Journal of Andrology 2020年第6期22卷 549-554页

作者： Christopher Kannady jonathan Clavell-Hernandez Division of Urology McGovern Medical School at The University of Texas Health Science Center at HoustonHoustonTX 77030USA St.Joseph Medical Center HoustonTX 77002USA

orgasm-associated urinary incontinence,or climacturia,is a common side effect after radical prostatectomy(RP)that is gaining more attention due to the distress it causes to patients.A range of treatment options have been reported in the literature and are outlined in this *** goal of our study is to review the pathophysiology and current management options for climacturia following RP.A PubMed search was used to review the current literature relating to the pathophysiology and the treatment of postprostatectomy *** reviewed the currently available treatment options and their success rates for *** techniques were found to subjectively help improve the amount and bother of patients'*** include pelvic floor muscle training(PFMT),penile variable tension loop,soft silicone occlusion loop,artificial urethral sphincter,male urethral sling,and the Mini-Jupette *** rates ranged from 48%to 100%depending on the modality *** patients with erectile dysfunction and climacturia,the Mini-Jupette graft could be a valuable *** the lack of validated measurement tools and management options,climacturia has become a challenge for *** a condition that has not garnered much attention,there are several management options from conservative to invasive treatments that have shown a hopeful promise for the treatment of *** options should be discussed with patients to determine the best treatment for each *** clinical trials are n eeded to assess the efficacy and impact of the d iff ere nt treatme nt options before a defi nitive recommendation regarding management can be made.

关键词： climacturia male urethral sling Mini-Jupette graft orgasm-associated urinary inc on tinence prostate can cer radical prostatectomy

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Distributed Majorization-Minimization for Laplacian Regularized Problems

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 45-52页

作者： jonathan Tuck David Hallac Stephen Boyd IEEE the Department of Electrical Engineering Stanford University

We consider the problem of minimizing a block separable convex function(possibly nondifferentiable, and including constraints) plus Laplacian regularization, a problem that arises in applications including model fitting, regularizing stratified models, and multi-period portfolio optimization. We develop a distributed majorization-minimization method for this general problem, and derive a complete, self-contained, general,and simple proof of convergence. our method is able to scale to very large problems, and we illustrate our approach on two applications, demonstrating its scalability and accuracy.

关键词： Convex optimization distributed optimization graphical networks Laplacian regularization

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Directional coherent light via intensity-induced sideband emission

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Light(Science & Applications) 2016年第1期5卷 33-38页

作者： Andrew J Traverso Chris o’Brien Brett H Hokr jonathan V Thompson Luqi Yuan Charles W Ballmann Anatoly A Svidzinsky Georgi I Petrov Marlan o Scully Vladislav V Yakovlev Texas A&M University College StationTX 77843USA Princeton University PrincetonNJ 08544USA Baylor University WacoTX 76798USA

We introduce a unique technique for generating directional coherent emissions that could be utilized to create coherent sources in a wide range of frequencies from the extreme ultraviolet(XUV)to the deep *** is accomplished without population inversion by pumping a two-level system with a far-detuned strong optical field that induces the splitting of the two-level system.A nonlinear process of four-wave mixing then occurs across the split system,driving coherent emission at sidebands both redand blue-detuned from the pump frequency,and propagates both forward and backward along the pump beam *** observed this phenomenon in dense rubidium vapor along both the D_(1) and D_(2) *** sideband emission exhibits a short pulse duration(o1 ns)with threshold-like behavior dependent on both the pump intensity and Rb vapor *** technique offers a new capability for manipulating the emission frequency simply through intensity-induced atomic modulation that can be scaled to most frequency regimes using various atomic/molecular ensembles and pump energies.

关键词： coherent emission collective coherence four-wave mixing

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Poly-and perfluoroalkyl substances(PFASs)in sediment samples from Roodeplaat and Hartbeespoort Dams,South Africa

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Emerging Contaminants 2020年第1期6卷 367-375页

作者： Bulelwa Batayi jonathan o.okonkwo Peter A.Daso Cornelius C.Rimayi Department of Environmental Water and Earth SciencesFaculty of ScienceTshwane University of TechnologyArcadia CampusPretoria0001South Africa Department of Water and Sanitation Resource Quality Information Services(RQIS)RoodeplaatP.Bag X3130001PretoriaSouth Africa

This study aimed at determining PFAS concentrations in sediments obtained from two important water systems in South Africa,namely,the Roodeplaat and Hartbeespoort *** samples were collected in March and June representing summer and winter *** analytes were extracted using the half-dry alkaline method followed by solid phase extraction and analysed with liquid chromatography-tandem mass *** mean PFASs concentrations in Roodeplaat Dam(0.14 e89.04 ng g^-1)were significantly higher(p=0.016)than in Hartbeespoort Dam(0.03e31.37 ng g^-1).Perfluoro-n-decane sulfonic acid(PFDS),perfluoro-n-heptyl sulfonate(PFHpS),perfluoro-n-nonane sulfonic acid(PFNS)and perfluoro-n-octane sulfonic acid(PFoS)were the most dominant PFASs *** were observed to be generally higher in summer compared to winter,however,the difference is statistically insignificant(p=0.659).The perfluorosulfonic acids(PFSAs)was more dominant than the perfluorocarboxylic compounds,suggesting possible preferential usage of PFSAs in this *** findings were different from reports from China and Korea,which reported long chain perfluorinated carboxylic acids(PFCAs)in sediments as the dominant *** results also revealed that the PFAS concentrations found in the present study were higher than the concentrations found in China,Germany,and Ethiopia but lower than the concentrations detected in the Western Cape Province in South Africa.

关键词： PFASs Concentrations Sediments Hartbeespoort and roodeplaat dams South Africa

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Exposure to inorganic arsenic can lead to gut microbe perturbations and hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2016年第5期6卷 426-429页

作者： jonathan Choiniere Li Wang Department of Physiology and Neurobiology The Institute for Systems GenomicsUniversity of Connecticut School of Pharmaceutical Sciences Wenzhou Medical University Veterans Affairs Connecticut Healthcare System Department of Internal Medicine Section of Digestive DiseasesYale University

Arsenic is a carcinogenic environmental factor found in food and drinking water around the *** mechanisms in which arsenic alters homeostasis are not fully *** the past few decades,light has been shed on varying mechanisms in which arsenic induces *** mechanisms include gut microbe perturbations,genotoxic effects,and epigenetic *** microbe perturbations have been shown to increase the level of pathogen-associated molecular patterns such as lipopolysaccharide(LPS) leading to uncontained *** in inflammation is the major factor in cirrhosis leading to hepatocellular *** in gut permeability and metabolites have also been observed as a fallout of arsenic induced gut microbe *** guts proximity and interaction through portal flow make the liver susceptible to gut perturbations and ensuing inflammatory *** and epigenetic dysregulation induced by arsenic and its toxic metabolites present a more direct mechanism that works synergistically with gut microbe perturbations to induce the incidence of *** pathways combined could be some of the main causes of arsenic-induced carcinogenesis.

关键词： Arsenic Microbiome Epigenetics Liver cancer Hepatocellular carcinoma Gut microbiota Lipopolysaccharide

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Accurate and scalable graph neural network force field and molecular dynamics with direct force architecture

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npj Computational Materials 2021年第1期7卷 650-658页

作者： Cheol Woo Park Mordechai Kornbluth jonathan Vandermause Chris Wolverton Boris Kozinsky jonathan P.Mailoa Robert Bosch Research and Technology Center CambridgeMA 02139USA Northwestern University EvanstonIL 60208USA Harvard School of Engineering and Applied Sciences CambridgeMA 02138USA

Recently,machine learning(ML)has been used to address the computational cost that has been limiting ab initio molecular dynamics(AIMD).Here,we present GNNFF,a graph neural network framework to directly predict atomic forces from automatically extracted features of the local atomic environment that are translationally-invariant,but rotationally-covariant to the coordinate of the *** demonstrate that GNNFF not only achieves high performance in terms of force prediction accuracy and computational speed on various materials systems,but also accurately predicts the forces of a large MD system after being trained on forces obtained from a smaller ***,we use our framework to perform an MD simulation of Li7P3S11,a superionic conductor,and show that resulting Li diffusion coefficient is within 14%of that obtained directly from *** high performance exhibited by GNNFF can be easily generalized to study atomistic level dynamics of other material systems.

关键词： neural AIMD dynamics

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Pangenome analysis of Enterobacteria reveals richness of secondary metabolite gene clusters and their associated gene sets

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Synthetic and Systems Biotechnology 2022年第3期7卷 900-910页

作者： omkar S.Mohite Colton J.Lloyd jonathan M.Monk Tilmann Weber Bernhard o.Palsson The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby2800Denmark Department of Bioengineering University of California San DiegoLa JollaCA92093USA

In silico genome mining provides easy access to secondary metabolite biosynthetic gene clusters(BGCs)encoding the biosynthesis of many bioactive compounds,which are the basis for many important drugs used in human ***,the association between BGCs and other functions encoded in the genomes of producers have remained ***,we present a systems biology workflow that integrates genome mining with a detailed pangenome analysis for detecting genes associated with a particular *** analyzed 3,889 enterobacterial genomes and found 13,266 BGCs,represented by 252 distinct BGC families and 347 additional singletons.A pangenome analysis revealed 88 genes putatively associated with a specific BGC coding for the colon cancer-related colibactin that code for diverse metabolic and regulatory *** presented workflow opens up the possibility to discover novel secondary metabolites,better understand their physiological roles,and provides a guide to identify and analyze BGC associated gene sets.

关键词： Pangenome analysis Workflow Secondary metabolites Colibactin Enterobacteria Secretion systems

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An evaluation of visual and measurement-based methods for estimating deposited fine sediment

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International Journal of Sediment Research 2016年第4期31卷 368-375页

作者： Elizabeth Conroy jonathan N.Turner Anna Rymszewicz Michael Bruen John J.o'Sullivan Mary Kelly-Quinn School of Biology and Environmental Science University College Dublin School of Geography Planning and Environmental PolicyUniversity College Dublin UCD Dooge Centre for Water Resources Research School of CivilStructural and Environmental EngineeringUCD Earth InstituteUniversity College Dublin

A wide range of methods are commonly used to measure deposited fine sediment and quantify substrate quality in rivers as part of bioassessment or monitoring *** this laboratory-based experiment known amounts of three sediment types(sand,topsoil,peat) were added to mesocosms and four methods of measuring deposited fine sediment;turbidity,estimation of released sediment,Turner-Hillis deposited sediment sampler(DSS) and visual estimation of%surface cover were *** objective of the study was to evaluate which of these methods for estimating deposited sediment best discriminates between levels of deposited fine sediment added and assesses the effects of inter-observer variability between%surface cover *** turbidity measurement and the resuspension method were strongly related to levels of added sediment,it proved difficult using the two methods to resolve differences between adjacent levels of added sediment e.g.50 g and 100 *** cover estimations were also strongly related to added sediment levels and were better able to distinguish between adjacent levels of added ***,we found no significant differences between the%surface cover estimations between *** from this laboratory experiment strongly endorse the use of visual estimation of surface cover in field *** work evaluating the turbidity and resuspension methods under field conditions would also be beneficial.

关键词： Deposited fine sediment Sediment sampling Turbidity Re-suspension Visual estimation

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The effect of platform switching on the levels of metal ion release from different implant–abutment couples

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International Journal of oral Science 2016年第2期8卷 117-125页

作者： Ghada o Alrabeah jonathan C Knowles Haralampos Petridis Division of Biomaterials and Tissue Engineering UCL Eastman Dental Institute University College London London UK Prosthodontic Unit Department of Restorative Dentistry UCL Eastman Dental Institute University College London London UK

The improved peri-implant bone response demonstrated by platform switching may be the result of reduced amounts of metal ions released to the surrounding tissues. The aim of this study was to compare the levels of metal ions released from platform-matched and platform-switched implant-abutment couples as a result of accelerated corrosion. Thirty-six titanium alloy （Ti-6AI-4V） and cobalt-chrome alloy abutments were coupled with titanium cylinders forming either platform-switched or platform-matched groups （n = 6）. In addition, 18 unconnected samples served as controls. The specimens were subjected to accelerated corrosion by static immersion in 1% lactic acid for 1 week. The amount of metal ions ion of each test tube was measured using inductively coupled plasma mass spectrometry. Scanning electron microscope （SEM） images and energy dispersive spectroscopy X-ray analyses were performed pre- and post-immersion to assess corrosion at the interface. The platform-matched groups demonstrated higher ion release for vanadium, aluminium, cobalt, chrome, and molybdenum compared with the platform-switched groups （P〈 0.05）. Titanium was the highest element to be released regardless of abutment size or connection （P〈0.05）. SEM images showed pitting corrosion prominent on the outer borders of the implant and abutment platform surfaces. In conclusion, implant-abutment couples underwent an active corrosion process resulting in metal ions release into the surrounding environment. The highest amount of metal ions released was recorded for the platform-matched groups, suggesting that platform-switching concept has a positive effect in reducing the levels of metal ion release from the implant-abutment couples.

关键词： corrosion dental implants ion release peri-implant bone loss platform-switching titanium

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Current hepatitis B treatment guidelines and future research directions

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Frontiers of Medicine 2014年第2期8卷 145-157页

作者： jonathan Skupsky Ke-Qin Hu Division of Gastroenterology and Hepatology University of California Irvine School of Medicine Orange CA 92868 USA

Hepatitis B virus （HBV） infection causes a tremendous clinical burden across the world with more than half a million people dying annually from HBV related disease. Significant advances have been made in HBV treatment in the past decade and several guidelines have been published by professional societies and expert panels. Although these recommendations have been valuable to help optimize HBV treatment, there is discordance in treatment criteria and many patients infected with HBV may fall outside of these recommendations. This paper systematically reviews the natural history of the disease and compares and contrasts the recommendations for initiation of treatment from the various societies. There is also discussion of special groups that require particular consideration and some of the open research questions and future research directions within the field.

关键词： chronic hepatitis B HBV treatment guidelines APASL guidelines EASL guidelines AASLD guidelines

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