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Par.icuology 2024年第6期89卷 258-269页

作者： martin Oelofse r.ber. r.ck Mar.elle Hilden Peter.Langguth Depar.ment of Phar.aceutical Technology and Biophar.aceutics Johannes Gutenberg UniversityMainzGermany Car.on Advanced Solutions GmbH HeuchelheimGermany

Spr.ying par.meter. dur.ng par.icle agglomer.tion pr.cesses can affect the agglomer.tion kinetics and par.icle *** study was conducted to better.under.tand the influence of the spr.ying par.meter. in a fluidized bed wet agglomer.tion pr.cess,and the influence on the stability char.cter.stics of car.on tablets.A for.ulation based on fine car.on and per.xide powder.as well as car.oxymethyl cellulose as a binder.was used to pr.duce agglomer.tes in a fir.t pr.duction *** in a second pr.duction step car.on tablets with a high por.sity wer. molded for.the customer.goods *** optimization of the compr.ssive str.ngth of these car.on tablets was the goal of the *** agglomer.tes wer. pr.duced with a labor.tor. scale gr.nulator.called“Pr.Cell”and wer. compr.ssed with a five-cavity mechanical *** scr.ening of the agglomer.tion pr.cess par.meter. and their.influence on the agglomer.tes quality,as well as the per.or.ance char.cter.stics of the car.on tablets,wer. investigated using a multilevel factor.al *** exper.mental r.ns wer. done by var.ing atomized air.pr.ssur. and feed r.te of the *** was deter.ined by the design *** findings of the statistical tr.als showed that low atomized air.pr.ssur. and a low feed r.te lead to a higher.tablet compr.ssive str.ngth.

关键词： Wet agglomer.tion Fluidized bed Design of exper.ments Car.on agglomer.tes and tablets

Second-or.er.er.or.analysis of the aver.ged L1 scheme L1 for.time-fr.ctional initial-value and subdiffusion pr.blems

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Science China Mathematics 2024年第7期67卷 1641-1664页

作者： Jinye Shen Fanhai Zeng martin Stynes School of Mathematics Southwestern University of Finance and EconomicsChengdu611130China School of Mathematics Shandong UniversityJinan250100China Applied and Computational Mathematics Division Beijing Computational Science Research CenterBeijing100193China

Fr.ctional initial-value pr.blems(IVPs) and time-fr.ctional initial-boundar. value pr.blems(IBVPs), each with a Caputo tempor.l der.vative of or.er.α ∈(0, 1), ar. consider.d. An aver.ged var.ant of the well-known L1 scheme is pr.ved to be O(N^(-2)) conver.ent for.IVPs on suitably gr.ded meshes with N points, ther.by impr.ving the O(N^(-(2-α))) conver.ence r.te of the standar. L1 scheme. The analysis r.lies on a delicate decomposition of the tempor.l tr.ncation er.or.that yields a shar. dependence of the or.er.of conver.ence on the degr.e of mesh gr.ding used. This aver.ged L1 scheme can be combined with a finite differ.nce or.piecewise linear.finite element discr.tization in space for.IBVPs, and under.a r.str.ction on the tempor.l mesh width, one gets again O(N^(-2)) conver.ence in time, together.with O(h^(2)) conver.ence in space,wher. h is the spatial mesh width. Numer.cal exper.ments suppor. our.r.sults.

关键词： time-fr.ctional subdiffusion aver.ged L1 scheme

Par.icle Size Optimization of Ther.ochemical Salt Hydr.tes for.High Ener.y Density Ther.al Stor.ge

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Ener.y & Envir.nmental Mater.als 2024年第2期7卷 326-333页

作者： Andr.w martin Dr.w Lilley r.νi Pr.sher.Sumanjeet Kaur Ener.y Technologies Ar.a Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Depar.ment of Mechanical Engineer.ng UC BerkeleyBerkeleyCA 94720USA

Ther.al ener.y stor.ge(TES)solutions offer.oppor.unities to r.duce ener.y consumption,gr.enhouse gas emissions,and ***,they can help r.duce the peak load and addr.ss the inter.ittency of r.newable ener.y sour.es by time shifting the load,which ar. cr.tical towar. zer. ener.y *** mater.als(TCMs)as a class of TES under.o a solid-gas r.ver.ible chemical r.action with water.vapor.to stor. and r.lease ener.y with high stor.ge capacities(600 kWh m^(-3))and negligible self-dischar.e that makes them uniquely suited as compact,stand-alone units for.daily or.seasonal ***,TCMs suffer.fr.m instabilities at the mater.al(salt par.icles)and r.actor.level(packed beds of salt),r.sulting in poor.multi-cycle efficiency and high-levelized cost of *** this study,a model is developed to pr.dict the pulver.zation limit or.r.r.t of var.ous salt hydr.tes dur.ng ther.al *** is cr.tical as it pr.vides design r.les to make mechanically stable TCM composites as well as enables the use of mor. ener.y-efficient manufactur.ng pr.cess(solid-state mixing)to make the *** model is exper.mentally validated on multiple TCM salt hydr.tes with differ.nt water.content,and effect of r.r.t on hydr.tion and dehydr.tion kinetics is also investigated.

关键词： high ener.y density hydr.tion kinetics long-ter. cycling ther.al ener.y stor.ge ther.ochemical mater.als

Car.on dioxide enr.chment affected flower.number. tr.nsiently and incr.ased successful post-pollination development stably but without alter.ng final acor. pr.duction in matur. pedunculate oak (Quer.us r.bur.L.)

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Jour.al of For.str. r.sear.h 2024年第4期35卷 1-12页

作者： r.an McClor. r.char. H.Ellis martin Lukac Jo Clar. Car.lina Mayor.l Kr.s M.Har. Andr.w r.G.Plackett A.r.b MacKenzie School of Agr.cultur. Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Faculty of For.str. and Wood Sciences Czech University of Life Sciences PraguePrague 165000Czechia Futur. Tr.es Tr.st Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Bir.ingham Institute of For.st r.sear.h University of BirminghamEdgbastonBirmingham B152TTUK School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUK School of Geogr.phy Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Acor. pr.duction in oak(Quer.us spp.)shows consider.ble inter.annual var.ation,known as masting,which pr.vides a natur.l defence against seed pr.dator. but a highly-var.able supply of acor.s for.uses such as in commer.ial tr.e planting each *** emissions of gr.enhouse gases have been ver. widely r.por.ed to influence plant gr.wth and seed or.fr.it size and quantity via the‘fer.ilisation effect’that leads to enhanced *** examine if acor. pr.duction in matur. woodland communities will be affected by fur.her.incr.ase in CO_(2),the contents of litter.tr.ps fr.m a Fr.e Air.Car.on Enr.chment(FACE)exper.ment in deciduous woodland in centr.l England wer. analysed for.number. of flower. and acor.s of pedunculate oak(Quer.us r.bur.L.)at differ.nt stages of development and their.pr.dation levels under.ambient and elevated CO_(2) ***-annual var.ation in acor. number. was consider.ble and cyclical between 2015 and 2021,with the gr.atest number. of matur. acor.s in 2015,2017 and 2020 but almost none in *** number. of flower.,enlar.ed cups,immatur. acor.s,empty acor. cups,and galls in the litter.tr.ps also var.ed amongst year.;compar.tively high number. of enlar.ed cups wer. r.cor.ed in 2018,suggesting *** at this site is a fr.it matur.tion masting species(i.e.,the extent of abor.ion of pollinated flower. dur.ng acor. development affects matur. acor. number. gr.atly).r.ising the atmospher.c CO_(2) concentr.tion by 150μL L^(−1),fr.m ear.y 2017,incr.ased the number. of immatur. acor.s,and all acor. evidence(empty cups+immatur. acor.s+matur. acor.s)detected in the litter.tr.ps compar.d to ambient contr.ls by 2021,but did not consistently affect the number. of flower.,enlar.ed cups,empty cups,or.matur. *** number.of flower. in the elevated CO_(2) plots’litter.tr.ps was gr.ater.in 2018 than 2017,one year.after.CO_(2) enr.chment began,wher.as number. declined in ambient *** with CO_(2) also incr.ased the number.o

关键词： Quer.us r.bur.L. Acor.s Masting Pedunculate oak Car.on dioxide

Exper.mental investigation of r.diative heat pr.pagation in a simplified gener.c packed bed

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Par.icuology 2024年第5期88卷 149-160页

作者： Matthias Tyslik Lukas Pör.ner.Siegmar.Wir.z martin Schiemann Institute of Ener.y Plant Technology Ruhr-University Bochum44780 BochumGermany

A novel test r.g for.the investigation of r.diative heat tr.nsfer.in packed beds has been developed and is intr.duced with r.pr.sentative exper.mental *** individual components and the calibr.tion ar. *** gener.c packed bed is r.alized in a simplified way by an ar.angement of par.llel r.ds,which r.pr.sent par.icles in *** this ar.angement,electr.cally heated r.ds pr.vide the r.diation pr.pagating thr.ugh the r.d ar.ay to heat the passive counter.ar.s.A sophisticated temper.tur.-contr.l scheme with a lar.e number.of ther.ocouples and infr.r.d-imaging pr.vides in-depth infor.ation about heat tr.nsfer.in the *** r.diation intensities ar. deter.ined with a Four.er.tr.nsfor. infr.r.d spectr.scopy,which has been modified and validated for.this specific *** or.er.to compar. the influence of differ.nt sur.ace pr.per.ies of par.icles on the heat pr.pagation and sur.ace r.flections,r.d samples made of stainless steel and magnesium oxide ar. *** influence of mater.al pr.per.ies becomes clear.y visible by compar.ng the high r.diation intensities r.sulting fr.m a stainless steel r.d ar.ay to the same geometr. built fr.m magnesium oxide *** addition,the influence of the sur.ace pr.per.ies is par.icular.y evident in the infr.r.d images since the r.flections ar. significantly higher.for.the stainless steel samples than for.the magnesium oxide *** exper.mental r.sults in the cur.ent wor. demonstr.te the ability of the test r.g to pr.vide data with a well-defined accur.cy as a validation base for.numer.cal r.diation simulations in packed beds.

关键词： Ther.al r.diation Spectr.l r.flections Four.er.tr.nsfor. infr.r.d spectr.scopy

Ar.bidopsis photoper.odic r.gulator.CONSTANS feeds back to contr.l the cir.adian clock

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Molecular.Plant 2024年第9期17卷 1338-1340页

作者： Abr.l San martin Mar.elo Javier.Yanovsky Instituto de Investigaciones Bioquimicas de Buenos Air.s(Fundacion Instituto Leloir.CONICET) Av.Patricias Argentinas 435Buenos AiresC1405BWE

Human beings live in a wor.d defined by daily cycles of light and dar.ness caused by the Ear.h's r.tation ar.und its ***,like most living or.anisms,have evolved inter.al cir.adian clocks that time biological pr.cesses in anticipation of these daily envir.nmental changes(Young and Kay,2001).The plant clock r.lies on cor. genes encoding tr.nscr.ption factor.(TFs),which r.gulate each other.s expr.ssion thr.ugh intr.cate networ.s of inter.ocking tr.nscr.ptional-tr.nslational feedback loops(Nohales and Kay,2016).These loops ultimately contr.l the expr.ssion of thousands of genes,allowing plants to adapt to daily fluctuations in light,temper.tur.,and humidity(Covington et al.,2008).In addition to daily r.ythms,the Ear.h exper.ences year.y seasonal cycles mar.ed by longer.war.er.days in spr.ng and summer.followed by shor.er.cooler.days in autumn and *** changes in day length and temper.tur. intensify with distance fr.m the ***,the ability of plants to adjust their.gr.wth and development in anticipation of seasonal changes deter.ines their.latitudinal distr.bution(McMillan,1960).

关键词： cir.adian seasonal Ar.bidopsis

Car.ocysteine as Adjuvant Ther.py in Acute r.spir.tor. Tr.ct Infections in Patients without Under.ying Chr.nic Conditions: Systematic r.view and Meta-Analysis

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Open Jour.al of r.spir.tor. Diseases 2024年第2期14卷 39-50页

作者： Myr.am Calle r.bio Olga de la Ser.a Blazquez José Luis r. martin Manuel r.iz Cuetos Pulmonology Depar.ment Hospital Clínico San Carlos Madrid Spain Depar.ment of Medicine School of Medicine Universidad Complutense de Madrid Madrid Spain Instituto de Investigacion Sanitar.a del Hospital Clínico San Car.os (IdISSC) Madrid Spain Pediatr.c Pulmonology Unit Pediatrics Department Hospital Universitario La Paz Madrid Spain Simplifying r.sear.h Institute Layos Spain Medical depar.ment in ITF r.sear.h Phar.a S.L.U. Alcobendas Spain

Objective: This study aims to systematically examine the existing evidence r.gar.ing the clinical benefits of car.ocysteine as an adjunctive tr.atment in acute br.nchopulmonar. and otor.inological pr.cesses. Design: Systematic r.view and meta-analysis. Data sour.es: An electr.nic sear.h was conducted acr.ss PubMed, Cochr.ne Libr.r., ***, and the Eur.pean Clinical Tr.al r.gister. with the sear.h dated to May 2023. Bibliogr.phic r.fer.nces fr.m other.liter.tur. r.views and meta-analyses wer. also r.viewed. The sear.h was limited to r.ndomized clinical tr.als published in any language and year. It was completed by cr.ss-checking the r.fer.nces of the located ar.icles. Methods: Inclusion cr.ter.a cover.d studies assessing systemic or.inhaled car.ocysteine, r.gar.less of dosing r.gimen. Concomitant medication use was acceptable if balanced between inter.ention and contr.l gr.ups. Author. independently extr.cted data, r.solving disagr.ements thr.ugh consensus. Methodological quality assessment r.lied on cr.tical r.ading of each study. Dichotomous var.ables wer. analyzed using odds r.tio (Or., and a final effect size was calculated. Statistical significance was established when confidence inter.als did not cr.ss the neutr.l value. Heter.geneity was assessed via the X2 test and I2 index. r.sults: Out of 318 initially identified studies, 4 met inclusion cr.ter.a. The meta-analysis for.poor.gener.l condition yielded an Or.of 0.45 in favor.of inter.ention, p = 0.013, with non-significant heter.geneity. Cough events showed a per.entage of 15.8% for.car.ocysteine vs. 27.2% for.placebo. On the seventh day, expector.tion r.tes wer. 18.37% for.car.ocysteinevs 33.3% for.placebo. Conclusions: The obser.ed clinical benefits align with car.ocysteine’s mucoactive and muco-r.gulator. pr.per.ies, complemented by anti-inflammator. and antioxidant actions. Car.ocysteine stands out among mucolytic agents. In the context of per.istent infectious diseases,

关键词： Acute r.spir.tor. Infections Car.ocystenine Systematic r.view Meta-Analysis

Haplotype-based phylogenetic analysis and population genomics uncover.the or.gin and domestication of sweetpotato

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Molecular.Plant 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming Li Yunze Wang Xinyi Wang M-Hossein Moeinzadeh Dor. G.Quispe-Huamanquispe Weijuan Fan Yijie Fang Yuqin Wang Haozhen Nie Zhangying Wang Aiko Tanaka Bettina Heider.Jan F.Kr.uze Godelieve Gheysen Hongxia Wang martin Vingr.n ralph Bock Jun Yang Shanghai Key Labor.tor. of Plant Functional Genomics and r.sour.es Shanghai Chenshan Botanical GardenShanghai 201602China College of Life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear.Technology r.sear.h Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Depar.ment of Computational Molecular.Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Depar.ment of Biotechnology Ghent University9000 GhentBelgium Guangdong Pr.vincial Key Labor.tor. of Cr.ps Genetics and Impr.vement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Gr.duate School of Bioagr.cultur.l Sciences Nagoya UniversityChikusaNagoya 464-8601Japan inter.ational Potato Center.CIP) LimaPeru CAS Center.for.Excellence of Molecular.Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Planck-Institut fur.Molekular. Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most impor.ant r.ot cr.ps ***,its genetic or.gin r.mains contr.ver.ial,and its domestication histor. r.mains *** this study,we used a r.nge of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two pr.bable pr.genitor. of *** diploid pr.genitor.was likely closely r.lated to lpomoea ae-quator.ensis and contr.buted the B,subgenome,IbT-DNA2,and the lineage 1 type of chlor.plast genome to *** tetr.ploid pr.genitor.of sweetpotato was most likely *** 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chlor.plast *** most likely or.ginated fr.m r.cipr.cal cr.sses between the diploid and tetr.ploid pr.genitor.,followed by a subsequent whole-genome *** addition,we detected biased gene exchanges between the subgenomes;the r.te of B,to B2 subgenome conver.ions was near.y thr.e times higher.than that of B2 to B subgenome *** analyses r.vealed that genes involved in stor.ge r.ot for.ation,maintenance of genome stabil-ity,biotic r.sistance,sugar.tr.nspor.,and potassium uptake wer. selected dur.ng the speciation and domestication of *** study sheds light on the evolution of sweetpotato and paves the way for.mpr.vementofthiscr.p.

关键词： sweetpotato or.gin gene conver.ion domestication IbT-DNA HPA

Conver.ent Data-Dr.ven r.gular.zations for.CT r.constr.ction

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1342-1368页

作者： Samir. Kabr. Alexander.Aur.s Danilo r.ccio Har.mut Bauer.eister.martin Benning Michael Moeller.martin Bur.er Helmholtz Imaging Deutsches Elektronen-Synchrotron DESYNotkestr.8522607 HamburgGermany Institute for.Vision and Gr.phics University of SiegenAdolf-Reichwein-Straße 2a57076 SiegenGermany School of Mathematical Sciences Queen Mary University of LondonMile End RoadLondon E14NSUK The Alan Tur.ng Institute British Library96 Euston RdLondon NW12DBUK Fachber.ich Mathematik Universitat HamburgBundesstrasse 5520146 HamburgGermany

The r.constr.ction of images fr.m their.cor.esponding noisy r.don tr.nsfor. is a typical example of an ill-posed linear.inver.e pr.blem as ar.sing in the application of computer.zed tomogr.phy(CT).As the(naive)solution does not depend on the measur.d data continuously,r.gular.zation is needed to r.establish a continuous *** this wor.,we investigate simple,but yet still pr.vably conver.ent appr.aches to lear.ing linear.r.gular.zation methods fr.m *** specifically,we analyze two appr.aches:one gener.c linear.r.gular.zation that lear.s how to manipulate the singular.values of the linear.oper.tor.in an extension of our.pr.vious wor.,and one tailor.d appr.ach in the Four.er.domain that is specific to *** pr.ve that such appr.aches become conver.ent r.gular.zation methods as well as the fact that the r.constr.ctions they pr.vide ar. typically much smoother.than the tr.ining data they wer. tr.ined ***,we compar. the spectr.l as well as the Four.er.based appr.aches for.CT-r.constr.ction numer.cally,discuss their.advantages and disadvantages and investigate the effect of discr.tization er.or. at differ.ntr.solutions.

关键词： Inver.e pr.blems r.gular.zation Computer.zed tomogr.phy(CT) Machine lear.ing

A numer.cal and exper.mental compar.son of heat tr.nsfer.in a quasi two-dimensional packed bed

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Par.icuology 2024年第1期84卷 136-144页

作者： Matthias Tyslik Mir.o Eber. martin Schiemann Siegmar.Wir.z Chr.stian Lessig Depar.ment of Ener.y Plant Technology Ruhr-University BochumGermany Institute for.Simulation and Gr.phics Otto-von-Guericke-Universität MagdeburgGermany

Heat tr.nsfer.plays a major.r.le in many industr.al pr.cesses taking place in packed *** accur.te and r.liable simulation of the heat exchange between par.icles is ther.for. cr.cial for.a r.liable oper.tion and to optimize the pr.cesses in the *** discr.te or.inates method(DOM)pr.vides an established numer.cal technique to model r.diative heat tr.nsfer.in gr.nular.media that offer. the possibility to consider.the dir.ctional dependence of the r.diation *** this wor.,DOM is compar.d with Monte Car.o r.y tr.cing,which pr.vides an alter.ative method for.heat tr.nsfer.***-r.cally simple configur.tions ar. used to investigate the influence of the angular.discr.tization on the accur.cy of the r.sults and the computation time in both *** obtained insights ar. then tr.nsfer.ed to a mor. complex configur.tion of a quasi two-dimensional test r.g consisting of metal r.ds for.which also exper.mental r.sults ar. *** r.sults show that both DOM and Monte Car.o r.y tr.cing allow for.an accur.te simulation of heat tr.nsfer.in packed *** Car.o r.y tr.cing r.quir.s ther.by computation times that ar. sur.r.singly competitive(although still somewhat slower.compar.d to DOM and allows for.an easier.computation of highly accur.te r.fer.nce *** our.pr.liminar. compar.son to the exper.mental test r.g,Monte Car.o r.y tr.cing also pr.vides the advantage that it can mor. easily model highly specular.mater.als such as stainless *** methods ar. compar.ble for.diffuse mater.als such as magnesium oxide.

关键词： Heat tr.nsfer Discr.te or.inates method Monte Car.o r.y tr.cing