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Update on human papillomavirus vaccination: Where are we now?

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World Journal of Obstetrics and Gynecology 2016年第1期5卷 5-15页

作者： Eloise chapman-Davis Lauren E Dockery Kendall Griffith Caroline Stroup Department of Obstetrics and Gynecology Division of Gynecologic Oncology Tufts University School of Medicine Tufts Medical Center

Infection with human papillomavirus(HPV) is the major cause of pre-invasive and invasive lesions of the urogenital tract, resulting in morbidity and mortality worldwide. HPV-related infection is responsible for most cases of cervical cancer, a leading cause of cancer death in women worldwide. Developed countries have screening programs in place to detect precancerous lesions at early stages; in resource-limited settings however, HPV related diseases are often identified in advanced stages. This is due to limitations in the availability and roll out of effective screening programs. The relatively recent availability of the HPV vaccine has provided a new public health opportunity to decrease the incidence of HPV-related disease. The high mortality rates seen in developing countries could be reduced through effective implementation of HPV vaccination programs. Large trials have proven the efficacy of bivalent, quadrivalent vaccine and most recently 9-valent vaccine. Uptake in vaccination remains low due to multiple barriers including lack of education, lack of access, and costs. New strategies are being assessed to increase access, increase knowledge and reduce costs that may result in feasible vaccination programs worldwide. The goal of this article is to review the effectiveness and safety of the current HPV vaccines available, vaccine delivery strategies, cost effectiveness, and efforts to improve the acceptability. A literature search was conducted through Pub Med using the terms "HPV vaccination, and safety, and males, and acceptability and strategies, and cost effectiveness,"focusing on articles published between 2006 and 2015. The most relevant and larger scale trials were evaluated for discussion.

关键词： Human papillomavirus Vaccines Cervical cancer Cancer prevention Public health

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销售培训必读 3版

A Weakly Supervised Deep Learning Framework for Sorghum Head Detection and Counting

丛书名：课里播企业培训课程.营销实务学习方案

2001年

作者：（美）Elwood N.chapman 信春霞译

中美合金:本书介绍销售的基本知识，内容包括：态度与销售的成功、怎样销售、重新出发三大部分。

ISBN: (纸本)7810495739

中美合金:本书介绍销售的基本知识，内容包括：态度与销售的成功、怎样销售、重新出发三大部分。

关键词：销售学科:方法

来源：汇雅图书（南通市图书馆... 评论

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Plant Phenomics 2019年第1期1卷 1-14页

作者： Sambuddha Ghosa Bangyou Zheng Scott chapman Andries B.Potgieter David R.Jordan Xuemin Wang Asheesh K.Singh Arti Singh Masayuki Hirafuji Seishi Ninomiya Baskar Ganapathysubramanian Soumik Sarkar Wei Guo Department of Mechanical Engineering Iowa State UniversityAmesIAUSA Department of Computer Science Iowa State UniversityAmesIAUSA CSIRO Agriculture and Food St.LuciaQLDAustralia School of Agriculture and Food Sciences The University of QueenslandGattonQLD 4343Australia Queensland Alliance for Agriculture and Food Innovation(QAAFI) The University of QueenslandGattonQLDAustralia Queensland Alliance for Agriculture and Food Innovation(QAAFI) The University of QueenslandWarwickQLDAustralia Department of Agronomy Iowa State UniversityAmesIAUSA International Field Phenomics Research Laboratory Institute for Sustainable Agro-Ecosystem Services

The yield of cereal crops such as sorghum(Sorghum bicolor ***)depends on the distribution of crop-heads in varying branching ***,counting the head number per unit area is critical for plant breeders to correlate with the genotypic variation in a specific breeding ***,measuring such phenotypic traitsmanually is an extremely labor-intensive process and suffers from low efficiency and human ***,the process is almost infeasible for large-scale breeding plantations or *** learning-based approaches like deep convolutional neural network(CNN)based object detectors are promising tools for efficient object detection and ***,a significant limitation of such deep learningbased approaches is that they typically require a massive amount of hand-labeled images for training,which is still a tedious ***,we propose an active learning inspired weakly supervised deep learning framework for sorghum head detection and counting from UAV-based *** demonstrate that it is possible to significantly reduce human labeling effort without compromising final model performance(R^(2)between human count and machine count is 0.88)by using a semitrained CNN model(i.e.,trained with limited labeled data)to perform synthetic *** addition,we also visualize key features that the network *** improves trustworthiness by enabling users to better understand and trust the decisions that the trained deep learning model makes.

关键词： Unmanned aerial vehicles (UAV)

流动家庭母亲的心声与社会工作的回应——基于T村母亲形象影像发声项目的分析

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中国青年政治学院学报 2013年第5期32卷 86-91页

作者：朱眉华吴世友 Mimi V.chapman 华东理工大学社会工作系上海200237 美国北卡罗来纳大学教堂山分校

运用影像发声法研究流动家庭母亲的生存状况与面临的挑战发现,子女教育、医疗健康、生活环境和闲暇时光是她们的主要关注点。这些主题既反映了她们在家庭教育、健康保护、生存环境和流动历程中的艰辛与困惑,同时也表达了她们对未来生活... 详细信息

运用影像发声法研究流动家庭母亲的生存状况与面临的挑战发现,子女教育、医疗健康、生活环境和闲暇时光是她们的主要关注点。这些主题既反映了她们在家庭教育、健康保护、生存环境和流动历程中的艰辛与困惑,同时也表达了她们对未来生活、社会保障及改善社会政策与社区环境等方面的强烈呼声。影像发声作为一种社区需求的评估方法,有利于社会工作有效地回应流动家庭的需求,并在此基础上提供更适切的专业服务。

关键词：流动家庭母亲社会工作需求评估社区服务影像发声

Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

The influence of resistance training on adipokines in post-menopausal women:A brief review

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Sports Medicine and Health Science 2022年第4期4卷 219-224页

作者： Tomas chapman-Lopez Dylan Wilburn Emma Fletcher Kathleen Adair Ahmed Ismaeel Jeffery Heileson Andrew Gallucci LesLee Funderburk Panagiotis Koutakis Jeffrey S.Forsse Department of Health Human Performance and Recreation Baylor UniversityWacoTX76706USA Clinical Muscle Biology Lab Biology DepartmentBaylor UniversityWacoTX76798USA Department of Physiology University of Kentucky780 Rose St.MS508LexingtonKY40536USA Human Sciences and Design Baylor UniversityWacoTX76798USA

The onset of menopause elicits changes in body composition that negatively influence adipokine ***,various health risk factors(e.g.,cardiovascular disease,osteoporosis,physical inactivity,obesity,arterial hypertension,hypercholesterolemia,sarcopenia)are influenced by adipokines due to changes in body composition after ***,improvements in body composition are considered the primary influencer of *** several therapeutic interventions(e.g.,medication,diet,meditation,exercise)are employed to target changes in body composition,resistance training appears to be more effective in positively improving body composition through changes in lean-muscle mass/fat-mass ***,due to the lack of research,very little is known about adipokines'anti/inflammatory response in postmenopausal women after completing resistance *** resistance training studies in postmenopausal women have focused on leptin,adiponectin,and resistin,with limited research assessing other adipokines that are important in metabolic regulation and inflammatory ***,the consistency of resistance training protocols as an intervention is not standardized or fully ***,the focus of this review is to establish a more comprehensive understanding of the benefits of resistance training on influencing adipokine levels based on changes to total body composition in postmenopausal women.

关键词： Adipokines Post-menopause Resistance training Body composition

Does the Location of the Cutting Flute of Self-Tapping Screws in Bony Substrate Affect the Removal Torque?

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Open Journal of Orthopedics 2015年第1期5卷 1-5页

作者： David James chapman Graham Alistair Spiers Eric Swarts Colin Whitewood Royal Perth Hospital Perth Australia Department of Engineering and Medical Physics Royal Perth Hospital Perth Australia Princess Margaret Hospital Perth Australia

Introduction: An observation was made that when removing self-tapping cortical screws from patients bones, stripping or shearing of the head of the screw occurred more often in screws whose cutting flutes sat in cortical bone compared with screws that had penetrated the distal cortex with flutes exposed. Method: A model was designed to simulate screws with their cutting flutes either in contact with cortical bone or deep to cortical bone. Screws were grouped depending on the location of their cutting flutes and removal torque was measured. Results: Eighteen screws were included in final analysis. There was a statistically significant difference in average initial removal torque and average maximal removal torque with screws with their cutting flutes in substrate requiring significantly more torque to remove. Conclusion: We conclude that self-tapping cortical screws whose cutting flutes sit in cortical substrate require more torque to remove and are therefore more likely to fail. This finding may be used as a guide in pre-operative planning for removal of metalwork from patients.

关键词： Stainless Steel Screws Removal Failure Metalwork Removal Self-Tapping Screws

Water System Condition and Asset Replacement Prioritization

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Journal of Water Resource and Protection 2023年第5期15卷 165-178页

作者： Frederick Bloetscher Zachary Farmer James Barton Teresa chapman Paula Fonseca Monica Shaner Civil Environmental and Geomatics Engineering Florida Atlantic University Boca Raton Florida USA Boynton Beach FL USA

The goal of asset management is to identify and track the maintenance and replacement of assets that have reached their useful life. For that reason, gathering data and collecting information is a critical step when developing an asset management plan. Such data gathering includes physical and operational properties of the assets as well as collecting and tracking important events during the lifespan of the asset (i.e., pipe breaks, replacement year, maintenance performed, etc.). Critical factors in the asset management plan may be overlooked when there is no data or poor quality data. However, many utilities lack the resources for examining buried infrastructure and lack good quality work order data, so other methods of data collection are needed. The concept for this paper was to develop a means to acquire data on the assets for a condition assessment to identify pipes that were most likely to break and those with the highest consequences for same. Three utilities were used as examples. It was found that for buried infrastructure, much more information was known than anticipated but the actual predictions relied on only a few factors related to pipe type. However, there is a need to track the consequences, in this case breaks, which would indicate a failure. The latter would be useful for predicting future maintenance needs and the most at-risk assets, but is often missing in utility systems as many utilities do not adequately track breaks sufficiently. In this case two utilities were analyzed and predication on a third was developed.

关键词： Water Main Predicted Failure Asset Management Pipe Failure Water Distributions

Three-dimensional assessment of movement patterns of Sichuan snub-nosed monkeys affected by habitat structure in temperate forests

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Zoological Research 2023年第2期44卷 361-365页

作者： Hai-Tao Yang Shun Li Rong Hou Wen-Tao Song Yan-Wen Fu Yong-Bo Li Xiao-Wei Wang Gang He Colin A.chapman Qing-Hua Guo Bao-Guo Li Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Institute of Remote Sensing and Geographic Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Ministry of Education Key Laboratory of Poyang Lake Wetland and Watershed Research College of Geography and EnvironmentJiangxi Normal UniversityNanchangJiangxi 330022China College of Life Sciences Beijing Normal UniversityBeijing 100875China Shaanxi Key Laboratory for Animal Conservation Shaanxi Institute of ZoologyShaanxi Academy of SciencesXi’anShaanxi 710032China Biology Department Vancouver Island UniversityBritish ColumbiaV5K0A1 Canada School of Life Sciences University of KwaZulu-NatalPietermaritzburg 3200South Africa

DEAR EDITOR,Movement patterns can reflect species-specific characteristics of individuals and animal groups at a given scale. Accurate three-dimensional(3D) assessment can quantify the relationship between movement patterns of an animal and its unique habitat. Here, we evaluated the effects of habitat structure on movement patterns of the golden snub-nosed monkey(Rhinopithecus roxellana). We used airborne light detection and ranging(LiDAR) to map the 3D structure of the temperate forest in the Qinling Mountains(Shaanxi, China).

关键词： habitat movement temperate