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BIOCELL 2016年第1期40卷 19-21页

作者： NIDIA FERRAROTTI ROSARIO MUSACCO-SEBIO CHRISTIAN SAPORITO-MAGRINA JUAN MANUEL ACOSTA marisa repetto Clinical Biochemistry Department Faculty of Pharmacy and BiochemistryInstitute of Biochemistry and Molecular Medicine(IBIMOL)University of Buenos Aires-CONICETBuenos AiresArgentina General and Inorganic Chemistry Faculty of Pharmacy and BiochemistryInstitute of Biochemistry and Molecular Medicine(IBIMOL)University of Buenos Aires-CONICETBuenos AiresArgentina.

The objective of this work was to study the in vivo time course of biochemical processes of oxidative damage in the brain of Sprague-Dawley rats that received an acute overload of the redox active metals iron(Fe)and copper(Cu),and the redox inactive cobalt(Co)and nickel(Ni).Oxidative stress indicators(phospholipid and protein oxidation),glutathione(GSH),antioxidant enzymes and NADPH oxidase activities,and the plasma inflam-matory cytokine(IL-6)were *** results showed that in brain oxidative mechanisms for both sets of metal are different,however in both cases are *** mechanism for Fe and Cu oxidative damage is mediated by the generation of the free radical hydroxyl(Fenton reaction and homolytic cleavage of hydroperoxides).Two events of antioxidant protection prior to oxidation of phospholipids and proteins by Fe and Cu are *** first process is the use of GSH and the second is the increased activity of the Cu,Zn-SOD and catalase *** oxidative mechanism for metal redox inactive is the consumption of GSH,NADPH oxidase activation and inflammatory response mediated by *** increased protein oxidation as a result of the inflammatory *** produced increments of phospholipid oxidation and SOD activity.

关键词： metals oxidative damage oxidative stress brain lipid peroxidation

Extreme Weather Disruptions and Emergency Preparedness Among Older Adults in Ohio: An Eight-County Assessment

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International Journal of Disaster Risk Science 2024年第2期15卷 213-225页

作者： Smitha Rao Fiona C.Doherty Anthony Traver marisa Sheldon Emma Sakulich Holly Dabelko‑Schoeny College of Social Work The Ohio State UniversityColumbusOH 43210USA Age Friendly Innovation Center College of Social WorkThe Ohio State UniversityColumbusOH 43210USA College of Public Health The Ohio State UniversityColumbusOH 43210USA

The disproportionate risks and impacts of climate change and extreme weather on older adults are increasingly evident. While especially true in disaster-prone areas, human-caused climate change introduces an element of uncertainty even in previously identified “safe” regions such as the Midwestern United States. Using a cumulative disadvantage and vulnerability-informed framework and descriptive statistics from multiple data sources, this article provides an overview of climate impacts, vulnerabilities, and county-level characteristics, focusing on older adults living in Central Ohio. A comparative multiple-case study methodology was used to triangulate regionally representative primary and secondary data sources to examine state and county-level measures of vulnerability, emergency preparedness, and disruptions caused by extreme weather among older adults across eight counties in Central Ohio. Seventy-eight percent of older adults in the sample reported being prepared for emergencies per Federal Emergency Management Agency guidelines. Older adults in Union County reported the highest rates of preparedness, while those in Fayette County reported the lowest. County-level rates of disruption of life activities by extreme weather ranged widely. Among the most rural in the region, Fayette County emerged as uniquely disadvantaged, with the lowest median income, the most vulnerable across multiple social vulnerability dimensions, and the most reported disruptions to life activities from extreme weather. County profiles offer a snapshot of existing vulnerabilities, socioeconomic conditions, special needs, preparedness, and current disruptions among older adults in the region and can inform resource mobilization across community and policy contexts.

关键词： Disaster preparedness Extreme weather Midwestern United States Older adults Regional assessment Social vulnerability

Utility of Preoperative Positron Emission Tomography (PET) in Localizing Perforator Vessels of Anterolateral Thigh Free Flap

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第4期13卷 275-284页

作者： Alexandra McMillan Sameer A. Alvi Zaid Al-Qurayshi Zachary Fleishacker Nitin A. Pagedar marisa R. Buchakjian Department of Otolaryngology University of Iowa Hospitals and Clinics Iowa City IA USA Division of Otolaryngology-Head & Neck Surgery North Shore University Health System Evanston IL USA Pritzker School of Medicine The University of Chicago Chicago IL USA Holden Comprehensive Cancer Center University of Iowa Iowa City IA USA

Objectives: The anterolateral thigh (ALT) flap is often considered the workhorse in soft tissue reconstruction of head and neck defects secondary to trauma, infection, or tumor resection. Despite its many advantages, ALT flaps have been criticized due to variability in vasculature, which may result in inadequate or non-existent perforators. This retrospective study aims to investigate the utility and validity of positron emission tomography (PET) scan to identify the location and characteristics of perforators to the ALT flap. Methods: We performed a 10-year retrospective review of ALT flaps at our institution to identify patients with preoperative PET scans available for analysis. Three reviewers (attending physician, fellow, and resident) were asked to identify the number, location, and characteristics (myocutaneous versus septocutaneous) of ALT perforators on imaging, and reviewer agreement was assessed. Results were then compared to available operative data. Results: One hundred twenty-one patients were identified who underwent ALT free flap surgery. Thirty-eight preoperative PET scans were identified for review. At least one perforator was identified in 92.1% of scans. Agreement percentages regarding the number of perforators ranged from 53% - 61% whereas agreement regarding the location of a single perforator ranged from 79% - 90%. However, reviewers did not agree regarding the type of perforator, with agreement ranging from 34% - 53%. Poor agreement was observed when compared to intraoperative data, with the number of perforators ranging from 26% - 34% and the type of perforator 11% - 24%. These findings are likely due to insufficient data available in operative reports. Conclusion: Although initial studies suggest that PET scan shows promising evidence to support the capacity to preoperatively identify ALT perforators, future prospective studies are warranted to fully validate these findings.

关键词： Anterolateral Thigh Flaps Positron Emission Tomography Head and Neck Defects Perforator Mapping

Improving the health and treatment success rates of in vitro fertilization patients with traditional Chinese medicine:Need for more robust evidence and innovative approaches

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Journal of Integrative Medicine 2022年第3期20卷 187-192页

作者： marisa Casale School of Public Health University of the Western CapeRobert Sobukwe RoadBellville 7535South Africa

Maximising access to and the success of fertility treatments should be a priority for global reproductive health,as should overall patient *** demand for in vitro fertilization(IVF)and other assisted fertility treatments has increased over the past decade and is likely to further increase in years to ***,there is still considerable unmet demand for infertility support ***,the high emotional,physical and financial burden experienced by individuals undergoing IVF cycles can be a risk for their mental and physical health,which in turn can influence treatment continuation and the likelihood of IVF *** from various parts of the world show that most individuals undergoing IVF also use adjunct alternative medicines and procedures,the most common being traditional Chinese medicine(TCM).The complementary and synergistic role of TCM for individuals undergoing IVF is an area that merits further attention and research,both for its potential positive effects on IVF success rates and for its broader physical and mental health ***,much of the existing evidence is not sufficiently robust or consistent for findings to be adopted with *** commentary argues that much work must be done to understand the efficacy and clinical best practices for these integrated *** can be achieved in part by developing more robust and clinically relevant randomized controlled trial protocols,collecting and triangulating evidence through a variety of study designs and methods,and strengthening the collection and pooling of clinic-level data.

关键词： In vitro fertilization Traditional Chinese medicine Mental health Pregnancy rates

An experimental model of vitreous motion induced by eye rotations

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Eye and Vision 2015年第1期2卷 85-94页

作者： Andrea Bonfiglio Alberto Lagazzo Rodolfo repetto Alessandro Stocchino Department of Civil Chemical and Environmental EngineeringUniversity of GenoaItalyVia Montallegro 116145 GenoaItaly

Background:During eye rotations the vitreous humour moves with respect to the eye *** relative motion has been suggested to possibly have an important role in inducing degradation of the gel structure,which might lead to vitreous liquefaction and/or posterior vitreous *** of the present work is to study the characteristics of vitreous motion induced by eye ***:We use an experimental setup,consisting of a Perspex model of the vitreous chamber that,for simplicity,is taken to have a spherical *** model is filled with an artificial vitreous humour,prepared as a solution of agar powder and hyaluronic acid sodium salt in deionised water,which has viscoelastic mechanical properties similar to those of the real *** model rotates about an axis passing through the centre of the sphere and velocity measurements are taken on the equatorial plane orthogonal to the axis of rotation,using an optical ***:The results show that fluid viscoelasticity has a strong influence on flow *** particular,at certain frequencies of oscillation of the eye model,fluid motion can be resonantly *** means that fluid velocity within the domain can be significantly larger than that of the ***:The frequencies for which resonant excitation occurs are within the range of possible eye rotations ***,the present results suggest that resonant excitation of vitreous motion is likely to occur in ***,in turn,implies that eye rotations produce large stresses on the retina and within the vitreous that may contribute to the disruption of the vitreous gel *** present results also have implications for the choice of the ideal properties for vitreous substitute fluids.

关键词： Vitreous motion Vitreous dynamics Retinal detachment Viscoelasticity

Smart mobility and public transport:Opportunities and challenges in rural and urban areas

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 88-97页

作者： Simone Porru Francesco Edoardo Misso Filippo Eros Pani Cino repetto T Bridge S.p.A. Genoua 16124Italy

Demographic changes in peripheral areas are pressuring the regional public transport systems to adopt innovative *** employment of internet of things(IoT)technologies has proven to be a valid response to mobility challenges in rural areas,and has brought up the concept of"smart land".Framed within the context of the Interreg Central Europe project RUMOBIL,this study tries to shed light on how the deployment of smart mobility solutions within the rural context compare to that within the urban *** a literature review,we compared the ease of implementation of different IoT solutions on the urban and the rural contexts,for planners,travellers,and operators,and the relative complexity of common smart mobility *** addition,we identified three major challenges for both rural and urban mobility,namely the need for standardized metrics for optimal routes’detection and a dynamic definition of optimal route,as well as the simplification of investments’planning and *** smart cities and smart land can benefit from smart mobility solutions,even if in most cases,each of the two contexts can gain more advantages than the other from the same *** considering the different levels of population scattering,technological infrastructures,social maturity,and economic opportunities,both rural and urban areas offer comparable *** the future of transport,it is up to all policy levels to consider the challenges deriving from expected trends and leverage the untapped potential of IoT technologies to satisfy future travellers’needs and ensure sustainability.

关键词： Transportation engineering Smart mobility Internet of things Public transport Smart city Smart land

Biosorption of mercury by Macrocystis pyrifera and Undaria pinnatifida:Influence of zinc,cadmium and nickel

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Journal of Environmental Sciences 2011年第11期23卷 1778-1786页

作者： Josefina Plaza marisa Viera Edgardo Donati Eric Guibal Centro de Investigacióny Desarrollo en Fermentaciones Industriales CINDEFI (CCT La Plata-CONICET UNLP)Facultad de Ciencias Exactas50 y 115(1900) La PlataArgentina Ecole des Mines d'Ale`s Laboratoire Ge'nie de l'Environnement Industriel6avenue de Clavie`resF-30319 Ale`s cedexFrance Ecole des Mines d‘Ale`s Laboratoire Ge'nie de l‘Environnement Industriel6avenue de Clavie`resF-30319 Ale`s cedexFrance

This study investigated the adsorption of Hg（Ⅱ） on Macrocystis pyrifera and Undaria pinnatifida in monometallic system in the presence of Zn（II）,Cd（Ⅱ） and Ni（II）.The two biosorbents reached the same maximum sorption capacity （q m = 0.8 mmol/g） for *** showed a greater affinity （given by the coefficient b of the Langmuir equation） for mercury compared to *** （4.4 versus 2.7 L/mmol）.Mercury uptake was significantly reduced （by more than 50%） in the presence of competitor heavy metals such as Zn（II）,Cd（II） and Ni（Ⅱ）.Samples analysis using an environmental scanning electron microscopy equipped with an energy dispersive X-ray microanalysis showed that mercury was heterogeneously adsorbed on the surface of both biomaterials,while the other heavy metals were homogeneous *** analysis of biosorbents by Fourier transform infrared spectrometry indicated that Hg（Ⅱ） binding occurred on S=O （sulfonate） and N-H （amine） functional groups.

关键词： mercury isotherm sorption M.pyrifera U.pinnatifida ESEM-EDX FT-IR spectrometry

Short-term captivity influences maximal cold-induced metabolic rates and their repeatability in summer-acclimatized American goldfinches Spinus tristis

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Current Zoology 2013年第4期59卷 439-448页

作者： David L. SWANSON marisa O. KING Department of Biology University of South Dakota Vermillion SD 57069 USA

Studies of metabolic variation in birds have involved both wild and captive individuals, but few studies have investi- gated whether captivity directly influences metabolic rates, despite such variation potentially confounding conclusions regarding how metabolic rates respond to the conditions under study. In addition, whether short-term captivity influences metabolic rate re- peatability in birds is currently uninvestigated. In this study, we measured Msum （maximal cold-induced metabolic rates） in sum- mer acclimatized American goldfinches Spinus tristis directly after capture from wild populations, after approximately 2 weeks of indoor captivity （Captive 1）, and again after an additional 1-2 weeks of captivity （Captive 2）. M~ increased significantly （16.9%） following the initial captive period, but remained stable thereafter. Body mass （Mb） also increased significantly （9.2%） during the initial captive period but remained stable thereafter, suggesting that muscle growth and/or remodeling of body composition pro- duced the observed metabolic variation. Mb and Msum were not significantly repeatable between wild and Captive 1 birds, but were significantly repeatable between Captive 1 and Captive 2 groups. These data suggest that caution must be exercised when extrapolating metabolic rates from short-term captive to wild populations. In addition, Msum was a repeatable trait for birds under conditions where mean metabolic rates remained stable, but Msum repeatability disappeared during acclimation to conditions pro- moting phenotypically flexible metabolic responses. This suggests that the capacity for phenotypic flexibility varies among indi- viduals, and such variation could have fitness consequences

关键词： Metabolic rates Msm Birds Captivity Repeatability Phenotypic flexibility

Cecal microbiota transplantation:unique influence of cecal microbiota from divergently selected inbred donor lines on cecal microbial profile,serotonergic activity,and aggressive behavior of recipient chickens

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畜牧与生物技术杂志:英文版 2023年第5期14卷 1986-2001页

作者： Yuechi Fu Jiaying Hu marisa A.Erasmus Huanmin Zhang Timothy A.Johnson Hengwei Cheng Department of Animal Sciences Purdue UniversityWest LafayetteIN 47907USA Avian Disease and Oncology Laboratory USDA-ARSEast LansingMI 48823USA Livestock Behavior Research Unit USDA-ARSWest LafayetteIN 47907USA

Background Accumulating evidence from human trials and rodent studies has indicated that modulation of gut microbiota affects host physiological homeostasis and behavioral ***,alterations in gut micro-biota could be a feasible strategy for reducing aggressive behavior and improving health in *** study was conducted to determine the effects of early-life cecal microbiota transplantation(CMT)on cecal microbial composi-tion,brain serotonergic activity,and aggressive behavior of recipient *** Chicken lines 63 and 72 with nonaggressive and aggressive behavior,respectively,were used as donors and a commercial strain Dekalb XL was used as recipients for ***-four 1-d-old male chicks were randomly assigned to 1 of 3 treatments with 7 cages per treatment and 4 chickens per cage(n=7):saline(control,CTRL),cecal solution of line 6_(3)(6_(3)-CMT),and cecal solution of line 7_(2)(7_(2)-CMT).Transplantation was conducted via oral gavage once daily from d 1 to 10,and then boosted once weekly from week 3 to *** weeks 5 and 16,home-cage behavior was recorded,and chickens with similar body weights were assigned to paired aggression tests between the *** of blood,brain,and cecal content were collected from the post-tested chickens to detect CMT-induced biological and microbiota *** 63-CMT chickens displayed less aggressive behavior with a higher hypothalamic serotonergic activity at week ***,two amplicon sequence variants(ASVs)belonging to Lachnospiraceae and one Ruminococ-caceae UCG-005 ASV were positively correlated with the levels of brain tryptophan and serotonin,respectively.7_(2)-CMT chickens had lower levels of brain norepinephrine and dopamine at week 5 with higher levels of plasma serotonin and tryptophan at week *** belonging to Mollicutes RF39 and GCA-900066225 in 7_(2)-CMT chickens were nega-tively correlated with the brain 5-hydroxyindoleacetic acid(5-HIAA)at week 5,and one Bac

关键词： Aggressive behavior Cecal microbiota transplantation Chicken Microbiota-gut-brain axis Serotonergic activity

Analysis of Pioneering Computable Biomedical Knowledge Repositories and their Emerging Governance Structures

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Data Intelligence 2022年第3期4卷 653-669页

作者： Philip Sahr Amara marisa Conte Allen Flynn Jodyn Platt Marie Grace Trinidad Department of Learning Health Sciences University of Michigan Medical SchoolMichigan 48109-0624USA Taubman Health Sciences Library University of Michigan Michigan 48109-1382USA School of Public Health University of MichiganMichigan 48109-2029USA

A growing interest in producing and sharing computable biomedical knowledge artifacts(CBKs) is increasing the demand for repositories that validate, catalog, and provide shared access to CBKs. However, there is a lack of evidence on how best to manage and sustain CBK repositories. In this paper, we present the results of interviews with several pioneering CBK repository owners. These interviews were informed by the Trusted Repositories Audit and Certification(TRAC) framework. Insights gained from these interviews suggest that the organizations operating CBK repositories are somewhat new, that their initial approaches to repository governance are informal, and that achieving economic sustainability for their CBK repositories is a major challenge. To enable a learning health system to make better use of its data intelligence, future approaches to CBK repository management will require enhanced governance and closer adherence to best practice frameworks to meet the needs of myriad biomedical science and health communities. More effort is needed to find sustainable funding models for accessible CBK artifact collections.

关键词： Computable Biomedical Knowledge Governance Repository Trust Sustainability