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Proline as a biochemical marker in relation to the ecology of two halophytic Juncus species

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Journal of Plant Ecology 2013年第2期6卷 177-186页

作者： Monica Boscaiu cristina Lull Josep Llinares Oscar vicente Herminio Boira Instituto Agroforestal Mediterráneo(IAM UPV)Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain RE-FOREST Departamento de Ingeniería Hidráulica y Medio AmbienteUniversitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain Instituto de Investigación para la Gestión Integral de Zonas Costeras(IGIC UPV)Universitat Politècnica de ValènciaCalle Paranimf 146730 Grau de GandíaValenciaSpain Instituto de Biología Molecular y Celular de Plantas(IBMCP UPV-CSIC)Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain

Aims osmolytes,used for maintaining osmotic balance and as‘osmoprotectants’,are synthesized in plants as a general,con-served response to abiotic stress,although their contribution to stress-tolerance mechanisms remains ***,the most common osmolyte,accumulates in many plant species in parallel with increased external salinity and is considered a reliable bio-chemical marker of salt *** have measured proline levels in two halophytic,closely related Juncus species under laboratory and field conditions to assess the possible relevance of proline biosynthesis for salt tolerance and therefore for the ecology of these two *** Proline was quantified in plants treated with increasing NaCl con-centrations and in plants sampled in two salt marshes located in the provinces of Valencia and alicante,respectively,in southeast *** conductivity,pH,Na+and Cl−concentrations were measured in soil samples collected in parallel with the plant *** Findings Treatment with NaCl inhibited growth of *** plants in a concentration-dependent manner,but only under high salt conditions for *** treatments led to proline accumulation in both species,especially in the more salt-tolerant *** results,obtained under laboratory conditions,were confirmed in plants sam-pled in the *** all the samplings,proline contents were signifi-cantly lower in *** than in the more tolerant *** growing in the same *** direct correlation between soil salinity and proline levels could be established,but seasonal variations were detected,with increased proline contents under accentuated water deficit *** results suggest that proline biosynthesis is not only an induced,general response to salt stress but also an important contributing factor in the physiological mechanisms of salt tolerance in Juncus,and that it therefore correlates with the ecology of both species.

关键词： halophytes Juncus acutus Juncus maritimus osmolytes salt stress

Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： Ana vicente Ana Calvo Ana P.Fernandes Teresa Nunes cristina Monteiro Casimiro Pio Célia Alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

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Translational Neurodegeneration 2023年第1期12卷 722-744页

作者： cristina de Dios Xenia Abadin vicente Roca-Agujetas Marina Jimenez-Martinez Albert Morales Ramon Trullas Montserrat Mari Anna Colell Department of Cell Death and Proliferation Institut d’Investigacions Biomèdiques de BarcelonaConsejo Superior de Investigaciones Científicas(CSIC)Institut d’Investigacions Biomèdiques August Pi I Sunyer(IDIBAPS)BarcelonaSpain Centro de Investigación Biomédica en Red Sobre Enferme-dades Neurodegenerativas(CIBERNED) MadridSpain Department of Biomedicine Faculty of MedicineUniversitat de BarcelonaBarcelonaSpain Present Address:Department of Biochemistry and Molecular Biology Faculty of PharmacyUniversidad de Sevilla.Instituto de Biomedicina de Sevilla(IBiS)-Hospital Universitario Virgen del Rocío/CSICSevilleSpain Present Address:Department of Clinical Immunology and Rheumatology Amsterdam UMCAmsterdamNetherlands

Background Persistent inflammatory response in the brain can lead to tissue damage and *** Alzheimer’s disease(AD),there is an aberrant activation of inflammasomes,molecular platforms that drive inflammation through caspase-1-mediated proteolytic cleavage of proinflammatory cytokines and gasdermin D(GSDMD),the executor of ***,the mechanisms underlying the sustained activation of inflammasomes in AD are largely *** have previously shown that high brain cholesterol levels promote amyloid-β(Aβ)accumulation and oxidative ***,we investigate whether these cholesterol-mediated changes may regulate the inflam-masome *** SIM-A9 microglia and SH-SY5Y neuroblastoma cells were cholesterol-enriched using a water-soluble cholesterol *** exposure to lipopolysaccharide(LPS)plus muramyl dipeptide or Aβ,activation of the inflammasome pathway was analyzed by immunofluorescence,ELISA and immunoblotting ***-labeled Aβwas employed to monitor changes in microglia *** medium was used to study how microglia-neuron interrelationship modulates the inflammasome-mediated *** In activated microglia,cholesterol enrichment promoted the release of encapsulated IL-1βaccompanied by a switch to a more neuroprotective phenotype,with increased phagocytic capacity and release of neurotrophic *** contrast,in SH-SY5Y cells,high cholesterol levels stimulated inflammasome assembly triggered by both bacterial toxins and Aβpeptides,resulting in GSDMD-mediated ***(GSH)ethyl ester treatment,which recovered the cholesterol-mediated depletion of mitochondrial GSH levels,significantly reduced the Aβ-induced oxidative stress in the neuronal cells,resulting in lower inflammasome activation and cell ***,using conditioned media,we showed that neuronal pyroptosis affects the function of the cholesterol-enriched microglia,lowering its phagocytic activity and,the

关键词： Neuroinflammation Mitochondrial oxidative stress Phagocytosis Alzheimer’s disease DAM signature NLRP3

I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life

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World Journal of Gastroenterology 2014年第26期20卷 8709-8716页

作者： vicente Lorenzo-Zú?iga Elba Llop cristina Suárez Beatriz álvarez Luis Abreu Jordi Espadaler Jordi Serra Gastroenterology Motility and Functional Gut Disorders UnitHospital Universitari Germans Trias i Pujol/CIBERehd Gstroenterology Hospital Puerta de Hierro AB-Biotics

AIM: To determine the dose-related effects of a novel probiotic combination, I.31, on irritable bowel syndrome (IBS)-related quality of life (IBS-QoL).

关键词： Irritable bowel syndrome Probiotic combination Irritable bowel syndrome Quality-of-life

Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment

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World Journal of Gastroenterology 2014年第38期20卷 13999-14003页

作者： cristina Sánchez-Montes vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra vicente Garrigues Julio Ponce Pilar Nos Gastroenterology Unit Hospital Universitari i Politécnic La Fe

AIM: To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth (SIBO) in patients with inactive Crohn’s disease (CD).

关键词： Crohn’ s disease Bacterial overgrowth Thiopurines Biologics Inflammatory bowel disease

Intestinal preparation prior to capsule endoscopy administration

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World Journal of Gastroenterology 2008年第37期14卷 5773-5775页

作者： vicente Pons Beltrán cristina Carretero Begoa Gonzalez-Suárez Iaqui Fernández-Urien Miguel Muoz-Navas Gastroenterology Department Hospital La FeValencia 46009 Spain Gastroenterology Department University of NavarraPamplona 31008 Spain Gastroenterology Department Hospital del MarBarcelona 08036 Spain

In order to have an adequate view of the whole small intestine during capsule endoscopy, the preparation recommended consists of a clear liquid diet and an overnight fast. However, visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents. To improve mucosal visualization, some authors have evaluated different regimens of preparation. There is no consensus about the necessity of intestinal preparation for capsule endoscopy and it should be interesting to develop adequate guidelines to improve its efficacy and tolerability. Moreover, the effect of preparation type (purgative) on intestinal transit time is not clear. Since a bowel preparation cannot defini-tively improve its visibility (and theoretically the yield of the test), it is not routinely recommended.

关键词： Capsule endoscopy Intestinal preparation Polyethylene glycol Aqueous sodium phosphate

A Pilot Test for A One-year Cognitive Training Intervention in Elderly Adults with Mild Cognitive Impairment

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Biomedical and Environmental Sciences 2020年第10期33卷 796-802页

作者： MENDOZA-HOLGADO cristina LOPEZ-ESPUELA Fidel MORAN Jose Maria RONCERO-MARTIN Raul LAVADO-GARCIA Jesus ALIAGA Ignacio PUERTO-PAREJO Luis Manuel LEAL-HERNANDEZ Olga VERA vicente PEDRERA-CANAL Maria Nursing Department Metabolic Bone Disease Research GroupUniversity of ExtremaduraNursing and Occupational Therapy CollegueAvd.Universidad s/n10003-CaceresSpain Facultad de Odontologia Universidad ComplutenseMadridSpain

In Spain,the proportion of elderly individuals has increased to 19.1%.By 2068,the proportion of elderly individuals is estimated to increase to 29.4% given the largest birth cohorts in Spain’s history(Instituto Nacional de Estadistica,INE).This challenge needs a supportive plan,as economic and caring problems may occur because of age-related health problems,including cognitive decline and dementia[1].

关键词： elderly Pilot Training

Intracameral 5-fluorouracil and viscous dispersive viscoelastic for diffuse epithelial downgrowth management in aphakia

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 845-847页

作者： Santiago Montolío-Marzo Ester Fernández-López Jose vicente Piá-Ludena Juan María Davó-Cabrera Enrique Antonio Alfonso-Munoz cristina Peris-Martínez FISABIO Oftalmología Médica Valencia 46015Spain

Dear Editor,I am *** Montolío-Marzo from FISABIO Oftalmología Médica,Valencia,Spain.I write you to present a case report of epithelial downgrowth in an aphakic *** epithelial downgrowth is one of the most feared complications in cases of penetrating ocular trauma or recurrent ocular *** progress can affect all the ocular structures,giving rise to corneal decompensation,retinal detachment,difficult-to-treat glaucoma or phthisis bulbi and many cases end in enucleation[1].Fortunately,the incidence of this condition is very low,there being between 0.08%and 0.12%after cataract surgery and 0.25%after penetrating *** infrequency means that scientific evidence is reduced to case series and the opinions of experts without there being a homogeneous criterion to guide the work of the doctor in *** these reasons,epithelial downgrowth is still a diagnostic and therapeutic challenge.

关键词： viscoelastic viscous camera

Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?

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World Journal of Gastroenterology 2014年第39期20卷 14472-14478页

作者： Ignacio Fernandez-Urien cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas vicente Pons Cesar Prieto Julio Valle Department of Gastroenterology Hospital de Navarra 31008 Pamplona Spain Department of Gastroenterology Clínica Universidad de Navarra 31008 Pamplona Spain Department of Gastroenterology Hospital Juan Canalejo 26131 La Coru?a Spain Department of Gastroenterology Hospital de Tarrasa 08509 Barcelona Spain Department of Gastroenterology Hospital del Mar 08509 Barcelona Spain Department of Gastroenterology Hospital General de Valencia 46367 Valencia Spain Department of Gastroenterology Hospital Puerta de Hierro 28816 Madrid Spain Department of Gastroenterology Hospital La Fe 46367 Valencia Spain Department of Gastroenterology Hospital Gregorio Mara?ón 28816 Madrid Spain Department of Gastroenterology Complejo Hospitalario de Toledo 45591 Toledo Spain

AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact.

关键词： Capsule endoscopy Small bowel Diagnostic accuracy Frames Lesions Landmarks