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Hemiarthroplasty for irreparable distal radius fractures in the elderly:A comprehensive review

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World Journal of Orthopedics 2024年第6期15卷 578-584页

作者： Adriano Cannella Ludovico Caruso giulia maria Sassara Giuseppe Taccardo Marco Passiatore Marina Marescalchi Rocco De Vitis Department of Orthopaedics Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy

BACKGROUND Elderly patients maintaining functional independence can now be candidates for primary wrist hemiarthroplasty to manage acute irreparable distal radius fractures(DRFs).However,further investigation with long-term follow-up is required to validate these initial *** To review the literature on the outcomes of distal radius hemiarthroplasty with available implants to assess its viability as a treatment *** A comprehensive review of the literature was conducted using electronic databases,including PubMed,Medline,and *** search terms employed were"distal radius fracture","hemiarthroplasty","wrist arthroplasty",and related *** search was restricted to articles published in English from 1980 until June *** criteria encompassed cases or case series of DRF treated with hemiarthroplasty,providing clinical or radiographic outcomes,and published in peer-reviewed *** A total of 2508 articles from PubMed and 883 from Scopus were identified *** screening and removal of duplicates,13 articles met the inclusion *** articles,predominantly clinical retrospective studies,provided insights into hemiarthroplasty outcomes,including functional improvements and *** was a treatment option for complex DRF,particularly those cases with severe comminution,intraarticular involvement,or severe *** outcomes demonstrated improvements in pain relief,wrist mobility,and grip strength,with variability across *** included implant loosening,infection,nerve injury,and stiffness,with varying incidence rates influenced by surgical techniques and implant ***-term outcomes were inadequately documented,warranting further *** Hemiarthroplasty is a promising treatment for irreparable DRF in the ***-term outcomes and complications require further study.

关键词： Irreparable distal radius fracture Hemiarthroplasty Osteoporosis Wrist prosthesis Elderly

Long-term assessment of collagenase treatment for Dupuytren’s contracture:A 10-year follow-up study

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World Journal of Orthopedics 2024年第4期15卷 355-362页

作者： Marco Passiatore Vitale Cilli Adriano Cannella Ludovico Caruso giulia maria Sassara Giuseppe Taccardo Rocco De Vitis Department of Bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy Department of Chirurgie de la Main Centre Hospitalier Interregional Edith CavellBruxelles 1160Belgium Department of Orthopedics Fondazione Policlinico Universitario Agostino Gemelli IRCSSRome 00168Italy

BACKGROUND Enzymatic fasciotomy with collagenase clostridium histolyticum(CCH)has revolutionized the treatment for Dupuytren’s contracture(DC).Despite its benefits,the long-term outcomes remain *** study presented a comprehensive 10-year follow-up assessment of the enduring effects of CCH on patients with *** To compare the short-term(12 wk)and long-term(10 years)outcomes on CCH treatment in patients with *** A cohort of 45 patients was treated with CCH at the metacarpophalangeal(MCP)joint and the proximal interphalangeal(PIP)joint and underwent systematic *** study adhered to multicenter trial protocols,and assessments were conducted at 12 wk,7 years,and 10 years *** Thirty-seven patients completed the 10-year *** 10 years,patients treated at the PIP joint exhibited a 100%***,patients treated at the MCP joint only showed a 50%*** satisfaction varied,with a lower satisfaction reported in PIP joint *** exceeding 20 degrees on the total passive extension deficit was observed,indicating a challenge for sustained *** differences were noted between outcomes at the 7-year and 10-year *** CCH demonstrated sustained efficacy when applied to the MCP ***,caution is warranted for CCH treatment at the PIP joint due to a high level of recurrence and low patient ***-intervention is needed within a decade of treatment.

关键词： Collagenase Xiapex Dupuytren disease Dupuytren recurrence Long term follow-up

Orthopedic manifestations of Li-Fraumeni syndrome:Prevention and treatment of a polymorphic spectrum of malignancies

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World Journal of Clinical Cases 2024年第26期12卷 5839-5844页

作者： giulia Cenci Valerio Pace Department of Trauma and Orthopedics Azienda Ospedaliera Santa Maria HospitalTerni 05100Italy Department of Trauma and Orthopedics AOSP TerniTerni 05100Italy

Li-Fraumeni syndrome(LFS)is a rare hereditary cancer predisposition syndrome characterized by a heightened risk of developing various malignancies at an early *** evidence suggests a correlation between LFS and orthopedic manifestations,underscoring the importance of orthopedic screening in individuals with this *** cancer is *** is estimated that more than 10%-15%of tumors are secondary to a pathogenic variant in a cancer predisposition *** than 100 cancer predisposition genes and their association with syndromes or isolated tumors have been *** is one of those who have been most widely *** with this syndrome present a high risk of developing one or more *** knowledge enables the establishment of a follow-up protocol for the patient and affected family members,facilitating early detection of new tumors and reducing tumor and treatment-related morbidity and *** primary objective of this invited editorial article is to provide a thorough review of the existing knowledge of LFS and its polymorphic spectrum of related malignancies,with a focus on aspects directly linked to orthopedic *** objective is to offer an update on the most modern prevention,treatment and follow up guidelines that could be useful for the physicians dealing with this cohort of patients.

关键词： Li-Fraumeni syndrome Tumor protein P53 Orthopedic diseases Osteosarcoma Chondrosarcoma Screening Prevention

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco maria Lisci Antonio maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi maria Chiara Spera Valeria De Masi Ester maria Marzo Francesca Abate Gianluca Boggio maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

Digitalization in Disaster Risk Reduction:The Use of Smartphones to Enhance the Safety of Informal Settlements in Iringa,Tanzania

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International Journal of Disaster Risk Science 2023年第2期14卷 171-182页

作者： giulia Jole Sechi Eefje Hendriks maria Pregnolato Department of Architecture Universitat Internacional de Catalunya08018BarcelonaSpain Faculty of Geo-Information Science and Earth Observation University of Twente7514 AEEnschedeThe Netherlands Department of Civil Engineering University of BristolBristolBS81QUUK

Housing in informal settlements often lacks construction techniques that adopt criteria of resilience to natural *** are rapidly diffusing in economically developing *** aim of this study was to assess the current use of smartphones by the masons of the informal settlements of Iringa,Tanzania,and to identify pathways for improving their construction *** were collected through a mixed method approach that includes in-depth interviews,surveys,and a focus group with *** results reveal that only a few masons received formal training,most of them have never interacted with a qualified engineer nor consulted trained professionals when *** masons own a smartphone and they extensively use it to gather technical information from the web,transfer money through mobile payments,share images of construction details,and promote their work on social *** broad use of smartphones shows potential for enhancing construction *** article presents a unique analysis of the use of smartphones in the construction of informal settlements in Tanzania,which could be extended to other *** on the findings,new strategies are proposed to engage with local stakeholders and foster the exchange of technical knowledge for safer settlements via smartphones.

关键词： Disaster risk reduction Housing Informal settlements-Smartphones Tanzania

Impact of microbiota-immunity axis in pancreatic cancer management

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World Journal of Gastroenterology 2022年第32期28卷 4527-4539页

作者： Ilenia Bartolini giulia Nannini Matteo Risaliti Francesco Matarazzo Luca Moraldi maria Novella Ringressi Antonio Taddei Amedeo Amedei Department of Experimental and Clinical Medicine HPB Surgery UnitAzienda Ospedaliero-Universitaria CareggiFlorence 50134Italy Department of Experimental and Clinical Medicine SOD of Interdisciplinary Internal MedicineAzienda Ospedaliera-Universitaria CareggiFlorence 50134Italy Division of Oncologic Surgery Department of OncologyCareggi University HospitalFirenze 50134Italy

The microbiota impact on human diseases is well-known,and a growing body of literature is providing evidence about the complex interplay between microbiotaimmune system-human physiology/pathology,including *** with the defined risk factors(e.g.,smoke habits,diet,diabetes,and obesity),the oral,gut,biliary,and intrapancreatic microbiota contribute to pancreatic cancer development through different pathways including the interaction with the immune ***,a great majority of the pancreatic cancer patients received a diagnosis in advanced stages not amenable to be radically treated and potentially *** the poor pancreatic cancer prognosis,complete knowledge of these complicated relationships could help researchers better understand the disease pathogenesis and thus provide early potential noninvasive biomarkers,new therapeutic targets,and tools for risk stratification that might result in greater therapeutic possibilities and eventually in a better and longer patient survival.

关键词： Gastrointestinal tumors Hepatopancreatobiliary tumors Pancreatic cancer Gut microbiota Dysbiosis Cancer development Carcinogenesis

The protective role of m A during stress-induced granulation

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Journal of Molecular Cell Biology 2020年第11期12卷 870-880页

作者： Marion Alriquet giulia Calloni Adrian Martinez-Limon Riccardo delli Ponti Gerd Hanspach Martin Hengesbach Gian G.Tartaglia R.Martin Vabulas Buchmann Institute for Molecular Life Sciences Goethe University Frankfurt60438 Frankfurt am MainGermany Institute of Biophysical Chemistry Goethe University Frankfurt60438 Frankfurt am MainGermany Centre for Genomic Regulation(CRG) The Barcelona Institute for Science and Technology08003 BarcelonaSpain Universitat Pompeu Fabra(UPF) 08003 BarcelonaSpain Institucio Catalana de Recerca i Estudis Avanqats(ICREA) 08010 BarcelonaSpain Institute for Organic Chemistry and Chemical Biology Goethe University Frankfurt60438 Frankfurt am MainGermany Department of Biology'Charles Darwin Sapienza University of Rome00185 RomeItaly Department of Neuroscience and Brain Technologies Istituto Italiano di Tecnologia16163 GenoaItaly Present address:Charite-Universitatsmedizin Berlin Institute of Biochemistry10117 BerlinGermany

Post-transcriptional methylation of N6-adenine and Nl-adenine can affect transcriptome turnover and ***,the regulatory function of N6-methyladenine(m6A)during heat shock has been uncovered,including the enhancement of the phase separation potential of *** response to acute stress,*** shock,the orderly sequestration of mRNAs in stress granules(SGs)is considered important to protect transcripts from the irreversible *** recently,the role of N1-methyladenine(m^(1)A)on mRNAs during acute stress response remains largely *** we show that the methyltransferase complex TRMT6/61A,which generates the tag,is involved in transcriptome protection during heat *** bioinformatics analysis indicates that occurrence of the motif is increased in mRNAs known to be enriched in ***,the m^(1)A-generating methyltransferase TRMT6/61A accumulated in SGs and mass spectrometry confirmed enrichment of in the SG *** insertion of a single methylation motif in the untranslated region of a reporter RNA leads to more efficient recovery of protein synthesis from that transcript after the return to normal *** results demonstrate far-reaching functional consequences of a minimal RNA modification on N1-adenine during acute proteostasis stress.

关键词： stress response stress granules N1-methyladenine

Toxic hepatitis in occupational exposure to solvents

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World Journal of Gastroenterology 2012年第22期18卷 2756-2766页

作者： giulia Malaguarnera Emanuela Cataudella maria Giordano Giuseppe Nunnari Giuseppe Chisari mariano Malaguarnera Research Centre "The Great Senescence" University of Catania Department of Infective Diseases Hospital "Garibaldi di Nesima" University of Catania Microbiology and Clinical Microbiology Department of Biomedical Science Hospital Policlinico University of Catania

The liver is the main organ responsible for the metabolism of drugs and toxic chemicals, and so is the primary target organ for many organic solvents. Work activities with hepatotoxins exposures are numerous and, moreover, organic solvents are used in various industrial processes. Organic solvents used in different industrial processes may be associated with hepatotoxicity. Several factors contribute to liver toxicity; among these are: species differences, nutritional condition, genetic factors, interaction with medications in use, alcohol abuse and interaction, and age. This review addresses the mechanisms of hepatotoxicity. The main pathogenic mechanisms responsible for functional and organic damage caused by solvents are: inflammation, dysfunction of cytochrome P450, mitochondrial dysfunction and oxidative stress. The health impact of exposure to solvents in the workplace remains an interesting and worrying question for professional health work.

关键词：有机溶剂毒性肝炎职业暴露细胞色素P450 工业生产过程职业卫生工作药物使用致病机制

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies

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Neural Regeneration Research 2020年第5期15卷 802-816页

作者： giulia Costa maria Antonietta De Luca Gessica Piras Jacopo Marongiu Liana Fattore Nicola Simola Department of Biomedical Sciences University of CagliariCagliariItaly National Institute of Neuroscience (INN) University of CagliariCagliariItaly National Research Council of Italy Institute of NeuroscienceCagliariItaly

Preclinical and clinical studies indicate that synthetic psychoactive substances,in addition to having abuse potential,may elicit toxic effects of varying severity at the peripheral and central ***,toxicity induced by synthetic psychoactive substances poses a serious harm for health,since recreational use of these substances is on the rise among young and adult *** present review summarizes recent findings on the peripheral and central toxicity elicited by “old” and “new” synthetic psychoactive substances in humans and experimental animals,focusing on amphetamine derivatives,hallucinogen and dissociative drugs and synthetic cannabinoids.

关键词： cannabinoids dissociatives hallucinogens ketamine MDMA methamphetamine methoxetamine neuroinflammation neurotoxicity NPS