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ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: what is the way forward?

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World Journal of Gastroenterology 2018年第29期24卷 3222-3238页

作者： Aleksandra Adamska marco Falasca Metabolic Signalling Group School of Pharmacy and Biomedical Sciences Curtin Health Innovation Research Institute Curtin University

Pancreatic ductal adenocarcinoma(PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATPbinding cassette(ABC) transporters in this resistance, the therapeutic potential of their pharmacological inhibition has not been successfully exploited yet. In spite of the discovery of potent pharmacological modulators of ABC transporters, the results obtained in clinical trials have been so far disappointing, with high toxicity levels impairing their successful administration to the patients. Critically, although ABC transporters have been mostly studied for their involvement in development of multidrug resistance(MDR), in recent years the contribution of ABC transporters to cancer initiation and progression has emerged as an important area of research, the understanding of which could significantly influence the development of more specific and efficient therapies. In this review, we explore the role of ABC transporters in the development and progression of malignancies, with focus on PDAC. Their established involvement in development of MDR will be also presented. Moreover, an emerging role for ABC transporters as prognostic tools for patients' survival will be discussed, demonstrating the therapeutic potential of ABC transporters in cancer therapy.

关键词： Pancreatic ductal adenocarcinoma Multidrug resistance ATP-binding cassette transporters Targeted therapies Pancreatic ductal adenocarcinoma prognosis Predictive markers

Image grid display:A study on automatic scrolling presentation

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Visual Informatics 2017年第1期1卷 16-24页

作者： marco Porta Stefania Ricotti Department of Electrical Computer and Biomedical EngineeringUniversity of PaviaPaviaItaly

In this paper we describe a study on image grid display with automatic vertical *** scroll operations are normally carried out manually by the user,in the context of RSVP(Rapid Serial Visual Presentation)techniques this work considers a presentation mode in which the image grid is automati-cally *** experiments carried out with 50 testers,we have investigated user performance while looking for specific target subjects within large collections of *** numbers of columns and scrolling speeds have been *** search task implied both clicking on the identified target pictures and simply vocally stating their visual *** this purpose,and to identify possible specific gaze behaviours,eye tracking technology has been *** obtained results show that number of columns and scroll speed do affect search ***,the user’s gaze tends to focus on different screen areas depending on the values of these two *** it is not possible to definitely find an optimal columns-speed combination that is valid in all cases,the particular context of use can suggest feasible solutions according to one’s *** the best of our knowledge,image grid display with automatic scrolling has never been studied to date.

关键词： Image griddisplay Automatic scrolling Image presentationmodes Image collections Rapid serialvisual presentation

Spontaneous fungal peritonitis: Epidemiology, current evidence and future prospective

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World Journal of Gastroenterology 2016年第34期22卷 7742-7747页

作者： marco Fiore Sebastiano Leone Department of Anesthesiological Surgical and Emergency SciencesSecond University of Naples Division of Infectious Diseases "San Giuseppe Moscati" Hospital

Spontaneous bacterial peritonitis is a complication of ascitic patients with end-stage liver disease(ESLD); spontaneous fungal peritonitis(SFP) is a complication of ESLD less known and described. ESLD is associated to immunodepression and the resulting increased susceptibility to infections. Recent perspectives of the management of the critically ill patient with ESLD do not specify the rate of isolation of fungi in critically ill patients,not even the antifungals used for the prophylaxis,neither optimal treatment. We reviewed,in order to focus the epidemiology,characteristics,and,considering the high mortality rate of SFP,the use of optimal empirical antifungal therapy the current literature.

关键词： Cirrhosis Critically ill patient Spontaneous fungal peritonitis Life-threatening infections Fungal ascitis Nosocomial spontaneous peritonitis

Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot Enrico Panettieri Antonio Cosculluela marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

Sensitivity of a solid Eu(Ⅲ) complex towards acetonitrile vapor:Structural and spectroscopic characterization

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Journal of Rare Earths 2020年第5期38卷 571-576页

作者： Fabio Piccinelli Veronica Paterlini Magda Monari marco Bettinelli Luminescent Materials Laboratory DBUniversita di Veronaand INSTMUdR VeronaStrada Le Grazie 1537134VeronaItaly Dipartimento di Chimica"G.Ciamician" Universita di BolognaVia Selmi 240126BolognaItaly

The Eu(Ⅲ)nitrate complex of the meso-N,N’-bis(2-pyridylmethylene)-1,2-(R,S)-cyclohexanediamine ligand was synthesized and characterized by single crystal and powder X-ray *** crystal lattice of the complex is capable of absorbing and desorbing selectively acetonitrile molecules,at 293 K upon an acetonitrile vapor pressure of^0.1×10^5 *** process,which is partially reversible,can be easily followed by both powder X-ray diffraction(P-XRD)and Eu(III)luminescence *** acetonitrile molecule,located in the outer coordination sphere of the metal ion,does not affect the radiative transition probability of 5 D0 level of Eu(Ⅲ)and also it does not activate further non-radiative channels from this *** the other hand,this molecule is capable of affecting the energy position and intensities of the crystal field components of the 5 D0→7 F2 *** complex in solid form can be considered a promising material for the optical sensing of acetonitrile vapors.

关键词： Eu(Ⅲ) X-ray diffraction Crystal structure Luminescence spectroscopy Rare earths

Minimally invasive esophagectomy

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World Journal of Gastroenterology 2010年第30期16卷 3811-3815页

作者： Fernando A Herbella marco G Patti Department of Surgery University of Chicago Pritzker School of MedicineChicagoIL 60637United States

Esophageal resection is associated with a high morbidity and mortality rate. Minimally invasive esophagectomy (MIE) might theoretically decrease this rate. We reviewed the current literature on MIE, with a focus on the available techniques, outcomes and comparison with open surgery. This review shows that the available literature on MIE is still crowded with heterogeneous studies with different techniques. There are no controlled and randomized trials, and the few retrospective comparative cohort studies are limited by small numbers of patients and biased by historical controls of open surgery. Based on the available literature, there is no evidence that MIE brings clear benef its compared to conventional esophagectomy. Increasing experience and the report of larger series might change this scenario.

关键词： Esophageal resection Transhiatal esophagectomy Transthoracic esophagectomy Esophageal cancer Minimally invasive esophagectomy Laparoscopy Thoracoscopy

Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

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World Journal of Gastroenterology 2008年第4期14卷 563-568页

作者： Edith Lahner marco Intraligi Massimo Buscema marco Centanni Lucy Vannella Enzo Grossi Bruno Annibale Department of Digestive and Liver Disease University "La Sapienza"2nd Medical SchoolOspedale Sant'AndreaRomeItaly Semeion Research Center Rome Italy Endocrinology Unit Department of Experimental Medicine and PathologyUniversity "La Sapienza"Polo PontinoLatinaItaly Bracco Imaging Spa MilanItaly

AIM: To investigate the role of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,T&T-IS protocol,TWIST protocol). The target variable was the presence of thyroid disease. RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. The increase of sensitivity of the TWIST protocol was statistically signifi cant compared to T&T-IS. CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

关键词： Atrophic body gastritis Thyroid disease Artificial neural networks

Discovering the Long:Current Theories and Trends in Research on the Chinese Dragon

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Frontiers of History in China 2021年第1期16卷 123-142页

作者： marco Meccarelli Department of History University of CatiniaCatinia 95125 Department of History University of MacerataMacerata 62100 Department of History University of UrbinoUrbino 61029Italy

After the 1980s,the world started addressing the challenges posed by economic globalization,and the protection of cultural diversity became a widely discussed ***,China is experiencing problems in defining the relationship between the past and present,as well as that between tradition and *** the 1990s,China’s opening-up policy,the advent of globalization,and an increase in cross-cultural communications strengthened the country’s need to preserve its cultural *** Chinese scholars reflected on the past and examined the potential of archaeological materials,inscriptions,myths,and ancient legends to explain the relationship between tradition and *** birth and evolution of the long龍,or the Chinese dragon,remains at the core of such international *** studies highlighted the necessity of promoting discussions on and demystifying the *** new perspective facilitates a connection between various theories on the origin of the Chinese dragon and the contemporary identity discourse,which has attracted the attention of Chinese *** paper bridges the gap by introducing reliable theories on the origin of the mythical animal and focusing on typology issues,classification,latest debates on the distinction between the long and the dragons of other cultures,and finally,main theories on the visual representation of the Chinese long.

关键词： dragon long loong thunder alligator totem theory mythical animal snake dragon motif

Choroidal vascularity index in thyroidassociated ophthalmopathy:a crosssectional study

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Eye and Vision 2021年第4期8卷 175-182页

作者： Pasquale Loiudice marco Pellegrini Michele Marinò Barbara Mazzi Ilaria Ionni Giuseppe Covello Michele Figus marco Nardi Giamberto Casini Department of Surgical Ophthalmology UnitMedicalMolecular and Critical Area PathologyUniversity of PisaVia Savi1056126 PisaItaly Ophthalmology Unit S.Orsola-Malpighi University HospitalUniversity of BolognaBolognaItaly Department of Clinical and Experimental Medicine Endocrinology Unit IUniversity Hospital of PisaPisaItaly

Background:Hemodynamic changes have been observed in patients with Graves’*** aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index(CVI)in patients with thyroidassociated ophthalmopathy(TAO).Methods:In this cross-sectional observational study,40 patients affected by TAO were *** healthy individuals,matched for age and sex,served as *** enhanced-depth imaging optical coherence tomography scans were obtained from all *** were binarized using the ImageJ software and luminal area(LA)and total choroidal area(TCA)were *** was calculated as the proportion of LA to *** relation between CVI or subfoveal choroidal thickness(SFCT)and clinical activity score,exophthalmometric value,diplopia status,gender,and age was ***:CVI was significantly higher in patients with TAO(P=0.004).No significant difference was observed in SFCT(P=0.200)and TCA(P=0.153)comparing TAO patients and healthy *** was significantly higher in TAO group(P=0.045).On multiple regression analysis,CVI was associated with TCA(P=0.043).No association was found between SFCT or CVI and TCA,clinical activity score,exophthalmometric value,Inami value,diplopia status,gender or age(P>0.05).Conclusions:This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.

关键词： Choroidal vascularity index Choroidal vasculature Enhanced depth optical coherence tomography Image binarization Luminal area Subfoveal choroidal thickness Thyroid-associate ophthalmopathy

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