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Synthesis and characterization of lanthanum bonded agar-carbomer hydrogel:a promising tool for biomedical research

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Journal of Rare Earths 2011年第3期29卷 259-264页

作者： Filippo Rossi marco Santoro Tommaso Casalini Giuseppe Perale Dipartimento di Chimica Materialied Ingegneria Chimica"G.Natta"Politecnico di MilanoVia Mancinelli7

Agar-Carbomer（branched poly（acrylic acid）） hydrogel,an injectable bio-resorbable scaffold with a controlled nanostructure specifically designed for neural cell housing,was developed together with a new protocol for building three dimensional biohybrid cell/hydrogel *** order to overcome classic structural analysis inconveniences due to the high water amount,which affects instruments results and reliability,agar-Carbomer hydrogels were synthesized by microwave-assisted block copolymerization together with La3＋ *** glycol,glycerol and buffered saline solution were used as cross-linking agents and solvent,*** properties were not affected by the presence of lanthanum,and were checked via swelling and rheological ***,the presence of La3＋ within the polymeric network was characterized by thermogravimetric analysis,environmental scanning electron microscopy and Fourier transformed infrared *** results showed that the rare earth presented uniform distribution in the hydrogel network due to the formation of chemical bonds after polymerization without being modified its luminescence emission spectrum that allowed hydrogel *** results made the obtained host-guest system a useful tool for analytical research studies concerning regenerative medical applications that could also be potentially taken up with in vivo experiments.

关键词： hydrogel acrylic acid agarose lanthanum luminescence drug delivery rare earths

Vegetation cover induces developmental plasticity of lateralization in tadpoles

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Current Zoology 2020年第4期66卷 393-399页

作者： Tyrone Lucon-Xiccato marco Dadda Angelo Bisazza department of Life Sciences and Biotechnology University of FerraraVia L.Borsari 4644121FerraraItaly Department of General Psychology University of PadovaVia Venezia 83511PadovaItaly

Lateralization of cognitive functions influences a large number of fitness-related behaviors and shows,in most species,substantial variation in strength and *** works and field data have suggested that this variation is often due to adaptive phenotypic *** lateralization should be favored in some ecological conditions,for example,under high risk of *** anuran tadpoles,the presence of cover affects predation risk,with tadpoles being more exposed to predators in environments with reduced *** tested the hypothesis that the amount of cover experienced early in life affects lateralization in the edible frog,Pelophylax escu-lentus,*** exposed embryos and larvae to high or low vegetation cover *** half of the subjects,the treatment was constant whereas the remaining subjects were switched to the opposite treatment after *** agreement with the theoretical expectation,tadpoles exposed to low vegetation cover for the entire development were more lateralized and showed a stronger alignment in directionality of lateralization compared with tadpoles exposed to high vege-tation *** indicates a possible role of natural variation in vegetation abundance and deve卜opmental plasticity as determinants of between-population and between-individual differences in *** also found that shifting from high to low vegetation cover treatments and vice versa disrupted lateralization alignment,suggesting that developmental trajectories for this trait are determined at the embryonic stage and need environmental stability to be fully expressed.

关键词： lateralization light exposure Pelophylax esculentus phenotypic plasticity

Force Analysis and Curve Design for Laying Pipe in Loop Laying Head of Wire Rod Mills

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Chinese Journal of Mechanical Engineering 2019年第2期32卷 36-52页

作者： Shuangji Yao marco Ceccarelli Giuseppe Carbone Bin Ma College of Material Science and Engineering Yanshan University Qinhuangdao 066004 China University of Cassino and South Latium Cassino 03043 Italy HBIS Group Co. Ltd Handan 056001 China

Laying head is a high-precision engineering device in hot-rolled high speed wire rod production line. Previously research works are focused on the laying pipe wear-resisting. Laying pipe curve design method based on wire rod kinematics and dynamics analyses are not reported before. In order to design and manufacture the laying pipe, the motion and force process of the wire rod in the laying pipe should be studied. In this paper, a novel approach is proposed to investigate the force modeling for hot-rolled wire rod in laying pipe. An idea of limited element method is used to analysis and calculates the forces between laying pipe inner surface and wire rod. The design requirements of laying pipe curve for manufacturing are discussed. The kinematics and dynamics modeling for numerical calculation are built. A laying pipe curve equation is proposed by discussing design boundary conditions. Numerical results with di erent laying pipe curves design parameters are plotted and compared. The proposed approach performs good result which can be applied for laying pipe curve design and analysis for engineering application.

关键词： Wire rod mills Laying head Laying pipe curve design Wire rod force analysis

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

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Neural Regeneration Research 2020年第1期15卷 30-35页

作者： Alejandro Romero Josémarco-Contelles Eva Ramos Department of Pharmacology&Toxicology Faculty of Veterinary MedicineComplutense University of MadridMadridSpain Laboratory of Medicinal Chemistry Institute of General Organic Chemistry(CSIC)MadridSpain

There is no effective treatment to face Alzheimer’s disease *** molecules are a good approach against the multiple physiopathological events associated with its development and *** this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising ***234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than ***,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and ***,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 *** about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant ***,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning *** we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.

关键词： AChE BuChE gene expression heat shock proteins inflammation in silico toxicology MAO A/B neuroprotection oxidative stress Wnt signaling

Dynamical Criticality:Overview and Open Questions

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Journal of Systems Science & Complexity 2018年第3期31卷 647-663页

作者： ROLI Andrea VILLANI marco FILISETTI Alessandro SERRA Roberto Department of Computer Science and Engineering (DISI) Campus of Cesena University of Bologna Italy Department of Physics Informatics and Mathematics University of Modena and Reggio Emilia Italy European Centre for Living Technology Venezia Italy Explora s.r.l. Roma Italy & European Centre for Living Technology Venezia Italy

Systems that exhibit complex behaviours are often found in a particular dynamical con- dition, poised between order and disorder. This observation is at the core of the so-called criticality hypothesis, which states that systems in a dynamical regime between order and disorder attain the highest level of computational capabilities and achieve an optimal trade-off between robustness and flexibility. Recent results in cellular and evolutionary biology, ueuroscience and computer science have revitalised the interest in the criticality hypothesis, emphasising its role as a viable candidate general law in adaptive complex systems. This paper provides an overview of the works on dynamical criticality that are -- To the best of our knowledge -- Particularly relevant for the criticality hypothesis. The authors review the main contributions concerning dynamics and information processing at the edge of chaos, and illustrate the main achievements in the study of critical dynamics in biological systems. Finally, the authors discuss open questions and propose an agenda for future work.

关键词： Attractors criticality dynamical regimes edge of chaos phase transitions.

Hybrid Design and Performance Tests of a Hovering Insect-inspired Flapping-wing Micro Aerial Vehicle

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Journal of Bionic Engineering 2016年第2期13卷 235-248页

作者： Quoc-Viet Nguyen Woei Leong Chan marco Debiasi Temasek Laboratories National University of Singapore Singapore 117411 Singapore

Hovering ability is one of the most desired features in Flapping-Wing Micro Air Vehicles （FW-MAVs）. This paper presents a hybrid design of flapping wing and fixed wing, which combines two flapping wings and two fixed wings to take advantage of the double wing clap-and-fling effect for high thrust production, and utilizes the fixed wings as the stabilizing surfaces for inherently stable hovering flight. Force measurement shows that the effect of wing clap-and-fling significantly enhances the cycle-averaged vertical thrust up to 44.82% at 12.4 Hz. The effect of ventral wing clap-and-fling due to presence of fixed wings produces about 11% increase of thrust-to-power ratio, and the insect-inspired FW-MAV can produce enough cycle-averaged vertical thrust of 14.76 g for lift-offat 10 Hz, and 24 g at maximum frequency of 12.4 Hz. Power measurement indicates that the power consumed for aerodynamic forces and wing inertia, and power loss due to gearbox friction and mechanism inertia was about 80% and 20% of the total input power, respectively. The proposed insect-inspired FW-MAV could endure three-minute flight, and demonstrate a good flight performance in terms of vertical take-off, hovering, and control with an onboard 3.7 V-70 mAh LiPo battery and control system.

关键词： insect-inspired flapping wing hovering clap-and-fling MAV vertical takeoff

Early changes of graft function,cytokines and superoxide dismutase serum levels after donor liver denervation and Kupffer cell depletion in a rat-to-rat liver transplantation model

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 152-156页

作者： Catena marco Ferla Gianfranco Liver Surgery Unit Scientific Institute Hospital San RaffaeleVita-Salute San Raffaele University School of Medicine

BACKGROUND: Hepatic reperfusion injury may cause acute inflammatory damage, producing significant organ dysfunction, and is an important problem in liver transplantation. This experiment aimed to study early changes of hepatic function after donor liver denervation and Kupffer cell depletion in rat-to-rat liver transplantation and to evaluate the effect of pre-treatment on liver reperfusion injury. METHODS: Donor rats were divided into four groups: control group; group G was pre-treated with gadolinium chloride (G), an inhibitor of Kupffer cells; group H with hexamethonium (H), a sympathetic ganglionic blocking agent; and group HG, with combined H and G pre-treatment. Under the same conditions, serum alanine aminotransferase (ALT), arterial ketone body ratio (AKBR), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and superoxide dismutase (SOD) of recipient rats were assessed at 4, 8, 16 and 24 hours after liver transplantation. Histological studies of the grafts were compared. RESULTS: HG pre-treatment significantly decreased ALT, TNF-alpha, and IL-6 levels, increased AKBR and SOD levels, and demonstrated less pathological damage at 8, 16 and 24 hours compared with the control group. Similar trends were also found in the other groups (G and H). However, the differences among them were not significant at 4 postoperative hours. CONCLUSIONS: Donor denervation and Kupffer cell depletion had preventive effect on liver reperfusion injury. HG pre-treatment is a feasible and reproducible method to protect grafts from reperfusion injury.

关键词： liver transplantation reperfusion injury macrophages denervation

Biomarkers for targeted rehabilitation strategies after breast cancer: Proposal for the next-generation management of survivorship issues

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BIOCELL 2022年第10期46卷 2221-2223页

作者： marco INVERNIZZI NICOLA FUSCO Translational Medicine Dipartimento AttivitàIntegrate Ricerca e Innovazione(DAIRI)Azienda Ospedaliera SS.Antonio e Biagio e Cesare ArrigoAlessandria15121Italy Physical and Rehabilitation Medicine Department of Health SciencesUniversity of Eastern PiedmontNovara28100Italy Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan20141Italy Department of Oncology and Hemato-Oncology University of MilanMilan20122Italy

Breast cancer(BC)is the most common malignant tumor and one of the top causes of cancer-related death worldwide(Sung et al.,2021).The recent advances in early tumor diagnosis coupled with more effective treatment strategies resulted in a steady increase of long-term survivors(Nardin et al.,2020;Invernizzi et al.,2022).These improved survival rates led to a significantly higher incidence of disabling complications related to breast cancer and/or its treatment(Invernizzi et al.,2020a;D’Egidio et al.,2017;Zhong et al.,2020).

关键词： Breast cancer Biomarkers Survivorship Rehabilitation Precision medicine

A Unified Dynamic Control Method for a Redundant Dual Arm Robot

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Journal of Bionic Engineering 2015年第3期12卷 361-371页

作者： Meiling Wang Minzhou Luo Tao Li marco Ceccarelli Department of Automation University of Science and Technology of China Hefei 230026 China Institute of Advanced Manufacturing Technology Hefei Institute of Physical Science Chinese Academy of Sciences Changzhou 213164 China LARM Laboratory of Robotics and Meehatronies DiMSAT-University of Cassino Via Di Biasio 43 03043 Cassino (Fr) Italy

Compared to single arm robot system, dual arm robot has the ability of performing human-like dexterity and cooperation. Dual arm cooperative operation has attracted more and more attention in industrial applications, such as in assembly of complex parts, manufacturing tasks and handling objects. A unified dynamic control method, which is divided into three modes, namely, independent mode, dependent mode, and half dependent mode, is proposed for a redundant dual arm robot with focus on the movement and force of the desired task being operated. Attention is devoted to develop a unified formulation of the above three modes. In addition, a closed form of inverse kinematic solution instead of numerical integration approach is proposed with the aim to guarantee position accuracy. Different from traditional dynamic controllers, where the independent redundancy resolution is obtained based on particular velocity or acceleration levels, here the two dynamic controllers are improved by combining a closed form of inverse kinematic solution with velocity and acceleration levels. Furthermore, the theoretical results of the proposed control method are validated by simulations and experiments.

关键词： unified control method dual arm robot dynamic constraints intemal force