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Inflammatory Bowel Disease Patients’Risk of Developing Prostate Cancer:A Meta-Analysis

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Journal of Clinical and Nursing Research 2023年第2期7卷 35-42页

作者： Mohammed A Amin Mina nicola Mohamed EA Abdelrahim Clinical Pharmacy Department Faculty of PharmacyBeni-Suef UniversityBeni-Suef 62511Egypt

Background:Inflammatory bowel disease(IBD)has been linked to an increased risk of prostate cancer(PC)in numerous ***,the exact relationship between them remains *** this meta-analysis,we focus on determining the relationship between PC incidence and ***:A comprehensive literature search was conducted up until January 2022,selecting 14 studies,comprising 127,323 subjects with IBD,at the beginning of the study,among which 61,985 were patients with ulcerative colitis(UC)and 37,802 were with Crohn’s disease(CD).The studies reported the differences between subjects with IBD and controls with regard to the incidence of *** order to investigate the relationship between IBD and the prevalence of PC,we estimated the odds ratio(OR)with 95%confidence intervals(CIs).Results:IBD significantly increased the incidence of PC(OR,3.46;95%CI,1.40-8.54,P=0.007)compared to *** significantly increased the incidence of PC(OR,1.43;95%CI,1.03-1.98,P=0.03)compared to ***,no significant difference was observed between CD and controls in relation to PC incidence(OR,0.89;95%CI,0.75-1.06,P=0.18).Conclusion:IBD,particularly UC,may increase the risk of developing *** relationship prompts us to advocate for increased PC and IBD screening to reduce the risk for possible complications that could occur in these subjects.

关键词： Prostate cancer Inflammatory bowel disease Ulcerative colitis Crohn’s disease Retrospective study

More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus

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General Psychiatry 2019年第4期32卷 197-205页

作者： Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius Department of Psychiatry National Institute of Mental Health and Neuro-SciencesBangaloreIndia Institute of Mental Health BelgradeSerbia Samatvam Endocrinology Diabetes Center and Jnana Sanjeevini Diabetes Hospital and Medical Center BangaloreIndia University of Lower Silesia WroclawPoland Center for Global Mental Health RawalpindiPakistan University of Nairobi NairobiKenya Faculty of Medicine Chulalongkorn UniversityBangkokThailand Pakistan Institute of Medical Sciences IslamabadPakistan Department of Psychiatry and Psychotherapy Medical FacultyUniversity of DusseldorfDusseldorfGermany ProConsult Owings MillsMarylandUSA 不详 Child Adolescent and Family Psychiatry National Institute of Mental HealthDhakaBangladesh Department of Psychiatry King Saud UniversityRiyadhSaudi Arabia IRCCS Ospedale Sacro Cuore Don Calabria NegrarItaly National Research Centre for Psychiatry and Narcology MoscowRussia IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli BresciaItaly University of Milano-Bicocca BicoccaItaly Department of Psychology Catholic UniversityMilanItaly Department of Psychiatry Wroclaw Medical UniversityWroclawPoland

Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted.

关键词： type 2 diabetes mellitus anxious depressed

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基于功能化S-层蛋白纳米阵列的单分子识别

基于功能化S-层蛋白纳米阵列的单分子识别

中国化学会第27届学术年会

作者：唐纪琳 Andreas Ebner Uwe B.Sleytr nicola Ilk Peter Hinterdorfer 中国科学院长春应用化学研究所电分析化学国家重点实验室 Institute of Biophysics Johannes Kepler University of Linz Center for NanoBiotechnology University of Natural Resources and Applied Life Sciences

＜正＞细菌的表面层（Surface layers）或称为S-层（S-layers）位于细胞壁或细胞膜外层,是由S-层蛋白质在菌体表面自装配形成的规则的晶格状结构。单体S-层蛋白可自组装形成斜线、方形和六角形对称排

关键词：单分子分子识别 S-层蛋白纳米阵列

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外貌心理学

Story of……Moon Fragment

作者： (英)尼古拉·拉姆齐(nicola Rumsey)，(英)黛安娜·哈考特(Diana Harcourt)

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明日风尚 2009年第6期 108-108页

作者： Jacqueline Yiu Ron Lam Kiki Feng nicola Lai

Cartier早前于东京国立博物馆举行了名为《Story of……》的艺术展览,负责这次装置设计的日本设计师吉冈德仁,特别为其设计了两款以Moon Fragment为题的香水瓶。这次他为Cartier所做设计的最引人入胜之处,在于两个瓶内各饰以一颗钻石。... 详细信息

Cartier早前于东京国立博物馆举行了名为《Story of……》的艺术展览,负责这次装置设计的日本设计师吉冈德仁,特别为其设计了两款以Moon Fragment为题的香水瓶。这次他为Cartier所做设计的最引人入胜之处,在于两个瓶内各饰以一颗钻石。吉冈德仁表示。

关键词： Fragment Cartier 东京国立博物馆 Story of 水瓶设计灵感艺术展览德仁

The Management of Digital Transformation in Higher Education:An Assessment Proposal

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Chinese Business Review 2022年第4期21卷 117-123页

作者： Manuel De nicola Umair Anees Anna Maria Maurizi University of Teramo TeramoItaly University of Chieti-Pescara PescaraItaly

The impacts of the current digital era are growing more and more on the way in which higher education(HE)offers learning programs at every *** learning(SL)represents the evolution of educational approaches and techniques that capitalizes on all the opportunities deriving from new digital *** study argues that the usefulness of HE can benefit from rethinking the traditional active learning(AL)model to smart ***,this research aims at investigating how to adapt the performance evaluation when the operations of HE turn to digitalized ***,this paper designs a research approach that allows accounting for the effects that the adoption of some SL strategies and tools has on the engagement of students and the aggregate performance of HE programs that adopt *** results of this study would help academics and HE managers assess the effectiveness of SL initiatives they plan to adopt.

关键词： higher education active learning smart education smart learning environment social learning theory digital technologies smart devices digital student-centricity on-line lectures COVID-19

Pediatric non-alcoholic fatty liver disease:New insights and future directions

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World Journal of Hepatology 2014年第4期6卷 217-225页

作者： Pierluigi Marzuillo Emanuele Miraglia del Giudice nicola Santoro Department of women and children and General and Specialized Surgery Seconda Università degli Studi di Napoli Department of Pediatrics Yale University School of Medicine

One of the most common complications of childhood obesity is the non-alcoholic fatty liver disease(NAFLD),which is the most common form of liver disease in *** is defined by hepatic fat infiltration > 5% hepatocytes,as assessed by liver biopsy,in the absence of excessive alcohol intake,viral,autoimmune and drug-induced liver *** encompasses a wide spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis,which,in turn,can evolve into cirrhosis and end stage liver *** and insulin resistance are the main risk factors for pediatric *** fact,NAFLD is strongly associated with the clinical features of insulin resistance especially the metabolic syndrome,prediabetes and type 2 diabetes mellitus(T2D).In particular,it has been clearly shown in obese youth that the prevalence of metabolic syndrome,pre-diabetes and type 2 diabetes increaseswith NAFLD severity *** that not all of the obese patients develop NAFLD suggests that the disease progression is likely to depend on complex interplay between environmental factors and genetic ***,a non-synonymous SNP(rs738409),characterized by a C to G substitution encoding an isoleucine to methionine substitution at the amino acid position 148 in the patatin like phospholipase containing domain 3 gene(PNPLA3),has been associated with hepatic steatosis in a multiethnic cohort of adults as well as in *** important polymorphisms that acts with PNPLA3 to convey susceptibility to fatty liver in obese youths is the rs1260326 polymorphism in the glucokinase regulatory *** pharmacological approach in NAFLD children poorly adherent to or being unresponsive/partially responsive to lifestyle changes,is aimed at acting upon specific targets involved in the *** are some therapeutic approaches that are being studied in *** article reviews the current knowledge regarding the pediatric fatty liver disease,t

关键词： Non alcoholic fatty liver disease PNPLA3 Obesity Insulin resistance Glucokinase regulatory protein Fructose

WONCA研究论文摘要汇编——全科医生在下背痛问诊中的安慰:一项定性研究

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中国全科医学 2015年第32期18卷 3987-3987页

作者： nicola H Tamar P Steven V 本刊编辑部《中国全科医学》编辑部

背景在初级医疗中,下背痛管理指南一般推荐医生对患者进行安慰,但是相关阐述不够充分,对患者的作用不明确。目的探讨下背痛患者在问诊中如何感知医生的安慰行为。方法选取23名近期接受全科医生问诊的非特异性下背痛患者。采用半结构采访... 详细信息

背景在初级医疗中,下背痛管理指南一般推荐医生对患者进行安慰,但是相关阐述不够充分,对患者的作用不明确。目的探讨下背痛患者在问诊中如何感知医生的安慰行为。方法选取23名近期接受全科医生问诊的非特异性下背痛患者。采用半结构采访,探究患者在问诊过程中认为得到安慰的情况和其带来的影响。采用主题框架法,对访谈记录进行分析。结果患者在访谈中回忆问诊经历、信任、期待和希望医生倾听和理解的担忧。在医生给予重视并希望提供帮助的时候,患者感到隐含的安慰;当医患建立关系和医生可以随时帮助患者的时候,患者同样感到隐含的安慰。只有在医生通过解释排除严重疾病直接解除患者担忧、帮助患者理解和应对疼痛的时候,患者才感受到直接的、信息性的安慰。结论本文探讨的隐含与直接安慰分别与情感安慰和认知安慰相对应。虽然研究证实利用信息与教育可以化解患者的担忧,但是通过建立关系和同情心带来的隐含安慰的作用依旧不明确。这些行为对结局的影响应成为未来研究的重点。

关键词：非特异性下背痛全科医生 WONCA 安慰问诊论文摘要汇编管理指南

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格兰萨索·轰动背后的落寞

环球科学 2012年第7期 62-65页

作者：尼古拉·诺森戈（nicola Nosengo）王栋（翻译）

这座世界上最大的地下实验室是意大利科学界的骄傲。但是，在其开工建造30周年之际，它却不知将何去何从。

关键词：科学界意大利实验室