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Challenge of liver disease in systemic lupus erythematosus:Clues for diagnosis and hints for pathogenesis

World Journal of Hepatology 2014年第6期6卷 394-409页

作者： Ferno Bessone Natalia Poles marcelo G Roma Gastroenterology and Hepatology Department University of Rosario School of Medicine Institute of Experimental Physiology (CONI-CET-UNR) Faculty of Biochemical and Pharmaceutical SciencesUniversity of Rosario

Systemic lupus erythematosus(SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows:(1) immunological comorbilities(overlap syndromes);(2) non-immunological comorbilities associated to SLE; and(3) a putative liver damage induced by SLE itself, referred to as "lupus hepatitis". In the first group, liver injury can be ascribed to overlapping hepatopathies triggered by autoimmune mechanisms other than SLE occurring with higher incidence in the context of lupus(e.g., autoimmune hepatitis, primary biliary cirrhosis). The second group includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoagulation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug-induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The pathological mechanisms underlying each of these liver disorders are also reviewed. Despite the high heterogeneity in the literature regarding the prevalence of SLE-associated liver diseases and, in most cases, lack of histopathological evidence or clinical studies large enough to support their existence, it is becoming increasingly apparent that liver is an important target of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drugs. Diagnosing liver disease in SLE patients is always challenging, and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding of pathogenesis and to build an appropriate work-up for diagnosis.

关键词： Systemic lupus erythematosus Lupus hepatitis Esteatosis Regenerative nodular hyperplasia Hepatitis C Autoimmune hepatitis Hepatotoxicity Nonsteroidal anti-inflammatory drugs Methotrexate

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Novel Brick Technology for Carbon Reduction Footprint in Steel Shop Linings

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China's Refractories 2024年第2期33卷 16-21页

作者： Carlos PAGLIOSA Leandro ROCHA marcelo BORGES Celio CAVALCANTE RHI MAGNESITA Contagem32210-000Brazil

Clean steel encompasses a multitude of concepts that are based on fulfilling customer requirements and can be produced in many ways depending on the existing equipment and detailed customer demands.A common feature of all clean steel production is tight process control along with continuous *** meet an increasing demand for cold-rolled(CR)steel sheets of improved mechanical properties,and to cope with the change of the annealing process from a batch-type to a continuous process,it is necessary to establish a technique for making ultralow carbon(ULC)steel with a C-concentration lower than 20 ppm for the steelmaking process associated with a major challenge to guarantee the competitiveness with observance of environmental *** ladle lining plays an important role on the energy consumption during the production and the refractory lining design contributes to minimize thermal bath loss,carbon pick up and shell temperature.A new generation of unfired zero carbon refractories was developed with two specific approaches:(1)replacement of firing bricks reducing CO_(2) footprint and(2)replacement of carbon containing with performance *** can be used in working and safety linings with a unique microstructure with better heat scattering and similar thermomechanical *** work presents customers’performance compared to traditional products highlighting energy savings.

关键词： steel ladle zero carbon energy saving

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The effects of additive outliers in INAR(1) process and robust estimation

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Statistical Theory and Related Fields 2018年第2期2卷 206-214页

作者： marcelo Bourguignon Klaus L.P.Vasconcellos Departamento de Estatística Universidade Federal do Rio Grande do NorteNatalRNBrazil Departamento de Estatística Cidade UniversitáriaUniversidade Federal de PernambucoRecifePEBrazil

In this paper, methods based on ranks and signs for estimating the parameters of thefirst-order integer-valued autoregressive model in the presence of additive outliers are proposed. In particular, we use the robust sample autocorrelations based on ranks and signsto obtain estimators for the parameters of the Poisson INAR(1) process. The effects ofadditive outliers on the estimates of parameters of integer-valued time series are examined. Some numerical results of the estimators are presented with a discussion of theobtained results. The proposed methods are applied to a dataset concerning the numberof different IP addresses accessing the server of the pages of the Department of Statistics of the University of Würzburg. The results presented here give motivation to use themethodology in practical situations in which Poisson INAR(1) process contains additiveoutliers.

关键词： Additive outliers Poisson INAR(1)process robustness squared difference estimator

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Follicular dendritic cell sarcoma of the liver:unusual presentation of a rare tumor and literature review

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 443-445页

作者： Paulo N Martins Sanjay Reddy Ann-Britt Martins marcelo Facciuto Department of Surgery Division of Hepatobiliary Surgery and TransplantationNew York Medical CollegeNew YorkUSA Department of Surgery New York Medical CollegeSt.Vincent's Catholic Medical CenterNew YorkUSA

BACKGROUND:Hepatic follicular dendritic cell (FDC) sarcoma is an extremely rare *** commonly,FDC sarcoma presents as a solitary mass in lymph nodes,however,several extra-nodal locations have been ***:We report a case of a 53-year-old female who presented with symptoms of abdominal pain,fever,anemia,and *** an extensive review of the literature,we have found only 12 cases of hepatic FDC ***:The tumor was 11.5 cm in diameter and composed of spindle and epithelioid cells with ovoid nuclei and associated with mixed inflammatory *** stains were positive for CD35 and *** patient underwent a left hepatic ***:Liver follicular dendritic cell sarcoma is a very rare *** cases present with abdominal pain and weight loss,and most of them can be managed by hepatic resection with excellent short-term outcomes.

关键词： follicular dendritic cell tumor liver neoplasms sarcoma jaundice

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Lattice Boltzmann Modeling of Miscible Multicomponent Gas Mixtures in the Rarefied Regime

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Communications in Computational Physics 2022年第9期32卷 1179-1216页

作者： Michel Ho Sami Ammar Sebastien Leclaire marcelo Reggio Jean-Yves Trepanier Departement of Mechanical Engineering Polytechnique Montreal2500 Chemin de PolytechniqueMontreal H3T 1J4Canada

An extension to rarefied flow regimes of the lattice Boltzmann methodbased model for miscible mixtures developed by Vienne et al.(Physical Review E 100.2(2019):023309)is *** model is applied to study the gas phase separation phenomenon in mixture flows that traditional macroscopic approaches fail to *** extension includes a wall function approach with an empirical coefficient to define an effectivemean free path in solid geometries,which locally defines the kinematic viscosity and binary diffusion *** algorithm is also modified by a local multi-relaxation time collision operator and slip boundary conditions at solid *** mixture flow simulations are conducted through a 2D plane microchannel within the slip and early transition flow *** a miscible gaseous phase,the mixture loses its homogeneity and independent velocity profiles for each component are observed in the rarefied regime and captured with the current *** addition,the gas separation phenomenon increases with the rarefaction rate and the molecular mass *** individual treatment of the species within mixture flows in the developed lattice Boltzmann model helps understanding the increasing independent behavior of the individual specieswithin themixture as the regime becomesmore rarefied.

关键词： Lattice Boltzmann gaseous mixtures rarefied regimes

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Skeletal muscle atrophy,regeneration,and dysfunction in heart failure:Impact of exercise training

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Journal of Sport and Health Science 2023年第5期12卷 557-567,F0003页

作者： Harrison Gallagher Paul W.Hendrickse marcelo G.Pereira T.Scott Bowen School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLeeds LS29JTUK

This review highlights some established and some more contemporary mechanisms responsible for heart failure(HF)-induced skeletal muscle wasting and *** first describe the effects of HF on the relationship between protein synthesis and degradation rates,which determine muscle mass,the involvement of the satellite cells for continual muscle regeneration,and changes in myofiber calcium homeostasis linked to contractile *** then highlight key mechanistic effects of both aerobic and resistance exercise training on skeletal muscle in HF and outline its application as a beneficial ***,HF causes multiple impairments related to autophagy,anabolic-catabolic signaling,satellite cell proliferation,and calcium homeostasis,which together promote fiber atrophy,contractile dysfunction,and impaired *** both wasting and weakness are partly rescued by aerobic and resistance exercise training in HF,the effects of satellite cell dynamics remain poorly explored.

关键词： Calcium Exercise training Heart failure Satellite cells Skeletal muscle wastingTagedAPTARAEnd

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Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord

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Asian Journal of Andrology 2020年第1期22卷 112-117页

作者： Diego Moreno Cristian M Sobarzo Livia Lustig marcelo G Rodriguez Pena Vanesa Anabella Guazzone National Scientific and Technical Research Council-University of Buenos Aires Institute of Biomedical Research(INBIOMEDUBA-CONICET)Buenos Aires C 1121ABGArgentina Central Militar Hospital"Cirujano Mayor Dr.Cosme Argerich" Buenos Aires C 1426BORArgentina University of Buenos Aires School of MedicineDepartment of Cellular Biology and Histology/Academic Unit IIBuenos Aires C 1121ABGArgentina Militar Hospital"Campo de Mayo" Buenos Aires 1659Argentina

The aim of this work was to study effects of ketotifen fumarate(KF)on prevention of tissue damage in testes of rats with experimental autoimmune orchitis(EAO)and on the contralateral testis in a model of prolonged testicular cord torsion(TCT).Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution(vehicle group).Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen *** cells(MC)were identified by histochemistry and *** EAO model,KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle *** also reduced the number of testicular MC compared to vehicle ***,in TCT model,multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium,seminiferous tubule atrophy,and interstitial *** signs of inflammation and fibrosis of seminiferous tubular walls were also *** contrast,sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features.A significant decrease in the number of MC was observed in rats treated with KF compared to untreated *** conclusion,we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT *** results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss.

关键词： ketotifen fumarate male infertility mast cells orchitis testicular cord torsion testis

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Mirizzi syndrome:History,current knowledge and proposal of a simplified classification

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World Journal of Gastroenterology 2012年第34期18卷 4639-4650页

作者： marcelo A Beltrán Department of Surgery La Serena HospitalLa Serena 1700000Chile

Chronic complications of symptomatic gallstone disease, such as Mirizzi syndrome, are rare in Western developed countries with an incidence of less than 1% a year. The importance and implications of this condition are related to their associated and potentially serious surgical complications such as bile duct injury, and to its modern management when encountered during laparoscopic cholecystectomy. The pathophysiological process leading to the subtypes of Mirizzi syndrome has been explained by means of a pressure ulcer caused by an impacted gallstone at the gallbladder infundibulum, leading to an inflammatory response causing first external obstruction of the bile duct, and eventually eroding into the bile duct and evolving to a cholecystocholedochal or cholecystohepatic fistula. This article reviews the life of Pablo Luis Mirizzi, describes the earlier and later descriptions of Mirizzi syndrome, discusses the pathophysiological process leading to the development of these uncommon fistulas, reviews the current diagnostic modalities and surgical approaches and finally proposes a simplified classification for Mirizzi syndrome intended to standardize the reports on this condition and to eventually develop a consensual surgical approach to this unexpected and seriously dangerous condition.

关键词： Cholelithiasis Chronic gallbladder disease Gallstone disease Mirizzi syndrome

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MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults

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World Journal of Gastroenterology 2013年第20期19卷 3043-3051页

作者： Marisa C Alvarez Juliana C Santos Nathália Maniezzo marcelo S Ladeira Artur LC da Silva Isabel CA Scaletsky José Pedrazzoli Jr marcelo L Ribeiro Unidade Integrada de Farmacologia e Gastroenterologia Universidade So FranciscoBragan a Paulista 12916-900SPBrazil Programa de Pós Gradua o em Genética e Biologia Molecular State University of CampinasCampinas 13083-970SPBrazil Departamento de Clínica Médica UNESPBotucatu 18618-970SPBrazil Departamento de Genética Universidade Federal do ParáBelém 68400-000PABrazil Departamento de Microbiologia Imunologia e ParasitologiaUniversidade Federal de So PauloSo Paulo 04021-001SPBrazil

AIM:To evaluate the association between Helicobacter pylori(***) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPCR) in gastric biopsy samples from uninfected or ***-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric cancer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PCR;PCR products were analysed by single strand conformation polymorphism followed by silver *** analyses were performed with either the χ 2 test with Yates continuity correction or Fisher's exact test,and statistical significance for expression analysis was assessed using an unpaired Student's ***:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of *** infection *** MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with *** infection(P < 0.05);this region was methylated in 66% of gastric cancer patients,and the difference in the percentage of methylated samples between these patients and those from ***-infected chronic gastritis patients was statistically significant(P < 0.05).MLH1 methylation frequencies among ***-infected and non-infected chronic gastritis adult patients were 13% and 7%,*** observed methylation of the MLH1 promoter(39%) and increased MSI levels(68%) in samples from gastric cancer patients in comparison to samples from ***-infected adult chronic gastritis patients(P < 0.001 and P < 0.01,respectively).The frequency of promoter methylation for both genes was higher in gastric cancer sam

关键词： Helicobacter pylori Microsatellite instability Promoter methylation MLH1 MGMT Gastric cancer

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Decentralized solar-powered cooling systems for fresh fruit and vegetables to reduce post-harvest losses in developing regions:a review

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Clean Energy 2023年第3期7卷 635-653页

作者： Waseem Amjad Anjum Munir Fatima Akram Aditya Parmar marcelo Precoppe Furqan Asghar Faisal Mahmood Department of Energy Systems Engineering University of Agriculture FaisalabadFaisalabadPakistan Department of Agricultural&Biological Engineering Purdue UniversityWest LafayetteINUSA Natural Resources Institute University of GreenwichChatham MaritimeChathamME44TBUK

The availability of on-farm storage and processing is a critical challenge facing small farmers,which hinders agricultural *** per cent of the food produced globally is lost after harvest,with the proportion being exceptionally high in low-and middle-income countries due to a lack of on-farm handling and storage *** cold-storage solutions have not taken off at the smallholder level,mainly due to a lack of availability and access to reliable grid ***,off-grid decentralized solar-powered cold-storage units can play a vital role in preserving the produce at production sites and enhancing livelihood and rural development with a minimal carbon *** maintain low temperatures at every step of the agricultural value chain,known as the‘cold chain’,several technology vendors aim to improve the shelf life and user ***-scale farmers,which account for two-thirds of all food losses,are another group they focus *** study examines the existing situation,importance and potential opportunities of decentralized cold-storage systems for fresh fruit and *** addition to economic,social,technological and environmental limitations,this study examines the triumphs and challenges of incorporating solar-energy-powered cold storage into developing *** the private sector,NGOs and some government agencies are working to promote decentralized cold-storage facilities,relatively little has been done so far to have a significant influence on post-harvest losses and food *** are still knowledge gaps on decentralized cold-storage *** primary operational constraint is the economic situation of end users and the lack of financing alternatives for smallholder farmers.

关键词： post-harvest losses solar energy on-farm cold storage GHG emission

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