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胃癌:多层螺旋CT(MDCT)纹理分析作为一个潜在术前预后评估的生物标志物

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国际医学放射学杂志 2017年第4期 480-480页

作者： F.Giganti S.Antunes A.Salerno A.Ambrosi P.marra R.Nicoletti 朱珍 Department of Radiology and Centre for Experimental Imaging San Raffaele Scientific Institute

摘要目的探讨MDCT术前纹理分析与胃癌病人总生存期的相关性。方法伦理委员会批准并签署知情同意书。56例经活检证实的胃癌病人行MDCT检查,并经手术治疗。使用经过滤过或没有滤过的粗细纹理对纹理分析的影像特征进行量化。使用Kaplan-Me...

摘要目的探讨MDCT术前纹理分析与胃癌病人总生存期的相关性。方法伦理委员会批准并签署知情同意书。56例经活检证实的胃癌病人行MDCT检查,并经手术治疗。使用经过滤过或没有滤过的粗细纹理对纹理分析的影像特征进行量化。使用Kaplan-Meier和Cox分析法评估与生存时间的相关性。结果根据不同的阈值,以下参数均与预后不良有

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Nat Genet:科学家设计新方法找到抑制癌症发育的新基因

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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Jorge de la Rosa, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Allan Bradley Juan Cadiñanos Jorge de la Rosa Juan Cadiñanos Jorge de la Rosa Carlos López-Otín Julia Weber Roland Rad Julia Weber Roland Rad Aurora Astudillo maría Teresa Fernández-García maría Soledad Fernández-García Gary J Hoffman Carlos López-Otín The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton UK Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA) Oviedo Spain Departamento de Bioquímica y Biología Molecular Facultad de Medicina Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo Oviedo Spain Department of Internal Medicine II Klinikum rechts der Isar Technische Universität München München Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Servicio de Anatomía Patológica Hospital Universitario Central de Asturias Oviedo Spain Unidad de Histopatología Molecular Facultad de Medicina IUOPA Universidad de Oviedo Oviedo Spain School of Medicine University of Western Australia Crawley Western Australia Australia Centro de Investigación Biomédica en Red de Cáncer Spain.

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在... 详细信息

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在国际学术期刊Nature Genetics上。该研究揭示了一些参与癌症发育的新途径，这些基因有望成为治疗PTEN突变癌症的新药物靶点。这项研究开发的一些方法也可以用于发现其他协同抑制癌症生长的基因。

关键词：新基因癌症发育 Nat 科学家设计肿瘤抑制基因国际学术期刊

Post-Hospital Syndrome and Hyponatremia

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Health 2021年第8期13卷 846-856页

作者： José Bellod-Tonda Julio Blázquez-Encinar maría Dolores Jover-Ríos Carmen Seguí-Pérez Juan Méndez-Mora Francisco Caparrós-Hernández Álex Méndez-Jover marc Seguí-Pérez David Baláž Leticia Espinosa del Barrio Jesús Corbacho-Redondo Carles García-Cervera Juan Manuel Núñez-Cruz Isidro Hernández-Isasi Javier Guzmán-martínez Angie Gómez-Uranga Pedro Esteve-Atiénzar Jorge Peris-García Veronica martínez-Sempere Eliana Damonte-White Óscar Hernando Ruiz-Ariza Juan Carlos López-Corbalán Lourdes Lajara-Villar Andrea Riaño-Pérez Paloma Chazarra-Pérez maría Escamilla-Espínola maria Luisa Asensio-Tomás Miguel Ángel Auladell-Alemany Laura Serna-Torres Asunción Pérez-Fullana Amparo Gómez-Siurana Sergio Menargues-Irles José Miguel Seguí-Ripoll Internal Medicine Department University Hospital of San Juan Alicante Spain Internal Medicine Department Torrevieja University Hospital Alicante Spain Internal Medicine Department Hospital La Vega Baja of Orihuela Alicante Spain CEU Cardinal Herrera University Veterinary Hospital Valencia Spain Secondary School Marist Brothers High School Alicante Spain Department of Clinical Medicine Miguel Hernández University Elche Spain Primary Care Medicine Benilloba Spain Sub-Delegation of the Government Alicante Spain Chemical Engineering Department University of Alicante Alicante Spain

Introduction: Post-hospital syndrome (PHS) is defined as a period of vulnerability during the first 30 days after a patient is discharged from hospital, in which multiple factors come into play. Hyponatremia is the most frequent hydroelectrolytic disorder in hospitalized patients and may be related to the appearance of PHS. Objective: The objective is to estimate the prevalence of PHS that is assessed as the rate of readmissions in the first 30 days after discharge, in patients with hyponatremia. Material and Methods: It is a descriptive observational study of patients with hyponatremia who were discharged from 1 September 2010 to 2 February 2020 at the Internal Medicine Service of the Hospital University of San Juan (Alicante, Spain). Results: Of the 25 included patients, 5 (20%) were readmitted within a month of discharge, after a mean of 11.4 days (standard deviation [SD] 5.1). The overall mortality of the study was 20% (n = 5), with one case of death in the first 30 days post-hospitalization (4%). In 12 patients (48%) the origin of the hyponatremia was undetermined. The most frequently recorded etiology for the condition was pharmacological (n = 7, 28%), and there was pronounced variability in its clinical and laboratory study. The most widely used corrective measure was drug withdrawal, in 16 patients (64%). Water intake restriction was the most common treatment after discharge (5 patients, 20%), followed by urea (2 patients, 8%), while tolvaptan was not used. Conclusion: Hyponatremia may be the cause of PHS, which could increase the rate of early readmission. Hyponatremia is an underdiagnosed and undertreated entity, so it is necessary to apply an appropriate system to optimize its management and, in future studies, to assess its impact on PHS.

关键词： Hospitalization Hyponatremia Patient Readmission Inappropriate ADH Syndrome

Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain:a prospective population-based screening study

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Infectious Diseases of Poverty 2024年第2期13卷 29-38页

作者： Sílvia Roure Xavier Vallès Olga Pérez-Quílez Israel López-Muñoz Anna Chamorro Elena Abad Lluís Valerio Laura Soldevila Sergio España Alaa H.A.Hegazy Gema Fernández-Rivas Ester Gorriz Dolores Herena Mário Oliveira maria Carme Miralles Carmen Conde Juan José Montero-Alia Elia Fernández-Pedregal Jose Miranda-Sánchez Josep M.Llibre mar Isnard Josep maria Bonet Oriol Estrada Núria Prat Bonaventura Clotet The Schisto-Stop study group International Health Program(PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious DiseasesCatalan Institute for HealthCAP La SalutPassatge dels Encants S/N08916 BadalonaSpain FundacióLluita contra les Infeccions c/Can Ruti s/n08916 BadalonaSpain Infectious Diseases Department Hospital Universitari Germans Trias i Pujolc/Can Ruti s/n08916 BadalonaSpain Germans Trias i Pujol Research Institute c/Can Ruti s/n08916 BadalonaSpain Microbiology Department Germans Trias i Pujol University Hospitalc/Can Ruti s/n08916 BadalonaSpain Department of Genetics and Microbiology Universitat Autònoma de Barcelonac/Can Ruti s/n08916 BadalonaSpain Faculty of Medicine University of AsyutEl FatehAssiut Governorate 71515Egypt Department of Urology Germans Trias i Pujol University Hospitalc/Can Ruti s/n08916 BadalonaSpain Canovelles Primary Health Care Unit Barcelona North Metropolitan Health DirectorateCatalan Institute for HealthC/Indústria 2308420 CanovellesSpain Primary Health Care Unit Mataró-3(Rocafonda-Palau) Barcelona North MetropolitanHealth DirectorateCatalan Institute for HealthCamíRal el Ravalet 208Mataró08302 BarcelonaSpain Barcelona North Metropolitan Primary Care Directorate Catalan Institute for HealthCtra.de Barcelona 473Sabadell08204 BarcelonaSpain Directorate for Innovation and Interdisciplinary Cooperation Barcelona North Metropolitan Health DirectorateCatalan Institute for HealthC/Can Ruti S/N08916 BadalonaSpain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospitalc/Can Ruti s/n08916 BadalonaSpain Infectious Diseases Directorate Barcelona North Metropolitan Health DirectorateCatalan Institute for HealthC/Can Ruti S/N08916 BadalonaSpain 不详

Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to *** urogenital manifestations are often *** aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology *** We carried out a prospective,community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in *** serology tests and microscopic urine examinations were carried out,and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males,mean age 43.5 years[Standard Deviation(SD)=12.0,range:18-76].The median time since migration to the European Union was 17[Interquartile range(IQR):11-21]*** most frequent country of origin was Senegal(N=179,46.1%).Of the 338,147(37.6%)tested positive for *** eggs were present in the urine of only 1.3%.Nine genitourinary clinical items were significantly associated with positive Schistosoma serology results:pelvic pain(45.2%;OR=1.57,95%CI:1.0-2.4),pain on ejaculation(14.5%;OR=1.85,95%CI:1.0-3.5),dyspareunia(12.4%;OR=2.45,95%CI:1.2-5.2),erectile dysfunction(9.5%;OR=3.10,95%CI:1.3-7.6),self-reported episodes of infertility(32.1%;OR=1.69,95%CI:1.0-2.8),haematuria(55.2%;OR=2.37,95%CI:1.5-3.6),dysuria(52.1%;OR=2.01,95%CI:1.3-3.1),undiagnosed syndromic STIs(5.4%),and orchitis(20.7%;OR=1.81,95%CI:1.0-3.1).Clinical signs tended to *** Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positive Schistosoma serology *** involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of *** research is needed to develop diagnostic tools and validate therapeutic approaches to chronic schistosomiasis.

关键词： Schistosomiasis Chronic schistosomiasis Urogenital schistosomiasis Male genital schistosomiasis Longterm migrant

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Selective Fetal Growth Restriction in MonochorionicDiamniotic Twins: Diagnosis and Management:Erratum

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Maternal-Fetal Medicine 2023年第1期5卷 57-57页

作者： Zumaeta, Alicia Mazer mar Gil, maria Rodriguez-Fernandez, Miguel Carretero, Pilar Hector Ochoa, Jose Cristina Casanova, maria Sonia Molina, Francisca Hosp Univ Clin San Cecilio Dept Obstet & Gynecol Granada 18016 Spain Hosp Materno Prov Dr Raul Felipe Lucini Dept Obstet & Gynecol RA-5000 Cordoba Argentina Diagnus SA Prenatal Diag & Fetal Med Ctr RA-5000 Cordoba Argentina Hosp Univ Torrejon Obstet & Gynecol Dept Madrid 28223 Spain Univ Francisco Vitoria Sch Med Madrid 28223 Spain Inst Invest Biosanitaria Ibs GRANADA Granada 18016 Spain

Following the original article’s publication,1the authors identified an error in the published *** authors and institution section should be corrected as follows:Alicia Mazer Zumaeta1,2,3,maríamarGil4,5,*,Miguel Rod... 详细信息

关键词： institution corrected Management

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五指丧失后手功能的重建

中华外科杂志 1952年第5期03卷 349-349页

作者： Bradford Cannon et al.Surgety mar. 易声禹

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钙质条件下施用风化煤腐植酸铁肥对大豆根系铁和腐植酸的积累

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腐植酸 2020年第1期 94-94页

作者： maría Teresa Cieschi Juan José Lucena 袁晓娜中国腐植酸工业协会

为了提高风化煤腐植酸铁(LIH)的利用率,研究了在钙质条件下,大豆根系腐植酸的积累、铁生物矿化与植株铁营养的关系。为此,特设置了2个水培试验:短期生物试验,时间为21天,试验设4种剂量(10、20、50、100微摩尔铁/盆),分3次(每周1次)施用L... 详细信息

为了提高风化煤腐植酸铁(LIH)的利用率,研究了在钙质条件下,大豆根系腐植酸的积累、铁生物矿化与植株铁营养的关系。为此,特设置了2个水培试验:短期生物试验,时间为21天,试验设4种剂量(10、20、50、100微摩尔铁/盆),分3次(每周1次)施用LIH;长期生物试验,时间为60天,只施用1次LIH,剂量为250微摩尔铁/盆。

关键词：生物试验铁营养水培试验铁肥大豆根系腐植酸生物矿化微摩尔

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融贯性在法律推理理论中的作用与价值

苏州大学学报（法学版） 2020年第3期7卷 150-160页

作者： [英]马克西米利安·德奥·马尔邢焱鹏(译) 方新军(校) 伦敦玛丽女王大学苏州大学王健法学院

融贯性理论的首要目的是为法律推理提供另一个视角。就融贯性在法律推理中的作用而言,麦考密克主张的是一种弱融贯论。融贯性属于麦考密克所说的“二次证明”,二次证明必须对相互对立的两个规则进行三次检验,继而再判断规则的一致性、... 详细信息

融贯性理论的首要目的是为法律推理提供另一个视角。就融贯性在法律推理中的作用而言,麦考密克主张的是一种弱融贯论。融贯性属于麦考密克所说的“二次证明”,二次证明必须对相互对立的两个规则进行三次检验,继而再判断规则的一致性、融贯性和效力性。法律规则层面的融贯性和一致性需要持续关注法律与融贯的基本价值体系的联系,但麦考密克并没有清晰地阐明基于融贯性的论辩与实质正义是如何关联起来的,也从未缓和融贯性更大的作用与多元价值主义所信奉的元伦理之间的紧张关系。关系伦理学要求尊重对价值问题的合理分歧,既涉及合议庭的法官之间的关系、法官与辩护人之间的关系,也涉及法官与各方当事人之间的关系。

关键词：融贯性价值多元主义法律推理关系伦理学

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Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari fernanda de Alves Freitas Guesdes marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-Food Canada Fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA Department of Plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions