检索结果-南通市图书馆

Geological Features,Mineralization Types and Metallogenic Setting of the Phlaythong Large Iron Deposit,Southern Laos

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2015年第4期89卷 1423-1424页

作者： LIU Shusheng FAN Wenyu LUO maojin YANG Yongfei College of Earth Sciences Chengdu University of Technology Chengdu Center China Geological Survey

The Phlaythong large iron deposit in Shampasak of southern Laos,is located in the Kon Tum microblock （Fig.1A）,central-southern part of the Indo-China block,and the geographic coordinate of the central mining area is... 详细信息

关键词： Geological Features,Mineralization Types and Metallogenic Setting of the Phlaythong Large Iron Deposit,Southern Laos TFe

Probing the Nucleation and Growth Kinetics of Bismuth Nanoparticles via In-situ Transmission Electron Microscopy

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 877-887页

作者：王浪李超凡 RAN maojin YUAN Manman 胡执一 LI Yu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Nanostructure Research Centre(NRC) Wuhan University of TechnologyWuhan 430070China Institute of Chemistry Henan Academy of SciencesZhengzhou 450002China Henan Academy of Sciences Zhengzhou 450046China

The nucleation and growth mechanism of nanoparticles is an important theory,which can guide the preparation of ***,it is still lacking in direct observation on the details of the evolution of intermediate state structure during nucleation and *** this work,the evolution process of bismuth nanoparticles induced by electron beam was revealed by in-situ transmission electron microscopy(TEM)at atomic *** experimental results demonstrate that the size,stable surface and crystallographic defect have important influences on the growth of Bi *** non-classical growth paths including single crystal growth and polycrystalline combined growth,as well as,corresponding layer-by-layer growth mechanism along{012}stable crystal plane of Bi nanoparticles with dodecahedron structure were revealed by in-situ TEM *** results provide important guidance and a new approach for in-depth understanding of the nucleation and growth kinetics of nanoparticles.

关键词： bismuth nanoparticles crystal growth transmission electron microscopy in-situ electron microscopy

Magmatic Hydrothermal Origin of the Wenyu Copper Polymetallic Deposit, Southern Lancangjiang Zone, SW China

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2015年第5期89卷 1769-1770页

作者： YANG Yongfei FAN Wenyu LUO maojin SHI Hongzhao Chengdu Center China Geological Survey

The Wenyu copper polymetallic deposit, with proven reserves of about 0.23 Mt Cu, 394 t Ag and 0.04 Mt Pb, is located in the central part of the Lancangjiang volcanic rock belt （Fig. l a）, which is one of the most po... 详细信息

关键词： Cu Southern Lancangjiang Zone SW China Magmatic Hydrothermal Origin of the Wenyu Copper Polymetallic Deposit

A Usable Selection Range Standard Based on Test Suite Reduction Algorithms

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2010年第3期15卷 261-266页

作者： MA Yanjun ZHAO Zhigang LIANG Yuchen YUN maojin College of Information Engineering Qingdao University Qingdao 266071 Shandong China College of Computing Blekinge Institute of Technology Karlskrona 37179 Blekinge Sweden College of Physics Science Qingdao University Qingdao 266071 Shandong China

In this paper, we analyze the features and distinctions of 6 classical algorithms： greedy algorithm （G）, greedy evolution algorithm （GE）, heuristics algorithm （H）, greedy heuristic G （GRE）, integer linear programming algorithm （ILP） and genetic algorithm （GA） to ensure the main influencing factors-the performance of algorithms and the running time of algorithms. What＇s more, we would not only present a research design that aims at gaining deeper understanding about the algorithm classification and its function as well as their distinction, but also make an empirical study in order to obtain a practical range standard that can guide the selection of reduction algorithms. When the size of a test object （product of test requirements and test cases） is smaller than 2000×2000, G algorithm is the commonly recommended algorithm. With the growth of test size, the usage of GE and GRE becomes more general.

关键词： test suite reduction algorithms influencing factor selection standard

Cellular origin of glioblastoma and its implication in precision therapy

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第8期15卷 737-739页

作者： maojin Yao Shu Li Xiaojun Wu Shuo Diao Guoxin Zhang Hua He Liuguan Bian Yicheng Lu Department of Microbiology Immunology and Cancer BiologySchool of MedicineUniversity of VirginiaCharlottesvilleVA 22903USA Department of Pathophysiology Wannan Medical CollegeWuhu 241002China Department of Neurosurgery Changzheng HospitalSecond Affiliated Hospital of Second Military Medical University415 Fengyang RoadShanghai 200003People's Republic of China Department of Neurosurgery First Affiliated HospitalDalian Medical UniversityDalian 116044People’s Republic of China Brain Tumor Institute University of CaliforniaSan DiegoCA 92093-0695USA State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesBeijing 201203China Department of Neurosurgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Glioblastoma(GBM)is the most common malignant primary tumor in the central nervous *** advances in neurosurgery,radiation therapy and chemotherapy,the median survival time of GBM patients is only 9 to 16 months.1 Therefore,GBM is considered one of the deadliest human *** the past two decades,many efforts have been made by scientists and clinicians to develop new drugs to improve current ***,most efforts have not achieved long-term remissions in clinical trials,even though some of them are promising in animal models,making treatment options still limited.

关键词： drugs chemotherapy clinical

Lycium ruthenicum Murr. treatment attenuates APP_(SWE)/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2023年第5期12卷 1618-1625页

作者： Min Wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao maojin Yao Jiaoyan Ren School of Food Science and Engineering South China University of TechnologyGuangzhou 510641China Guangzhou Institute of Respiratory Disease&China State Key Laboratory of Respiratory Disease The First Affi liated Hospital of Guangzhou Medical UniversityGuangzhou 510182China

Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease(AD). However, it is unclear whether different mouse models with mitochondrialrelated diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APP_(SWE)/PS1ΔE9 transgenic mouse were examined using transmission electron microscope(TEM). Both young Slc25a46 knockout mice and aged APP_(SWE)/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD.

关键词： Mitochondria dysfunction Ageing Slc25a46 knockout mouse Alzheimer’s disease Lycium ruthenicum Murr.

木麻黄速生抗风害性状的育种值预测与优良个体的初步选择

在线全文

学校读者我要写书评

暂无评论

林业科学 2024年第12期60卷 92-100页

作者：李茂瑾福建省晋江坫头国有防护林场晋江362200

【目的】以台风袭击后的木麻黄国际种源试验林为研究对象,以速生抗风性为主要选育目标,开展短枝木麻黄抗风种质的评价和优良个体的选择。【方法】以澳大利亚林木种子中心引进的10个国家23个种源109个家系的10年生短枝木麻黄种源试验林... 详细信息

【目的】以台风袭击后的木麻黄国际种源试验林为研究对象,以速生抗风性为主要选育目标,开展短枝木麻黄抗风种质的评价和优良个体的选择。【方法】以澳大利亚林木种子中心引进的10个国家23个种源109个家系的10年生短枝木麻黄种源试验林作为材料,基于“杜苏芮”台风袭击后灾害调查数据,利用基于BLUP的混合线性模型方法对生长性状、遗传力和育种值进行测定和估算,并结合折干率、倒伏率、保存率和台风受损程度对短枝木麻黄优良家系和优良个体进行综合选择。【结果】不同家系间树高、胸径、材积和保存率差异达极显著水平(P0.05)。除了保存率外,木麻黄基因库的其他性状家系遗传力都小于单株遗传力。以材积育种值大于0、剔除保存率小于平均值的家系和入选率为20%为标准,筛选了22个速生优良家系,其树高、胸径、单株立木材积和冠幅能获得的遗传增益分别为18.27%、23.2%、49.9%和24.3%;采用单株材积育种值为正且入选率为10%为标准,筛选了106株优良个体,树高、胸径、单株立木材积和冠幅能获得的遗传增益分别为21.0%、44.4%、101.8%和38.5%,可提供木麻黄第1代种子园建园材料并充实核心生产群体。【结论】台风袭击后不同木麻黄家系生长性状差异显著,具有较强选择潜力。根据材积性状育种值结合保存率筛选出22个优良家系和106株优良个体,可作为进一步遗传改良的材料。

关键词：木麻黄基因资源抗风害育种值选择

MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2016年第5期13卷 658-668页

作者： Hua He maojin Yao Wenhao Zhang Bangbao Tao Feili Liu Shu Li Yan Dong Chenran Zhang Yicheng Meng Yuxin Li Guohan Hu Chun Luo Hui Zong Yicheng Lu Department of Neurosurgery Changzheng Hospital Second Affiliated Hospital of Second Military Medical University 415 Fengyang Road Shanghai 200003 P.R.China Department of Microbiology Immunology and Cancer Biology School of Medicine University of Virginia USA Department of Hematology Xinhua Hospital School of Medicine Shanghai Jiaotong University Shanghai China Department of Neurosurgery Xinhua Hospital School of Medicine Shanghai Jiaetong University Shanghai China Department of Pathophysiology Wannan Medical College 22 Wenchang Road Wuhu 241002 China

Although temozolomide （TMZ） is the first-line chemotherapeutic agent for glioblastoma, it is often non-curative due to drug resistance. To overcome the resistance of glioblastoma cells to TMZ, it is imperative to identity prognostic markers for outcome prediction and to develop chemo-sensitizing agents. Here, the gene expression profiles of TMZ-resistant and TMZ-sensitive samples were compared by microarray analysis, and mitogen-activated protein kinase kinase 2 （MEK2） was upregulated specifically in resistant glioma cells but not in sensitive tumor cells or non-tumor tissues. Moreover, a comprehensive analysis of patient data revealed that the increased level of MEK2 expression correlated well with the advancement of glioma grade and worse prognosis in response to TMZ treatment. Furthermore, reducing the level of MEK2 in U251 glioma cell lines or xenografted glioma models through shRNA-mediated gene knockdown inhibited cell proliferation and enhanced the sensitivity of cells toward TMZ treatment. Further analysis of tumor samples from glioma patients by real-time PCR indicated that an increased MEK2 expression level was closely associated with the activation of many drug resistance genes. Finally, these resistance genes were downregulated after MEK2 was silenced in vitro, suggesting that the mechanism of MEK2-induced chemo-resistance could be mediated by the transcriptional activation of these resistance genes. Collectively, our data indicated that the expression level of MEK2 could serve as a prognostic marker for glioma chemotherapy and that MEK2 antagonists can be used as chemo-sensitizers to enhance the treatment efficacy of TMZ.

关键词： glioma MEK2 temozolomide

Metastatic tumor to the iris and ciliary body as an initial sign of lung cancer: a case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2005年第13期118卷 1131-1133页

作者： SUIRui-fang ZHAOJia-liang ZHANGShun-hua FENGRui-e CHENGGang-wei MAJian-min maojin DepartmentofOphthalmologyPekingUnionMedicalCollegeHospital ChineseAcademyofMedicalSciencesBeijing100730China DepartmentofPathologyPekingUnionMedicalCollegeHospital ChineseAcademyofMedicalSciencesBeijing100730China

The most common sites of lung cancer metastases are pleura, bone, brain,pericardium and liver. Tumor metastasis to the eye is a rare complication of lung cancer. Metastaticcancer to the ocular region most often involves the uveal tract, however, most uveal metastasesoccur in the posterior uvea, and iris metastases are relatively rare. We describe a patient withadenocarcinoma of the lung metastatic to the iris as the first clinical sign without symptoms oflung cancer.

关键词： metastatic tumor iris lung cancer