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Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

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BIOCELL 2023年第8期47卷 1793-1802页

作者： FU-MING TSAI PING-HSUN LU LU-KAI WANG CHAN-YEN KUO mao-liang chen CHUN-HUA WANG Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi UniversityHualien970Taiwan Department of Life Sciences National Science and Technology CouncilTaipei106Taiwan Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Medicine Tzu Chi UniversityHualien970Taiwan

Background:Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human *** often reduce the use of cisplatin due to its side effects,which in turn affects its *** study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for ***:Primary human follicle dermal papilla cells(HFDPCs)were used as target cells for cisplatininduced damage to hair *** blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs *** survival and cell cycle were analyzed by mitochondrial staining reagent WST-1 and propidium ***:Cisplatin could reduce the viability of HFDPCs without causing cell *** increased the level of phospho-Rad17 in HFDPCs and activated the Chk1/Cdc25C signaling to reduce the expression of Cdc2 protein,thereby arresting the cells in the G2/M *** combination of safflower extract and the flavonoids could effectively inhibit the signal transduction of Rad17/Chk1/Cdc25 in cisplatin-treated cells and reduce the cell population in the G2/M ***,we also confirmed that safflower extract could effectively inhibit the damage to HFDPCs caused by cisplatin,mainly at the level of reducing the DNA damage caused by ***:Safflower extract can be used as an adjuvant Chinese medicine for chemotherapy to reduce the damage caused by chemotherapy to normal hair follicle cells.

关键词： Safflower extract Cisplatin Human hair follicle dermal papilla cells Rad17 Hair loss Cell cycle

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting Liu Quan‑liang Zhao chen‑Sha Li mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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Super-high bed sintering for iron ores:variation and optimization of bed resistance

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Journal of Iron and Steel Research International 2025年第1期32卷 40-51页

作者： liang-ping Xu Lin Xiong Hui-bo Liu Xi-duan Yang Ai-xiang mao Pei-dun chen Guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Central Research Institute Baosteel Group Co.Ltd.Shanghai201900China Manufacturing Management Department Guangdong Zhongnan Iron and Steel Co.Ltd.Shaoguan512123GuangdongChina Technology and Development Center Shandong Taishan Iron and Steel Group Co.Ltd.Jinan271100ShandongChina

As the bed depth increases,sintering yield increases,but the productivity *** reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the *** results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 *** improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 *** using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 *** bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 *** optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.

关键词： Super-high bed sintering Bed resistance Permeability Productivity Wet zone Combustion zone

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Wave effect of gravitational waves intersected with a microlens field II:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 237-250页

作者： Xikai Shan Guoliang Li Xuechun chen Wen Zhao Bin Hu Shude mao Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Department of Astronomy Tsinghua UniversityBeijing 100084China Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China School of Physics and Astronomy Beijing Normal UniversityBeijing 100875China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves(SLGWs).This effect presents both challenges and opportunities for the detection and appli-cation of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses(10^(3)-10^(6)).Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algo-rithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work(***.66,239511,2023),this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs(from saddle position of the time delay surface)due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%(11%)of SLGWs have a mismatch larger than 1%(3%)compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10^(−3),and 61%(25%)of signal pairs have a mismatch larger than 1%(3%).Theref

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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Correlation between grain size,mechanical properties and deformed microstructure of Fe-20Mn-6Al-0.6C-0.15Si low-density steel

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Journal of Iron and Steel Research International 2025年第1期32卷 282-292页

作者： Qi Zhang Guang-hui chen Zheng-liang Xue Zheng-kun chen Guang Xu State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Red Eagle Novel Refractory Materials Research Institute Zhejiang Red Eagle Group Co.Ltd.Huzhou313000ZhejiangChina

The effects of austenite grain size on the deformed microstructure and mechanical properties of an Fe-20Mn-6Al-0.6C-0.15Si(wt.%)low-density steel were *** microstructure of the experimental steel after solution treatment was single austenitic *** austenite grain size increased with solution temperature and time.A model was established to show the relationship between temperature,time and austenite grain size for the experimental *** addition,as the solution temperature increased,the strength decreased,while the elongation first increased and then *** decrease in elongation after solution treatment at 1100℃ for 90 min is contributed to the over-coarse austenite ***,after solution treatment at 900℃ for 90 min,the strength-elongation product reached the highest value of 44.4 GPa%.As the austenite grain size increased,the intensity of//tensile direction fiber *** was accompanied by a decrease in dislocation density,resulting in a lower fraction of low-angle grain boundaries and a lower work hardening ***,the austenite grain size has a critical influence on the mechanical properties of the low-density *** grains lead to a lower yield strength due to the Hall-Petch effect and a lower tensile strength because of lower dislocation strengthening.

关键词： Austenitic low-density steel Solution treatment Grain size Mechanical property Deformed microstructure

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Unraveling the reaction mechanism of high reversible capacity CuP_(2)/C anode with native oxidation PO_(x) component for sodium-ion batteries

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Chinese Chemical Letters 2025年第1期36卷 574-578页

作者： Huixin chen chen Zhao Hongjun Yue Guiming Zhong Xiang Han liang Yin Ding chen State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China CAS key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China Laboratory of Advanced Spectro-electrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Physics Chinese Academy of SciencesBeijing 100190China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi institutesChinese Academy of SciencesXiamen 361021China

Phosphorus-based anode is a promising anode for sodium-ion batteries(SIBs)due to its high specific capacity,however,suffers from poor electronic conductivity and unfavorable electrochemical *** metals such as copper(Cu)into phosphorus has been demonstrated to not only improve the electronic conductivity but also accommodate the volume change during cycling,yet the underline sodiation mechanism is not ***,take a copper phosphide and reduced graphene oxide(CuP_(2)/C)composite as an example,which delivers a high reversible capacity of>900 mAh/***,it is revealed that the native oxidation PO_(x)components of the CuP_(2)/C composite show higher electrochemical reversibility than the bulk Cu P_(2),based on a quantitative analysis of high-resolution solid-state^(31)P NMR,ex-situ XPS and synchrotron X-ray diffraction characterization *** sodiation products Na_(3)PO_(4) and Na_(4)P_(2)O_(7) derived from PO_(x) could react with Na-P alloys and regenerate to PO_(x) during charge process,which probably accounts for the high reversible capacity of the Cu P_(2)/C *** findings also illustrate that the phosphorus transforms into nanocrystalline Na_(3)P and Na_(x)P alloys,which laterally shows crystallization-amorphization evolution process during cycling.

关键词： CuP_(2)/C composite POx component Reaction mechanism Solid-state NMR Sodium-ion batteries

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Arbuscular mycorrhizal fungi promote functional gene regulation of phosphorus cycling in rhizosphere microorganisms of Iris tectorum under Cr stress

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Journal of Environmental Sciences 2025年第5期151卷 187-199页

作者： Sixi Zhu Huan mao Suxia Sun Xiuqin Yang Wei Zhao Luying Sheng Zhongbing chen College of Eco-environment Engineering Guizhou Minzu UniversityThe Karst Environmental Geological Hazard Prevention of Key Laboratory of State Ethnic Affairs CommissionGuiyang 550025China Department of Applied Ecology Faculty of Environmental SciencesCzech University of Life Sciences PragueKamycka 129Praha-Suchdol 16500Czech Republic

The mutualistic symbiotic system formed by clumping arbuscular mycorrhizal fungi(AMF)and plants can remediate heavy metal-contaminated ***,the specific mechanisms underlying the interaction between AMF and inter-root microbial communities,particularly their impact on organic phosphorus(P)cycling,remain *** study investigated the gene regulation processes involved in inter-root soil phosphorus cycling in wetland plants,specifically Iris tectorum,following inoculation with AMF under varying concentrations of chromium(Cr)*** macro-genome sequencing,we analyzed the composition and structure of the inter-root soil microbial community associated with Iris tectorum under greenhouse pot *** results demonstrated significant changes in the diversity and composition of the inter-root soil microbial community following AMF inoculation,with Proteobacteria,Actinobacteria,Chloroflexi,Acidobacteria,and Bacteroidetes being the dominant *** Cr stress,species and gene co-occurrence network analysis revealed that AMF promoted the transformation process of organic phosphorus mineralization and facilitated inorganic phosphorus ***,network analysis of functional genes indicated strong aggregation of(pstS,pstA,pstC,***,phoR,pp-gppA)genes,which collectively enhanced phosphorus uptake by *** findings shed light on the inter-root soil phosphorus cycling process during the co-remediation of Cr-contaminated soil by AMF-Iris tectorum symbiosis,providing valuable theoretical support for the application of AMF-wetland plant symbiosis systems to remediate heavy metal-contaminated soil.

关键词： Metagenome Arbuscular mycorrhizal fungi Phosphorus Iris tectorum Cr

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： liang Chu Haoyu Shen Hudie Wei Hongyu chen Guoqiang Ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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Precision storage lifetime measurements of highly charged heavy ions in the CSRe storage ring using a Schottky resonator

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Nuclear Science and Techniques 2025年第1期36卷 150-160页

作者： Qian Wang Xin-liang Yan Guang-Yu Zhu Shahab Sanjari Li-Jun mao He Zhao Yuri ALitvinov Rui-Jiu chen Meng Wang Yu-Hu Zhang You-Jin Yuan Jun-Xia Wu Hong-Yang Jiao Yue Yu Zu-Yi chen Yin-Fang Luo Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China GSI Helmholtzzentrum für Schwerionenforschung Planckstrasse 164291 DarmstadtGermany FH Aachen University of Applied Sciences Heinrich-Mussmann-Str.152428 JülichGermany

Schottky mass spectrometry utilizing heavy-ion storage rings is a powerful technique for the precise mass and decay half-life measurements of highly charged *** to the nondestructive ion detection features of Schottky noise detectors,the number of stored ions in the ring is determined by the peak area in the measured revolution frequency *** of their intrinsic amplitude-frequency characteristic(AFC),Schottky detector systems exhibit varying sensitivities at different *** low-energy electron-cooled stored ions,a new method is developed to calibrate the AFC curve of the Schottky detector system of the Experimental Cooler Storage Ring(CSRe)storage ring located in Lanzhou,*** the amplitude-calibrated frequency spectrum,a notable refinement was observed in the precision of both the peak position and peak *** a result,the storage lifetimes of the electron-cooled fully ionized^(56)Fe^(26+)ions were determined with high precision at beam energies of 13.7 and 116.4 MeV/u,despite of frequency drifts during the *** electron cooling was turned off,the effective vacuum condition experienced by the 116.4 MeV/u^(56)Fe^(26+)ions was determined using amplitude-calibrated spectra,revealing a value of 2×10^(−10)mbar,which is consistent with vacuum gauge readings along the CSRe *** method reported herein will be adapted for the next-generation storage ring of the HIAF facility under construction in Huizhou,*** can also be adapted to other storage ring facilities worldwide to improve precision and enhance lifetime measurements using many ions in the ring.

关键词： Lifetime measurement Schottky mass spectrometry Sensitivity response Highly charged heavy ion Resonator UH vacuum Nondestructive diagnostics

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Federated local causal structure learning

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Science China(Information Sciences) 2025年第03期68卷 110-124页

作者： Kui YU chen RONG Hao WANG Fuyuan CAO Jiye liang School of Computer and Information Hefei University of Technology School of Computer and Information Technology Shanxi University

Local causal structure learning(LCS) efficiently identifies a set of direct neighbors of a specified variable from observational data. Additionally, it distinguishes direct causes and direct effects of this variable without learning the entire causal structure. While many LCS algorithms have been proposed, they do not consider the data privacy-preserving problem,which has attracted extensive attention from academia and industry. To address this issue, we propose a federated local causal structure learning(FedLCS) algorithm to learn local causal structures in privacy-preserving data in a federated ***, FedLCS introduces a layer-wise federated local skeleton learning algorithm to construct the local skeleton. Based on this skeleton, it introduces a federated local skeleton orientation algorithm and an extension-and-backtracking orientation algorithm to orient the edges. Finally, FedLCS uses a federated local extension-and-backtracking orientation algorithm to orient the remaining edges. Extensive experiments on benchmark, synthetic, and real datasets demonstrate that FedLCS can learn the local causal structure of a given variable in a federated setting.

关键词： local causal structure learning federated learning directed acyclic graph privacy-preserving data federated layer-wise strategy

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