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A phase Ⅳ study of homoharringtonine, cytarabine, aclacinomycin and G-CSF(HCAG) regimen compared with traditional IA regimen in the treatment of newly diagnosed elderly acute myeloid leukemia patients

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上海交通大学学报（医学版） 2017年第8期37卷 1100-1105页

作者：刘钊张赟翔王丽宁 XIA Zheng mao yuan-fei ZHAO Hui-jin YOU Jian-hua YU Yang ZHAO Yu-bing REN Yu-hong LI Ya WANG Yan CHEN Qiu-sheng 李军民陈瑜 Shanghai Institute of Hematology Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Objective · To compare the efficacy and prognostic factors of HCAG regimen with traditional IA regimen in the treatment of newly diagnosed elderly acute myeloid leukemia(AML) patients. Methods · Forty-one patients with AML(aged 55-71 years) were randomly divided into two groups(Group HCAG and Group IA) between 2014 and 2016 for induction and consolidation therapy. Multivariate analysis was applied to identify prognostic factors for relapse-free survival(RFS). Results · A total of 29 patients(70.7%) achieved complete remission(CR). The estimated 2-year overall survival(OS) was 66.8% in Group HCAG and 75.4% in Group IA(P=0.913). The estimated 2-year RFS was 61.8% in Group HCAG and 49.1% in Group IA(P=0.411). Age remained as the unfavorable prognostic factor, leading to significant differences in OS and RFS. In addition, RFS was influenced by cytogenetic/molecular risk stratification. Conclusion · Although HCAG seemed not to particularly benefit the group, the dose reduction of anthracyclines may be applied in elderly patients with comparable short-time outcome. Furthermore, the introduction of homoharringtonine resulted in an improvement of treatment response for more than 20% compared with CAG regimen.

关键词： homoharringtonine long-term survival risk factors acute myeloid leukemia elderly patient

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Multi-Stage Voltage Control Optimization Strategy for Distribution Networks Considering Active-Reactive Co-Regulation of Electric Vehicles

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Energy Engineering 2025年第1期122卷 221-242页

作者： Shukang Lyu fei Zeng Huachun Han Huiyu Miao Yi Pan Xiaodong yuan Electric Power Research Institute State Grid Jiangsu Electric Power Co.Ltd.Nanjing211103China

The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution ***,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are ***,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the *** optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy ***,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time ***-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control *** results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution *** effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network.

关键词： Electric vehicle(EV) distribution network multi-stage optimization active-reactive power regulation voltage control

Effects of Chlorine-Based Fertilizers on Tomato Growth under Soilless Culture

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 243-250页

作者： fei Li Meili Ding Hui yuan Siping Wang Bin Liang College of Agriculture and Forestry Technology Weifang Vocational CollegeWeifang262737China College of Resources and Environment Qingdao Agricultural UniversityQingdao266109China

This study investigated the effects of chlorine-based fertilizers under varying nitrogen solution concentrations in a soilless culture system. The experiment included four nitrogen solution concentration levels, with nitrogen concentrations of 6 mmol/L (C1), 12 mmol/L (C2), 18 mmol/L (C3), and 24 mmol/L (C4). Each nutrient concentration level was further divided into four chloride ion treatments (R1, R2, R3, and R4), where 100%, 60%, 33%, and 0% of the NH4+ and K+ ions were derived from NH4Cl and KCl, respectively. The length, surface area and volume of root were significantly higher by 25.3%~136.9%, 40.1%~173.1%, 27.9%~178.0%, respectively, in the R4 treatment than in the R1 and R2 treatments at flowering stage. The aboveground biomass and yield in the R4 treatment were significantly higher, by approximately 15.6%~43.5% and 16.6%~28.6%, respectively, than in the R1, R2, and R3 treatments at the picking stage. The C3 and C4 treatments significantly decreased biomass and yield by 31.9%~50.2% and 20.7%~50.5%, respectively, compared to the C1 and C2 treatments at the picking stage. Besides, the higher nutrient solution increased the incidence of blossom-end rot. In conclusion, high concentrations of chloride ions in nutrient solutions, especially when the Cl− concentration exceeded 10 mmol/L, have been shown to inhibit tomato growth in soilless culture systems. Therefore, replacing sulfur-based fertilizers by chlorine-based fertilizers is not recommended for tomato production under the studied conditions.

关键词： Sand culture chloride ion nitrogen solution concentration tomato yield blossom-end rot

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming yuan Guo-Da Zhang Chao Wang Shu-Juan Sun Peng-fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

Understanding and probing progression of localized corrosion on inner walls of steel pipelines:an overview

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Journal of Iron and Steel Research International 2025年第1期32卷 1-18页

作者： Ming-yu Wang Hai-yuan Yao Yong-fei Liu Ye-sen Zhu Wan-bin Chen Yun-ze Xu Yi Huang School of Naval Architecture and Ocean Engineering Dalian University of TechnologyDalian 116024LiaoningChina China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024LiaoningChina

Corrosion poses a major threat to the safety of transportation ***,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline *** research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis *** advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was *** on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical ***,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is ***,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.

关键词： Pipeline steel Localized corrosion Corrosion type Corrosion monitoring Corrosion mechanism

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang fei-Long Guo Jing-Yu Wu mao-Xiu yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

慢性粒细胞白血病患者慢性期和急变期骨髓己糖激酶Ⅰ水平变化的研究

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中华肿瘤防治杂志 2012年第12期19卷 913-916页

作者：朱锋毛原飞周丽泰山医学院附属医院血液科山东泰安271000 上海交通大学医学院附属瑞金医院血液科上海200025

目的:研究骨髓中己糖激酶Ⅰ(HKⅠ)在慢性粒细胞白血病(CML)患者由慢性期(CP)向急变期(BP/BC,急髓变)转变过程中表达水平的变化。方法:选择慢性粒细胞白血病患者71例,其中实验组51例(包括24例急变期患者、27例慢性期患者),对照组20例。... 详细信息

目的:研究骨髓中己糖激酶Ⅰ(HKⅠ)在慢性粒细胞白血病(CML)患者由慢性期(CP)向急变期(BP/BC,急髓变)转变过程中表达水平的变化。方法:选择慢性粒细胞白血病患者71例,其中实验组51例(包括24例急变期患者、27例慢性期患者),对照组20例。取实验组和对照组患者骨髓液,RT-PCR法检测HKⅠmRNA;免疫组织化学法检测HKⅠ在组织中的表达水平。用图像分析系统计算IOD值作为mRNA和蛋白表达量。结果:转录表达水平测定,CML急变期患者IOD值为0.836±0.105,慢性期患者为0.418±0.107,对照组为0.122±0.051,急变期患者明显高于慢性期患者,后者高于对照组,P<0.01;蛋白表达水平测定,CML急变期患者为1.230±0.187,慢性期为0.671±0.110,对照组为0.214±0.083,急变期患者明显高于慢性期患者,后者高于对照组,P<0.01。结论:转录表达水平及蛋白表达水平均显示,HKⅠ表达急变期、慢性期、对照组逐渐降低,提示HKⅠ可能参与了CML的发病机制,HKⅠ表达改变可能是促使CML由慢性期向急变期转变的另外一个条件,可联合其他指标一起作为病情监测的指标。

关键词：己糖激酶白血病髓样慢性免疫组织化学

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-mao yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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Impact of net-zero emissions on atmospheric CO2 concentration in China: Ideal simulations based on the GEOS-Chem model

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Science China Earth Sciences 2025年第3期68卷 867-881页

作者： Jingye TAN Jun WANG Huiqin mao Hengmao WANG Zhiqiang LIU Meirong WANG Ran YAN Xunmei WANG fei JIANG Frontiers Science Center for Critical Earth Material Cycling International Institute for Earth System Science Nanjing University Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Key Laboratory for Land Satellite Remote Sensing Applications of Ministry of Natural Resources School of Geography and Ocean Science Nanjing University Satellite Environmental Application Center Ministry of Environmental Protection CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological Sciences State Key Laboratory of Climate System Prediction and Risk Management Key Laboratory of Meteorological Disaster Ministry of EducationCollaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Xizang Field Station for Scientific Observation and Research on Atmospheric Water Cycle in Mêdog Xigazê and Mêdog National Climate ObservatoryXizang Meteorological Service

Elevated atmospheric carbon dioxide（CO2） concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to curb the rising CO2concentrations. To investigate the impact of China's carbon neutrality goal on atmospheric CO2concentrations, we conducted a series of ideal simulations from 2015 to 2019 using a global 3D chemistry transport model, Goddard Earth Observing System Chemistry（GEOS-Chem）. Compared with the column-averaged dry-air mole fraction of atmospheric CO2（XCO2） from Orbiting Carbon Observatory-2（OCO-2） and surface CO2measurements in Obs Pack, we find that GEOS-Chem effectively reproduces the spatiotemporal variability of CO2. The model exhibits a root mean square error（RMSE） of 1.51 ppm（R2=0.89） for OCO-2 XCO2in China and 2.65 ppm（R2=0.75） for surface CO2concentrations at the WLG station. Further, compared to 2.83 ppm yr-1in the control experiment, we suggest that net-zero CO2emissions in China decelerate the increasing trends of XCO2to 1.81 ppm yr-1,making a decrease of approximately 35.89%. Meanwhile, the seasonal cycle amplitude（SCA） of XCO2is moderately reduced from 7.39±0.81 to 6.75±0.70 ppm, representing a relative reduction of 9.91%. Spatially, net-zero CO2emissions induce a more significant decrease in XCO2trends over northern and southern China, while their impact on SCA is more evident in northern and northeastern China. Moreover, ideal experiments demonstrate that zero fossil CO2emissions lead to a greater attenuation of the linear trends of XCO2by 40.81%, while the absence of terrestrial CO2sinks largely diminishes the SCA by 16.61%. Additionally,trends and SCA in surface CO2concentrations exhibit almost identical decreasing responses to net-zero CO2emissions but display greater sensitivities compared to XCO2. Overall, our study underscores the potential of China's carbon neutrality goal in mitigating global warming, underscoring the need

关键词： XCO2 GEOS-Chem Carbon neutrality Net-zero emissions Surface CO2 concentrations

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