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Randomized controlled trial of the absorbency of four dressings and their effects on the evaporation of burn wounds

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Chinese Medical Journal 2007年第20期120卷 1788-1791页

作者： chen Jiong HAN Chun-mao SU Guo-liang TANG Zhi-jian SU Shi-jie LIN Xiao-wei Department of Bum Surgery Thrid Affiliated Hospital of Wenzhou Medical College Wenzhou 325200 China Department of Burn Surgery Second Affiliated Hospital Medical College of Zhejiang University Hangzhou 310006 China

Background Wound dressings are divided into traditional and new types. The new dressings are thought to accelerate wound healing. The purpose of this study was to supplement the scanty data on the absorbency of the new dressings and their effects on evaporation from the burn surface.Methods The water absorption rate of four dressings （carbon fiber dressing, hydrogel dressing, silver nanoparticle dressing, and vaseline gauze） were measured by the immersion-weight gain method. A total of 120 inpatients with 10% superficial partial-thickness burn wounds were randomly assigned to four groups, each with 30 participants. Carbon fiber dressing, hydrogel dressing, and silver nanoparticle dressing were used in groups A, B, and C as the primary dressing, and traditional vaseline gauze was used in group D as the control. Multi-spot evaporation from normal skin and naked wound, and from wounds covered with each of the four dressings was measured post-burn on days 1, 3, 5, and 7 by an EP-I evaporimeter under conditions of 21℃ -22℃ ambient temperature and 74%-78% humidity.Results The absorption rates of the four dressings were 988% with carbon fiber dressing, 96% with silver nanoparticle, 41% with vaseline gauze, and 6% with hydrogel. Evaporation from the naked burn wounds was about 1/3 higher than from normal skin （P〈0.01）. Compared with wounds without applied dressing, evaporation from dressed wounds decreased and was time-dependent （P〈0.01）. The evaporation of wounds with carbon fiber dressing was the lowest （（13.40 ± 2.82） ml·h^-1·m^-2, P〈0.01） on day 1 post-burn, compared with the other groups. Conclusion All four dressings have water retention capacity while carbon fiber dressing has the highest absorption rate and shows the best containment and evaporation from the burn wound.

关键词： burns dressing absorption evaporation

Study on Revising Running Parameter in Embedded System and its Application

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微计算机信息 2008年第17期 85-86+82页

作者： (1East China Institute of Technology (Nanchang Campus) Nachang 330013 China)TAN Hai chen Hong-mao ZHOU Xin-qin XIONG Guo-quan

The article expounds the technology that UPD protocol is applied when revising configured the parameter remotely in embedded system. It also introduces the process in realizing the system with the corresponding codes in detail and related communication protocols. Finally gives a example how the research being applied for the "home- school- communication"system。

关键词： Protocol Parameter UDP Home-school-communication

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金属板材服役状态下应力场的动态检测方法

机械工程学报 2008年第11期44卷 267-271页

作者：陈志红任学平陈冷毛卫民北京科技大学材料科学与工程学院北京100083

对304不锈钢板材服役条件下动态力学行为检测进行设计和探索。通过X射线衍射(X-ray diffraction,XRD)在线检测,对不锈钢板材在圆形孔模拟缺陷存在时,不同加载方式、载荷大小条件下的动态服役过程中的应力分布进行研究。明确金属板材在... 详细信息

对304不锈钢板材服役条件下动态力学行为检测进行设计和探索。通过X射线衍射(X-ray diffraction,XRD)在线检测,对不锈钢板材在圆形孔模拟缺陷存在时,不同加载方式、载荷大小条件下的动态服役过程中的应力分布进行研究。明确金属板材在动态服役过程中的应力分布与载荷大小、加载方式之间的关系。利用自行设计开发的金属板材服役行为动态检测系统,测得的304不锈钢薄板内孔周边的应力分布与理论值吻合很好,且外加载荷与最大应力成线性关系。初步实现了金属板材服役状态下力学行为的检测,该检测方法可为开发全方位的检测系统提供一定的技术基础。

关键词：应力分布 X射线衍射面探仪十字拉伸在线检测

Evaluation on Safety and Reliability of High-Pressure Vessel in Missile System

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International Journal of Plant Engineering and Management 2002年第3期7卷 133-140页

作者： YANG Jian-hong chen Fei chenG Shu WANG You-Jun YU mao-hong Department of Civil Engineering Xi'an Jiaotong University Xi'an 710049 P. R. China The Second Artillery Engineering College Xi'an 710025 P. R. China The Second Artillery Engineering College Xi'an 710025 P. R. China

Through theoretical analysis of reliability and simulation analysis of dispersivi of d a/ d N based on Monte Carlo method, the distribution function of n and c was set up. Meanwhile, the distribution of critical opening displacement(COD)δ c was defined by the use of coherent coefficient method, and the probabilistic model of defects assessment of military special vessel was built. Thereby the theoretical and practical fundamental research on evaluation of reliability of military high pressure vessels was carried out.

关键词： high pressure vessel safety reliability coherent coefficient distribution

Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients

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Cancer Biology & Medicine 2019年第3期16卷 556-564页

作者： Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru mao Hai Huang Qian Chu chengping Hu Department of Medical Oncology Cancer HospitalChinese Academy of Medical SciencesBeijing100021China Department of Pulmonary Medicine Second Affiliated Hospital of Fujian Medical UniversityQuanzhou362100China Department of Respiratory Medicine West China HospitalSichuan UniversityChengdu610041China Department ofRespiratory Medicine Daping HospitalChongqing400042China Department of Respiratory Medicine Xinqiao HospitalArmy Medical UniversityChongqing400037China Department of Medical Oncology Tianjin Medical University CancerInstitute and HospitalNational Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical Research Center for Cancer Tianjin300060China Department of Thoracic Oncology TianjinMedical University General HospitalTianjin300052China Department of Medical Oncology Hunan Cancer HospitalChangsha410006China Department of Pathology Xiangya HospitalCentral South UniversityChangsha410008China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangsha410008China Burning RockBiotech Guangzhou510300China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhongUniversity of Science and TechnologyWuhan430022China

Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach *** evidence suggests inherited genetic susceptibility to lung *** present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) ***: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 ***: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline ***: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC *** suggested a lack of association between germline BRCA status and treatment outcome of *** addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC.

关键词： Germline BRCA mutations non-small cell lung cancer prevalence BRCA1 BRCA2

SGLT2抑制剂通过调控TLR通路诱导糖尿病肾病大鼠足细胞自噬的机制研究

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免疫学杂志 2021年第10期37卷 868-874页

作者：陈利佳毛楠成都医学院 610500

目的探究钠梯度依赖性葡萄糖转运蛋白(sodium-glucose cotransporter,SGLT)2抑制剂通过调控Toll样受体(Toll like receptor,TLR)通路诱导糖尿病肾病(diabetes nephropathy,DN)大鼠足细胞自噬的机制。方法大鼠分为Sham组、DN组和DN+达格列净组(n=12)。通过腹腔注射链脲佐菌素建立DN模型,达格列净通过灌胃干预(1.0 mg/kg)。通过HE染色验证建模结果和达格列净对肾组织的保护作用。检测并比较各组的肾功能指标、炎性因子、凋亡、固有免疫TLR通路和自噬的水平。结果3组大鼠的各项指标比较差异均显著(P<0.05)。DN组的空腹血糖、肾小球面积、24 h尿蛋白、肌酐、IL-6、TNF-α、凋亡指数水平显著高于Sham组(P<0.05)。DN+达格列净组的空腹血糖、肾小球面积、24 h尿蛋白、肌酐、IL-6、TNF-α、凋亡指数水平显著低于DN组(P<0.05)。DN组的Beclin1和LC3II蛋白水平显著低于Sham组(P<0.05)。DN+达格列净组的Beclin1和LC3II蛋白水平显著高于DN组(P<0.05)。DN组的TLR2、TLR4、MyD88 mRNA和蛋白水平显著高于Sham组(P<0.05)。DN+达格列净组的上述指标显著低于DN组(P<0.05)。结论SGLT2抑制剂达格列净可以通过抑制TLRs/MyD88通路调节固有免疫并发挥抗炎、抗凋亡和促进自噬的作用,从而缓解DN模型大鼠的肾损伤。

关键词：糖尿病糖尿病肾病钠梯度依赖性葡萄糖转运蛋白达格列净自噬固有免疫

硝基苯在离子液体EMimBF_4中的选择性电还原

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高等学校化学学报 2007年第10期28卷 1935-1939页

作者：陈松马淳安褚有群毛信表浙江工业大学化工与材料科学学院绿色化学合成技术国家重点实验室培育基地

采用循环伏安法和恒电位电解法研究了离子液体EMimBF4中硝基苯在微铂电极上的选择性电还原特性.研究结果表明,硝基苯在铂电极上的电还原反应为双分子八电子三步骤电化学过程:第一步反应为准可逆单电子转移步骤,产生阴离子自由基;第二步... 详细信息

采用循环伏安法和恒电位电解法研究了离子液体EMimBF4中硝基苯在微铂电极上的选择性电还原特性.研究结果表明,硝基苯在铂电极上的电还原反应为双分子八电子三步骤电化学过程:第一步反应为准可逆单电子转移步骤,产生阴离子自由基;第二步为二电子转移步骤,并伴有随后的双分子不可逆自由基偶合反应和快速质子化及脱水反应,主要产物为氧化偶氮苯;第三步是二电子转移产生偶氮苯的过程.通过控制电位,可以选择性地合成氧化偶氮苯和偶氮苯;在EMimBF4中,硝基苯和水的浓度变化对电化学行为产生较大影响.

关键词：硝基苯 EMimBF4 电还原绿色化学选择性

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基于Feammox的生物膜反应器性能研究

中国环境科学 2017年第9期37卷 3353-3362页

作者：吴胤陈琛毛小云彭晓春华南农业大学资源环境学院广东广州510642 环境保护部华南环境科学研究所国家环境保护城市生态环境模拟与保护重点实验室广东广州510535

铁还原氨氮氧化反应(Feammox)是近年来被证明在厌氧条件下由微生物驱动的氨氧化协同铁还原过程,为废水除氨提供了全新的思路.为了探究以Feammox建立生物膜反应器进行污水脱氮的可能,本研究通过接种Feammox菌落,在封闭条件下探讨了不同... 详细信息

铁还原氨氮氧化反应(Feammox)是近年来被证明在厌氧条件下由微生物驱动的氨氧化协同铁还原过程,为废水除氨提供了全新的思路.为了探究以Feammox建立生物膜反应器进行污水脱氮的可能,本研究通过接种Feammox菌落,在封闭条件下探讨了不同氨氮浓度对Feammox反应的影响,并在连续进水条件下构建基于Feammox的生物膜反应器研究其脱氮反应特征.结果表明,中(低)氨氮浓度有利于Feammox反应的发生,氨氮浓度为75mg/L时15d可达最高氨氮转化率41.49%.构建的基于Feammox的生物膜反应器连续运行90d,在进水氨氮浓度为75mg/L、水力停留时间为10d时,氨氮最高转化率达到33.78%;出水氮素和铁形态分析结果显示,氮素转化反应前期(10~60d)氨氮氧化产物为氮气,此阶段存在反硝化作用,后期(60~90d)氨氮氧化产物为硝态氮,此时反应器反硝化作用较弱;16Sr RNA测序结果显示,反应器内的Feammox反应主要由酸微菌和微小杆菌驱动.

关键词： Feammox 生物膜反应器氨氧化微生物群落

Efficient initials for computing maximal eigenpair

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Frontiers of Mathematics in China 2016年第6期11卷 1379-1418页

作者： Mu-Fa chen School of Mathematical Sciences Beijing Normal University Laboratory of Mathematics and Complex Systems (Beijing Normal University) Ministry of Education Beijing 100875 China

This paper introduces some efficient initials for a well-known algorithm （an inverse iteration） for computing the maximal eigenpair of a class of real matrices. The initials not only avoid the collapse of the algorithm but are also unexpectedly efficient. The initials presented here are based on our analytic estimates of the maximal eigenvalue and a mimic of its eigenvector for many years of accumulation in the study of stochastic stability speed. In parallel, the same problem for computing the next to the maximal eigenpair is also studied.

关键词： Perron-Frobenius theorem power iteration Rayleigh quotient iteration efficient initial tridiagonal matrix Q-matrix