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Early prediction of acute kidney injury in children: known biomarkers but novel combination

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World Journal of Pediatrics 2018年第6期14卷 617-620页

作者： Qian Lin Jian-hua mao Department of Nephrology Children's HospitalZhejiang University School of MedicineNo.57 Zhugan LaneHangzhou 310003China

Acute kidney injury (AKI) is a global public health concern with rapid decline in glomerular filtration rate and signifi-cant increase in serum creatinine and blood urea nitrogen, which is an independent risk factor for short-term and long-term mortality (1, 2)In addition to kidney disease, AKI can occur secondary to a variety of diseases, such as multi-organ dysfunction, respiratory distress syndrome, sepsis, losing of gastrointestinal fluids, cardiac surgery, using of nephrotoxic drugs and tumors. The most common causes for AKI of children include sepsis, ischemia and reperfusion injury and tubulointerstitial lesions (3)Additionally, morbidity and mortality were high in critically ill patients, especially for those who were admitted to pediatric intensive care unit (PICU) and underwent cardiac surgery (2–4)Although renal replacement therapies have greatly improved and can pro-vide relief for most patients, the mortality remained high for critically ill children as high as 10%, about six times higher than non-AKI patients (2)In the past few years, studies have reported that even mild elevation of serum creatinine levels may increase the risk of complications and mortality (5)In a prospective cohort study, 10.3% of survivors from AKI in the PICU eventually progress to chronic kidney disease [6].

关键词： Early prediction acute kidney injury novel combination

Characterization of human metapneumoviruses isolated in Chongqing, China

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Chinese Medical Journal 2008年第22期121卷 2254-2257页

作者： mao hua-wei YANG Xi-qiang ZHAO Xiao-dong Department of Immunology Children's Hospital Chongqing University of Medical Sciences Chongqing 400014 China

Background Human metapneumovirus （hMPV） has recently been recognized as a notable respiratory pathogen in children. However, no isolation processes and only a limited understanding of hMPV epidemiology present in Chinese children are documented by far. Methods Nasopharyngeal aspirates from 86 hospitalized children with acute respiratory tract infections from December 2004 to July 2005 were inoculated onto Vero-E6 cells for hMPV isolation. Total RNA was extracted from infected cells with a cytopathic effect and then subjected to a RT-PCR amplification of the N and F genes of the hMPV. Nucleotide sequences of amplified F gene products were examined using a variation analysis with the MegAlign program and the phylogenetic tree construction using the neighbor-joining algorithm with a Phylip package. Results Six strains of hMPV were isolated from the samples during winter, spring and summer. The most common symptoms were coughing and cyanosis, and the diagnoses were bronchiolitis, bronchopneumonia, infantile asthma, or upper respiratory tract infection. All isolates were in the A2 genetic sublineage and shared a high percentage of homology with the F gene in the nucleotide （99.8%--100%） and amino acid （99.3%--100%） sequences. Conclusions This report indicates that hMPV is an important viral agent for acute respiratory tract infections present in Chongqing, China. Knowledge of phylogeny and genes will benefit the studies on the treatment and prophylaxis of hMPV infection.

关键词： metapneumovirus isolation phylogeny China

基于多场耦合求解的大规格镁合金扁锭差相脉冲电磁半连续铸造

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中国有色金属学报 2024年第6期34卷 1982-1997页

作者：段文超李金宝潘艳林朱新杰韩峰毛华邱明坤周古昕郎玉婧张志强中国兵器科学研究院宁波分院宁波315103 东北大学材料电磁过程研究教育部重点实验室沈阳110819

本文以大规格镁合金扁锭半连续铸造为研究对象,采用基于多场耦合的数值模拟技术模拟了差相脉冲磁场作用下镁合金扁锭半连续铸造过程中的宏观物理场,研究了差相脉冲磁场相位差对电磁力、温度场、凝固过程、溶质元素分布及宏观偏析的影响... 详细信息

本文以大规格镁合金扁锭半连续铸造为研究对象,采用基于多场耦合的数值模拟技术模拟了差相脉冲磁场作用下镁合金扁锭半连续铸造过程中的宏观物理场,研究了差相脉冲磁场相位差对电磁力、温度场、凝固过程、溶质元素分布及宏观偏析的影响。结果表明:相位差对凝固中后期影响更明显。当相位差从0°增至72°时,凝固初期换热有所减弱;而凝固中后期换热增强,液穴深度明显变浅,中心部位凝固速度加快,横截面内温度场变均匀。此外,适当提高相位差至72°有利于缓解两相区内贫溶质的问题,减少凝固后横截面内最大负偏析率和整体偏析率;相位差继续增大到108°不仅明显削弱了凝固前期的换热强度,而且还会削弱凝固中后期的换热强度,使液穴变深,凝固速度减慢,偏析率增大。

关键词：数值模拟多场耦合镁合金扁锭半连续铸造差相脉冲电磁

Coronavirus disease 2019 vaccine for children in China:when to start?Mandatory or voluntary?

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Chinese Medical Journal 2021年第24期134卷 3015-3016页

作者： Fei Liu Hai-Dong Fu Jian-hua mao Department of Nephrology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterHangzhouZhejiang 310052China

To the Editor:As the coronavirus disease 2019(COVID-19)pandemic continues to expand in many countries,and the more transmissible variants emerged,the second wave could be more severe and result in a greater peak of infection and *** is an urgent need to develop effective vaccines,which remains a critical tool to control the *** is equally important in areas where outbreaks persist and in well-controlled countries.

关键词： mortality vaccine equally

A Triphenylphosphonium Functionalized AIE Conjugated Macrocyclic Tetramal&mide for Mitochondrial-targeting Bioimaging

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Chinese Journal of Chemistry 2022年第1期40卷 39-45页

作者： Wei Zeng mao-hua Lin Ling-Yun Zhu Mei-Jin Lin Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhouFujian 350116China College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian 350116China

Developme nt of subcellular orga nelle-targeted bioimagi ng probes is of great imports nee in the field of early detection of diseases and exploring the behaviors of subcellular ***,we present a triphenyIphosphonium functionalized conjugated macrocyclic tetramaleimide(TPP-CMT)as a mitochondrial-targeting bioimaging *** core of TPP-CMT is obtained by connecting two pyrenes and two benzenes through four *** unique structure endows TPP-CMT with exceptional far red/near-i nfirared aggregati on-induced emissi on(FR/NIR-AIE)***-CMT is an excelle nt fluoresce nt emitter in most solve nts and eve n in solid *** qua ntum yield of TPP-CMT was higher tha n 27% when dissolved in comm on middle-polarity orga nic solve nt and this value remained at 28.2% in its solid *** in troducti on of four triphe ny Iphosph onium on maleimide positions endows TPP-CMT with mitochondrial-targeting *** to the FR/NIR-AIE characteristics and the mitochondri-al-targeti ng ability,this well-desig ned fluoresce nt probe was successfully employed for mitochondrial targeti ng bioimaging of HeLa and HepG2 cells.

关键词： Fluorescent probes Macrocycles Photophysics FR/NIR-AIE Mitochondrial-targeting bioimaging

Efficacy and safety of huaiqihuang granule as adjuvant treatment for primary nephrotic syndrome in children: a meta-analysis and systematic review

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World Journal of Pediatrics 2021年第3期17卷 242-252页

作者： Jiao Lin Li-Min huang Jing-Jing Wang Jian-hua mao Department of Nephrology National Clinical Research Center For Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background huaiqihuang(HQH)granule is a traditional Chinese herbal complex that has been used as an adjuvant treatment in clinics for the primary nephrotic syndrome(PNS)for many ***,the effectiveness and safety of HQH have not been systematically *** review aimed to evaluate the effectiveness and safety of HQH in paediatric patients with *** The following databases were searched from inception to Mar 2019:MEDLINE,Cochrane Library,EMBASE,CNKI,Wanfang Database,the Chinese Scientific Journal Database and the Chinese biomedical literature service *** the randomized controlled trials(RCTs)eligible for inclusion were *** primary outcomes were relapse,infection,remission and adverse *** secondary outcomes included serum immunoglobulin levels(IgA,IgG or IgM),T-lymphocyte subtype(CD3+,CD4+,CD8+,CD4+/CD8+),IL-10,TNF-α,TNF-γ,total cholesterol and time of proteinuria turning *** Fourteen RCTs(885 patients)were *** with HQH reduced the chance of relapse[relative risk(RR):0.47;95%CI:0.34,0.66;P<0.001]and infections(RR:0.47;95%Cl:0.35,0.62;P<0.001).No significant difference was found in adverse *** also increased the serum levels of IgA[weighted mean difference(WMD):0.40;95%Cl:0.20,0.60;P<0.001]and IgG(WMD:1.58;95%Cl:1.38-1.78;P<0.001),as well as CD4+[standard mean difference(SMD):0.90;95%Cl:0.12-1.68;P=0.02],CD3+(WMD:4.04;95% CI:3.27-4.82;P<0.001),and the CD4^(+)/CD8^(+)ratio(WMD:0.31;95% CI:0.21-0.41;P<0.001),but decreased the level of CD8+cells(WMD:-3.39;95% CI:-5.73-1.05;P=0.004).No statistically significant difference was found in IgM(WMD:0.05;95% CI:-0.13,0.24;P=0.57).Conclusions HQH could reduce the rate of relapse and the frequency of infection in children with *** apparent adverse effects were ***,the beneficial influence of HQH may act through *** multi-center,large-sample,high-quality studies are needed to confirm the effectiveness and safety of

关键词： Children huaiqihuang Nephrotic syndrome Meta-analysis

内生真菌对醉马草不同生长期土壤酶活性和养分的影响

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草地学报 2024年第6期32卷 1770-1778页

作者：刘荣贵邓茂桦张瀚文郑蓉唐仲龙王超王剑峰兰州大学草种创新和草地农业生态系统全国重点实验室/兰州大学草地微生物研究中心/兰州大学草地农业科技学院甘肃兰州730020 临夏州农业科学院甘肃临夏731100

醉马草-内生真菌共生体是研究生态系统中地上与地下生物联系的独特模式,但该共生体对不同生长期土壤酶活性和养分含量的影响知之甚少。本研究采集休眠期和返青期携带内生真菌(E+)和未携带内生真菌(E-)醉马草的生境土壤,测定E+和E-醉马... 详细信息

醉马草-内生真菌共生体是研究生态系统中地上与地下生物联系的独特模式,但该共生体对不同生长期土壤酶活性和养分含量的影响知之甚少。本研究采集休眠期和返青期携带内生真菌(E+)和未携带内生真菌(E-)醉马草的生境土壤,测定E+和E-醉马草土壤酶活性和养分含量。结果表明:在休眠期和返青期,内生真菌显著增加了醉马草土壤速效磷含量,较E-醉马草分别提高34.7%和36.7%。在返青期内生真菌增加了醉马草土壤硝态氮含量,较E-醉马草提高了32.3%。此外,返青期温度升高增强了E+和E-醉马草土壤蔗糖酶和碱性磷酸酶活性,这提高了土壤N、P的有效性,为醉马草的生长返青提供基本养分。以上结果表明内生真菌通过调节土壤养分提高土壤肥力,返青期土壤酶活性和养分含量的变化保证了醉马草顺利返青。本研究为深入理解禾草-内生真菌共生体的生态学作用提供理论依据。

关键词：醉马草内生真菌土壤酶活性和养分含量休眠期和返青期

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Performance improvement of Fe-6.5Si soft magnetic composites with hybrid phosphate-silica insulation coatings

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Journal of Central South University 2021年第4期28卷 1266-1278页

作者： WANG Jian LIU Xin LI La mao Xin-hua Institute of Materials and Processing Guangdong Academy of SciencesGuangzhou 510650China Guangdong Provincial Key Laboratory of Metal Toughening Technology and Application Guangzhou 510650China National Engineering Research Center of Powder Metallurgy of Titanium&Rare Metals Guangzhou 510650China

Fe-6.5Si soft magnetic composites(SMCs)with hybrid phosphate-silica insulation coatings have been designed to improve their comprehensive property via chemical coating combining sol-gel method in this *** microstructure and magnetic performance of the Fe-6.5Si SMCs with hybrid phosphate-silica insulation coatings were *** hybrid phosphate-silica coatings with high heat resistance and high withstand pressure,formed on the surface of the Fe-6.5Si ferromagnetic powders,were found stable in the *** with Fe-6.5Si SMCs coated by single phosphate or single silica,Fe-6.5Si SMCs with hybrid phosphate-silica show much higher permeability and lower core *** work provides a new way to optimize the magnetic performance of soft magnetic composites.

关键词： soft magnetic composites phosphate-silica insulation coatings heat resistance magnetic performances

先天性左心耳发育不良或是左心耳未发育—探寻其影像学诊断及其临床意义

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中国CT和MRI杂志 2024年第7期22卷 74-76页

作者：李炜庞茂华周华王伟袁明远方明上海浦东新区周浦医院放射科上海200000 上海中医药大学附属龙华医院心病科上海200000

目的探寻左心耳发育不良和左心耳未发育的影像学表现,并了解此类先天性畸形的临床意义。方法收集我院2018年10月至2021年12月期间影像学诊断左心耳缺如患者5例,均有心脏CT血管造影(CT angiography,CTA)、经食道超声心动图(transesophage... 详细信息

目的探寻左心耳发育不良和左心耳未发育的影像学表现,并了解此类先天性畸形的临床意义。方法收集我院2018年10月至2021年12月期间影像学诊断左心耳缺如患者5例,均有心脏CT血管造影(CT angiography,CTA)、经食道超声心动图(transesophageal echocardiography,TEE)及肺部CT平扫检查,对他们的影像和临床资料进行回顾性分析。结果5例食管超声检查中,3例报告左心耳未见显示,2例报告左心耳极细小且自发显影;5例肺静脉CTA中,1例肺静脉期及延迟期均未见左心耳显影;2例肺静脉期未见左心耳显影,延迟期极少量对比剂充盈左心耳;2例肺静脉期左心耳线状对比剂充盈,延迟期左心耳显影范围略扩大。5例肺部CT平扫均可以在正常位置显示极小的左心耳解剖形态。所有患者冠状静脉窦结构正常,管径不同程度扩张。5例房颤患者CHA2DS2-VASc卒中评分为7分,7分,6分,7分,6分,均为高危卒中患者,4例患者有反复腔隙性脑梗塞,1例患者曾发生有大面积脑梗塞。结论本组影像学初步诊断左心耳缺如的5例患者,结合其胸部CT平扫,发现左侧房肺沟均存在类似极小指状结构且其内部梳状肌发达、残余管腔极为细小,因此,类似病例是否左心耳真正解剖意义上的缺如值得商榷,归结为左心耳发育不良似乎更为妥当。左心耳发育不良的房颤患者,临床血栓事件并未减少,其临床卒中风险可能仅与CHA2DS2-VASc评分相关。

关键词：左心耳发育不良左心耳缺如血栓栓塞多模态影像学