检索结果-南通市图书馆

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui mao xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Establishment and characterization of two new human embryonic stem cell lines,SYSU-1 and SYSU-2

引用

Chinese Medical Journal 2007年第7期120卷 589-594页

作者： HUANG Guo LI Wei-qiang CHEN Rui CHEN Zhen-guang ZHANG Xiu-ming mao fu-xiang HUANG Shao-liang LI Shu-nong Bruce T Lahn Andy Peng xiang Centre for Stem Cell Biology and Tissue Engineering Sun Yat-sen University Guangzhou 510080 China Fourth People＇s Hospital of Shenzhen Shenzhen 518033 China Department of Thoracic Surgery First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China

Background Human embryonic stem cells can propagate indefinitely in vitro and are able to differentiate into derivatives of all three embryonic germ layers. The excitement surrounding human embryonic stem cells lies largely in their potential to produce specialized cells that can be used for transplant therapies. However, further investigation requires additional cell lines with varying genetic background. Therefore, efforts to derive and establish more human embryonic stern cell lines are highly warranted. Methods Surplus embryos （blastocysts） from donors were used to isolate the inner cell mass by immunosurgery. All cells were cultured continuously on irradiated murine embryonic fibroblasts feed layer and likely human embryonic stem cell colonies were subsequently characterized by cell surface marker staining, karyotyping and teratoma formation. Results Two human embryonic stern cell lines （SYSU-1 and SYSU-2） were established from surplus embryos. The two lines express several pluripotency markers including alkaline phosphatase, SSEA- 4, Tra-1-60, Oct-4, Nanog and Rex-1. They remain in undifferentiated state with normal karyotype after prolonged passages and can form embryoid bodies in vitro and teratoma in vivo. Conclusion Two new human embryonic stem cell lines have been established from surplus embryos. They can be used to understand selfrenewal and differentiating mechanisms and provide more choices for regenerative medicine.

关键词： embryonic stem cells blastocysts inner cell mass cell differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantum public-key crypto via EPR pairs

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 54-59页

作者： xiang-Qun fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering UniversityZhengzhou 450004China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

With the development of quantum computing technology,quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key *** paper designs a quantum trapdoor one-way function via EPR pairs and quantum *** on this,a new quantum public-key cryptosystem is presented,which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext *** with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition,which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theoretical Study on CO_(2)Hydrogenation on In_(2)O_(3)(111)Supported Single-Atom Catalysts:Horiuti-Polanyi versus Non-Horiuti-Polanyi Mechanism

引用

Chinese Journal of Chemical Physics 2025年第1期38卷 54-62,I0055,I0056页

作者： xiang Li Gang fu State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

In the field of catalytic hydro-genation,two primary mecha-nistic pathways,namely the Ho-riuti-Polanyi(HP)mechanism and the non-HP mechanism,have been extensively *** understandings suggested that the non-HP mechanism preferred to occur on the coinage metal surfaces,such as copper,silver,and gold,which exhibited low activity towards H_(2) ***,we offered a detailed theoretical investigation into the mechanisms of CO_(2)hydrogenation to formic acid on M_(1)-In_(2)O_(3)(111)surfaces,using density functional theory *** calculations provided novel in-sights into the preference of the non-HP mechanism on reduced single-atom noble metal cata-lysts,such as r-Rh_(1)-In_(2)O_(3)(111)and r-Ir_(1)-In_(2)O_(3)(111).In these cases,molecularly adsorbed H_(2) would be polarized into H^(δ−)-H^(δ+),thus facilitating the electrophilic attack to the O in CO_(2).Conversely,the H^(δ+)species,derived from heterolytically dissociated H_(2),exhibited a strong affinity on the adjacent oxygen site at the M-O-In *** strong adsorption resulted in a higher energy barrier for CO_(2)hydrogenation,thereby rendering the HP mechanism less viable than the non-HP *** results were anticipated to provide a deeper understanding of hydrogenation reactions on oxide-supported noble single-atom catalysts and theoretical guidance for the development of novel high-performance catalysts for catalytic hydrogena-tion reactions.

关键词： Reduced single-atom catalysts CO_(2)hydrogenation Density functional theory calculation Heterolytic dissociation of H_(2) Molecular adsorption of H_(2)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioenergy recovery and carbon emissions benefits of short-term bio-thermophilic pretreatment on low organic sewage sludge anaerobic digestion:A pilot-scale study

引用

Journal of Environmental Sciences 2025年第2期148卷 321-335页

作者： Hui Wang xiang fu Haozhe Huang Danni Shen Dongdong Fan Liming Zhu Xiaohu Dai Bin Dong College of Environmental Science and Engineering Tongji UniversityShanghai 200092China Yangtze Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China Yangtze River Eco-Environmental Engineering Research Center Shanghai InvestigationDesign and Research Institute Co.LTDShanghai 200092China China Construction Third Engineering Bureau First Engineering Co. Ltd.Wuhan 430000China

Sewage sludge in cities of Yangzi River Belt,China,generally exhibits a lower organic content and higher silt contentdue to leakage of drainage system,which caused low bioenergy recovery and carbon emission benefits in conventional anaerobic digestion(CAD).Therefore,this paper is on a pilot scale,a bio-thermophilic pretreatment anaerobic digestion(BTPAD)for low organic sludge(volatile solids(VS)of 4%)was operated with a long-term continuous flow of 200 *** VS degradation rate and CH_(4) yield of BTPAD increased by 19.93%and 53.33%,respectively,compared to those of *** analysis of organic compositions in sludge revealed that BTPAD mainly improved the hydrolysis of proteins in *** analysis of microbial community proportions by high-throughput sequencing revealed that the short-term bio-thermophilic pretreatment was enriched in Clostridiales,Coprothermobacter and Gelria,was capable of hydrolyzing acidified proteins,and provided more volatile fatty acid(VFA)for the subsequent *** combined with fluorescence quantitative polymerase chain reaction(PCR)analysis showed that the number of bacteria with high methanogenic capacity in BTPAD was much higher than that in CAD during the medium temperature digestion stage,indicating that short-term bio-thermophilic pretreatment could provide better methanogenic conditions for ***,the greenhouse gas emission footprint analysis showed that short-term bio-thermophilic pretreatment could reduce the carbon emission of sludge anaerobic digestion system by 19.18%.

关键词： Sludge Anaerobic digestion Bio-thermophilic pretreatment Pilot scale Molecular microbiology Carbon emissions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Joint Retrieval of PM_(2.5) Concentration and Aerosol Optical Depth over China Using Multi-Task Learning on FY-4A AGRI

引用

Advances in Atmospheric Sciences 2025年第1期42卷 94-110页

作者： Bo LI Disong fu Ling YANG Xuehua FAN Dazhi YANG Hongrong SHI xiang’ao XIA Electronic Engineering College Chengdu University of Information TechnologyChengdu 610225China Tianjin Meteorological Radar Research Trial Center Tianjin Meteorological BureauTianjin 300074China Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Research Centre on Meteorological Observation Engineering Technology China Meteorological AdministrationBeijing 100081China Key Laboratory of Atmospheric Environment and Extreme Meteorology Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China University of Chinese Academy of Sciences Beijing 100049China

Aerosol optical depth(AOD)and fine particulate matter with a diameter of less than or equal to 2.5μm(PM_(2.5))play crucial roles in air quality,human health,and climate ***,the complex correlation of AOD–PM_(2.5)and the limitations of existing algorithms pose a significant challenge in realizing the accurate joint retrieval of these two parameters at the same *** this point,a multi-task learning(MTL)model,which enables the joint retrieval of PM_(2.5)concentration and AOD,is proposed and applied on the top-of-the-atmosphere reflectance data gathered by the Fengyun-4A Advanced Geosynchronous Radiation Imager(FY-4A AGRI),and compared to that of two single-task learning models—namely,Random Forest(RF)and Deep Neural Network(DNN).Specifically,MTL achieves a coefficient of determination(R^(2))of 0.88 and a root-mean-square error(RMSE)of 0.10 in AOD *** comparison to RF,the R^(2)increases by 0.04,the RMSE decreases by 0.02,and the percentage of retrieval results falling within the expected error range(Within-EE)rises by 5.55%.The R^(2)and RMSE of PM_(2.5)retrieval by MTL are 0.84 and 13.76μg m~(-3)*** with RF,the R^(2)increases by 0.06,the RMSE decreases by 4.55μg m~(-3),and the Within-EE increases by 7.28%.Additionally,compared to DNN,MTL shows an increase of 0.01 in R^(2)and a decrease of 0.02 in RMSE in AOD retrieval,with a corresponding increase of 2.89%in *** PM_(2.5)retrieval,MTL exhibits an increase of 0.05 in R^(2),a decrease of 1.76μg m~(-3)in RMSE,and an increase of 6.83%in *** evaluation suggests that MTL is able to provide simultaneously improved AOD and PM_(2.5)retrievals,demonstrating a significant advantage in efficiently capturing the spatial distribution of PM_(2.5)concentration and AOD.

关键词： AOD PM_(2.5) FY-4A multi-task learning joint retrieval

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

引用

Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang JIANG Tian mao Jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping fu Nan JIA Tianfang WANG National Space Science Center Chinese Academy of SciencesBeijing100090China Beijing Key Laboratory of Space Environment Exploration Beijing100090China Key Laboratory of Environmental Space Situation Awareness Technology Beijing100090China National Satellite Meteorological Center China Meteorological AdministrationBeijing100081China

The Triple Ionosphere Photo Meter(TRIPM)is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E(FY-3E),which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:(1)135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight(nighttime channel);(2)135.6 nm airglow from the OI when sunlight is present(daytime/dusk-dawn 135.6 nm channel);and(3)Airglow in the N_(2)LBH of the TRIPM(daytime/dusk-dawn N_(2)LBH channel).FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N_(2)derived from the 135.6 nm channel and N_(2)LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content(TEC)*** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N_(2)is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Super-high bed sintering for iron ores:variation and optimization of bed resistance

引用

Journal of Iron and Steel Research International 2025年第1期32卷 40-51页

作者： Liang-ping Xu Lin Xiong Hui-bo Liu Xi-duan Yang Ai-xiang mao Pei-dun Chen Guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Central Research Institute Baosteel Group Co.Ltd.Shanghai201900China Manufacturing Management Department Guangdong Zhongnan Iron and Steel Co.Ltd.Shaoguan512123GuangdongChina Technology and Development Center Shandong Taishan Iron and Steel Group Co.Ltd.Jinan271100ShandongChina

As the bed depth increases,sintering yield increases,but the productivity *** reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the *** results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 *** improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 *** using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 *** bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 *** optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.

关键词： Super-high bed sintering Bed resistance Permeability Productivity Wet zone Combustion zone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Rhamnolipids Biosurfactant on the Anodic Electrochemical Performance in Marine Sediment Microbial fuel Cell and the Acceleration Degradation of Crude Petroleum

引用

Journal of Ocean University of China 2025年第1期24卷 139-146页

作者： HOU Luyao ZAI Xuerong MENG Yao LIANG Shengkang CAO Yali CHEN Yan ZHANG Huaijing HUANG xiang fu Yubin College of Materials Science and Engineering Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China College of Marine Geosciences Ocean University of ChinaQingdao 266100China

Crude petroleum pollution causes some serious ecological disasters in the *** sediment microbial fuel cells(MSMFCs)have been utilized as a novel method for in-situ degradation and a long-term power ***,the effect of different concentrations of rhamnolipids biosurfactant on the electrochemical performance of MSMFCs anode and the higher efficiency of oil degradation are creatively *** results indicate that the anode in sediment containing rhamnolipids effectively enriches the indigenous electrogenic Pseudophaeobacter and Pseudomonas,which significantly enhances the electrochemical performance of the *** rhamnolipids at the concentration of 200 mg kg^(-1)in sediment,the anode specific capacitance(401.45 Fm^(-2)),exchange current density(4.87×10^(-2)mAm^(-2)),and cell maximum power density(140.24 mWm^(-2))increase by 2.50,38.65,and 2.11 times,respectively,in comparison with its natural *** the oil degradation rate(40.06%)was higher than the blank(17.55%).It demonstrates that the synergistic effect between electrochemical catalytic degradation and emulsifying solubilization of rhamnolipids surfactant directly accelerates the degradation of petroleum in marine sediment,which will provide a novel method and theoretical guidance for in-situ degradation and efficient removal of crude petroleum on ocean floor.

关键词： marine sediment microbial fuel cells petroleum pollution rhamnolipids biosurfactant electrochemical performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice

引用

Journal of Environmental Sciences 2025年第5期151卷 54-67页

作者： xiang Zuo Minghe Sun Huijuan Bai Shuhui Zhang Jialu Luan Qian Yu Zhenhua fu Qili Zhao Mingzhu Sun Xin Zhao Xizeng Feng College of Life Science State Key Laboratory of Medicinal Chemical BiologyThe Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071China Institute of Robotics&Automatic Information System College of Artificial IntelligenceNankai UniversityTianjin 300071China

17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly ***,17-TB acts as a hormone with properties similar to testosterone,and the consequences of juvenile exposure on adult social behavior remain *** A(BPA)acts as an estrogen-like hormone,compared to ***-week-old male Balb/c mice were exposed orally to 17-TB(100μg/(kg·day))and BPA(4 mg/(kg·day))for 28 *** of social interactions and a three-chamber test showed that 17-TB increased virility in male mice,intensified both male and female sexual behavior,and attracted and accepted female *** also increased social dominance through tube tests inmalemice and markedly activated the c-Fos^(+)immune response in themedial prefrontal cortex(mPFC)and basal amygdala(BLA).ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone(GnRH),growth hormone(GH),estradiol(E2),and luteinizing hormone(LH)levels,as well as testicular lesions and androgen receptor(ARβ)and estrogen receptor(ERα)*** transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic *** findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice,possibly through modulation of the hypothalamic-pituitary-gonadal *** study provides insights relevant to human reproductive health and neuro-social behavioral research,and the potential risk of environmental disturbances should not be overlooked.

关键词： 17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) Sex hormones Social dominance Sexual behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：