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The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi gen Ba Zhenyu Xia Zhengsheng mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

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Influences of shale microstructure on mechanical properties and bedding fractures distribution

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Petroleum Science 2024年第3期21卷 1944-1954页

作者： Ming-Zhe Gu mao Sheng Shi-Zhong Cheng Fan-Hao Gong gen-Sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture

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Predictive Analysis of Susceptibility of Different Species to SARS-CoV-2 based on ACE2 Receptors

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Biomedical and Environmental Sciences 2020年第11期33卷 877-881页

作者： XU Xiao Gang WANG Huan WANG San Ying ZHANG Jing SUN Chuan WEI Ming xiang YAN Jing mao gen xiang Zhejiang Provincial Key Lab of Geriatrics&Geriatrics Institute of Zhejiang Province Department of GeriatricsZhejiang HospitalHangzhou 310013ZhejiangChina The George Washington University Department of BiostatisticsWashington DC 20052USA

Coronavirus Disease 2019(COVID-19)is a pulmonary inflammatory disease caused by infection with the highly pathogenic new coronavirus(SARSCo V-2)[1].To date,COVID-19 has spread to at least210 countries and territories,infected more than10.94 million people,and killed more than 519,000 people,according to Johns Hopkins *** April 15,2020,the COVID-19 outbreak was declared a global health emergency[2].

关键词： ACE2 Hopkins Receptor

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The influences of perforating phase and bedding planes on the fracture deflection in laminated shale

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Petroleum Science 2024年第2期21卷 1221-1230页

作者： Ming-Zhe Gu mao Sheng Xiao-Ying Zhuang Xin-Yi Li gen-Sheng Li National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Petroleum Engineering China University of PetroleumBeijing102249China College of Civil Engineering Tongji UniversityShanghai200092China

The perforating phase leads to complex and diverse hydraulic fracture propagation behaviors in laminated shale formations. In this paper, a 2D high-speed imaging scheme which can capture the interaction between perforating phase and natural shale bedding planes was proposed. The phase field method was used to simulate the same conditions as in the experiment for verification and hydraulic fracture propagation mechanism under the competition of perforating phase and bedding planes was *** results indicate that the bedding planes appear to be no influence on fracture propagation while the perforating phase is perpendicular to the bedding planes, and the fracture propagates along the perforating phase without deflection. When the perforating phase algins with the bedding planes, the fracture initiation pressure reserves the lowest value, and no deflection occurs during fracture propagation. When the perforating phase is the angle 45°, 60°and 75°of bedding planes, the bedding planes begin to play a key role on the fracture deflection. The maximum deflection degree is reached at the perforating phase of75°. Numerical simulation provides evidence that the existence of shale bedding planes is not exactly equivalent to anisotropy for fracture propagation and the difference of mechanical properties between different shale layers is the fundamental reason for fracture deflection. The findings help to understand the intrinsic characteristics of shale and provide a theoretical basis for the optimization design of field perforation parameters.

关键词： Shale Propagation Perforating Bedding Structure

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Current Status of Forest Medicine Research in China

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Biomedical and Environmental Sciences 2018年第7期31卷 551-554页

作者： HUANG Qing Dong WU Qing mao gen xiang WANG San Ying JIA Bing Bing WANG Guo Fu Department of Geriatrics Zhejiang Hospital Zhejiang Provincial Key Lab of Geriatrics

In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and ... 详细信息

关键词： Current Status of Forest Medicine Research in China

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Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China

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Biomedical and Environmental Sciences 2012年第3期25卷 317-324页

作者： mao gen xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing Zhejiang Hospital & Zhejiang Provincial Key Lab of Geriatrics Hangzhou 310013 Zhejiang China ForestryDepartment of Zhejiang Province Hangzhou 310020 Zhejiang China Zhejiang Forestry Academy Hangzhou310023 Zhejiang China.

Objective To investigate the effects of short-term forest bathing on human health. Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10. One group was sent on a two-night trip to a broad-leaved evergreen forest, and the other was sent to a city area. Serum cytokine levels reflecting inflammatory and stress response, indicators reflecting oxidative stress, the distribution of leukocyte subsets, and plasma endothelin-1 （ET-1） concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments. A profile of mood states （POMS） evaluation was used to assess changes in mood states. Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment. Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level, as evidenced by decreased malondialdehyde, interleukin-6, and tumor necrosis factor a levels compared with the urban group. Serum cortisol levels were also lower than in the urban group. Notably, the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment. The POMS evaluation showed that after exposure to the forest environment, subjects had lower scores in the negative subscales, and the score for vigor was increased. Conclusion Forest bathing is beneficial to human health, perhaps through preventive effects related to several pathological factors.

关键词： Forest bathing Oxidative stress Inflammation Endothelin-1 Cortisol level

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Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease

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Biomedical and Environmental Sciences 2016年第3期29卷 212-218页

作者： JIA Bing Bing YANG Zhou Xin mao gen xiang LYU Yuan Dong WEN Xiao Lin XU Wei Hong LYU XIAO Ling CAO Yong Bao WANG Guo Fu Zhejiang Hospital&Zhejiang Provincial Key Laboratory of Geriatrics&Geriatrics Institute of Zhejiang Province Hangzhou 310013ZhejiangChina Wenzhou Medical University Wenzhou 325035ZhejiangChina

Forest bathing trip is a short, leisurely visit to forest. In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease （COPD）. The patients were randomly divided into two groups. One group was sent to forest, and the other was sent to an urban area as control. Flow cytometry, ELISA, and profile of mood states （POMS） evaluation were performed. In the forest group,

关键词： COPD Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease

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Salidroside Reduces PDE2A Expression by Down-regulating p53 in Human Embryonic Lung Fibroblasts

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Biomedical and Environmental Sciences 2019年第2期32卷 140-143页

作者： XING Wen Min CHEN Sha Sha WANG San Ying GAO Wen Yan WAN Xiao Qing SU Hui Li YANG Yi ZHANG Jing YAN Jing mao gen xiang Zhejiang Provincial Key Lab of Geriatrics Department of Geriatrics Zhejiang Hospital Institute of Materia Medica Zhejiang Academy of Medical Sciences

Salidroside(SAL) is a glucoside of tyrosol and a key constituent of Rhodiola rosea L. The diverse pharmacological activities of SAL include anti-inflammatory, cardioprotective, and neuroprotective effects(1)Our previous investigation showed that the anti-aging effects of SAL involve reductions of the levels of advanced glycation end products in a D-galactose induced mouse model(2)Additionally.

关键词： PDE SAL Figure

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Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure

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Biomedical and Environmental Sciences 2018年第2期31卷 159-162页

作者： mao gen xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu Zhejiang Provincial Key Lab of Geriatrics Department of GeriatricsZhejiang HospitalHangzhou 320013ZhejiangChina Department of Rehabilitation Hangzhou Sanatorium of PLAHangzhou 310007ZhejiangChina Zhejiang Forestry Academy Hangzhou 320023ZhejiangChina Hangzhou Forestry Academy Hangzhou 310022ZhejiangChina

Chronic heart failure （CHF）, a clinical syndrome resulting from the consequences of various cardiovascular diseases （CVDs）, is increasingly becoming a global cause of morbidity and mortality. We had earlier demonstrated that a 4-day forest bathing trip can provide an adjunctive therapeutic influence on patients with CHF. To further investigate the duration of the impact and the optimal frequency of forest bathing trips in patients with CHF, we recruited those subjects who had experienced the first forest bathing trip again after 4 weeks and randomly categorized them into two groups, namely, the urban control group （city） and the forest bathing group （forest）. After a second 4-day forest bathing trip, we observed a steady decline in the brain natriuretic peptide levels, a biomarker of heart failure, and an attenuated inflammatory response as well as oxidative stress. Thus, this exploratory study demonstrated the additive benefits of twice forest bathing trips in elderly patients with CHF, which could further pave the way for analyzing the effects of such interventions in CVDs.

关键词： CHF Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure BNP

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采用DGS降低相位噪声和提高输出功率的倒扣集成振荡器(英文)

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红外与毫米波学报 2008年第6期27卷 401-404页

作者：程知群李进毛祥根谭松陈敬杭州电子科技大学射频电路与系统教育部重点实验室浙江杭州310018 香港科技大学电子与计算机工程系中国香港

设计了一种新型的缺陷接地结构（DGS）并将之应用到倒扣集成毫米波振荡器中．分析并比较了具有DGS结构和没有DGS结构的两种振荡器性能．测试数据显示具有DGS结构的振荡器与没有DGS结构的振荡器相比，相位噪声降低4—6dB，输出功率增加0... 详细信息

设计了一种新型的缺陷接地结构（DGS）并将之应用到倒扣集成毫米波振荡器中．分析并比较了具有DGS结构和没有DGS结构的两种振荡器性能．测试数据显示具有DGS结构的振荡器与没有DGS结构的振荡器相比，相位噪声降低4—6dB，输出功率增加0．8dBm．研究结果表明DGS结构嵌入到振荡器的谐振电路和输出端时，振荡器的相位噪声降低且输出功率增大．

关键词：缺陷接地结构相位噪声输出功率倒扣芯片振荡器

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