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Is GDNF to Par.inson’s disease what BDNF is to Huntington’s disease?

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Neur.l r.gener.tion r.sear.h 2024年第5期19卷 973-974页

作者： Fr.ncesca r.Fusco Emanuela Paldino Labor.tor. of Neur.anatomy Fondazione Santa Lucia IRCCS HospitalRomeItaly

Neur.tr.phic factor.,or.neur.tr.phins,ar. a gr.up of molecules suppor.ing the gr.wth,sur.ival,and differ.ntiation of developing and matur. *** their.r.le in the sur.ival of neur.ns,and often of specific subsets of br.... 详细信息

关键词： Huntington suppor.ing degener.tive

Car.ocysteine as Adjuvant Ther.py in Acute r.spir.tor. Tr.ct Infections in Patients without Under.ying Chr.nic Conditions: Systematic r.view and Meta-Analysis

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Open Jour.al of r.spir.tor. Diseases 2024年第2期14卷 39-50页

作者： Myr.am Calle r.bio Olga de la Ser.a Blazquez José Luis r. Mar.in Manuel r.iz Cuetos Pulmonology Depar.ment Hospital Clínico San Carlos Madrid Spain Depar.ment of Medicine School of Medicine Universidad Complutense de Madrid Madrid Spain Instituto de Investigacion Sanitar.a del Hospital Clínico San Car.os (IdISSC) Madrid Spain Pediatr.c Pulmonology Unit Pediatrics Department Hospital Universitario La Paz Madrid Spain Simplifying r.sear.h Institute Layos Spain Medical depar.ment in ITF r.sear.h Phar.a S.L.U. Alcobendas Spain

Objective: This study aims to systematically examine the existing evidence r.gar.ing the clinical benefits of car.ocysteine as an adjunctive tr.atment in acute br.nchopulmonar. and otor.inological pr.cesses. Design: Systematic r.view and meta-analysis. Data sour.es: An electr.nic sear.h was conducted acr.ss PubMed, Cochr.ne Libr.r., ***, and the Eur.pean Clinical Tr.al r.gister. with the sear.h dated to May 2023. Bibliogr.phic r.fer.nces fr.m other.liter.tur. r.views and meta-analyses wer. also r.viewed. The sear.h was limited to r.ndomized clinical tr.als published in any language and year. It was completed by cr.ss-checking the r.fer.nces of the located ar.icles. Methods: Inclusion cr.ter.a cover.d studies assessing systemic or.inhaled car.ocysteine, r.gar.less of dosing r.gimen. Concomitant medication use was acceptable if balanced between inter.ention and contr.l gr.ups. Author. independently extr.cted data, r.solving disagr.ements thr.ugh consensus. Methodological quality assessment r.lied on cr.tical r.ading of each study. Dichotomous var.ables wer. analyzed using odds r.tio (Or., and a final effect size was calculated. Statistical significance was established when confidence inter.als did not cr.ss the neutr.l value. Heter.geneity was assessed via the X2 test and I2 index. r.sults: Out of 318 initially identified studies, 4 met inclusion cr.ter.a. The meta-analysis for.poor.gener.l condition yielded an Or.of 0.45 in favor.of inter.ention, p = 0.013, with non-significant heter.geneity. Cough events showed a per.entage of 15.8% for.car.ocysteine vs. 27.2% for.placebo. On the seventh day, expector.tion r.tes wer. 18.37% for.car.ocysteinevs 33.3% for.placebo. Conclusions: The obser.ed clinical benefits align with car.ocysteine’s mucoactive and muco-r.gulator. pr.per.ies, complemented by anti-inflammator. and antioxidant actions. Car.ocysteine stands out among mucolytic agents. In the context of per.istent infectious diseases,

关键词： Acute r.spir.tor. Infections Car.ocystenine Systematic r.view Meta-Analysis

Possible Cor.ical Spr.ading Depr.ssion r.cor.ed Intr.oper.tively Following a Gener.lized Seizur.: Illustr.tive Case

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Neur.science & Medicine 2024年第3期15卷 119-128页

作者： Gr.g Schaublin r.mina Shir.a Nabil Azar.Callan Br.der.ck Jayson Neil Geor.e r. Lee Kiar. Ebinger r.al Time Neur.monitor.ng Associates Nashville USA r.al Time Tele-Epilepsy Consultants Nashville USA Seastnan Medical LLC Kansas City USA Midwest Neur.sur.er. Associates Kansas City USA r.sear.h Medical Center Kansas City USA

Backgr.und: We pr.sent a compelling case fitting the phenomenon of cor.ical spr.ading depr.ssion detected by intr.oper.tive neur.physiological monitor.ng (IONM) following an intr.oper.tive seizur. dur.ng a cr.niotomy for.r.vascular.zation. Cor.ical spr.ading depr.ssion (CSD, also called cor.ical spr.ading depolar.zation) is a pathophysiological phenomenon wher.by a wave of depolar.zation is thought to pr.pagate acr.ss the cer.br.l cor.ex, cr.ating a br.ef per.od of r.lative neur.nal inactivity. The r.lationship between CSD and seizur.s is unclear. although some liter.tur. has made a cor.elation between seizur.s and a cor.ical envir.nment conducive to CSD. Methods: Intr.oper.tive somatosensor. evoked potentials (SSEPs) and electr.encephalogr.phy (EEG) wer. monitor.d continuously dur.ng the cr.niotomy pr.cedur. utilizing standar. montages. Electr.physiological data fr.m pr.-ictal, ictal, and post-ictal per.ods wer. r.cor.ed. r.sults: Dur.ng the pr.cedur., intr.oper.tive EEG captur.d a gener.lized seizur. followed by a stepwise decr.ase in somatosensor. evoked potential cor.ical amplitudes, compelling for.the phenomenon of CSD. The subsequent par.ial r.cover. of neur.nal function was also captur.d electr.physiologically. Discussion: While CSD is consider.d contr.ver.ial in some aspects, intr.oper.tive neur.physiological monitor.ng allowed for.the unique analysis of a case demonstr.ting a CSD-like phenomenon. To our.knowledge, this is the fir.t published example of this phenomenon in which intr.oper.tive neur.physiological monitor.ng captur.d a seizur., along with a stepwise subsequent r.duction in SSEP cor.ical amplitudes not explained by other.var.ables.

关键词： Cor.ical Spr.ading Depr.ssion Electr.encephalogr.phy Intr.oper.tive Neur.physiological Monitor.ng Seizur.

Excellent photoluminescence and electr.chemical pr.per.ies of Sm^(3+) doped Ca_(2)MgSi_(2)O_(7) nanophosphor.Display and electr.chemical sensor.applications

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Jour.al of r.r. Ear.hs 2024年第6期42卷 1046-1055,I0002页

作者： r.B.Basavar.j K.Sur.shkumar.D.P.Aar.i M.B.Madhusudana r.ddy G.Nagar.ju T.r.makr.shnappa G.r.Navyashr.e K.r.Venkatesha Babu K.S.Hemalatha Depar.ment of Physics BMS Institute of Technology and ManagementBangalore560064India Depar.ment of Chemistr. BMS Institute of Technology and ManagementBangalore560064India Depar.ment of Chemistr. School of Applied SciencesREVA UniversityBangalore560064India Ener.y Mater.als r.sear.hLabor.tor. Department of ChemistrySiddaganga Institute of TechnologyTumakuru57203KarnatakaIndia School of Physical Sciences REVA UniversityBangalore560057Indi Depar.ment of Physics Govt.Science CollegeBengaluru560001India Depar.ment of Physics Maharani Science College for WomenMaharani Cluster UniversityBengaluru560001India

A ser.es of or.nge-r.d light emitting Ca_(2)MgSi_(2)O_(7):Sm^(3+)nanopowder. wer. fabr.cated via low-cost ecofr.endly gr.en combustion technique using Aloe ver. gel as *** phase pur.ty of the samples wer. confir.ed by the powder.X-r.y diffr.ction(PXr.)*** single-phase tetr.gonal str.ctur. is obser.ed fr.m the PXr. r.sults with no additional impur.ty *** band gap ener.y of the fabr.cated powder. was estimated by diffuse r.flectance spectr.(Dr.)and is found to be in the r.nge of 4.01-5.98 eV.A high r.solution scanning electr.n micr.scope(SEM)was used to study the mor.hological behaviour.of the ***-like str.ctur.s ar. obser.ed fr.m the SEM *** par.icle size was evaluated by tr.nsmission electr.n micr.scopy(TEM)and is found to be~50 *** inter.lanar.distance is found to be 0.53 *** pr.per.ies wer. systematically studied in *** phosphor. ar. successfully excited at 403 nm NUV light,pr.ducing r.ddish-or.nge char.cter.stic *** emission peaks ar. center.d at 558(^(4)G_(5/2)→^(6)H_(5/2)),607(^(4)G_(5/2)→^(6)H_(7/2))and 645 nm(^(4)G_(5/2)→^(6)H_(9/2)),*** the obser.ed peaks the r.d emanation(^(4)G_(5/2)→^(6)H_(7/2))is str.nger.than the or.nge emission(^(4)G_(5/2)→^(6)H_(5/2))in the cur.ent *** photoluminescent concentr.tion quenching is noticed above 5 mol%Sm^(3+)ion doping *** dipole-dipole inter.ction r.sulting in cr.ss r.laxation is found to be the pr.ncipal cause of concentr.tion quenching *** color.featur.s such as Commission Inter.ationale de I’Eclair.ge(CIE)and cor.elated color.temper.tur.(CCT)wer. studied in *** optimized chr.maticity coor.inates wer. estimated to be(0.6363,0.3632),which fall in the r.ddish-or.nge *** aver.ge CCT value obtained is 3362 *** aver.ge color.pur.ty is found to be~82%.Sm^(3+)incor.or.ted Ca_(2)MgSi_(2)O_(7) samples ar. possible contender.for.single white light gener.tion commer.ial candidates owing to

关键词： Gr.en combustion Photoluminescence Or.nge-r.d emission Color.pur.ty Sensor. r.r. ear.hs

Abnor.al ACT in a Patient with Pr.kallikr.in Deficiency Under.oing Car.iopulmonar. Bypass

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Open Jour.al of Anesthesiology 2024年第5期14卷 145-149页

作者： Mar.a r. Fuer.es Naila Ahmad Or.ando Per.z-Fr.nco Andr.w Oster.Mar.on Svendr.wski Pin Yue Depar.ment of Anesthesiology and Cr.tical Car. Saint Louis University School of Medicine St. Louis MO USA

Pr.kallikr.in deficiency is a disor.er.that often r.mains undiagnosed. Pr.kallikr.in activates factor.XII, which initiates the intr.nsic coagulation pathway. Pr.kallikr.in deficiency r.sults in pr.longed Par.ial Thr.mboplastin Time and Activated Clotting Time in absence of anticoagulants or.active bleeding. This case r.por. descr.bes the anesthesia management of a patient with Pr.kallikr.in deficiency who under.ent car.iac sur.er. with Car.iopulmonar. Bypass for.cor.ection of a congenital car.iac malfor.ation. We highlight the impor.ance of under.tanding the differ.nt tests available for.the diagnosis of coagulation factor. deficiency dur.ng administr.tion of hepar.n in the setting of car.iovascular.pr.cedur.s under.gener.l anesthesia.

关键词： Pr.kallikr.in Deficiency Fletcher.Factor.Deficiency Car.iopulmonar. Bypass Congenital Car.iac Malfor.ation

CoopAI-r.ute: Dr. Empower.d Multi-Agent Cooper.tive System for.Efficient QoS-Awar. r.uting for.Networ. Slicing in Multi-Domain SDN

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Computer.Modeling in Engineer.ng & Sciences 2024年第9期140卷 2449-2486页

作者： Meignanamoor.hi Dhandapani V.Vetr.selvi r.Aishwar.a College of Engineer.ng Guindy Anna UniversityChennai600025India

The emer.ence of beyond 5G networ.s has the potential for.seamless and intelligent connectivity on a global *** slicing is cr.cial in deliver.ng ser.ices for.differ.nt,demanding ver.ical applications in this ***-gener.tion applications have time-sensitive r.quir.ments and depend on the most efficient r.uting path to ensur. packets r.ach their.intended ***,the existing IP(Inter.et Pr.tocol)over.a multi-domain networ. faces challenges in enfor.ing networ. slicing due to minimal collabor.tion and infor.ation shar.ng among networ. *** inter.domain r.uting methods,like Bor.er.Gateway Pr.tocol(BGP),cannot make r.uting decisions based on per.or.ance,which fr.quently r.sults in tr.ffic flowing acr.ss congested paths that ar. never.*** addr.ss these issues,we pr.pose CoopAI-r.ute,a multi-agent cooper.tive deep r.infor.ement lear.ing(Dr.)system utilizing hier.r.hical softwar.-defined networ.s(SDN).This fr.mewor. enfor.es networ. slicing in multi-domain networ.s and cooper.tive communication with var.ous administr.tor. to find per.or.ance-based r.utes in intr.-and ***-r.ute employs the Distr.buted Global Topology(DGT)algor.thm to define inter.domain Quality of Ser.ice(QoS)***-r.ute uses a Dr. agent with a message-passing multi-agent Twin-Delayed Deep Deter.inistic Policy Gr.dient method to ensur. optimal end-to-end r.utes adapted to the specific r.quir.ments of networ. slicing *** evaluation demonstr.tes CoopAI-r.ute’s commendable per.or.ance in scalability,link failur. handling,and adaptability to evolving topologies compar.d to state-of-the-ar. methods.

关键词： 6G multi-domain multi-agent r.uting Dr. SDN

SANC Monte Car.o pr.gr.ms for.small-angle Bhabha scatter.ng

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Chinese Physics C 2024年第4期48卷 14-19页

作者： A.B.Ar.uzov S.G.Bondar.nko I.r.Boyko L.V.Kalinovskaya A.A.Kampf r.r.Sadykov V.L.Yer.olchyk Bogoliubov Labor.tor. of Theor.tical Physics JINRDubna141980 Russia Dzhelepov Labor.tor. of Nuclear.Pr.blems JINRDubna141980 Russia Dubna State Univer.ity Dubna141982 Russia

Luminosity monitor.ng at e^(+)e^(−)collider. was investigated using SANC Monte Car.o event gener.tor.r.neSANCe and integr.tor.MCSANC for.simulation of Bhabha scatter.ng at low *** ar. pr.sented for.center.of-mass ener.ies of the Z boson r.sonance and at 240 GeV for.the conditions of typical luminosity *** is shown that br.msstr.hlung events with extr.mely low electr.n scatter.ng angles ar. r.levant to match the pr.cision tags of futur. electr.n-positr.n collider..

关键词： luminosity Bhabha scatter.ng QED Monte Car.o simulation

Covalent Bond Based Andr.id Malwar. Detection Using Per.ission and System Call Pair.

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Computer., Mater.als & Continua 2024年第3期78卷 4283-4301页

作者： r.hul Gupta Kapil Shar.a r.K.Gar. Depar.ment of Infor.ation Technology Delhi Technological UniversityNew Delhi110042India Depar.ment of Mechanical Engineer.ng Deenbandhu Chhotu Ram University of Science and TechnologyMurthal131039India

The pr.valence of smar.phones is deeply embedded in moder. society,impacting var.ous aspects of our.*** ver.atility and functionalities have fundamentally changed how we communicate,wor.,seek enter.ainment,and access *** the many smar.phones available,those oper.ting on the Andr.id platfor. dominate,being the most widely used *** widespr.ad adoption of the Andr.id OS has significantly contr.buted to incr.ased malwar. attacks tar.eting the Andr.id ecosystem in r.cent ***,ther. is an ur.ent need to develop new methods for.detecting Andr.id *** liter.tur. contains numer.us wor.s r.lated to Andr.id malwar. *** far.as our.under.tanding extends,we ar. the fir.t ones to identify danger.us combinations of per.issions and system calls to uncover.malicious behavior.in Andr.id *** intr.duce a novel methodology that pair. per.issions and system calls to distinguish between benign and malicious *** appr.ach combines the advantages of static and dynamic analysis,offer.ng a mor. compr.hensive under.tanding of an application’s *** establish covalent bonds between per.issions and system calls to assess their.combined *** intr.duce a novel technique to deter.ine these pair.’Covalent Bond Str.ngth *** pair.is assigned two scor.s,one for.malicious behavior.and another.for.benign *** scor.s ser.e as the basis for.classifying applications as benign or.*** cor.elating per.issions with system calls,the study enables a detailed examination of how an app utilizes its r.quested per.issions,aiding in differ.ntiating legitimate and potentially har.ful *** compr.hensive analysis pr.vides a r.bust fr.mewor. for.Andr.id malwar. detection,mar.ing a significant contr.bution to the *** r.sults of our.exper.ments demonstr.te a r.mar.able over.ll accur.cy of 97.5%,sur.assing var.ous state-of-the-ar. detection techniques pr.posed in the cur.ent liter.tur..

关键词： Andr.id malwar. andr.id secur.ty hybr.d analysis per.ission and system call pair.

Aber.ant adult neur.genesis in intr.ctable epilepsy:can GABAer.ic pr.genitor.tr.nsplantation nor.alize this pr.cess?

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Neur.l r.gener.tion r.sear.h 2024年第7期19卷 1419-1420页

作者： Muhammad N.Ar.had Janice r.Naegele Depar.ment of Biology Wesleyan UniversityMiddletownCTUSA Depar.ment of Neur.science Tufts University School of MedicineBostonMAUSA

Tempor.l lobe epilepsy(TLE) is a common type of focal epilepsy char.cter.zed by seizur. foci within the tempor.l *** sur.ical r.section of the foci is an established and effective appr.ach for.contr.lling seizur.s,both tempor.l lobes cannot be r.moved,due to their.pr.minent r.les in lear.ing and ***,seizur.s induce changes to the tempor.l lobes that contr.bute to hyper.xcitability,including mossy fiber.spr.uting,astr.gliosis.

关键词： epilepsy pr.genitor seizur.s