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烯胺酰化/缩合一锅法构建5,6,7,8-四氢吡啶[4,3-d]嘧啶核心结构及其在5HT_(2A)受体拮抗剂合成上的应用(英文)

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复旦学报（自然科学版） 2012年第5期51卷 637-643页

作者：邓晓虎 mani neelakandha S 强生制药公司研究与发展部

报道了1条5HT_(2A)受体拮抗剂的高选择性合成路线.烯胺酰化/缩合一锅法可用于有效构建5,6,7,8-四氢吡啶[4,3-d]嘧啶核心结构,其中哌啶催化剂的使用对于这一新方法至关重要.

关键词： 5HT_2A受体拮抗剂烯胺酰化/缩合哌啶催化剂

Controlling Tendons to Modulate Stiffness of a Planar-to-Spatial Tendon-Driven Continuum manipulator Under External Uncertain Forces

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Journal of Bionic Engineering 2024年第2期21卷 821-841页

作者： Vipin Pachouri Pushparaj mani Pathak Indian Institute of Technology Roorkee Roorkee247667India

Continuum manipulators(CM)are soft and flexible manipulators with large numbers of degrees of freedom and can perform complex tasks in an unstructured ***,their deformability and compliance can deviate distal tip under uncertain external *** address this challenge,a novel tension-based control scheme has been proposed to modulate the stiffness of a tendon-driven CM,reducing the tip position errors caused by uncertain external *** minimize the tip position error,a virtual spring is positioned between the deviated and the desired tip *** proposed algorithm corrects the manipulator deviated tip position,improving tension distribution and stiffness profile,resulting in higher stiffness and better *** corresponding task space stiffness and condition numbers are also computed under different cases,indicating the effectiveness of the tension control scheme in modulating the manipulator's *** validation conducted on an in-house developed prototype confirms the practical feasibility of the proposed approach.

关键词： Continuum arm Hyper-redundant robots Variable stiffness manipulator Tension-based control Mechatronic systems

Optimization Algorithms of PERT/CPM Network Diagrams in Linear Diophantine Fuzzy Environment

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1095-1118页

作者： mani Parimala Karthikeyan Prakash Ashraf Al-Quran Muhammad Riaz Saeid Jafari Department of Mathematics Bannari Amman Institute of TechnologySathyamangalamTamil Nadu638401India Basic Sciences Department Preparatory Year DeanshipKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Mathematics University of the PunjabLahorePakistan College of Vestsjaelland South Herrestraede 11Slagelse4200Denmark

The idea of linear Diophantine fuzzy set(LDFS)theory with its control parameters is a strong model for machine learning and optimization under *** activity times in the critical path method(CPM)representation procedures approach are initially static,but in the Project Evaluation and Review Technique(PERT)approach,they are *** study proposes a novel way of project review and assessment methodology for a project network in a linear Diophantine fuzzy(LDF)*** LDF expected task time,LDF variance,LDF critical path,and LDF total expected time for determining the project network are all computed using LDF numbers as the time of each activity in the project *** primary premise of the LDF-PERT approach is to address ambiguities in project network activity timesmore simply than other approaches such as conventional PERT,Fuzzy PERT,and so *** LDF-PERT is an efficient approach to analyzing symmetries in fuzzy control systems to seek an optimal *** also present a new approach for locating LDF-CPM in a project network with uncertain and erroneous activity *** the available resources and activity times are imprecise and unpredictable,this strategy can help decision-makers make better judgments in a project.A comparison analysis of the proposed technique with the existing techniques has also been *** suggested techniques are demonstrated with two suitable numerical examples.

关键词： Linear Diophantine fuzzy graphs project management PERT CPM linear Diophantine fuzzy numbers score function accuracy function

Bio-analysis of Saliva Using Paper Devices and Colorimetric Assays

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Journal of Analysis and Testing 2024年第1期8卷 114-132页

作者： Adhan Narasimhan Harshil Jain Kowshika Muniandy Raja Chinnappan Naresh Kumar mani Microfluidics Sensors and Diagnostics(μSenD)LaboratoryCentre for MicrofluidicsBiomarkersPhotoceutics&Sensors(μBioPS)Department of BiotechnologyManipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India College of Medicine Alfaisal UniversityRiyadh 11533SaudiArabia Tissue/Organ Bioengineering&BioMEMS Lab Organ Transplant Centre of ExcellenceTransplant Research&Innovation DepartmentKing Faisal Specialist Hospital and Research CentreRiyadhSaudi Arabia

In light of the evolving nature of various diseases,time becomes a crucial factor in diagnosis and identifying the underlying causes.A point-of-care device provides a rapid diagnosis of a disease without using complex and advanced instruments,which are costly and difficult to transport.A paper-based device is a relatively frugal solution wherein the paper is used as a substratum in which the reactions are carried *** methods are non-invasive,and the sample collection is relatively *** is one such body fluid in which various biomarkers are present for numerous *** of saliva has attracted more attention recently due to its non-invasiveness and *** the discovery of clinical biomarkers from salivary analysis has the potential to revolutionize the healthcare sector by providing crucial information to monitor the health status of individuals and disease progression which enables personalized *** review provides the limitation of the traditional methods in clinical applications and highlights the significance of saliva as a non-invasive biological fluid that is a source of multiple biomarkers associated with various *** also provides insights into the different paper-based colorimetric microfluidic devices developed against salivary biomarkers in the past *** major challenges in the point-of-care application and the future prospects have been discussed as ***,we also emphasize the importance of this approach in dental disease diagnosis which is least explored and holds potential applications.

关键词： Paper-based assay Salivary analysis Non-invasive Point-of-care Body fluids Biomarkers Qualitative detection

Nonlinear Coupling of Kinetic Alfvén Waves and Ion Acoustic Waves in the Inner Heliosphere

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Research in Astronomy and Astrophysics 2024年第10期24卷 141-158页

作者： mani K.Chettri Vivek Shrivastav Rupak Mukherjee Nidhi Gaur R.P.Sharma Hemam D.Singh Department of Physics Sikkim UniversityGangtokSikkimIndia DAV Public School Sector 14GurugramHaryanaIndia Plasma Simulation Laboratory Department of Energy Science and EngineeringIndian Institute of Technology DelhiDelhiIndia

We study the nonlinear coupling of kinetic Alfvén waves with ion acoustic waves applicable to the Earth’s radiation belt and near-Sun streamer belt solar wind using dynamical equations in the form of modified Zakharov *** simulations show the formation of magnetic field filamentary structures associated with density humps and dips which become turbulent at later times,redistributing the energy to higher *** magnetic power spectra exhibit an inertial range Kolmogorov-like spectral index value of-5/3 for k_(⊥)ρ_(i)<1 followed by a steeper dissipation range spectra with indices~-3 for the radiation belt case and~-4 for the nearSun streamer belt solar wind case,here k_(⊥)andρ_(i)represent the wavevector component perpendicular to the background magnetic field and the ion thermal gyroradius,*** quasilinear theory in terms of the Fokker-Planck equation in the region of wavenumber turbulent spectra,we find the particle distribution function flattening in the superthermal tail population which is the signature of particle energization and plasma heating.

关键词： Sun:chromosphere Sun:corona Sun:heliosphere

A Study on Outlier Detection and Feature Engineering Strategies in Machine Learning for Heart Disease Prediction

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Computer Systems Science & Engineering 2024年第5期48卷 1085-1112页

作者： Varada Rajkumar Kukkala Surapaneni Phani Praveen Naga Satya Koti mani Kumar Tirumanadham Parvathaneni Naga Srinivasu Department of Computer Science&Engineering(AIML) MLR Institute of TechnologyHyderabad500043India Department of Computer Science and Engineering Prasad V.Potluri Siddhartha Institute of TechnologyVijayawada520007India Department of Computer Science&Engineering Sir C.R.Reddy College of EngineeringEluru534001India Amrita School of Computing Amrita Vishwa VidyapeethamAmaravati522503India Department of Teleinformatics Engineering Federal University of CearáFortaleza60455-970Brazil

This paper investigates the application ofmachine learning to develop a response model to cardiovascular problems and the use of AdaBoost which incorporates an application of Outlier Detection methodologies namely;Z-Score incorporated with GreyWolf Optimization(GWO)as well as Interquartile Range(IQR)coupled with Ant Colony Optimization(ACO).Using a performance index,it is shown that when compared with the Z-Score and GWO with AdaBoost,the IQR and ACO,with AdaBoost are not very accurate(89.0%vs.86.0%)and less discriminative(Area Under the Curve(AUC)score of 93.0%vs.91.0%).The Z-Score and GWO methods also outperformed the others in terms of precision,scoring 89.0%;and the recall was also found to be satisfactory,scoring 90.0%.Thus,the paper helps to reveal various specific benefits and drawbacks associated with different outlier detection and feature selection techniques,which can be important to consider in further improving various aspects of diagnostics in cardiovascular ***,these findings can enhance the knowledge of heart disease prediction and patient treatment using enhanced and innovativemachine learning(ML)*** findings when combined improve patient therapy knowledge and cardiac disease prediction through the use of cutting-edge and improved machine learning *** work lays the groundwork for more precise diagnosis models by highlighting the benefits of combining multiple optimization *** studies should focus on maximizing patient outcomes and model efficacy through research on these combinations.

关键词： Grey wolf optimization ant colony optimization Z-Score interquartile range(IQR) AdaBoost outlier

Navigating emotional challenges:A journey with patients undergoing chemotherapy

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World Journal of Clinical Oncology 2024年第9期15卷 1132-1135页

作者： Nisha mani Pandey Pooja Ramakant Department of Geriatric Mental Health King George's Medical UniversityLucknow 226003India Department of Endocrine Surgery King Georges Medical UniversityLucknow 226003India

A recent article reported that cancer patients with subthreshold depression are more likely to develop major depression within a *** regression analysis revealed that regular exercise was a protective factor against cancerrelated fatigue,whereas advanced age,radiotherapy,pain,and low hemoglobin were risk factors for cancer-related fatigue.A limitation of this study was the lack of methodological details about leukemia patients receiving depressive treatment at a specific *** assessment,behavioral modification plans,communication,destressing techniques,and educational plans may help chemotherapy patients manage emotional issues and reduce ***,these strategies can inspire patients to create,facilitate their treatment,and help them to remain healthy.

关键词： Leukemia patients Cancer patients Emotional distress Subthreshold depression Chemotherapy

Rare etiology of colonic intussusception involving an adult with emphysematous cystic enteropathy:A case report and review of literature

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World Journal of Clinical Cases 2024年第17期12卷 3161-3167页

作者： Eric Bergeron Maude Pichette Geneviève Boisvert Thibaut manière Étienne Désilets Department of Surgery Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Medical Imaging Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Gastroenterology Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada

BACKGROUND Pneumatosis cystoides intestinalis(PCI),characterized by a collection of gas-filled cysts in the intestinal wall,is an uncommon but well-known condition in *** pain is the most frequent symptom associated with *** represents a potential cause of recurrent abdominal pain or emergency ***,the occurrence of colonic intussusception secondary to PCI is very unusual in *** SUMMARY A 52-year-old male,known with idiopathic PCI,presented seventeen months after initial diagnosis with a new right upper quadrant pain.A computed tomographyscan demonstrated a colonic intussusception at the hepatic *** did not progress compared with initial *** patient underwent an emergency right *** Resection was recommended in this case because PCI proved to be persisting with no identified curable *** allowed to address the underlying pathology,the potential relapse of intussusception,and the likely cause of recurrent abdominal pain,either invagination or PCI itself.

关键词： Pneumatosis cystoides intestinalis Colonic intussusception Colonic obstruction Colonoscopy Case report

Designing sodium alloys for dendrite‐free sodium‐metal batteries

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Information ＆ Functional Materials 2024年第2期1卷 242-263页

作者： Kaitong Yao Shitan Xu Yang Yang Yun Zheng Karma Zuraqi Dan Yang Jue Liu Ulaganathan mani Xianhong Rui Guangdong Provincial Key Laboratory on Functional Soft Condensed Matter School of Materials and EnergyGuangdong University of TechnologyGuangzhouChina Key Laboratory of Optoelectronic Chemical Materials and Devices(Ministry of Education) Jianghan UniversityWuhanChina Department of Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoriaAustralia Neutron Scattering Division Oak Ridge National LaboratoryOak RidgeTennesseeUSA Department of Physics Amrita School of Physical Sciences‐CoimbatoreAmrita Vishwa VidyapeethamCoimbatoreIndi

Sodium metal,with a high theoretical specific capacity(~1165 mA h g−1)and a low redox potential(−2.71 V ***)as well as low cost,becomes an attractive option for high‐energy‐density sodium secondary ***,the practical application of sodium metal anodes is hindered by dendrite growth,which results in low energy efficiency,poor lifetime and serious safety *** address this challenge,researchers propose various strategies,including the formation of sodium alloys(Na‐M alloys,M=Sn,Sb,Bi,In,etc.)through alloying *** alloying effect has a positive impact in terms of reducing the local current density,mitigating the volume expansion,and inhibiting the dendrite *** is thus an effective solution for constructing high‐performance sodium secondary *** review systematically de-scribes the mechanism of dendrite growth and the alloying process of Na‐M alloys,summarizes recent research progress and strategies for applying Na‐M alloys to create dendrite‐free sodium secondary batteries,as well as pre-sents prospects for the development of Na‐M alloys and offers clear sugges-tions for future *** review aims to inspire further efforts to build dendrite‐free,high‐performance sodium secondary batteries and broaden a new aspect for the next‐generation battery systems.

关键词： dendrite‐free anode sodium alloy sodium anode sodium‐metal battery