检索结果-南通市图书馆

烯胺酰化/缩合一锅法构建5,6,7,8-四氢吡啶[4,3-d]嘧啶核心结构及其在5HT_(2A)受体拮抗剂合成上的应用(英文)

在线全文

学校读者我要写书评

暂无评论

复旦学报（自然科学版） 2012年第5期51卷 637-643页

作者：邓晓虎 mani neelakandha S 强生制药公司研究与发展部

报道了1条5HT_(2A)受体拮抗剂的高选择性合成路线.烯胺酰化/缩合一锅法可用于有效构建5,6,7,8-四氢吡啶[4,3-d]嘧啶核心结构,其中哌啶催化剂的使用对于这一新方法至关重要.

关键词： 5HT_2A受体拮抗剂烯胺酰化/缩合哌啶催化剂

Streptomyces ghanaensis VITHM1 mediated green synthesis of silver nanoparticles： Mechanism and biological applications

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2016年第4期10卷 542-551页

作者： mani Abirami Krishnan Kannabiran Biomolecules and Genetic Division School of Biosciences and Technology VIT University Tamil Nadu 623014 India

We present the microbial green synthesis of silver nanoparticles （hiPs） by Streptomyces ghanaensis VITHM1 strain （MTCC No. 12465）. The secondary metabolites in the cell free supernatant of this bacterium when incubated with 1 mmol/L AgNO3, mediated the biological synthesis of AgNPs. The synthesized AgNPs were characterized by UV-visible spectrum, X-ray diffrac- tion （XRD）, atomic force microscope, scanning electron microscopy equipped with energy dispersive spectroscopy, transmission electron microscopy, FT-IR spectroscopy, dynamic light scattering and zeta potential. They were highly stable and, spherical in shape with the average size of 30-50 nm. The secondary metabolites involved in the formation of AgNPs were identified gas chromatographymass spectrography. The 3D structure of the unit cell of the synthesized AgNPs was determined using XRD data base. The synthesized AgNPs exhibited significant antibacterial activity against tested bacterial pathogens, and did not show haemolysis on human red blood cells. This green synthesis could provide a new platform to explore and use AgNPs as antibacterial therapeutic agents.

关键词： Streptomyces ghanaensis VITHM1 nanopar-ticles 3D structure antibacterial activity

Controlling Tendons to Modulate Stiffness of a Planar-to-Spatial Tendon-Driven Continuum manipulator Under External Uncertain Forces

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第2期21卷 821-841页

作者： Vipin Pachouri Pushparaj mani Pathak Indian Institute of Technology Roorkee Roorkee247667India

Continuum manipulators(CM)are soft and flexible manipulators with large numbers of degrees of freedom and can perform complex tasks in an unstructured ***,their deformability and compliance can deviate distal tip under uncertain external *** address this challenge,a novel tension-based control scheme has been proposed to modulate the stiffness of a tendon-driven CM,reducing the tip position errors caused by uncertain external *** minimize the tip position error,a virtual spring is positioned between the deviated and the desired tip *** proposed algorithm corrects the manipulator deviated tip position,improving tension distribution and stiffness profile,resulting in higher stiffness and better *** corresponding task space stiffness and condition numbers are also computed under different cases,indicating the effectiveness of the tension control scheme in modulating the manipulator's *** validation conducted on an in-house developed prototype confirms the practical feasibility of the proposed approach.

关键词： Continuum arm Hyper-redundant robots Variable stiffness manipulator Tension-based control Mechatronic systems

Aerodynamic Characteristics of Conventional and Innovative High Lift Swept Wings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2019年第3期16卷 432-441页

作者： Mojtaba Ramezani Voloojerdi Mahmoud mani Aerospace Engineering Department Amirkabir University of Technology 424 Hafez Ave Tehran 158757413 Iran

The new bird inspired wing sweep was introduced and compared with straight and conventional swept wings in gliding flight by an experimental test setup. Due to the similarity with the birds, wing, all test models have S1223 airfoil. Swept models inspired from the bird consist of two parts: the straight part near the root and the swept part near the tip. Aerodynamic forces on each wing were measured from 0° to 24° angles of attack and Reynolds numbers of 4.3×10^4, 8.6×10^4, 1.3×10^5, and 1.7× 10^5. Wind tunnel test results show that wings with an innovative sweep at α> 0 have more lift for Reynolds numbers between 4.3× 10^4 and 8.6×10^4. Also, innovative sweep increases the stall angle, and the wing did not stall until α = 24° for Reynolds between 1.3×10^5 and 1.7×10^5. An increase in lift and having sufficient aerodynamic performance in low Reynolds numbers for birds' inspired wing sweep in gliding flight may be the answer to why the wing sweep of birds is not like conventional sweeps.

关键词： bio-inspired wing wing sweep wing aerodynamics bird wing low Reynolds number

Numerical Study of Double Diffusive Convection in Partially Heated Vertical Open Ended Cylindrical Annulus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Applied Mathematics and Mechanics 2010年第6期2卷 763-783页

作者： mani Sankar Department of Mathematics East Point College of Engineering and TechnologyBangalore-560049India

A numerical investigation of laminar natural double diffusive convection in an open ended vertical cylindrical annulus with unheated entry and unheated exit is *** boundary conditions of uniform wall temperature/uniform wall concentration(UWT/UWC)and uniform heat flux/uniform mass flux(UHF/UMF)are *** of dimensionless induced volume rate Q,average Nusselt number Nu and Sherwood number Sh are obtained for air flow under various buoyancy ratio N,Grashof numbers due to heat and mass transfer GrT and GrM,Schmidt number Sc and combinations of unheated entry,heated section and unheated exit *** the flow under consideration is a boundary layer type,the governing partial differential equations was discretized to a linear system of equations by the use of an implicit finite difference *** nonlinear convective terms are approximated by second upwind difference method for the numerical *** numerical results reveal that the presence of unheated entry and unheated exit severely affects the heat and mass transfer *** numerical solutions are found to approach asymptotically the closed form solutions for fully developed ***,the present numerical results are validated with the existing solutions for pure thermal convection and are found to be in good agreement.

关键词： Discrete heating cylindrical annulus upwind difference doubles diffusive convection buoyancy ratio

Pulmonary Toxicity of a Formulated Preparation of Fenvalerate in Rats Subchronically Exposed by Nose Only Inhalation for 90 Days

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2001年第4期14卷 333-340页

作者： U.mani FAKRULISLAM 等 InhalationToxicologyLaboratory IndustrialToxicologyResearchCentreM.G.MargP.Box.No.80M.G.MargLucknow－226001India DepartmentofMedicalElementolgoy＆Toxicology HamdardUniversityNewDelhi

Objective The pulmonary toxicity of a commercially available formulated preparation of Fenvalerate (Fen), a synthetic pyrethroid has been studied in rats following subchronic nose only inhalation exposure route. Method Adult male rats were exposed to Fen for 4h/day, 5 days a week for 90 days by using Flow Past Dynamic Nose only Inhalation Chamber. Results Fen exposed rats showed a significant increase in enzymatic activities of lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and γ-glutamyl transferase (γ-GT) which are considered as biochemical indicators of pulmonary damage. The concomitant histopathological examination of Fen exposed rats' lung revealed inflammatory changes viz., influx of mononuclear cells admixed with a few giant cells in alveolar lumen, hypetrophied bronchiolar and alveolar epithelial lining cells and presence of edematous fluid in alveolar lumen alongwith congested parenchymatous blood vessels. Conclusion These results for the first time indicate the pulmonary toxic effects of a commonly used formulated Fen preparation by using rat model and nose only inhalation as the route of exposure.

关键词： Animals Behavior, Animal Body Weight Inhalation Exposure Insecticides Lung Male Nitriles Nose Organ Size Pyrethrins Rats Rats, Wistar

Single-phase Thirteen-level Dual-boost Inverter Based Shunt Active Power Filter Control Using Resonant and Fuzzy Logic Controllers

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2022年第3期8卷 849-863页

作者： Shaik Gouse Basha Venkatesan mani Subbarao Mopidevi Vignan's Foundation for Science Technology and Research Andhra Pradesh522213India Vignan's Lara Institute of Technology and Science Vadlamudi522213India

This paper addresses the power quality improvement of a single-phase utility grid using a thirteen-level dualboost inverter(TLDBI)-shunt active filter(SAF).The TLDBI uses a single DC source of low voltage magnitude and five switched capacitor arrangement to achieve self-balanced thirteen level output ***,the charging and voltage balancing of the capacitor is achieved by proper switching sequence control in a series,through which boosted inverter output voltage levels are *** with the tradional H-bridge multilevel inverters(MLIs),all the elements in the proposed TLDBI are able to withstand a voltage stress which is equal to the input DC *** feature ensures the performance of the proposed TLDBI in high-frequency *** power at the electrical grid is highly affected by a wide range of non-linear *** proposed SAF is used for measuring and controlling the current flow from source to *** difference between the targeted and actual currents from the utility grid is measured by using the modified synchronous reference frame(SRF)*** estimated error current is used by the controllers to predict the optimum suitable switching angle and modulation index(MI)to the *** this paper,the traditional proportional-integral(PI)controller,fuzzy logic controller(FLC)and proportional resonant controller(PRC)are compared and the results are presented to validate the performance of *** stability and robustness of the proposed controller is evaluated using Bode,Root locus,and Nyquist *** modeling and analysis of the proposed system are done using MATLAB/Simulink *** simulation results are presented in the various MI of TLDBI and also subjected to non-linear load *** results are also compared to the claim novelty of the proposed study.

关键词： FLC power quality PRC thirteen-level DBI shunt active filter single-phase utility grid SRF

Studies on solar flat plate collector evaporation systems for tannery effluent(soak liquor)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1870-1877页

作者： SRITHAR K. mani A. Department of Mechanical Engineering Thiagarajar College of Engineering Madurai 625015 India Department of Mechanical Engineering Indian Institute of Technology Madras Chennai 600036 India

Heat and mass transfer analysis of an incompressible, laminar boundary layer over solar flat plate collector evapora- tion systems for tannery effluent (soak liquor) is investigated. The governing equations are solved for various liquid to air velocity ratios. Profiles of velocity, temperature and concentration as well as their gradients are presented. The heat transfer and mass transfer coefficients thus obtained are used to evaluate mass of water evaporated for an inclined fibre-reinforced plastic (FRP) solar flat plate collector (FPC) with and without cover. Comparison of these results with the experimental performance shows encouraging trend of good agreement between them.

关键词： Boundary layer Solar flat plate collector Fibre-reinforced plastic flat plate collector Open flat plate collector,Tannery effluent treatment Pollution

Effect of Orientation of Fibers and Holes on the Radial Strain Amplification of Campaniform sensilla

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2010年第4期7卷 314-320页

作者： Nickolas L.M.mani Carlo Menon MENRVA Research Group School of Engineering ScienceSimon Fraser University MENRVA Research Group School of Engineering Science Simon Fraser University

In this paper,a structural analysis is performed to gain insights on the synergistic mechanical amplification effect thatCampaniform sensilla have when combined in an array *** order to simplify the analysis performed in this preliminaryinvestigation,an array of four holes in a single orthotropic lamina is ***,a Finite Element Method(FEM) analysis is performed to discretely assess the influence that different geometrical parameters have on the mechanicalamplification properties of the ***,an artificial neural network is used to obtain an approximated multi-dimensionalcontinuous function,which models the relationship between the geometrical parameters and the amplification properties of ***,an optimization is performed to identify the geometrical parameters yielding the maximum mechanical ***,results are validated with an additional FEM simulation performed by varying geometrical parameters in theneighborhood of the identified optimal *** method proposed in this paper can be fully automated and used to solvea wide range of optimization problems aimed at identifying optimal configurations of strain sensors inspired by Campaniformsensilla.

关键词： Campaniform sensillum strain sensor FEM ANN optimization