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Journal of Geographical Sciences 2018年第12期28卷 1933-1952页

作者： OMID Abdi ZEINAB Shirvani manfred f.buchroithner Institute for Cartography Geosciences DepartmentTU Dresden

Developing countries must consider the influence of anthropogenic dynamics on changes in rangeland habitats. This study explores happened degradation in 178 rangeland management plans for Northeast Iran in three main steps:(1) conducting a trend analysis of rangeland degradation and anthropogenic dynamics in 1986–2000 and 2000–2015,(2) visualizing the effects of anthropogenic drivers on rangeland degradation using bivariate local spatial autocorrelation(BiLISA), and(3) quantifying spatial dependence between anthropogenic driving forces and rangeland degradation using spatial regression approaches. The results show that 0.77% and 0.56% of rangelands are degraded annually during the first and second periods. The BiLISA results indicate that dry-farming, irrigated farming and construction areas were significant drivers in both periods and grazing intensity was a significant driver in the second period. The spatial lag(SL) model(wi=0.3943, Ei=1.4139) with two drivers of dry-farming and irrigated farming in the first period and the spatial error(SE) model(wi=0.4853, Ei=1.515) with livestock density, dry-farming and irrigated farming in the second period showed robust performance in quantifying the driving forces of rangeland degradation. To conclude, the BiLISA maps and spatial models indicate a serious intensification of the anthropogenic impacts of ongoing conditions on the rangelands of northeast Iran in the future.

关键词： rangeland degradation Landsat GIS anthropogenic driving forces BiLISA spatial regression

多通道多极化合成孔径雷达数据用于高山地质填图

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国外地质勘探技术 1992年第1期 30-31页

作者： manfred f.buchroithner

在多极化方式中的多通道SAR数据的运用是专题制图,特别是地貌/地质制图的一个有效手段.它与陆地卫星TM和SPOT卫星HRV多光谱数据相结合,可最大限度地获得信息.由于高山地带地形严重畸变,所以,充分利用上述多通道多极化探测数据进行高精... 详细信息

在多极化方式中的多通道SAR数据的运用是专题制图,特别是地貌/地质制图的一个有效手段.它与陆地卫星TM和SPOT卫星HRV多光谱数据相结合,可最大限度地获得信息.由于高山地带地形严重畸变,所以,充分利用上述多通道多极化探测数据进行高精度的地理编码是非常必要的.

关键词：地理编码多通道盖层地层

Current status of research and application in vascular stents

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Chinese Science Bulletin 2013年第35期58卷 4362-4370页

作者： QI PengKai YANG Ying MAITZ f manfred HUANG Nan Key Laboratory of Advanced Technology of Materials of Education Ministry Southwest Jiaotong University School of Materials Science and Engineering Southwest Jiaotong University Max Bergmann Center of Biomaterials Dresden Leibniz Institute of Polymer Research Dresden Dresden 01097 Germany

Cardiovascular diseases have been the leading cause of death in modern *** vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical *** the twenty-five years’development of vascular stents,revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have *** this review,the evolution of vascular stents is summarized,aiming to provide a glimpse into the future of vascular *** designs,focusing on the investigations of new substrates,new platforms,new drugs and new biomolecules are currently under evaluation with promising clinical *** concept of"time sequence functional stent"has been raised in this *** presents anti-proliferative properties in the first phase after implantation and subsequently support *** also shows long-term inertness without release of toxic ions or toxic degradation *** success of this concept is briefly presented with a clinical study in this model stents.

关键词：血管支架心血管疾病应用冠状动脉内皮祖细胞干预措施生物分子时间序列

Real-Time Characterization of fibrinogen Interaction with Modified Titanium Dioxide film by Quartz Crystal Microbalance with Dissipation

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Chinese Journal of Chemical Physics 2014年第3期27卷 355-360页

作者： An-sha Zhao Zhao Wang Xiao-hua Zhu manfred f. Maitz Nan Huang Key Laboratory of Advanced Materials Technology of Ministry of:Education Department of Materials Science and Engineering Southwest Jiaotong University Chengdu 510031 China Leibniz Institute of Polymer Research Dresden Max Bergmann Center of Biomaterials Dresden Dresden Germany

The adsorption of fibrinogen can be used as a quick indicator of surface haemocompatibility because of its prominent role in coagulation and platelet adhesion. In this work the molecular interaction between fibrinogen and a modified titanium oxide surface/platelet has been studied by quartz crystal microbalanee with dissipation （QCM-D） in situ. In order to further characterize the conformation of adsorbed fibrinogen, αC and γ-chain antibody were used to check the orientation and denaturation of fibrinogen on solid surface. QCM-D investiga- tions revealed the fibrinogen have the trend to adsorb on hydropllilic surface in a side-on orientation by positively charged αC domains, which would reduce the exposure of platelet bonding site on γ chain and enable less platelet adhesion and be activated. These obser- vations suggest that certain conformations of adsorbed fibrinogen are less platelet adhesive than others, which opens a possibility for creating a non-platelet adhesive substrates.

关键词： Quartz crystal microbalance with dissipation fibrinogen adsorption Confor- mation change Blood platelet

Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids

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中国科学:化学英文版 2023年第9期66卷 2435-2436页

作者： manfred T.Reetz frank Hollmann Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 145480 MülheimGermany Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China Department of Biotechnology Delft Universityvan der Maasweg 92629 HZ DelftNetherlands

Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired synthetic organic and pharmaceutical chemists to test them as catalysts in the oxidative hydroxylation of steroids. Unfortunately, wildtype P450s generally proved to show low levels of regio-and diastereoselectivity as well as suboptimal activity.

关键词： steroids catalyzed synthesis

Efficiency of surface inactivation disinfectants for bacteria studied in an aquaculture microbiology laboratory

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Journal of Biosafety and Biosecurity 2023年第2期5卷 84-86页

作者： manfred Weidmann Institute of Aquaculture University of StirlingStirlingScotlandUK Medizinische Hochschule Brandenburg Institut für Virologie und MikrobiologieUniversitätsplatz 101986 SenftenbergGermany

Routine microbial inactivation procedures used in microbiology laboratories must be *** this study,the efficacy of surface disinfection using 70%Isopropanol,0.45%Presept,and 1%Virkon was tested against 24 bacterial strains commonly handled in aquaculture microbiology *** was ineffective against Nocardia asteroides NCIMB 1290,while Virkon was not effective against Aeromonas eucrenophila NCIMB 74 or Pediococcus acidilacti R52037.

关键词： Inactivation Aquaculture Bacterial pathogens Aeromonas eucrenophila Nocardia asteroides Pediococcus acidilacti

A“built-up”composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility

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Bioactive Materials 2023年第7期25卷 223-238页

作者： Zhenglong Dou Shuiling Chen Jiacheng Wang Li Xia manfred f.Maitz Qiufen Tu Wentai Zhang Zhilu Yang Nan Huang Key Lab of Advanced Technology of Materials of Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong523059China Guangdong Provincial Key Laboratory of Cardiac function and Microcirculation GuangzhouGuangdong510080China Department of Cardiology Third People’s Hospital of Chengdu Affiliated to Southwest Jiaotong UniversityChengdu610031China Max Bergmann Center of Biomaterials Dresden Leibniz Institute of Polymer Research DresdenHohe Strasse 601069DresdenGermany

Control of premature corrosion of magnesium(Mg)alloy bioresorbable stents(BRS)is frequently achieved by the addition of rare earth ***,limited long-term experience with these elements causes concerns for clinical application and alternative methods of corrosion control are sought ***,we report a“built-up”composite film consisting of a bottom layer of Mgf2 conversion coating,a sandwich layer of a poly(1,3-trimethylene carbonate)(PTMC)and 3-aminopropyl triethoxysilane(APTES)co-spray coating(PA)and on top a layer of poly(lactic-co-glycolic acid)(PLGA)ultrasonic spray coating to decorate the rare earth element-free Mg-2Zn-1Mn(ZM21)BRS for tailoring both corrosion resistance and biological *** developed“built-up”composite film shows synergistic functionalities,allowing the compression and expansion of the coated ZM21 BRS on an angioplasty balloon without cracking or *** special importance is that the synergistic corrosion control effects of the“built-up”composite film allow for maintaining the mechanical integrity of stents for up to 3 months,where complete biodegradation and no foreign matter residue were observed about half a year after implantation in rabbit iliac ***,the functionalized ZM21 BRS accomplished re-endothelialization within one month.

关键词： Magnesium alloys Bioresorbable stents Composite coating Corrosion control Biocompatibility

Human-as-a-security-sensor for harvesting threat intelligence

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Cybersecurity 2018年第1期1卷 652-666页

作者： manfred Vielberth florian Menges Gunther Pernul Universitat Regensburg Universitatstr.3193053 RegensburgDEGermany

Humans are commonly seen as the weakest link in corporate information *** led to a lot of effort being put into security training and awareness campaigns,which resulted in employees being less likely the target of successful *** approaches,however,do not tap the full potential that can be gained through these *** the one hand,human perception offers an additional source of contextual information for detected incidents,on the other hand it serves as information source for incidents that may not be detectable by automated *** approaches only allow a text-based reporting of basic incident information.A structured recording of human delivered information that also provides compatibility with existing SIEM systems is still *** this work,we propose an approach,which allows humans to systematically report perceived anomalies or incidents in a structured *** approach furthermore supports the integration of such reports into analytics ***,we identify connecting points to SIEM systems,develop a taxonomy for structuring elements reportable by humans acting as a security sensor and develop a structured data format to record data delivered by humans.A prototypical human-as-a-security-sensor wizard applied to a real-world use-case shows our proof of concept.

关键词： Cyber threat intelligence Human awareness Human-as-a-security-sensor Security information and event management(SIEM)

Selective Suspension in Aqueous Sodium Dodecyl Sulfate According to Electronic Structure Type Allows Simple Separation of Metallic from Semiconducting Single-Walled Carbon Nanotubes

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Nano Research 2009年第8期2卷 599-606页

作者： Kai Moshammer frank Hennrich manfred M.Kappes forschungszentrum Karlsruhe Institut für NanotechnologieD-76021 KarlsruheGermany Institut für Physikalische Chemie Universität KarlsruheD-76128 KarlsruheGermany

Both density gradient centrifugation and gel electrophoresis have been reported to allow high throughput separation of metallic from semiconducting single-walled carbon nanotubes(SWNTs)when using aqueous sodium dodecyl sulphate(SDS)*** show here that both methods rely on an initial dispersion-by-sonication step,which is already selective with respect to electronic structure *** corresponding aqueous SDS“starting”suspensions obtained after sonication and purifi cation by simple centrifugation(70,000 g,1 h)contain semiconducting SWNTs primarily in the form of small bundles whereas metallic SWNTs are predominantly suspended as individual *** gradient centrifugation then separates the bundles from the individual tubes on the basis of differences in their overall buoyant *** electrophoresis separates the longer bundles from the shorter individual tubes on the basis of their different *** also demonstrate that such starting suspensions can be fractionated according to electronic structure type by even simpler techniques such as size exclusion chromatography or gel fi ltration,thus opening the way for simple scale-up.

关键词： Single-walled carbon nanotubes metallic–semiconducting separation electrophoresis density gradient centrifugation size exclusion chromatography

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

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Science China Materials 2018年第4期61卷 501-515页

作者： Ping Li Ningling Zhou Hua Qiu manfred f Maitz Juan Wang Nan Huang Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China Leibniz Institute of Polymer Research Dresden Max Bergmann Center of Biomaterials Dresden Dresden 01069 Germany Department of Anesthesiology School of Medicine Yale University New Haven CT 06511 USA

Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood *** studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.

关键词： magnesium stent cytocompatibility in vitro in vivo