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成人复发难治性急性髓系白血病治疗进展

医学与哲学（B） 2018年第8期39卷 20-24页

作者：马立元上海交通大学医学院附属新华医院血液内科上海200025

复发急性髓系白血病(AML)患者的预后差,约半数以上复发患者存在耐药难治,其治疗面临着诸多挑战和难题。对于复发后获得再次完全缓解的患者,异基因造血干细胞移植(alloHSCT)是最有效的治疗方式之一,但移植相关死亡率(TRM)和复发率(CIR)... 详细信息

复发急性髓系白血病(AML)患者的预后差,约半数以上复发患者存在耐药难治,其治疗面临着诸多挑战和难题。对于复发后获得再次完全缓解的患者,异基因造血干细胞移植(alloHSCT)是最有效的治疗方式之一,但移植相关死亡率(TRM)和复发率(CIR)均很高,从而部分抵消了移植带来的益处。因此,allo-HSCT对于部分患者并不适合,亟待寻找新的治疗手段。近几年,随着我们对AML发病机制认识的加深。新药物新疗法层出不穷,极大改善了复发难治性AML的预后。多个小分子靶向药物和免疫疗法目前正处于临床试验阶段,初步试验结果鼓舞人心。虽然新疗法治疗相关副作用越来越少,疗效越来越好,但allo-HSCT是治愈复发难治性AML的唯一途径。

关键词：复发难治急性髓细胞白血病造血干细胞移植

一种高阶累积量的模态参数辨识方法改进及其应用

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海军工程大学学报 2012年第1期24卷 101-104页

作者：李永军马立元王天辉段永刚军械工程学院导弹工程系石家庄050003

高阶累积量的模态参数辨识方法能够消除高斯噪声的影响。但基于传统的高阶累积量降阶方法的子空间模态参数辨识方法具有一定的缺陷。为此,提出2种降阶方法用于高阶累积量的子空间模态参数辨识方法,并对这2种方法进行了比较。利用主切片... 详细信息

高阶累积量的模态参数辨识方法能够消除高斯噪声的影响。但基于传统的高阶累积量降阶方法的子空间模态参数辨识方法具有一定的缺陷。为此,提出2种降阶方法用于高阶累积量的子空间模态参数辨识方法,并对这2种方法进行了比较。利用主切片方法对某变截面轴进行了模态参数识别,获得了与有限元法相一致的计算结果,从而证明了该方法的可靠性。该方法的辨识质量较高,能够用于一般结构的模态参数辨识。

关键词：高阶累积量子空间模态参数辨识有限元

Anisotropic stimulated emission cross-section measurement in Nd:YVO_4

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Chinese Physics B 2019年第4期28卷 202-206页

作者： Rui Guo Yijie Shen yuan Meng mali Gong Department of Precision Instrument State Key Laboratory of Precision Measurement and Instruments Tsinghua University Department of Precision Instrument State Key Laboratory of Tribology Tsinghua University

As a crucial parameter in the design and analysis of laser performances, stimulated emission(SE) cross-section is currently considered to be dependent on several factors, such as temperatures and eigen-polarizations for anisotropic crystals. In contrast with these factors, impact of propagating directions upon SE cross-section has garnered less *** this paper, to investigate the SE cross-section in arbitrary propagating directions, fluorescence spectra for the transition ~4F_(3/2)→~4I_(11/2) in Nd:YVO_4 are measured in different propagating directions. Based on Fuchtbauer–Ladenburg equation model, the propagating direction-dependent SE cross-section spectra in Nd:YVO_4 are obtained for the first time, to our best knowledge. A novel concept of anisotropic SE cross-section is proposed to interpret the propagating direction-dependent effect. The experiment results reveal that for an arbitrary propagating direction the SE cross-section of e light around 1064 nm can be expressed as a superposition from two principle axial propagating directions with a weight of plane projection.

关键词： solid-state lasers stimulated emission cross-section Nd:YVO4 laser spectroscopy

Optical vortices 30 years on:OAM manipulation from topological charge to multiple singularities

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Light(Science & Applications) 2019年第1期8卷 339-367页

作者： Yijie Shen Xuejiao Wang Zhenwei Xie Changjun Min Xing Fu Qiang Liu mali Gong Xiaocong yuan Key Laboratory of Photonic Control Technology(Tsinghua University) Ministry of Education100084 BeijingChina State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua University100084 BeijingChina National Engineering Laboratory for Public Safety Risk Perception and Control by Big Data(NELPSRPC) China Academy of Electronics and Information Technology of CETCChina Electronic Technology Group Corporation100041 BeijingChina Nanophotonics Research Center Shenzhen University518060 ShenzhenChina

Thirty years ago,Coullet et *** that a special optical field exists in laser cavities bearing some analogy with the superfluid *** then,optical vortices have been widely studied,inspired by the hydrodynamics sharing similar *** to a fluid vortex with a central flow singularity,an optical vortex beam has a phase singularity with a certain topological charge,giving rise to a hollow intensity *** a beam with helical phase fronts and orbital angular momentum reveals a subtle connection between macroscopic physical optics and microscopic quantum *** amazing properties provide a new understanding of a wide range of optical and physical phenomena,including twisting photons,spin–orbital interactions,Bose-Einstein condensates,etc.,while the associated technologies for manipulating optical vortices have become increasingly tunable and ***,owing to these salient properties and optical manipulation technologies,tunable vortex beams have engendered tremendous advanced applications such as optical tweezers,high-order quantum entanglement,and nonlinear *** article reviews the recent progress in tunable vortex technologies along with their advanced applications.

关键词： tunable optics charge

Spatio-temporal breather dynamics in microcomb soliton crystals

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Light(Science & Applications) 2024年第11期13卷 2620-2633页

作者： Futai Hu Abhinav Kumar Vinod Wenting Wang Hsiao-Hsuan Chin James F.McMillan Ziyu Zhan yuan Meng mali Gong Chee Wei Wong Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCAUSA State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua UniversityBeijingChina

Solitons,the distinct balance between nonlinearity and dispersion,provide a route toward ultrafast electromagnetic pulse shaping,high-harmonic generation,real-time image processing,and RF photonic *** we uniquely explore and observe the spatio-temporal breather dynamics of optical soliton crystals in frequency microcombs,examining spatial breathers,chaos transitions,and dynamical deterministic switching–in nonlinear measurements and *** understand the breather solitons,we describe their dynamical routes and two example transitional maps of the ensemble spatial breathers,with and without chaos *** elucidate the physical mechanisms of the breather dynamics in the soliton crystal microcombs,in the interaction plane limit cycles and in the domain-wall understanding with parity symmetry breaking from third-order *** present maps of the accessible nonlinear regions,the breather frequency dependences on third-order dispersion and avoided-mode crossing strengths,and the transition between the collective breather spatio-temporal *** range of measurements matches well with our first-principles theory and nonlinear *** image these soliton ensembles and their breathers,we further constructed panoramic temporal imaging for simultaneous fast-and slow-axis two-dimensional mapping of the *** the phasedifferential sampling,we present two-dimensional evolution maps of soliton crystal breathers,including with defects,in both stable breathers and breathers with *** fundamental studies contribute to the understanding of nonlinear dynamics in soliton crystal complexes,their spatio-temporal dependences,and their stability-existence zones.

关键词： theory. soliton dynamics

Optical meta-waveguides for integrated photonics and beyond

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Light(Science & Applications) 2021年第12期10卷 2263-2306页

作者： yuan Meng Yizhen Chen Longhui Lu Yimin Ding Andrea Cusano Jonathan A.Fan Qiaomu Hu Kaiyuan Wang Zhenwei Xie Zhoutian Liu yuanmu Yang Qiang Liu mali Gong Qirong Xiao Shulin Sun Minming Zhang Xiaocong yuan Xingjie Ni State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua University100084 BeijingChina Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing and School of Information Science and TechnologyFudan UniversityShanghai 200433China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Department of Electrical Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA Optoelearonic Division Department of EngineeringUniversity of Sannio1-82100 BeneventoItaly Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Nanophotonics Research Centre Shenzhen Key Laboratory of Micro-Scale Optical Information TechnologyShenzhen UniversityShenzhen 518060China Key Laboratory of Photonic Control Technology Ministry of EducationTsinghua University100084 BeijingChina Yiwu Research Institute of Fudan University Chengbei RoadYiwu City 322000 ZhejiangChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074 HubeiChina

The growing maturity of nanofabrication has ushered massive sophisticated optical structures available on a photonic *** integration of subwavelength-structured metasurfaces and metamaterials on the canonical building block of optical waveguides is gradually reshaping the landscape of photonic integrated circuits,giving rise to numerous metawaveguides with unprecedented strength in controlling guided electromagnetic ***,we review recent advances in meta-structured waveguides that synergize various functional subwavelength photonic architectures with diverse waveguide platforms,such as dielectric or plasmonic waveguides and optical *** results and representative applications are comprehensively *** physical models with explicit design tutorials,either physical intuition-based design methods or computer algorithms-based inverse designs,are cataloged as *** highlight how meta-optics can infuse new degrees of freedom to waveguide-based devices and systems,by enhancing light-matter interaction strength to drastically boost device performance,or offering a versatile designer media for manipulating light in nanoscale to enable novel *** further discuss current challenges and outline emerging opportunities of this vibrant field for various applications in photonic integrated circuits,biomedical sensing,artificial intelligence and beyond.

关键词： waveguides waveguide beyond

A New Cyrtodactylus Species(Reptila:Gekkonidae)from Nan Province,Northern Thailand

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Asian Herpetological Research 2022年第2期13卷 96-108页

作者： Siriwadee CHOMDEJ Waranee PRADIT Parinya PAWANGKHANANT Chakkrapong KUENSAEN Apichaya PHUPANBAI mali NAIDUANGCHAN Promporn PIBOON Korakot NGANVONGPANIT Zhiyong yuan Yinpeng ZHANG Jing CHE Phuping SUCHARITAKUL Chatmongkon SUWANNAPOOM Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Research Center in Bioresources for Agriculture Industry and MedicineDepartment of BiologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Division of Fishery School of Agriculture and Natural ResourcesUniversity of PhayaoPhayao 56000Thailand International College of Digital Innovation Chiang Mai UniversityChiang Mai 50200Thailand Rabbit in the Moon Foundation Ratchaburi 70180Thailand Animal Bone and Joint Research Laboratory Department of Veterinary Biosciences and Public HealthFaculty of Veterinary MedicineChiang Mai UniversityChiang Mai 50100Thailand Excellence Center in Veterinary Bioscience Chiang Mai 50100Thailand Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationSouthwest UniversityChongqing 400715China State Key Laboratory of Genetic Resources and Evolution and Center for Excellence in Animal Evolution and GeneticsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223YunnanChina School of Environment Tsinghua UniversityBeijing 100084China

Here,a new species of bent-toed gecko,Cyrtodactylus phukhaensis ***.,is described from Doi Phu Kha,Nan province,Thailand based on molecular and morphological evidence.A phylogeny based on NADH dehydrogenase subunit 2(ND2)and its flanking tRNAs places the new species in the chauquangensis group as a sister taxon to Cyrtodact ylus *** new species can be differentiated from other members of the chauquangensis group by having a unique combina tion of 7 or 8 suprala bials,23-28 longitudinal rows of dorsal tubercles,8-10 infrala bials,9 femoral pores,7 precloacal pores,40-47 ventral scales,and a lack of bands crossingthe temporal *** addition,results from a chromosome study of *** *** that the new species has a diploid chromosome number of 40 with a fundamental number of *** formula of the karyotype was as follows:2n(40)=2m+4sm+*** findings suggest that further studies of Cyrtodactylus biodiversity in northern Thailand are needed.

关键词： bent-toed gecko Cyrtodactylus wayakonei Cyrtodactylus chauquangensis karyotype phylogeny taxonomy

大模面积光纤中折射率和掺杂分布的设计和分析

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中国激光 2008年第9期35卷 1355-1359页

作者：袁艳阳巩马理清华大学精仪系光子与电子技术研究中心摩擦学国家重点实验室北京100084

从无源光纤的模场理论和有源光纤的速率方程理论出发,给出了任意折射率分布和掺杂分布光纤的有效模面积和基模提取效率的计算方法,并且通过数值计算对几种典型折射率分布和掺杂分布的光纤性能进行了分析和比较,说明复合折射率光纤与其... 详细信息

从无源光纤的模场理论和有源光纤的速率方程理论出发,给出了任意折射率分布和掺杂分布光纤的有效模面积和基模提取效率的计算方法,并且通过数值计算对几种典型折射率分布和掺杂分布的光纤性能进行了分析和比较,说明复合折射率光纤与其他传统光纤相比,在百微米量级的大模面积光纤中更具有实用性。

关键词：激光器光纤激光器大模面积光纤折射率分布掺杂分布

Effect of Hypoxia on Ca^(2+) Concentration in Broiler's Cardiac Muscle Cells

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Agricultural Sciences in China 2007年第9期6卷 1133-1137页

作者： DONG Shi-shan WANG Ying-chun mali-qin LI Kai ZHANG Jian-jun OU De-yuan ZHAO Li-hong LIU Ju-xiang QIAO Jian College of Animal Science and Technology Agricultural University ofHebei Baoding 071001 P.R.China College of Veterinary Medicine China Agricultural University Beijing 100094 P.R.China College of Animal Science and Technology Hebei North University Zhangjiakou 075001 P.R.China

The purpose of this research was to study the effect of hypoxia on the Ca^2＋ concentration in broiler＇s cardiac muscle cells （CMCs）. The concentration of Ca^2＋ in the CMC was observed using a laser scanning confocal microscope （LSCM）. The results showed that hypoxia could significantly increase intracellular Ca^2＋（normal oxygen, 99.3 ＋_ 13.1; hypoxia, 129.4 ＋_ 24.3, P 〈 0.01） in CMCs. The Ca^2＋ antagonist （nifedipine, verapamil） could significantly restrain the Ca^2＋ influx across the cell membrane of CMC treated by hypoxia （CMC： hypoxia ＋ verapamil, 100.9± 28.2; hypoxia ＋ nifedipine, 107.6± 27.7; P 〈 0.01）. The results showed hypoxia could increase intracellular Ca^2＋ concentration of CMC, and the Ca^2＋ antagonist could restrain the Ca^2＋ influx across the cell membrane of CMC treated by hypoxia.

关键词： broiler chicken cardiac muscle cell,Ca^2+ hypoxia