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Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku Asano Shinji Kudo Taisuke maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro Hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

日本学界中国古代逻辑思想研究的历程及其特点

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逻辑学研究 2024年第1期17卷 30-54页

作者：深川真树南京师范大学公共管理学院哲学系

19世纪西方文明的冲击,促使东亚知识分子重新审视传统学术,并在中国古代思想中发现逻辑思想。日本学界较早接受西方学术,其对中国古代逻辑思想的研究也取得丰硕成果。日本学者最初是以西方传统形式逻辑为标准,考察中国古代思想,后来逐... 详细信息

19世纪西方文明的冲击,促使东亚知识分子重新审视传统学术,并在中国古代思想中发现逻辑思想。日本学界较早接受西方学术,其对中国古代逻辑思想的研究也取得丰硕成果。日本学者最初是以西方传统形式逻辑为标准,考察中国古代思想,后来逐渐开始关注中国古代汉语的特性,从语言学的角度探究中国古代逻辑思想。这些是日本学界中国古代逻辑思想研究的独特途径。此外,日本在这个领域的研究,从以西方逻辑学为标准看待中国的逻辑思想,转向探究中国独有的逻辑思想。中国学界对中国古代逻辑思想的研究也呈现出类似的趋势。两国学界应加强交流,共同推动中国古代逻辑思想的研究。

关键词：日本中国逻辑思维汉学

Effect of the Arrangement of a New-Type of Turbulator Inserts on Heat Pipe Exchanger Performances

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Fluid Dynamics & Materials Processing 2023年第10期19卷 2749-2759页

作者： Ibtisam A.Hasan Wafa maki Department of Electromechanical Engineering The University of TechnologyBaghdadIraq

This research tests the effect of introducing turbulators of a new type into a circular tube heat exchanger under a constant and uniform longitudinal heatﬂux condition.A 45 mm diameter copper tube with a length of 1,350 mm is utilized with a solid disk being inserted inside the tube,which consists of three sections,each one containing two *** slot is cut at a 45 degree angle toward the inner tube surface,which results in diverging theﬂow toward the inner hot tube surface in order to enhance the heat transfer *** is considered as the workingﬂuid with Prandtl number *** Reynolds number spans the interval from 6,000–13,500,which indicates that the consideredﬂow is *** heat exchanger performance is studied and analyzed in terms of average Nusselt *** experimental results show that the Nusselt number value is directly proportional to the increase of the Reynolds number,and the number of turbulators *** the use of three novel turbulators,the heat transfer was about 3.15 times higher than that in the smooth tube and the friction factor was about 1.11.

关键词： Heat pipe exchanger heat transfer inserts(NT inserts) turbulators(novel turbulators) disk(solid disk)

Ablation for Benign Liver Tumors:Current Concepts and Limitations

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 244-252页

作者： Hitoshi Maruyama maki Tobari Hiroaki Nagamatsu Tadashi Yamaguchi Shuichiro Shiina Department of Gastroenterology Juntendo UniversityTokyoJapan Center for Frontier Medical Engineering Chiba UniversityChibaJapan

Percutaneous ablation under imaging guidance is a curative treatment that can induce complete tumor necrosis with advantages of minimal invasiveness and a low risk of *** ablation,which includes radiofrequency ablation and microwave ablation,is a representative technique that has sufficient antitumor effects in cases of hepatocellular carcinoma with≤3 lesions measuring≤3 cm and preserved liver *** short-and long-term outcomes of patients are comparable with those achieved with surgical *** their nonmalignant nature,some benign liver tumors require treatment for symptoms caused by the presence of the tumor and/or continuous *** may be the treatment of choice because it has lower burden on patients than surgical *** review describes the recent concepts,progress,and limitations of ablation-based treatment for benign liver tumors.

关键词： Liver tumor Radiofrequency ablation Microwave ablation Benign

Long-term survival of the Sister Mary Joseph nodule originating from breast cancer:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8205-8211页

作者： Koji Kanayama maki Tanioka Yoshitsugu Hattori Takuya Iida Mutsumi Okazaki Department of Plastic and Reconstructive Surgery The University of TokyoTokyo 113-8655Japan Department of Medical Oncology National Cancer Center HospitalTokyo 104-0045Japan

BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced *** typically originate from intra-abdominal sources,rarely from breast *** suggests a poor prognosis with a median survival of approximately 8 mo after *** patients with SMJNs is challenging,as most receive limited palliative care *** optimal strategy for long-term survival of these patients remains *** SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical *** years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph *** umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional *** initial removal,the nodule recurred and grew,leading to her referral to our *** patient underwent extensive excision of the umbilical tumor and immediate abdominal wall *** therapy was continued *** years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN *** This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive *** presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment *** findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive *** approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.

关键词： Sister Mary Joseph nodule Breast cancer Cutaneous metastasis Long-term survival Abdominal wall reconstruction Case report

Anthropogenic Pedofeature in Andosols in Santome Shinden, One of the Representative Sites of the Satoyama Environment in Japan

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Open Journal of Soil Science 2022年第12期12卷 586-604页

作者： Takao Shibusawa Kenji Tamura maki Asano Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Tsukuba Center Japan International Cooperation Agency Tsukuba Japan Faculty of Life and Environmental Sciences University of Tsukuba Tsukuba Japan

Santome Shinden, a representative site of the Satoyama landscape in Japan, has its origins in 1696 when the common land of wild grass on the Musashino plateau was developed into a strip-shaped land division, which consists of residential area, upland field, and secondary forest. We investigated soils with different land use over 300 years;they are under the secondary forest, and in the upland field where fallen leaves compost derived from secondary forest has been applied continuously for about 300 years since the development. The measured exchangeable cation values suggested that the nutrients in the secondary forest were taken out to the field as fallen leaves. On the surface layer of the upland field soil, characteristic granules of dark brown coated peds (DBC peds) were developed strongly. However, on the surface layer of the secondary forest soil, the DBC peds were not found. Electron probe micro analyzer analysis showed that the outside (dark brown part) of the DBC peds, which was observed only in the upland fields was rich in carbon. The dark brown coated pedofeature was suggested to have an anthropogenic effect due to the long-term application of fallen leaves compost. The anthropogenic activities, which were fallen leaves compost application and cultivation for about 300 years, were thought to affect the soil micromorphology. Therefore, the peds newly found in the Santome shinden field were considered to be a soil microstructure that symbolizes anthropogenic activities.

关键词： Anthropogenic Pedofeature Fallen Leaves Compost Long-Term Cultivation Satoyama Soil Micromorphology

Direct ethanol production from rice straw by coculture with two high-performing fungi

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 139-145页

作者： maki TAKANO Kazuhiro HOSHINO Graduate School of Science and Engineering University of Toyama Toyama 930-8555 Japan

To develop efficient and economical direct ethanol production from fine rice straw crashed mechanically, two high-performing fungi, which can secret hyperactive cellulases and/or ferment effectively various sugars, were selected from some strains belong to Mucor circinelloides preserved in our laboratory. The simultaneous saccharification and fermentation （SSF） by coculture with these fungi was investigated. The screening of high- performing fungi resulted in the selection of NBRC 4572 as an ethanol-producing fungus and NBRC 5398 as a cellulase-secreting fungus. The strain 4572 produced ethanol aerobically from glucose and xylose in high yields of 0.420 g/g at 36 h and 0.478 g/g at 60 h, respectively, but secreted fairly low cellulases. On the other hand, the strain 5398 also produced ethanol from glucose in yield of 0.340 g/g though it had a little growth in xylose culture. However, it secreted hyperactive cellulases that are essential for hydrolysis of rice straw in culture and the maximum activities of endo-β-glucanase and β-glucosi- dase were 2.11 U/L and 1.47 U/L, respectively. In SSF of rice straw by coculture with two fungi selected, the ethanol production reached 1.28 g/L after 96 h when the inoculation ratio of the strain 5398 to the strain 4572 was 9.

关键词： Mucor circinelloides ethanol production cellulase secretion SSF coculture rice straw

Antibodies in celiac disease:implications beyond diagnostics

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Cellular & Molecular Immunology 2011年第2期8卷 103-109页

作者： Sergio Caja Markku maki Katri Kaukinen Katri Lindfors Pediatric Research Centre University of Tampere and Tampere University HospitalTampereFinland Medical School University of Tampere and Department of Gastroenterology and Alimentary Tract SurgeryTampere University HospitalTampereFinland

Celiac disease is a multisystemic dietary,gluten-induced autoimmune disorder characterized by the presence of transglutaminase(TG)2 serum *** autoantibodies targeting members of the TG family(TG2,TG3 and TG6)are found deposited in small-bowel mucosa and in extraintestinal tissues affected by the *** autoantibodies against other self-antigens also emerge in untreated celiac disease *** villous atrophy and crypt hyperplasia in small-bowel biopsy samples are still the gold standards in diagnostics,celiac disease-specific antibodies are widely used as diagnostic ***-induced small-bowel mucosal T-cell response is the cornerstone in the pathogenesis of the disorder,but humoral immunity may also play a central *** review article is focused on the autoantibodies that occur in the context of celiac *** article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease.

关键词： antibody celiacdisease diagnostics pathogenesis

Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein

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Science China(Life Sciences) 2011年第8期54卷 770-779页

作者： Masatoshi maki Hironori SUZUKI Hideki SHIBATA Department of Applied Molecular Biosciences Graduate School of Bioagricultural SciencesNagoya University Structural Biology Research Center Photon FactoryInstitute of Materials Structure ScienceHigh Energy Accelerator Research Organization

ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical ***-2 is the most conserved protein among the PEF family members and its homologs are widely found in eukaryotes.X-ray crystal structures of various PEF proteins including ALG-2 have common features:presence of eightα-helices and dimer formation via paired EF5s that are positioned in anti-parallel ***-2 forms a homodimer and a heterodimer with its closest paralog *** calmodulin,a well-known four-EF-hand protein,ALG-2 interacts with various proteins in a Ca2+-dependent fashion,but the binding motifs are completely *** some exceptions,ALG-2-interacting proteins commonly contain Pro-rich regions,and ALG-2 recognizes at least two distinct Pro-containing motifs:PPYP(X) nYP(X,variable;n=4 in ALIX and PLSCR3) and PXPGF(represented by Sec31A) .A shorter alternatively spliced isoform,lacking two residues and designated ALG-2 GF122,does not bind ALIX but maintains binding capacity to Sec31A.X-ray crystal structural analyses have revealed that binding of calcium ions induces the configuration of the side chain of R125 so that it opens Pocket 1,which accepts PPYP,but Pocket 1 remains closed in the case of ALG-2 ***-2 dimer has two ligand-binding sites,each in a monomer molecule,and appears to function as a Ca2+-dependent adaptor protein to either stabilize a preformed complex or to bridge two proteins on scaffolds in systems of the endosomal sorting complex required for transport(ESCRT) and ER-to-Golgi transport.

关键词：晶体结构分析钙蛋白酶 ALG 接头异源二聚体蛋白相互作用手型选择性剪接