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The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL magdy myoussef AHMED EL-SEBAIE SHERIF REFAAT AFAF EL-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,p<0.001)and dominant(GT+TT ***,OR=5.4,p<0.001)*** cyclophosphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

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Performance Assessment of a Real PV System Connected to a Low-Voltage Grid

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Energy Engineering 2024年第1期121卷 13-26页

作者： Gaber magdy Mostafa Metwally Adel A.Elbaset Esam Zaki Electrical Engineering Department Faculty of Energy EngineeringAswan UniversityAswanEgypt `2Faculty of Engineering King Salman International UniversityEl-Tor46511Egypt Electrical Engineering Department Faculty of EngineeringMinia UniversityMiniaEgypt Department of Electromechanics Engineering Faculty of EngineeringHeliopolis UniversityCairoEgypt Computer Department Faculty of EngineeringModern Academy of Engineering&TechnologyCairoEgypt

The generation of photovoltaic(PV)solar energy is increasing continuously because it is renewable,unlimited,and clean *** the past,generation systems depended on non-renewable sources such as oil,coal,and ***,this paper assesses the performance of a 51 kW PV solar power plant connected to a low-voltage grid to feed an administrative building in the 6th of October City,*** performance analysis of the considered grid-connected PV system is carried out using power system simulator for Engineering(PSS/E)*** the PSS/E program,monitors and uses the power analyzer that displays the parameters and measures some parameters such as current,voltage,total power,power factor,frequency,and current and voltage harmonics,the used inverter from the type of grid inverter for the considered *** results conclude that when the maximum solar radiation is reached,the maximum current can be obtained from the solar panels,thus obtaining the maximum power and power *** total voltage harmonic distortion,a current harmonic distortion within permissible limits using active harmonic distortion because this type is fast in processing up to 300 *** connection between solar stations and the national grid makes the system more efficient.

关键词： Low-voltage grid photovoltaic(PV)system total harmonic distortion grid-connected PV system

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Enable Excel-Based Basic Cybersecurity Features for End Users by Using Python-Excel Integration

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Journal of Software Engineering and Applications 2024年第6期17卷 522-529页

作者： Mohamed Breik Osama magdy Essam Amin Tarek Aly Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Cairo Egypt

In the digital age, the global character of the Internet has significantly improved our daily lives by providing access to large amounts of knowledge and allowing for seamless connections. However, this enormously interconnected world is not without its risks. Malicious URLs are a powerful menace, masquerading as legitimate links while holding the intent to hack computer systems or steal sensitive personal information. As the sophistication and frequency of cyberattacks increase, identifying bad URLs has emerged as a critical aspect of cybersecurity. This study presents a new approach that enables the average end-user to check URL safety using Microsoft Excel. Using the powerful VirusTotal API for URL inspections, this study creates an Excel add-in that integrates Python and Excel to deliver a seamless, user-friendly interface. Furthermore, the study improves Excel’s capabilities by allowing users to encrypt and decrypt text communications directly in the spreadsheet. Users may easily encrypt their conversations by simply typing a key and the required text into predefined cells, enhancing their personal cybersecurity with a layer of cryptographic secrecy. This strategy democratizes access to advanced cybersecurity solutions, making attentive digital integrity a feature rather than a daunting burden.

关键词： Python End-User Approach Excel Excel Add-In Cybersecurity URL Check API Virustotal API Encryption Decryption Vigenère Cipher Python-Excel Integration

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Enhancing Data Analysis and Automation: Integrating Python with Microsoft Excel for Non-Programmers

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Journal of Software Engineering and Applications 2024年第6期17卷 530-540页

作者： Osama magdy Ali Mohamed Breik Tarek Aly Atef Tayh Nour El-Din Raslan Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Giza Egypt

Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.

关键词： Python End-User Approach Microsoft Excel Data Analysis Integration Spreadsheet Programming Data Visualization

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Sodium-Glucose Cotransporter-2 Inhibitors: Who, When & How? Guidance for Use from a Multidisciplinary Practical Approach

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International Journal of Clinical Medicine 2024年第9期15卷 413-435页

作者： Khalifa Abdullah magdy ElSharkawy Emad R. Issak Ahmed Shawky ElSerafy Samah Idris Ahmed Bendary Haytham Reda Badr May Shehata Ashraf Reda Internal Medicine Department Diabetes & Metabolism Unit Faculty of Medicine Alexandria University Alexandria Egypt Nephrology Department Faculty of Medicine Ain Shams University Cairo Egypt Internal Medicine Department Faculty of Medicine Ain Shams University Cairo Egypt Cardiology Department Faculty of Medicine Ain Shams University Cairo Egypt Internal Medicine and Nephrology Department Faculty of Medicine Alexandria University Alexandria Egypt Cardiology Department Faculty of Medicine Benha University Benha Egypt Internal Medicine Department Diabetes and Endocrinology Unit Faculty of Medicine Menoufia University Menoufia Egypt Product Manager Al-Esraa Pharma Cairo Egypt Cardiology Department Faculty of Medicine Menoufia University Menoufia Egypt

Sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) have transformed diabetes management by targeting renal glucose reabsorption. Designed initially as antidiabetic agents, their ability to lower blood glucose levels independently of insulin is well-documented. Beyond glycemic control, emerging research has unveiled their profound cardiorenal benefits. By inhibiting SGLT-2 protein, these drugs enhance glucose excretion in urine, reducing blood glucose levels. This mechanism has translated into significant cardiovascular and renal protection, establishing SGLT-2 inhibitors as pivotal in managing not only diabetes but also cardiovascular and renal diseases. Recent studies have illuminated the broader therapeutic potential of SGLT-2 inhibitors beyond diabetes. Evidence indicates their efficacy in managing heart failure, chronic kidney disease (CKD), and cardiovascular complications in individuals with or without diabetes. This expanded therapeutic landscape has catalyzed a paradigm shift in SGLT-2 inhibitor use, positioning them as key agents in the cardiorenal metabolic continuum. Moreover, their role in the secondary prevention of cardiovascular events and slowing CKD progression in T2DM patients has garnered considerable attention. This consensus-based review aims to offer practical guidance in an algorithmic approach to primary care healthcare professionals to optimize SGLT-2 inhibitors utilization and maximize their benefits. The review seeks to empower clinicians to effectively manage patients who may benefit from SGLT-2 inhibitor therapy by addressing common initiation barriers and optimizing treatment strategies. Additionally, it aims to raise awareness among primary care physicians regarding the multifaceted benefits of these medications and overcome clinical inertia in their adoption into routine clinical practice.

关键词： Sodium-Glucose Cotransporter-2 Inhibitors Cardiorenal Benefits Therapeutic Potential Cardiovascular Protection Primary Care Optimization

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Linear instability of the electrified free interface between two cylindrical shells of viscoelastic fluids through porous media

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Acta Mechanica Sinica 2012年第6期28卷 1572-1589页

作者： magdy A. Sirwah Department of Mathematics Faculty of Science Tanta University

In this paper, we have discussed the linear stabil- ity analysis of the electrified surface separating two coaxial Oldroyd-B fluid layers confined between two impermeable rigid cylinders in the presence of both interfacial insoluble surfactant and surface charge through porous media. The case of long waves interfacial stability has been studied. The dispersion relation is solved numerically and hence the ef- fects of various parameters are illustrated graphically. Our results reveal that the influence of the physicochemical pa- rameterβ is to shrink the instability region of the surface and reduce the growth rate of the unstable normal modes. Such important effects of the surfactant on the shape of in- terfacial structures are more sensitive to the variation of the βcorresponding to non-Newtonian fluids-model compared with the Newtonian fluids model. In the case of long wave limit, it is demonstrated that increasing r, has a dual role in- fluence （de-stabilizing effects） depending on the viscosity of the core fluid. It has a destabilizing effect at the large values of the core fluid viscosity coefficient, while this role is ex- changed to a regularly stabilizing influence at small values of such coefficient.

关键词： Modified Darcy's law Oldroyd-B model Cap-illary stability flow Insoluble surfactant Surface charges Porous media

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Effective Control of Smart Hybrid Power Systems:Cooperation of Robust LFC and Virtual Inertia Control Systems

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CSEE Journal of Power and Energy Systems 2022年第6期8卷 1583-1593页

作者： Gaber magdy Hossam Ali Dianguo Xu Electrical Engineering Department Faculty of Energy EngineeringAswan UniversityAswan 81528Egypt Institute of Technology HarbinHeilongjiang 150001Chinaand Electrical Engineering DepartmentFaculty of Energy EngineeringAswan UniversityAswan 81528Egypt Harbin Institute of Technology HarbinHeilongjiang 150001China

A modern power system is expected to consist primarily of renewables,which either lack or have less rotating masses(i.e.,source of inertia)compared to the traditional generation ***,the growth of renewables generation,based on power electronics,can substantially decrease the inertia levels of renewable power grids,which can create several frequency stability issues,resulting in power system *** address this issue,this paper presents a recent virtual inertia scheme predicated on electric vehicles(EVs)to mimic the necessary inertia power in low-inertia smart hybrid power systems(SHPSs),thus regulating the system frequency and avoiding system ***,to guarantee robust performance and more stability for SHPSs against multiple perturbations,system uncertainties,and physical constraints,this paper also proposes a robust control strategy relying on a coefficient diagram method(CDM)for the load frequency control(LFC)of SHPSs considering high renewables penetration and *** efficacy of the proposed system(i.e.,robust LFC with the proposed VIC strategy)is validated by comparison with a conventional LFC with/without the proposed VIC *** addition,the simulation outcomes show that the proposed system can considerably support smart low-inertia hybrid power systems for many different contingencies.

关键词： Electric vehicles renewable energy sources robust frequency control smart hybrid power system virtual inertia control

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Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome

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World Journal of Gastroenterology 2020年第13期26卷 1427-1438页

作者： magdy El-Salhy Section for Gastroenterology Department of MedicineStord HospitalStord 5409Norway Department of Clinical Medicine University of BergenBergen 5021Norway

The pathophysiology of irritable bowel syndrome(IBS)is not completely ***,several factors are known to play a role in pathophysiology of IBS such as genetics,diet,gut microbiota,gut endocrine cells,stress and low-grade *** the pathophysiology of IBS may open the way for new treatment *** density of intestinal stem cells and low differentiation toward enteroendocrine cells has been reported recently in patients with *** abnormalities are believed to be the cause of the low density of enteroendocrine cells seen in patients with *** cells regulate gastrointestinal motility,secretion,absorption and visceral *** dysmotility,abnormal absorption/secretion and visceral hypersensitivity are all seen in patients with IBS and haven been attributed to the low density the intestinal enteroendocrine cells in these *** present review conducted a literature search in Medline(Pub Med)covering the last ten years until November 2019,where articles in English were *** about the intestinal stem cells and their possible role in the pathophysiology of IBS are discussed in the present *** present review discusses the assumption that intestinal stem cells play a central role in the pathophysiology of IBS and that the other factors known to contribute to the pathophysiology of IBS such as genetics,diet gut microbiota,stress,and lowgrade inflammation exert their effects through affecting the intestinal stem *** reports further the data that support this assumption on genetics,diet,gut microbiota,stress with depletion of glutamine,and inflammation.

关键词： Diet Gut enteroendocrine cells Gut microbiota Low grade inflammation Stress

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Fractional thermoelasticity applications for porous asphaltic materials

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Petroleum Science 2016年第3期13卷 550-560页

作者： magdy Ezzat Shereen Ezzat Department of Mathematics Faculty of Science and Letters in Al Bukayriyyah Al-Qassim University Faculty of Education Alexandria University

A new mathematical model of poro-thermoelasticity has been constructed in the context of a new consideration of heat conduction with fractional ***-dimensional application for a poroelastic half-space saturated with fluid is *** surface of the halfspace is assumed to be traction-free,permeable,and subjected to *** Laplace transform technique is used to solve the *** inversion of the Laplace transform will be obtained numerically and the numerical values of the temperature,stresses,strains,and displacements will be illustrated graphically for the solid and the liquid.

关键词： Generalized thermo-poroelasticity Asphaltic material Thermal shock Fractional calculus Numerical results

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Recent developments in the pathophysiology of irritable bowel syndrome

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World Journal of Gastroenterology 2015年第25期21卷 7621-7636页

作者： magdy El-Salhy Section for Gastroenterology Department of Medicine Stord Hospital Section of Neuroendocrine Gastroenterology Division of Gastroenterology Department of Clinical MedicineUniversity of Bergen National Centre for Functional Gastrointestinal Disorders Department of Medicine Haukeland University Hospital

Irritable bowel syndrome(IBS) is a common gastrointestinal disorder, the pathophysiology of which is not completely known, although it has been shown that genetic/social learning factors, diet, intestinal microbiota, intestinal low-grade inflammation, and abnormal gastrointestinal endocrine cells play a major role. Studies of familial aggregation and on twins have confirmed the heritability of IBS. However, the proposed IBS risk genes are thus far nonvalidated hits rather than true predisposing factors. There is no convincing evidence that IBS patients suffer from food allergy/intolerance, with the effect exerted by diet seemingly caused by intake of poorly absorbed carbohydrates and fiber. Obesity is a possible comorbidity of IBS. Differences in the microbiota between IBS patients and healthy controls have been reported, but the association between IBS symptoms and specific bacterial species is uncertain. Low-grade inflammation appears to play a role in the pathophysiology of a major subset of IBS, namely postinfectious IBS. The density of intestinal endocrine cells is reduced in patients with IBS, possibly as a result of genetic factors, diet, intestinal microbiota, and low-grade inflammation interfering with the regulatory signals controlling the intestinal stem-cell clonogenic and differentiation activities. Furthermore, there is speculation that this decreased number of endocrine cells is responsible for the visceral hypersensitivity, disturbed gastrointestinal motility, and abnormal gut secretion seen in IBS patients.

关键词： Diet Endocrine cells Genetic factors Low-grade inflammation Microbiota Stem cells

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